[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"laser-speckle-contrast-imaging\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:laser-speckle-contrast-imaging":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100648184","coloflow-laser-speckle-contrast-imaging-versus-near-infrared-fluorescence-imaging-with-indocyanine-green-100648184",false,"NCT07720505","COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green","COLOFLOW","Inclusion Criteria:\n\n* Adults ≥18 years.\n* Undergoing elective colon resection with primary anastomosis.\n* Able to provide consent for postoperative analysis of intraoperative imaging\n\nExclusion Criteria:\n\n* Palliative surgery.\n* Factors that severely limit intraoperative visualization (per investigator judgement).\n\nConditions interfering with perfusion assessment (e.g., severe peripheral vascular compromise).","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of indocyanine green (ICG) fluorescence during colorectal surgery. In approximately 30 patients undergoing elective colon or rectal resection with primary anastomosis, both imaging modalities will be performed intraoperatively. The surgeons will base their clinical decisions solely on standard ICG fluorescence imaging, while LSCI measurements are collected for research purposes and do not influence treatment. Postoperatively, quantitative ICG parameters will be analysed and compared with LSCI perfusion maps to determine whether objective ICG analysis improves agreement with LSCI over subjective interpretation alone. In addition, the study will evaluate the feasibility of using the PerfusiX-IGS LSCI system during open colorectal surgery and describe postoperative outcomes, including anastomotic leakage. The ultimate goal is to contribute to more objective and standardized perfusion assessment during colorectal surgery",[24,25,26,27,28,29,30,31,32],"Leakage, Anastomotic","Colon Cancer","Colon Anastomosis","Colon and Rectal Cancer","Colon Benign Tumor","Colon and Rectal Diseases","Laser Speckle Contrast Imaging","Indocyanine Green (ICG)","Near-Infrared Spectroscopy",[34,35,36,37,38,39],"colon","anastomosis","laser speckle contrast imaging","indocyanine green","ICG","Near-infrared","NOT_YET_RECRUITING","2026-07-17",{"date":43,"type":44},"2026-07-22","ACTUAL",{"date":46,"type":20},"2026-08-01",{"date":48,"type":20},"2027-09-30",{"name":50,"class":51},"Leiden University Medical Center","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100633489","analysis-of-the-reliability-and-validity-of-laser-speckle-contrast-imaging-100633489","NCT07527351","Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging","Analysis of the Reliability and Validity of Laser Speckle Contrast Analysis for the Measurement of Gingival Vascularisation","LSCI","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Non-smokers\n* Good systemic health\n* Good periodontal health\n* No current systemic medication\n* Good oral hygiene\n* For the retrospective surgical component: availability of previously documented clinical records from closed mucogingival surgical wounds or open palatal donor-site wounds, with prior consent allowing use of documented clinical material for research\n\nExclusion Criteria:\n\n* Pregnancy\n* Use of anti-inflammatory medication within 7 days before evaluation\n* Oral treatment within 6 months before evaluation\n* For the prospective healthy-gingiva component: any condition not compatible with good systemic or periodontal health\n* For the retrospective surgical component: absence of adequate previously documented clinical records or absence of prior consent for research use of the documented material",true,{"count":62,"type":20},24,"INTERVENTIONAL",[65],"NA","This study is designed to validate laser speckle contrast imaging (LSCI) as a non-invasive method for measuring superficial gingival blood perfusion. Accurate assessment of vascularization is essential for understanding periodontal and peri-implant wound healing, yet current clinical methods are limited by subjective interpretation and low reproducibility. Repeated LSCI measurements will be performed in healthy gingival tissues and in tissues undergoing different mucogingival healing patterns, including primary and secondary intention healing. The study will also evaluate factors that may influence perfusion readings, such as angulation, retractors, mirror use, temperature, and heart rate. The primary objective is to determine the reproducibility of LSCI measurements and to support its use as a reliable tool for monitoring oral soft-tissue vascularization and healing.",[68,69,30,70],"Gingival Vascularization","Oral Soft Tissue Wound Healing","Periodontal Wound Healing",[72,58,73,74,75,76,77,78,79,80,81],"Laser speckle contrast imaging","Gingival microcirculation","Oral soft tissue wound healing","Periodontal wound healing","Mucogingival surgery","Palatal donor site","Blood perfusion","Reproducibility","Reliability","PeriCam PSI","RECRUITING","2026-04-17",{"date":85,"type":44},"2026-04-22",{"date":87,"type":44},"2026-04-13",{"date":89,"type":20},"2026-05-20",{"name":91,"class":51},"Universidad Complutense de Madrid",1]