[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-osteoarthritis":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,257,0,25,[9,51,83,107,138,159,176,202,229,254,280,298,330,351,378,400,420,446,472,493,517,539,568,591,611],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643683","prospective-case-series-evaluating-6-month-and-12-month-outcomes-after-cryoneurolysis-for-chronic-pain-100643683",false,"NCT07639060","Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain","Inclusion Criteria:\n\n* Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.\n* Planned cryoneurolysis procedure as part of standard clinical care.\n* Ability to provide written informed consent.\n* Ability and willingness to complete baseline and follow-up questionnaires.\n\nExclusion Criteria:\n\n* Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.\n* Active infection or other clinical contraindication to the procedure as determined by the treating clinician.\n* Life expectancy of less than 12 months in the judgment of the treating clinician.\n* Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.",[24,25,26,27,28,29,30,31,32,33,34,35,36,37],"Chronic Pain","PERIPHERAL NEUROPATHY","Occipital Neuralgia","Chronic Hip Pain","Hip Osteoarthritis","Knee Osteoarthritis","Spasticity","Chronic Low Back Pain","Lumbar Spondylosis","Cervical Spondylosis","Shoulder Arthritis","Causalgia","Chronic Pain Syndrome","Chronic Neck Pain","RECRUITING","2026-08-19",{"date":41,"type":42},"2026-08-21","ACTUAL",{"date":44,"type":42},"2026-06-20",{"date":46,"type":20},"2028-07",{"name":48,"class":49},"Yale University","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100479739","evaluating-the-effect-of-adipose-tissue-processed-with-the-syntrfuge-system-for-knee-osteoarthritis-100479739","NCT05526898","Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis","Multi-Center, Randomized Controlled Trial Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis","Inclusion Criteria\n\n* Subjects aged of 35-80 years old\n* Patients with knee osteoarthritis grade II, III, and IV Kellgren-Lawrence\n* Chronic knee pain or symptoms for at least 3 months\n* BMI between 20 and 34.9\n* Willing and able to read and sign the informed consent and other study materials\n* Written informed consent has been obtained prior to any study-related procedures\n* Written Authorization for Use and Release of Health and Research Study Information has been signed\n* Subjects are ambulatory\n* Subject is willing and able to comply with study instructions and commit to all follow-up visits for the duration of the study\n* Females of childbearing potential must have a negative urine pregnancy test result and not be lactating\n* Subject is in good general health and free of any systemic disease state or physical condition that might impair evaluation or which in the Investigator's opinion, exposes the Subject to an unacceptable risk by study participation\n\nExclusion Criteria:\n\n* Subjects with previous traumatic lesion (tibial fracture, osteothomy) of the knee\n* Subjects with osteonecrosis\n* Subjects with meniscal surgery in the previous 6 weeks\n* Subjects with gout, hyperlipidemia\n* Subjects without decisional capacity\n* Subjects with inflammatory arthritis\n* Subjects with active infection\n* Subjects with any uncontrolled systemic disease\n* Subjects with a history of severe allergic\u002Fanaphylactic reactions or multiple allergies\n* Subjects planning to become pregnant, are pregnant, or are breast-feeding\n* Subjects with history or current evidence of drug or alcohol abuse within 36 months prior to screening visit\n* Subjects who have active autoimmune disease\n* Subjects who have coagulation disorders\n* Subjects who have received any other therapy, which, in the opinion of the investigator, could interfere with safety or efficacy evaluations\n* Subjects with current enrollment in an investigational drug or device study or participation in such a study within 30 days of entry into this study\n* Subjects with any other condition that, in the opinion of the investigator, makes the subject inappropriate to take part in this study\n* Subjects who have received anti-coagulation, anti-platelet, or thrombolytic medications (e.g., warfarin), anti- inflammatory drugs (NSAIDs, e.g., aspirin, ibuprofen), or other substances known to increase coagulation time from 7 days pre- to 3 days post injection. A wash out period of 7 days is allowed\n* Subjects who have undergone immunosuppressive therapy, chemotherapy, biologics or systemic corticosteroids within 3 months prior to each study visit.\n* No intra-articular injection of corticosteroids within the last 24 weeks\n* No intra-articular injection of any other cellular therapy within the last 24 weeks",true,"70 Years",{"count":61,"type":20},180,"INTERVENTIONAL",[64],"NA","This is an multi-center study with the aim of evaluating the efficacy of adipose tissue processed with the SyntrFuge™ system in Orthopedic Surgery, specifically Knee Osteoarthritis. Patients will be enrolled to the treatment group with adipose tissue processed with the SyntrFuge™ system followed by an injection of autologous microsized adipose tissue in the treatment sites or Standard of Care.",[29],[68,69,70,29,71],"Microsized Fat Tissue","Adipose Tissue","Fat Transfer","Orthopedic Surgery","NOT_YET_RECRUITING",{"date":74,"type":42},"2026-08-20",{"date":76,"type":20},"2027-12-01",{"date":78,"type":20},"2030-12",{"name":80,"class":81},"Syntr Health Technologies, Inc.","INDUSTRY",2,{"id":84,"slug":85,"hasResults":12,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":16,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":62,"phases":91,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":50},"100630989","images-identifying-metabolic-imaging-association-with-genicular-artery-embolization-success-100630989","NCT07494838","IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success","Inclusion Criteria:\n\n* Provided informed consent\n* Age ≥ 40 years\n* Ineligibility for or refusal of surgical management\n* Moderate-severe knee pain as determined by visual analog scale \\> 5 out of 10\n* Osteoarthritis based on X-ray. Kellgren-Lawrence score \\> 2 based on radiograph completed within 3 months of procedure date\n* Resistant\u002Ffailed some form of conservative treatment (e.g. NSAIDS\u002Fphysical therapy\u002Fsteroid joint injection\u002Fhyaluronic acid joint injection) for at least 3 months\n* Able to comply with all treatments and protocol follow-up visits\n\nExclusion Criteria:\n\n* Mild knee pain as determined by visual analog scale \\\u003C 5 out of 10\n* OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation\n* Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL\u002Fmin.\n* Significant arterial atherosclerosis that would limit selective angiography\n* History of fibromyalgia, autoimmune, or inflammatory disorder\n* History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine\n* Allergy to iodinated contrast agents\n* Active infection or malignancy\n* Recent (within 12 months) or active cigarette use\n* Prior total or partial knee replacement in the subject knee\n* Active pregnancy\n* Uncorrectable bleeding diathesis\n* Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET\u002FMRI","40 Years",{"count":7,"type":20},[64],"Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography\u002Fmagnetic resonance imaging (PET\u002FMRI) system in subjects undergoing GAE.",[29,94,95,96],"Knee Discomfort","Knee Pain Chronic","Knee Swelling Pain",[98],"GAE","2026-08-17",{"date":39,"type":42},{"date":102,"type":20},"2026-12-30",{"date":104,"type":20},"2027-06-30",{"name":106,"class":49},"Lucas R. Cusumano, MD",{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":62,"phases":117,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":130,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":50},"100604584","phase-2-use-of-corticosteroid-in-intraopertive-injections-in-total-knee-replacement-surgery-100604584","NCT07151417","Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.","Adjunctive Use of Corticosteroid in Periarticular Injections in Primary Total Knee Arthroplasty","TKACSI","Inclusion Criteria:\n\n* Patients within the MHS who are DEERS eligible undergoing primary TKA at Walter Reed National Military Medical Center (WRNMMC), Surgery Center of Chevy Chase or District Surgery Center\n* Age 18 or older\n* successful surgical intervention\n\nExclusion Criteria:\n\n* Unicompartmental knee arthroplasty (UKA)\n* Revision total knee arthroplasty (rTKA)\n* Females who are pregnant or nursing\n* Allergic to ingredients in PAI or previous adverse reaction to steroids being used in this study\n* Diabetics will be excluded from Group 2 (standard PAI + methylprednisolone)",{"count":116,"type":20},240,[118,119],"PHASE2","PHASE3","The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury.\n\nThe main questions it aims to answer are:\n\nDoes adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)?\n\nResearchers will compare:\n\nStandard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function.\n\n(Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.)\n\nParticipants will:\n\nBe randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint\n\nBe followed after surgery to measure:\n\nPain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function",[29,122,123],"Musculoskeletal Disease","Surgery",[125,126,127,128,129],"total knee arthroplasty (TKA)","manipulation under anesthesia (MUA)","corticosteroid","periarticular injection\u002Fpericapsular injection (PAI)","zilretta",{"date":39,"type":42},{"date":132,"type":20},"2026-09-01",{"date":134,"type":20},"2027-08-31",{"name":136,"class":137},"Walter Reed National Military Medical Center","FED",{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":16,"minAge":145,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":62,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":50},"100652338","formative-evaluation-of-a-mobile-application-facilitated-self-directed-rehabilitation-programme-for-knee-osteoarthritis-100652338","NCT07773480","Formative Evaluation of a Mobile Application Facilitated Self-directed Rehabilitation Programme for Knee Osteoarthritis","Formative Evaluation of a Mobile Application Facilitated Self-Directed Rehabilitation Programme for the Conservative Management of Knee Osteoarthritis","Inclusion Criteria:\n\n* Meet the National Institute for Health and Care Excellence (NICE) osteoarthritis clinical criteria (7)\n* aged 45 years and over\n* activity related knee joint pain\n* morning stiffness ≤30 min\n* History of knee pain on most days for ≥3 months\n* Able to give informed consent and to participate fully in the interventions and assessment procedures\n* Has a smartphone and be willing to use it during the study.\n* Able to share photos\u002F videos with other phone contacts using smartphone\n\nExclusion Criteria:\n\n* Patients who meet any of the exclusion criteria mentioned below will be excluded from participation.\n* Rheumatoid arthritis and other systemic arthritis\n* A previous history of stroke and other major neurological conditions\n* An intention to undergo knee joint replacement surgery or have had a knee joint replacement\n* Has significant back or other non-knee pain","45 Years",{"count":147,"type":20},30,[64],"In Singapore, knee osteoarthritis (OA) is a prevalent musculoskeletal condition, reflecting global trends of an aging population and lifestyle factors. With Singapore's rapidly aging population and the rising prevalence of obesity and sedentary lifestyles, knee OA has become increasingly common. According to recent studies, symptomatic OA of the knee affects around one-fifth (\\~300K) of Singaporeans aged 50 years or older. Individuals with advanced knee OA and severe disability often require a total knee replacement (TKR) surgery. While knee replacement surgery is an effective option for severe knee OA, it is costly and there are risks of complications, and should only be considered when all appropriate non-surgical treatment options have been exhausted. Existing research suggests at least a quarter of knee replacements could have been avoided through more optimal conservative treatments.\n\nDespite established healthcare systems and treatment pathways, studies in several settings report that the majority of patients with OA do not receive appropriate and optimal medical care. In Singapore, several factors such as cost, extended wait times, cultural factors and travel inconvenience pose barriers to accessing physiotherapy services. These factors hinder patients' ability to access care resulting in suboptimal care, poor outcomes, and needless economic burden. Thus, there is a large unmet need for innovative and flexible strategies to deliver effective conservative management and treatment for knee OA widely and at a relatively low cost.\n\nSolutions that empower individuals and allow for self-directed rehabilitation without the need for real-time human supervision could be the key to improve effectiveness, accessibility and reduce the reliance on healthcare manpower. Given the prevalence of mobile phone, mobile applications offer a promising avenue for delivering self-directed rehabilitation programs to adults with knee OA. Previous self-directed rehabilitation programs for patients with knee OA have shown promise, however, the adoption and adherence to these programmes remain low, particularly among older adults who may not be technologically savvy. Developing an application that is tailored to the needs and capabilities of older adults with knee osteoarthritis is crucial to improve engagement and long-term adherence to the programme.\n\nThe investigators have previously developed a technology-enabled self-directed rehabilitation program for patients who have undergone TKR for primary knee OA. Subsequently, Managing Osteoarthritis of the knee using Therapist-Technology Optimized Rehabilitation (MO-knee-TOR) - a standalone mobile app to facilitate self-directed rehabilitation and complement a \"blended\" care approach involving an initial face-to-face session with the physiotherapist was developed. MO-knee-TOR was developed for patients with TKR and subsequently evaluated in 2 pilot randomised controlled trials (RCTs). In one of the RCTs, it was found that self-directed rehabilitation post TKR facilitated using the mobile application improved exercise adherence without compromising safety and clinical outcomes. In this current proposal, MO-knee-TOR is adapted for conservative knee OA management through a single-arm pre-post feasibility study with a nested qualitative component.",[29],"2026-08-14",{"date":39,"type":42},{"date":154,"type":20},"2026-08-01",{"date":156,"type":20},"2027-12-31",{"name":158,"class":49},"Singapore General Hospital",{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":12,"sex":16,"minAge":145,"maxAge":59,"enrollmentInfo":165,"targetDuration":4,"studyType":62,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":172,"leadSponsor":174,"locationsCount":50},"100652330","efficacy-of-ai-driven-and-traditional-physical-therapy-programs-in-patients-with-knee-osteoarthritis-100652330","NCT07774195","Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Participants will be recruited through outpatient orthopedic clinics and community health centers affiliated with the study sites.\n* Their age will be ranged from 45-70 years.\n* Their body mass index (BMI) will be ranged from 24.9 to 30 kg \u002Fm2 .\n* With a clinical and radiographic diagnosis of knee osteoarthritis based on American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis, and who will able to ambulate\n* Independently walk without assistive devices.\n\nExclusion Criteria:\n\n* Prior knee replacement surgery, inflammatory arthritis (e.g., rheumatoid arthritis).\n* Recent intra-articular steroid injections within three months.\n* Neurologic impairments affecting lower limb function.\n* Inability to comprehend or use the mobile application due to cognitive or sensory impairments.",{"count":166,"type":20},40,[64],"This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.\n\nForty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.\n\nBoth groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.\n\nThe study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.",[29],{"date":39,"type":42},{"date":41,"type":20},{"date":173,"type":20},"2026-11-30",{"name":175,"class":49},"Cairo University",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":16,"minAge":145,"maxAge":4,"enrollmentInfo":184,"targetDuration":185,"studyType":21,"phases":4,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":50},"100647638","sonographic-thigh-adjustment-ratio-and-subcutaneous-fat-thickness-as-predictors-of-genicular-nerve-block-response-in-knee-osteoarthritis-100647638","NCT07712419","Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis","Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Patients With Knee Osteoarthritis Undergoing Genicular Nerve Block: A Prospective Observational Study","STAR-GNB","Inclusion Criteria:\n\n* Age ≥45 years.\n* Symptomatic bilateral knee osteoarthritis with Kellgren-Lawrence grade 3 or 4.\n* Visual Analog Scale (VAS) pain score ≥4 at rest or during movement.\n* Scheduled to undergo first ultrasound-guided genicular nerve block.\n* No intra-articular knee injection within the previous 3 months.\n* Considered unsuitable for or awaiting total knee arthroplasty.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Inflammatory arthritis, rheumatoid arthritis, or crystal arthropathy.\n* Previous knee surgery or knee prosthesis.\n* Active local or systemic infection.\n* Anticoagulant therapy or bleeding disorders.\n* Contraindication to corticosteroids (including uncontrolled diabetes mellitus).\n* Allergy to study medications.\n* Neurological disorders causing neuropathic knee pain.\n* Dementia or inability to complete study assessments.\n* Additional interventional procedures or surgery during follow-up.",{"count":147,"type":20},"3 Months","Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably. Identifying imaging biomarkers that predict clinical response may improve patient selection and optimize treatment outcomes.\n\nThis prospective observational study aims to evaluate whether the Sonographic Thigh Adjustment Ratio (STAR), calculated as anterior quadriceps muscle thickness divided by body mass index (BMI), and subcutaneous fat thickness are associated with pain relief following genicular nerve block in patients with symptomatic knee osteoarthritis. Ultrasound measurements will be obtained before the procedure, and clinical outcomes will be assessed during follow-up. The primary objective is to determine whether sonographic muscle parameters can predict treatment response after GNB.",[29,188],"Chronic Knee Pain",[190,29,191,192],"Genicular Nerve Block","Ultrasonography","Sonographic Thigh Adjustment Ratio","2026-08-13",{"date":99,"type":42},{"date":196,"type":42},"2026-05-15",{"date":198,"type":20},"2026-11",{"name":200,"class":201},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":16,"minAge":210,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":62,"phases":213,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":4},"100634881","effect-of-ai-assisted-anatomical-visualization-on-anxiety-and-kinesiophobia-in-knee-arthroplasty-patients-100634881","NCT07545447","Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients","The Effect of AI-Assisted Anatomical Visualization Training on Anxiety and Kinesiophobia in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Study","AI-KNEE","Inclusion Criteria:\n\n* Adults aged 55 years and older\n* Patients scheduled for elective total knee arthroplasty due to knee osteoarthritis\n* Able to understand and communicate in Turkish\n* Willing to participate in the study and provide written informed consent\n* No prior total knee arthroplasty on the study knee\n* Cognitively able to complete questionnaires and follow study procedures\n\nExclusion Criteria:\n\n* Patients scheduled for revision total knee arthroplasty\n* Patients with active infection\n* Presence of severe neurological or psychiatric disease (conditions that would prevent reliable application of scales)\n* Severe visual or hearing loss\n* Diagnosed dementia or cognitive impairment\n* Individuals who refused to participate in the study","55 Years",{"count":212,"type":20},150,[64],"Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration. However, it is known that surgical success is not limited to the operation itself; pre- and post-operative processes are at least as important as the surgical technique. In particular, active patient participation, early mobilization, and adherence to exercises during the rehabilitation period directly affect treatment outcomes.\n\nPatient education plays a critical role in this process. Accurate and sufficient information reduces patients' anxieties about the surgical process and increases their confidence in the recovery process. It also prevents the development of kinesiophobia (fear of movement), supporting patients in participating in physical activity more quickly and safely.\n\nPatient education can be provided through various methods. Traditional approaches include face-to-face clinical training, verbal information provided by nurses or physiotherapists, written brochures, and visual materials. While this standard clinical training is effective in conveying basic information, it may have limitations in patients' ability to recall information and adapt it to daily life.\n\nIn recent years, technology-based training methods have gained increasing importance. In particular, AI-assisted video-based anatomical visualization training can present the structure of the surgery, the placement of the prosthesis, and the movement mechanism to patients in a more understandable and visual way. Such interactive and visually rich training offers advantages in terms of increasing patients' knowledge levels, reducing anxiety, and strengthening their participation in treatment.\n\nIn conclusion, success after total knee arthroplasty depends not only on the surgical intervention but also on effective patient education. Comparing standard clinical training with AI-assisted visual training methods constitutes an important area of research for improving patient outcomes.",[29,216],"Total Knee Arthroplasty",[216,218,219,220],"AI-Assisted Training","Anxiety","Kinesiophobia","2026-08-11",{"date":193,"type":42},{"date":224,"type":20},"2026-08-15",{"date":226,"type":20},"2026-11-15",{"name":228,"class":49},"Munzur University",{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":12,"sex":16,"minAge":237,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":62,"phases":239,"briefSummary":241,"conditions":242,"keywords":243,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":252,"locationsCount":82},"100548647","phase-4-effect-of-perioperative-duloxetine-administration-on-opioid-consumption-following-total-knee-arthroplasty-relife-100548647","NCT06423716","Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)","Effect of Perioperative Duloxetine Administration on Opioid Consumption Following Total Knee Arthroplasty","RELIFE","Inclusion Criteria:\n\n1. Age \\>=50\n2. Presence of knee osteoarthritis\n3. Planned for elective unilateral total knee arthroplasty\n4. ASA I - III\n5. Baseline creatinine clearance (CrCl) ≥ 30 mL\u002Fmin within 60 days prior to enrolment, if available. If not available, verbal report from patient of no known renal disease.\n\nExclusion Criteria:\n\n1. Lack of patient consent; unlikely to comply with follow-up\n2. Presence of contraindications to study drug use:\n\n   * Known hypersensitivity to the drug or components of the product\n   * Known liver disease - history of cirrhosis, non-alcoholic steatohepatitis\n   * Uncontrolled narrow - angle glaucoma\n   * Severe renal impairment (CrCl\\\u003C30mL\u002Fmin)\n   * Concurrent use of thioridazine\n   * Concurrent use of potent CYP1A2 inhibitors (e.g. fluvoxamine) and some quinolone antibiotics (e.g. ciprofloxacin or enoxacin)\n   * Concurrent use of antidepressants (e.g. MAOI, SSRI, SNRI, TCA, St. John's Wort, buspirone)\n   * Concurrent use of triptan or lithium\n3. Chronic and high dose opioid use (\\>30mg oral morphine equivalent per day)\n4. Substance use disorder (cannabis and related products, alcohol use disorder, opioid used disorder, illicit drugs)\n5. Uncontrolled hypertension (systolic BP \\> 180mmHg)\n6. Untreated psychiatric illness (e.g. depression, suicidal ideation, bipolar disorder)\n7. Involved in worker's compensation case\u002Flaw suit (verbally declared by patient)","50 Years",{"count":212,"type":20},[240],"PHASE4","Knee replacement surgery for osteoarthritis is a commonly performed procedure in Canada with 75,000 of these surgeries performed each year. Success rate for knee replacement surgery is high but more than 20% of patients are still dissatisfied mainly due to reports of ongoing pain. Pain control following knee surgery is important in order to allow patients to engage in recovery and rehabilitation. The current standard of pain management after surgery centers around the use of opioids which is a concerning practice as highlighted by the opioid epidemic. Duloxetine is an antidepressant that has pain relieving properties and it has been studied in patients undergoing knee replacement surgery. Studies to date have not been designed optimally to demonstrate the full effects of opioid dose reduction and the use of duloxetine as a medication following knee replacement surgery. This research study seeks to start duloxetine before surgery, at the recommended therapeutic dose, and for the duration of the early rehabilitation period. If the study is successful, this low-cost medication can improve satisfaction rates and change the standard way the pain management is typically carried out for patients undergoing the knee replacement surgery.",[29],[244,245,246],"total knee arthroplasty","duloxetine","postoperative pain",{"date":248,"type":42},"2026-08-12",{"date":250,"type":42},"2024-11-01",{"date":156,"type":20},{"name":253,"class":49},"Sunnybrook Health Sciences Centre",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":16,"minAge":89,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":62,"phases":265,"briefSummary":266,"conditions":267,"keywords":268,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":278,"locationsCount":50},"100499640","diet-interventions-remitted-and-evaluated-as-complementary-treatments-for-pain-100499640","NCT05785884","Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain","Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain (DIRECTPain)","DIRECTPain","Inclusion Criteria:\n\n1. diagnosis of knee OA\n2. pain in at least 4\u002F7 days\u002Fweek for the past 3 months (pain of ≥3\u002F10 on 0-10 scale)\n3. age between 40-75\n4. average daily consumption of \\>100 g carbohydrates (based on Phase 1 food checklist)\n5. understanding of verbal and written English\n6. self-identification as either NHB or NHW\n7. BMI between 25 and 40 kg\u002Fm2\n\nExclusion Criteria:\n\n1. unmedicated diabetes\n2. unwillingness to follow prescribed diets\n3. recent weight change (\\>4 kg in past month)\n4. currently on a diet\n5. history of eating disorders or other psychiatric disorders requiring hospitalization within the past 6 months\n6. digestive diseases\n7. difficulty chewing or swallowing\n8. reliance on others for meal preparation\n9. cardiovascular or pulmonary disease\n10. daily opioid pain medications\n11. use of medications known to alter metabolism or digestion (e.g., proton-pump inhibitors)\n12. use of anti-hypertensive medications that affect glucose tolerance\n13. use of tobacco\n14. participation in extreme exercise\n15. knee replacement","75 Years",{"count":264,"type":20},200,[64],"Knee osteoarthritis (OA) is the most prevalent form of arthritis, a significant cause of disability in the U.S. With an aging population and the rise in obesity rates, the prevalence of knee OA is expected to climb, significantly reducing quality of life (QOL) for those suffering from this debilitating condition. Current national efforts to reduce analgesic utilization highlight the critical need for safe, effective, and accessible alternatives for pain relief. Low-carbohydrate diets (LCDs) reduce inflammation and pain independent of weight loss, indicating that diet interventions offer a non-pharmacological complementary treatment. However, differences exist in metabolism that are rarely addressed in diet intervention studies. Thus, it is important to assess the potential of different diets in a broad population of chronic pain sufferers to determine the potential of diets to reduce knee OA pain. We have shown that a LCD was associated with reduced evoked knee OA pain, daily pain and oxidative stress when compared to either a USDA diet or a diet-as-usual control. Both experimental diets reduced weight to a similar degree, arguing that diet quality was likely the key factor in pain reduction, as opposed to weight loss. However, previous studies comparing diets have utilized diet prescriptions with less control for adherence to the diets. To overcome this obstacle, and in line with our recent work, we will provide all snacks and meals during the diet intervention to increase adherence and retention in the study, allowing for better control over diet interventions and consistency of foods within each study group. We will recruit adults with knee OA (N=200) to complete our two-phase protocol. Phase 1 will involve a 1-week diet run-up that will allow for quantification of pain measures, psychosocial variables (socioeconomic status, nutritional knowledge, proximity to grocery stores, food insecurity), and diet quality to provide a baseline for comparison. Phase 2 will be a 6-week randomized diet intervention (LCD or USDA diet) in which both groups will be provided with all meals at the direction of study personnel and input from participants. Evoked pain tasks, measures of pain disability, severity, catastrophizing, and interference will be assessed every 3 weeks in addition to QOL measures, mood, and depression. Physiological variables will be assessed through blood draws (inflammatory profile) and dual-energy X-ray absorptiometry scans (DXA; body composition, visceral fat) at the end of Phases 1 and 2. This will be the first study to examine the efficacy of these diets to reduce knee OA pain with an emphasis on interactions with biopsychosocial variables. Changes in all pain measures following Phase 2 will be assessed with respect to published measures of clinically-meaningful differences in pain and disability, as well as for statistical significance. The central hypothesis is that the LCD will improve pain and QOL in participants with knee OA more than the USDA diet, but that both will be beneficial.\n\nSpecific Aim 1: To investigate the efficacy of the diets to reduce pain and improve QOL.\n\nHypothesis 1: The LCD group will show significantly greater reductions in: a) self-reported pain (\\>1.7 in pain intensity) and, b) evoked pain (\\>30%) when compared to the USDA diet.\n\nHypothesis 2: The LCD group will show greater improvements in: a) QOL, b) mood, and c) self-reported improvement (\\>50% participants reporting \"much improved\" or \"very much improved\").\n\nHypothesis 3 (secondary): Both diets will result in improved pain disability, severity, catastrophizing and pain related fear; the LCD will outperform the USDA diet.\n\nSpecific Aim 2: To explore individual differences in diet and baseline measures.\n\nHypothesis 1: Baseline diet quality will be negatively associated with baseline pain sensitivity Hypothesis 2: Those reporting greater a) food insecurity and\u002F or b) proximity to grocery stores will report poorer-quality diets.\n\nSpecific Aim 3: To determine whether physiological variables contribute to diet effects or lack thereof. Hypothesis 1: Baseline physiological measures (inflammatory profile) will predict: a) pain sensitivity, and b) reductions in pain.\n\nHypothesis 2: Change in physiological measures (inflammatory profile, adiposity, leptin) will be related to: a) change in pain measures, b) change in QOL, c) self-reported improvement and, d) mood.",[29],[269,270,271,272],"diet","chronic pain","knee osteoarthritis","racial differences","2026-08-10",{"date":248,"type":42},{"date":276,"type":42},"2023-02-01",{"date":104,"type":20},{"name":279,"class":49},"University of Alabama at Birmingham",{"id":281,"slug":282,"hasResults":12,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":62,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":296,"locationsCount":50},"100644127","cryoneurolysis-versus-radiofrequency-in-knee-osteoarthritis-100644127","NCT07664371","Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis","Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis: A Randomised Controlled Trial","Inclusion Criteria:\n\nAdults with a clinical diagnosis of refractory knee OA who suffered from refractory knee pain (patients who had failed conservative medical and physical therapy for 6 months .\n\nExclusion Criteria:\n\n1. Patients with OA show improvement in pain after conservative medical and physical therapy.\n2. Patients evaluated by an orthopedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.\n3. Patients with allergies to local anesthetics.\n4. patients on anticoagulation therapy, who were not permitted to stop anticoagulation.\n5. Patients with knee tumors.\n6. Patients with acute infections.\n7. Patients with implanted cardiac devices.\n8. Pregnant patients.",{"count":147,"type":20},[64],"The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.",[29],"2026-08-09",{"date":221,"type":42},{"date":294,"type":42},"2026-06-10",{"date":198,"type":20},{"name":297,"class":49},"Tanta University",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":16,"minAge":89,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":62,"phases":309,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":50},"100649891","effects-of-imt-on-cardiopulmonary-endurance-and-functional-mobility-in-koa-100649891","NCT07738627","Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA","Inspiratory Muscle Training as an Adjunct to Standard Care: Effects on Cardiopulmonary Endurance and Functional Mobility in Knee Osteoarthritis","IMT","Inclusion Criteria:\n\n* Age 40-65 years\n* Male and Female participants\n* Bilateral Knee Osteoarthritis\n* Diagnosed according to American College of Rheumatology criteria\n* Kellgren and Lawrence Grade II-III\n* Able to walk independently\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Participation in structured physical activity programs\n* Intra-articular corticosteroid injection within last 3 months\n* Hyaluronic acid injection within last 6 months\n* Lower limb trauma or surgery history\n* Planned surgery during study period\n* Severe cardiovascular disease\n* Severe pulmonary disease\n* Neurological disorders\n* Psychological disorders","65 Years",{"count":308,"type":20},65,[64],"The purpose of the study is to investigate whether adding Inspiratory Muscle Training (IMT) to the usual treatment of patients with knee osteoarthritis improves their cardiopulmonary endurance and functional mobility more than standard care alone.",[29],[29,313,314,315,316,317,318,319,320],"Inspiratory Muscle Training","Cardiopulmonary Endurance","Aerobic capacity","Respiratory Muscle Strength","Functional Mobility","6-Minute Walk Test","WOMAC","TUG Test","2026-08-05",{"date":323,"type":42},"2026-08-07",{"date":325,"type":20},"2026-08",{"date":327,"type":20},"2027-12-11",{"name":329,"class":49},"Riphah International University",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":16,"minAge":336,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":334,"conditions":339,"keywords":340,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":82},"100651032","a-multicenter-open-label-single-arm-extension-study-to-evaluate-the-safety-and-efficacy-of-furestem-oa-kit-inj-in-knee-osteoarthritis-patients-who-received-placebo-in-the-k0701-phase-2a-trial-100651032","NCT07754175","A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial","Inclusion Criteria:\n\n* Participants who received placebo in the K0701 clinical trial and completed the Long-term follow-up study\n* Participants who voluntarily provide written informed consent to participate in this extension study\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria:\n\n* Participants whom the investigator considers unsuitable for participation in this extension study.\n* Pregnant or breastfeeding women, and women of childbearing potential or men who do not agree to use an appropriate method of contraception during the study","19 Years",{"count":338,"type":20},36,[29],[341,342],"FURESTEM-OA Kit Inj.","Knee Osteoarthritis Stem cell","2026-08-04",{"date":273,"type":42},{"date":346,"type":42},"2026-07-20",{"date":348,"type":20},"2032-02-28",{"name":350,"class":81},"Kang Stem Biotech Co., Ltd.",{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":58,"sex":16,"minAge":358,"maxAge":4,"enrollmentInfo":359,"targetDuration":361,"studyType":21,"phases":4,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":376,"locationsCount":50},"100650226","knee-ligament-stiffness-across-ethnicities-before-and-after-osteoarthritis-treatment-100650226","NCT07744789","Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment","Across Ethnicities of Norm of Knee Ligament Stiffness and Its Association With Osteoarthritis Before\u002FAfter Treat-ment: a Sonoelastography Model","Inclusion Criteria\n\n* Healthy volunteers:\n* Adults aged 20 years or older.\n* Able to understand the study procedures and provide written informed consent.\n* Able to ambulate independently without walking aids.\n* No pain in either knee during the previous 6 months.\n* Patients with symptomatic knee osteoarthritis:\n* Adults aged 20 years or older.\n* Able to understand the study procedures and provide written informed consent.\n* Pain in at least one knee during the previous year.\n* Knee pain, soreness, or stiffness documented within the previous month.\n* Radiographic knee osteoarthritis defined by at least one of the following:\n* Kellgren-Lawrence grade ≥2 on anteroposterior radiographs.\n* Kellgren-Lawrence grade ≥2 on skyline radiographs.\n* Superior or inferior patellar osteophytes or posterior tibial osteophytes on lateral radiographs.\n\nExclusion Criteria\n\n* Healthy volunteers:\n* Previous knee surgery.\n* Rupture of any cruciate or collateral ligament.\n* Major knee or periarticular trauma.\n* Rheumatic or autoimmune disease.\n* Diagnosis of knee osteoarthritis within the previous 6 months.\n* Patients with symptomatic knee osteoarthritis:\n* Rheumatic or autoimmune disease.\n* Malignancy.\n* Previous major knee trauma or knee surgery.\n* Corticosteroid injection into the affected knee within the previous 3 months.","20 Years",{"count":360,"type":20},208,"1 Month","This prospective clinical study aims to establish normative values of knee ligament stiffness across different ethnic populations using shear wave elastography (SWE) and to investigate biomechanical alterations associated with knee osteoarthritis (OA). Healthy adults and patients with symptomatic knee OA will undergo standardized SWE examinations of the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), and lateral collateral ligament (LCL), together with clinical assessments. For patients who subsequently receive clinically indicated ultrasound-guided injection therapy, follow-up SWE and clinical evaluations will be performed to investigate changes in ligament stiffness after treatment.",[29],[29,365,366,367,368,369,370],"Shear Wave Elastography","Anterior Cruciate Ligament","Posterior Cruciate Ligament","Medial Collateral Ligament","Lateral Collateral Ligament","Ultrasound",{"date":372,"type":42},"2026-08-06",{"date":374,"type":42},"2023-07-26",{"date":76,"type":20},{"name":377,"class":49},"National Taiwan University Hospital",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":62,"phases":387,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":50},"100547396","evaluating-the-efficacy-of-a-mobile-application-in-postoperative-rehabilitation-100547396","NCT06407427","Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation","Using a Mobile Application for In-Bed Conditioning Exercises for Orthopedic Postoperative Patients","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* English reading\u002Fspeaking\n* Are status post low-energy hip fracture, total knee\u002Fhip arthroplasty, or single to multilevel spinal fusion without paralysis\n* Must be able bodied enough to participate in a mobile app tool for physical therapy\n* Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration\\]\n\nExclusion Criteria:\n\n* Severe cognitive impairment: Not alert and oriented to person, place, time, and reason for being the hospital; and unable to follow 2 step commands\n* Severe physical impairment:\n\n  * Neurologic paralysis\n  * Polytraumas with restrictions incompatible with anti-gravity exercises\n  * Knee immobilization, bed rest\n* Unstable medical conditions:\n\n  * On ventilatory support\n  * Utilizing high degrees of oxygen support (continuous BiPAP, high flow nasal cannula, nonrebreather mask, aerosol mask \\>3L\u002Fmin)\n  * Hemodynamic instability requiring pressor medication support (can include those on pressors for elevated mean arterial pressure goals (MAPs))\n  * Neurologically instable with strokes, hemorrhages, increased intracranial pressures\n* Open wounds or surgical incisions\n\n  * Tenuous closed wounds requiring immobilization or bending restrictions\n  * Open wounds that are either packed\u002Fdressed or dressed with a wound vacuum\n  * Surgical wounds that are draining fluid or purulence\n* Vulnerable populations\n\n  * Incarcerated individuals\n* Patients without access to a mobile phone with iOS capability",{"count":386,"type":20},100,[64],"This study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.",[390,391,29,392],"Spine Degeneration","Hip Arthritis","Hip Fractures","2026-08-03",{"date":321,"type":42},{"date":396,"type":42},"2025-07-21",{"date":398,"type":20},"2026-12",{"name":48,"class":49},{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":16,"minAge":89,"maxAge":262,"enrollmentInfo":407,"targetDuration":4,"studyType":62,"phases":408,"briefSummary":409,"conditions":410,"keywords":412,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":414,"startDateStruct":415,"completionDateStruct":416,"leadSponsor":418,"locationsCount":50},"100604575","phonophoresis-with-bee-venom-evaluating-its-efficacy-in-managing-pain-and-enhancing-mobility-in-knee-osteoarthritis-patients-100604575","NCT07151300","Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients","BEE-KNEE","Inclusion Criteria:\n\n* Age 40-75 years\n* Clinically and radiographically confirmed knee osteoarthritis\n* Moderate to severe pain (VAS ≥ 4)\n* Willingness to provide informed consent\n\nExclusion Criteria:\n\n* Allergy to bee products or topical agents used in the study\n* Knee surgery or trauma in the past year\n* Intra-articular injection in the past 6 months\n* Other musculoskeletal or systemic conditions affecting the knees (e.g., rheumatoid arthritis)\n* Pregnancy or contraindication to ultrasound therapy",{"count":147,"type":20},[64],"Brief Summary:\n\nThis single-blind, randomized controlled trial will investigate the efficacy of bee venom phonophoresis in managing pain and improving mobility in patients with knee osteoarthritis. Thirty adults aged 40-75 years with clinically and radiographically confirmed knee osteoarthritis will be randomly assigned to receive either bee venom phonophoresis or placebo phonophoresis with a neutral gel. Ultrasound parameters will be standardized for all participants.\n\nPrimary outcomes are pain reduction, measured by the Visual Analog Scale (VAS), and functional mobility, assessed by the Timed Up and Go (TUG) test. The secondary outcome is walking endurance, measured by the Six-Minute Walk Test (6MWT). Assessments will be conducted at baseline and post-intervention.\n\nThe study is designed to determine whether bee venom phonophoresis offers greater clinical benefit compared to placebo phonophoresis, potentially providing a non-invasive, adjunctive treatment option for knee osteoarthritis. Ethical approval has been obtained from the Faculty of Physical Therapy, Sinai University, and all participants will provide written informed consent.",[29,411],"Osteoarthritis",[411,413],"Osteoarthritis, Knee",{"date":343,"type":42},{"date":224,"type":20},{"date":417,"type":20},"2027-12-25",{"name":419,"class":49},"Sinai University",{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":16,"minAge":145,"maxAge":427,"enrollmentInfo":428,"targetDuration":4,"studyType":62,"phases":430,"briefSummary":431,"conditions":432,"keywords":434,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":441,"completionDateStruct":442,"leadSponsor":444,"locationsCount":4},"100649829","suprainguinal-fascia-iliaca-block-vs-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty-100649829","NCT07739108","Suprainguinal Fascia Iliaca Block vs. Adductor Canal Block for Analgesia After Total Knee Arthroplasty","Comparing Suprainguinal Fascia Iliaca Block Versus Adductor Canal Block for Postoperative Pain Control Following Total Knee Arthroplasty;A Prospective, Double-Blind Controlled Trial","Inclusion Criteria:\n\n* ASA Physical Status I, II, or III\n* Scheduled for elective unilateral primary total knee arthroplasty\n* Able to understand and operate the PCA device\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Pre-existing lower-extremity neurological deficit or motor weakness (e.g., severe diabetic neuropathy)\n* Chronic opioid use (\\>30 mg oral morphine equivalents\u002Fday for \\>3 months)\n* Infection at the block site or systemic sepsis\n* Coagulopathy or bleeding diathesis\n* Allergy to local anesthetics or study medications\n* Revision TKA or bilateral knee procedures\n* Cognitive impairment or inability to perform mobility\u002Fpain assessments","100 Years",{"count":429,"type":20},60,[64],"This study evaluates the analgesic efficacy and motor-sparing properties of ultrasound-guided Suprainguinal Fascia Iliaca Block (S-FIB) compared with Adductor Canal Block (ACB) in patients undergoing primary total knee arthroplasty (TKA). The main hypothesis is that ACB better preserves quadriceps muscle strength, allowing earlier functional mobilization, while providing comparable (non-inferior) analgesia to S-FIB.",[433,29],"Arthroplasty",[435,436,437,438],"Suprainguinal Fascia Iliaca Block","Adductor Canal Block","Ultrasound-Guided Nerve Block","Regional Anesthesia","2026-07-31",{"date":393,"type":42},{"date":248,"type":20},{"date":443,"type":20},"2027-09-12",{"name":445,"class":201},"Bursa Yuksek Ihtisas Training and Research Hospital",{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":16,"minAge":89,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":62,"phases":455,"briefSummary":456,"conditions":457,"keywords":459,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":471,"locationsCount":50},"100649967","paraspinal-nmes-and-spinopelvic-alignment-after-knee-arthroplasty-100649967","NCT07741162","Paraspinal NMES and Spinopelvic Alignment After Knee Arthroplasty","Effect of Paraspinal Neuromuscular Electrical Stimulation Added to Rehabilitation Program on Spinopelvic Alignment Parameters After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 40 and 80 years\n* Diagnosis of primary knee osteoarthritis scheduled for total knee arthroplasty\n* Radiographic evidence of Kellgren-Lawrence grade 3-4 knee osteoarthritis\n* Preoperative knee flexion contracture ≥ 5°\n* Measurable spinopelvic malalignment, defined as meeting at least one of the following criteria: pelvic tilt (PT) \\> 20°, sagittal vertical axis (SVA) \\> 50 mm, or lumbar lordosis (LL) \\\u003C 40°\n* IIntact cognitive function based on clinical judgment, sufficient to understand and follow verbal commands, cooperate with the rehabilitation program, and reliably comply with functional assessment procedures\n* Provision of written informed consent\n* Able to stand independently and undergo standing lateral radiography\n\nExclusion Criteria:\n\n* Prior lumbar or thoracic spinal surgery\n* History of hip arthroplasty\n* Prior knee arthroplasty (revision arthroplasty patients)\n* Active inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis)\n* Neurological disease, including stroke, Parkinson's disease, peripheral neuropathy, or spinal cord pathology\n* Contraindications to NMES, including active cardiac pacemaker, implanted defibrillator, deep vein thrombosis, skin integrity impairment, malignancy, or epilepsy\n* Severe hip osteoarthritis or other lower extremity pathology significantly affecting spinopelvic alignment (e.g., leg length discrepancy, developmental hip dysplasia, contracture)\n* Inability to complete the standard rehabilitation protocol due to postoperative complications\n* Osteoporotic vertebral fracture or significant osteoporosis (T-score \\\u003C -2.5 at L1-L4)\n* Active treatment for malignancy\n* Psychiatric or medical condition that would prevent completion of the follow-up period\n* General contraindications to exercise","80 Years",{"count":19,"type":20},[64],"Total knee arthroplasty (TKA) is a widely performed surgical procedure for patients with severe knee osteoarthritis. Following TKA, changes in lower extremity alignment and gait mechanics may influence the spinopelvic sagittal alignment, and postoperative rehabilitation programs traditionally focus on the knee joint without addressing the lumbopelvic chain.\n\nThis study aims to investigate whether adding paraspinal neuromuscular electrical stimulation (NMES) to a standard postoperative rehabilitation program (which includes quadriceps NMES) affects spinopelvic sagittal alignment parameters in patients undergoing TKA for primary knee osteoarthritis, compared with standard rehabilitation and quadriceps NMES alone.\n\nIn this single-center, prospective, randomized, single-blind (outcome assessor-blinded) controlled trial, eligible participants aged 40-80 years with primary knee osteoarthritis scheduled for TKA and with measurable spinopelvic malalignment will be randomly assigned in a 1:1 ratio to receive either standard rehabilitation with quadriceps NMES plus paraspinal NMES (intervention group) or standard rehabilitation with quadriceps NMES alone (control group) for 4 weeks (20 sessions).\n\nThe primary outcome is the change in radiographic spinopelvic parameters - including pelvic tilt, sacral slope, pelvic incidence, lumbar lordosis, sagittal vertical axis, and spinosacral angle - measured on standing lateral whole-spine radiographs at baseline (preoperative), before rehabilitation, after the 4-week intervention, and at 6-month follow-up. Secondary outcomes include knee and back pain (VAS), functional and quality-of-life measures (WOMAC, Knee Society Score, Forgotten Joint Score, Oswestry Disability Index, Nottingham Health Profile), performance-based tests (Timed Up and Go, 6-Minute Walk Test), and knee range of motion.\n\nThe investigators hypothesize that adding paraspinal NMES to standard rehabilitation will result in greater improvement in spinopelvic alignment parameters, and potentially in clinical\u002Ffunctional outcomes, compared with standard rehabilitation alone.",[29,458],"Postoperative Rehabilitation",[460,461,462,463,464],"Total knee arthroplasty","Spinopelvic alignment","Neuromuscular electrical stimulation","Postoperative rehabilitation","Paraspinal muscles","2026-07-27",{"date":393,"type":42},{"date":468,"type":20},"2026-07-30",{"date":470,"type":20},"2027-07-30",{"name":445,"class":201},{"id":473,"slug":474,"hasResults":12,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":4,"eligibilityCriteria":478,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":306,"enrollmentInfo":479,"targetDuration":4,"studyType":62,"phases":480,"briefSummary":481,"conditions":482,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":488,"completionDateStruct":489,"leadSponsor":491,"locationsCount":4},"100649580","exploration-of-appropriate-bis-range-and-propofol-effect-site-concentration-during-total-intravenous-anesthesia-with-concomitant-adjuvants-100649580","NCT07736352","Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.","A Prospective, Randomized Study to Determine the Appropriate Bispectral Index Range and Propofol Effect-Site Concentration During Total Intravenous Anesthesia Combined With Midazolam, Dexmedetomidine or Esketamine.","Inclusion Criteria:\n\n* Age 18 to 65 years\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Body Mass Index (BMI) 18 to 30 kg\u002Fm²\n* Scheduled for elective unilateral total knee replacement surgery\n* Willing to participate in the study and signed informed consent form, and able to comply with the intervention and assessment procedures\n\nExclusion Criteria:\n\n* History of neurological disorders\n* Cognitive dysfunction assessed by the Mini-Cog scale\n* History of antipsychotic or sedative medication use in the past 4 weeks\n* Poorly controlled or untreated hypertension\n* Sinus bradycardia, cardiac conduction block, or severe heart failure\n* Acute angle-closure glaucoma\n* Allergic to intravenous anesthetics\n* Hearing impairment, could not cooperate in intervention and evaluation\n* Contraindications to tourniquet use on the upper arm",{"count":386,"type":20},[64],"The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA) combined with midazolam, dexmedetomidine, or esketamine in patients undergoing unilateral knee replacement surgery. The main questions it aims to answer are:\n\n1. What are the appropriate BIS range and propofol effect-site concentration for maintaining adequate anesthesia depth when combined with each of the three medications (midazolam, dexmedetomidine, or esketamine) during TIVA?\n2. How these combination regimens affect the quality of recovery and postoperative pain in patients？\n\nParticipants will:\n\n1. Receive one of four anesthesia regimens during surgery: propofol alone, propofol combined with midazolam, dexmedetomidine, or esketamine.\n2. Undergo a stepwise reduction of propofol effect-site concentration towards the end of surgery.\n3. Have their consciousness assessed using the isolated forearm technique, while BIS, EEG signals, and vital signs are continuously monitored throughout the procedure.\n4. Have their recovery quality and postoperative pain assessed after surgery.",[29,483,484,485],"Replacement, Knee","Elective Surgical Patients","ASA Class I\u002FII Patients","2026-07-26",{"date":468,"type":42},{"date":154,"type":20},{"date":490,"type":20},"2027-07-31",{"name":492,"class":49},"China-Japan Friendship Hospital",{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":498,"acronym":4,"eligibilityCriteria":499,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":262,"enrollmentInfo":500,"targetDuration":4,"studyType":62,"phases":502,"briefSummary":503,"conditions":504,"keywords":506,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":513,"leadSponsor":515,"locationsCount":50},"100649290","phase-3-a-study-of-econoglutide-injection-in-obese-participants-with-knee-osteoarthritis-koa-100649290","NCT07734311","A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)","A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of Ecnoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)","Inclusion Criteria:\n\n1. Body mass index (BMI) ≥ 28.0 kg\u002Fm\\^2;\n2. The target knee must meet the diagnostic criteria of American College of Rheumatology (ACR) for knee osteoarthritis (clinical and radiological), with moderate radiographic changes (Kellgren-Lawrence grade 2 or 3). The target knee is defined as the knee with the most symptomatic knee at screening period; if pain in both knees are equal, the target knee will be the most dominant leg (preferred leg);\n3. Prior to screening, target knee pain lasting more than 12 weeks, and according to participant's self-report or medical history at screening, target knee pain lasting more than 15 days in the past month;\n4. At screening and prior to randomization, WOMAC pain score (NRS 0-10) of the target knee must be between 4 and 9 (to avoid bias in reporting, participants must not be informed of the pain score used to determine eligibility for the study);\n5. Self-reported by the participant who has a history of unsuccessful weight loss attempt by diet and exercise.\n\nExclusion Criteria:\n\n1. The target knee has undergone joint replacement surgery;\n2. The target knee has undergone arthroscopy within 12 months prior to screening;\n3. At the time of screening, the target knee joint has any clinical features and symptoms of other active infections or crystal-induced arthropathies, as well as any other active joint diseases that may interfere with assessment;\n4. The target knee has received intra-articular injections of hyaluronic acid, any other investigational drugs, or biologics within 3 months prior to screening; or has undergone any procedures that result in persistent sensory loss in the target knee (e.g., ablation) within 6 months prior to screening;\n5. Has received any intramuscular or oral corticosteroids (investigational or marketed) within 30 days prior to screening, or has received any intra-articular corticosteroid injections (investigational or marketed) in any joint within 90 days prior to screening;\n6. History of joint instability in either knee within 12 months prior to screening, such as anterior cruciate ligament rupture or recent trauma;\n7. History of any other potentially causative and\u002For confounding diseases, including Reiter's syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, inflammatory bowel disease-associated arthritis, sarcoidosis, amyloidosis, or fibromyalgia;\n8. Presence of symptomatic hip osteoarthritis at the time of screening, with the exception of those who have undergone hip replacement surgery;\n9. Conditions that may interfere with the assessment of target knee pain during screening include, but are not limited to:\n\n   * Pain in any part of the lower limb or back equal to or more severe than the pain in the target knee;\n   * Pain radiating to the knee from other areas, such as hip pain affecting the knee or radicular pain;\n   * Chronic widespread pain (including neuropathic pain);\n10. Change of body weight \\>5% within 3 months prior to screening (selfreported);\n11. Diagnosis of diabetes (excluding gestational diabetes), or with a history of diabetic ketoacidosis or hyperosmolar state\u002Fcoma",{"count":501,"type":20},360,[119],"The main purpose of the study is to evaluate the efficacy and safety of ecnoglutide injections versus placebo in obese participants with KOA.",[29,505],"Obesity",[507,508,505],"Ecnoglutide","KOA","2026-07-24",{"date":511,"type":42},"2026-07-29",{"date":439,"type":20},{"date":514,"type":20},"2028-06-30",{"name":516,"class":81},"Hangzhou Sciwind Biosciences Co., Ltd.",{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":521,"acronym":522,"eligibilityCriteria":523,"healthyVolunteers":12,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":524,"targetDuration":526,"studyType":21,"phases":4,"briefSummary":527,"conditions":528,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":538},"100477312","innovations-in-genicular-outcomes-registry-100477312","NCT05495334","Innovations in Genicular Outcomes Registry","iGOR","Inclusion Criteria:\n\n1. Planned to receive treatment for knee OA pain including, but not limited to, knee injections, nerve blocking procedures, or knee arthroplasty within 60 days of screening\n2. Able to understand the informed consent and assessment questionnaires and have the ability to complete them in the opinion of the investigator\n3. Have access to a smartphone or internet access with a computer\u002Ftablet to complete the questionnaires using the registry application\n\nExclusion Criteria:\n\n1. Actively enrolled in an investigational trial that would preclude patients from receiving the site's standard of care for knee OA pain or knee arthroplasty recovery protocol\n2. Planning to have a surgery other than on the target knee",{"count":525,"type":20},10000,"18 Months","The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA. The OA pain therapies may include cryo nerve block, radiofrequency ablation (RFA), intra-articular (IA) corticosteroids, viscosupplementation, opioids, and others (e.g., non-steroidal anti-inflammatory drugs \\[NSAIDs\\]).",[29],"2026-07-21",{"date":531,"type":42},"2026-07-23",{"date":533,"type":42},"2021-09-23",{"date":535,"type":20},"2033-12-30",{"name":537,"class":81},"Pacira Pharmaceuticals, Inc",19,{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":58,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":547,"targetDuration":549,"studyType":21,"phases":4,"briefSummary":550,"conditions":551,"keywords":555,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":50},"100648320","artificial-intelligence-assisted-advanced-analysis-of-knee-imaging-and-outcome-prediction-100648320","NCT07721116","Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction","Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction for Ultrasound-Guided Injections","AI; R-CNN","Objective 1: Development of an AI-Based Normative Model for the Healthy Knee\n\nInclusion Criteria:\n\n* Clinical diagnosis of healthy adult without major systemic disease\n* Age ≥18 years\n* Able to understand and follow study instructions\n* Ambulatory without walking aids\n* No pain in either knee for at least 6 months before enrollment\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Rupture of one or more cruciate ligaments\n* Knee injection within the preceding 6 months\n* Major trauma involving the knee or periarticular region\n* Rheumatic or autoimmune disease\n\nObjective 2: Development of an AI-Based Model for the Identification of Pathological Knee Structures\n\nInclusion Criteria:\n\n* Clinical diagnosis of radiographic knee osteoarthritis\n* Age ≥18 years\n* Knee pain in at least one knee during the preceding year\n* Medical records confirming knee pain, soreness, or stiffness within 1 month before enrollment\n* Radiographic evidence of knee osteoarthritis, defined by at least one of the following:\n* Kellgren-Lawrence grade ≥2 on anteroposterior radiographs\n* Kellgren-Lawrence grade ≥2 on skyline (patellofemoral) radiographs\n* Superior or inferior patellar osteophytes or posterior tibial osteophytes on lateral radiographs\n\nExclusion Criteria:\n\n* Systemic rheumatic disease (e.g., rheumatoid arthritis or ankylosing spondylitis)\n* Malignancy\n* Previous major knee trauma (including fracture)\n* Previous knee surgery\n* Intra-articular corticosteroid injection within the preceding 3 months\n\nObjective 3: Development of an AI-Assisted Predictive Model for Injection Treatment Outcomes\n\nInclusion Criteria:\n\n* Clinical diagnosis of radiographic knee osteoarthritis requiring ultrasound-guided injection therapy\n* Age ≥18 years\n* Knee pain in at least one knee during the preceding year\n* Medical records confirming knee pain, soreness, or stiffness within 1 month before enrollment\n* Radiographic evidence of knee osteoarthritis, defined by at least one of the following:\n* Kellgren-Lawrence grade ≥2 on anteroposterior radiographs\n* Kellgren-Lawrence grade ≥2 on skyline (patellofemoral) radiographs\n* Superior or inferior patellar osteophytes or posterior tibial osteophytes on lateral radiographs\n* Willingness to undergo ultrasound-guided injection therapy and complete scheduled follow-up assessments\n\nExclusion Criteria:\n\n* Systemic rheumatic disease (e.g., rheumatoid arthritis or ankylosing spondylitis)\n* Malignancy\n* Previous major knee trauma (including fracture)\n* Previous knee surgery\n* Intra-articular corticosteroid injection within the preceding 3 months",{"count":548,"type":20},310,"1 Day","This study aims to develop and validate an artificial intelligence (AI)-assisted platform for musculoskeletal knee ultrasonography and to establish an interpretable prediction model for clinical outcomes following ultrasound-guided injection therapies in patients with degenerative knee disorders. The project seeks to improve the standardization, reproducibility, and clinical utility of knee ultrasound by reducing operator dependency and providing quantitative image analysis and outcome prediction.\n\nThe study will be conducted in three phases. First, an AI foundation model for knee ultrasonography will be developed using standardized image acquisition protocols to enable automated localization, segmentation, and quantitative assessment of major anatomical structures, including tendons, ligaments, cartilage, fat pads, and peripheral nerves. Second, supervised machine learning models will be trained to classify normal and pathological ultrasound findings, including common degenerative and inflammatory abnormalities affecting the knee. Third, retrospective and prospective clinical data from approximately 150 patients receiving ultrasound-guided injection therapies will be integrated to develop and validate a predictive model for treatment outcomes using imaging biomarkers and clinical variables. Treatment response will be evaluated using validated patient-reported outcome measures, and explainable AI methods will be applied to improve model interpretability.\n\nThe anticipated outcome of this study is the development of a comprehensive AI-assisted knee ultrasound platform that supports standardized image interpretation, quantitative assessment of musculoskeletal pathology, and personalized prediction of treatment response to ultrasound-guided injection therapies in degenerative knee disorders.",[552,29,553,554],"Degenerative Knee Disorders","Musculoskeletal Ultrasonography","Artificial Intelligence",[556,557,558,559],"artificial intelligence","ultrasonography","knee","ultrasound-guided injections","2026-07-19",{"date":562,"type":42},"2026-07-22",{"date":564,"type":20},"2026-07-01",{"date":566,"type":20},"2029-12-31",{"name":377,"class":49},{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":58,"sex":16,"minAge":89,"maxAge":575,"enrollmentInfo":576,"targetDuration":4,"studyType":62,"phases":578,"briefSummary":579,"conditions":580,"keywords":581,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":82},"100630201","integrated-trunk-stabilization-with-osteoarthritis-rehabilitation-in-knee-spine-syndrome-100630201","NCT07484594","Integrated Trunk Stabilization With Osteoarthritis Rehabilitation in Knee-Spine Syndrome","Integrating Trunk Stabilization Exercises With Conventional Rehabilitation Protocol for Osteoarthritis in Patients With Knee-Spine Syndrome","Inclusion Criteria:\n\n* Age 40-60 years\n* Both Genders\n* Bilateral Knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system\n* Kellgren \\& Lawrence grade 2 and 3 with complaint of pain, crepitations, stiffness and bony enlargement\n* History of backpain for the past 3 months with no complaint of radiating pain\n* Able to walk independently\u002Funaided\n\nExclusion Criteria:\n\n* Kellgren \\& Lawrence grade 4\n* Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the previous 6 months.\n* History of lower limb or lumbar trauma\u002Fsurgery, presence of fracture or deformity, or planned surgery within the study period\n* Lumbar pathologies, for example, spondylolisthesis, ankylosing spondylitis, or any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease or impairment except lumbar spondylosis\n* BMI\\>30\n* Presence of infection, cauda equina syndrome, or meningitis","60 Years",{"count":577,"type":20},70,[64],"This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis",[29],[29,582,583],"Knee-Spine Syndrome","Trunk Exercise","2026-07-17",{"date":346,"type":42},{"date":587,"type":42},"2026-05-11",{"date":589,"type":20},"2026-10-15",{"name":329,"class":49},{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":58,"sex":16,"minAge":89,"maxAge":306,"enrollmentInfo":598,"targetDuration":4,"studyType":62,"phases":600,"briefSummary":601,"conditions":602,"keywords":603,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":606,"startDateStruct":607,"completionDateStruct":608,"leadSponsor":610,"locationsCount":50},"100630196","comparison-of-aquatic-and-land-based-mulligan-mobilization-with-movement-in-knee-osteoarthritis-100630196","NCT07484529","Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis","Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement on Pain, and Function in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Age 40-65 years\n* Bilateral knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system for at least 1 year\n* Kellgren \\& Lawrence grade 2 and 3\n* Able to walk independently\u002Funaided\n\nExclusion Criteria:\n\n* Active participation in gyms, pool(swimming), or any other physical activity\n* Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the last 6 months.\n* History of lower limb trauma\u002Fsurgery, presence of fracture or lower limb deformity, or planned surgery within the study period\n* Any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease\u002Fimpairment.\n* Individuals with aquaphobia (fear of water), discomfort performing aquatic exercises, or allergy\u002Fsensitivity to chlorine or other pool treatment chemicals.",{"count":599,"type":20},66,[64],"This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes.",[29],[29,604,605],"Mobilization with Movement","Aquatic Exercises",{"date":346,"type":42},{"date":587,"type":42},{"date":609,"type":20},"2026-10",{"name":329,"class":49},{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":453,"enrollmentInfo":618,"targetDuration":4,"studyType":62,"phases":620,"briefSummary":621,"conditions":622,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":50},"100555050","the-personalknee-trial-100555050","NCT06507046","The personalKNEE Trial","Robotic Assisted Surgery Comparing Personalized Alignment Versus Mechanical Alignment of Total Knee Arthroplasty - A Randomized Controlled Trial","Inclusion Criteria:\n\n• femoro-tibial or patello-femoral osteoarthritis (Kellgren-Lawrence, K-L) grade 2-4 with persistent pain, referred to Kristiansund Hospital for primary TKA\n\nExclusion Criteria:\n\n* serious psychiatric disorders\n* dementia\n* drug abuse\n* patients not able to speak and read Norwegian language making them noncompliant or unable to perform an informed consent\n* Patients with ongoing cancer therapy\n* Patients with ASA (The American Society of Anesthesiologists physical status class risk stratification system) classification \\>3\n* Patients in the need of walking aid devices\n* Patients in need of primary revision arthroplasty or more than 15 degrees of varus or 5 degrees of valgus on preoperative HKA images.",{"count":619,"type":20},152,[64],"Robotic knee surgery makes it possible to adopt different alignment philosophies in total knee arthroplasty. The classical operation where the knee is placed in a neutral manner, the so called mechanical alignment, has been used for decades. The kinematical alignment has recently won popularity. With this technique the focus is to render the natural knee anatomy even if this means to end up with a varus or valgus position. In this study, the investigators will compare the mechanical alignment and kinematical alignment and test the patients clinically and with a special CT scan to see if this technique gives equal or better longevity of the implants.",[29],{"date":529,"type":42},{"date":625,"type":42},"2024-08-25",{"date":627,"type":20},"2035-05-01",{"name":629,"class":201},"Helse Møre og Romsdal HF"]