[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"leakage-anastomotic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:leakage-anastomotic":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100648184","coloflow-laser-speckle-contrast-imaging-versus-near-infrared-fluorescence-imaging-with-indocyanine-green-100648184",false,"NCT07720505","COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green","COLOFLOW","Inclusion Criteria:\n\n* Adults ≥18 years.\n* Undergoing elective colon resection with primary anastomosis.\n* Able to provide consent for postoperative analysis of intraoperative imaging\n\nExclusion Criteria:\n\n* Palliative surgery.\n* Factors that severely limit intraoperative visualization (per investigator judgement).\n\nConditions interfering with perfusion assessment (e.g., severe peripheral vascular compromise).","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of indocyanine green (ICG) fluorescence during colorectal surgery. In approximately 30 patients undergoing elective colon or rectal resection with primary anastomosis, both imaging modalities will be performed intraoperatively. The surgeons will base their clinical decisions solely on standard ICG fluorescence imaging, while LSCI measurements are collected for research purposes and do not influence treatment. Postoperatively, quantitative ICG parameters will be analysed and compared with LSCI perfusion maps to determine whether objective ICG analysis improves agreement with LSCI over subjective interpretation alone. In addition, the study will evaluate the feasibility of using the PerfusiX-IGS LSCI system during open colorectal surgery and describe postoperative outcomes, including anastomotic leakage. The ultimate goal is to contribute to more objective and standardized perfusion assessment during colorectal surgery",[24,25,26,27,28,29,30,31,32],"Leakage, Anastomotic","Colon Cancer","Colon Anastomosis","Colon and Rectal Cancer","Colon Benign Tumor","Colon and Rectal Diseases","Laser Speckle Contrast Imaging","Indocyanine Green (ICG)","Near-Infrared Spectroscopy",[34,35,36,37,38,39],"colon","anastomosis","laser speckle contrast imaging","indocyanine green","ICG","Near-infrared","NOT_YET_RECRUITING","2026-07-17",{"date":43,"type":44},"2026-07-22","ACTUAL",{"date":46,"type":20},"2026-08-01",{"date":48,"type":20},"2027-09-30",{"name":50,"class":51},"Leiden University Medical Center","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100631003","the-transit-bipartition-with-the-use-of-a-metallic-anastomosis-clip-and-circular-fundocorporeal-gastroplication-100631003","NCT07495020","The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication","The Laparoscopic Transit Bipartition Without Gastrectomy With Use of Metallic Anastomosis Clip (MAC) and Circular Fundocorporeal Gastroplication for Treating Type 2 Diabetes Mellitus and Obesity","MACBIPARTFCG","Inclusion Criteria:\n\n* Clinical diagnosis of Type 2 Diabetes Mellitus\n* BMI 25-35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Insulin dependent diabetes\n* BMI \\\u003C25 and \\>35 kg\u002Fm2\n* History of surgery on the stomach\n* Less than 18 or more than 65 years of age\n* Psychiatric illness\n* Patients unwilling or unable to provide informed consent","65 Years",{"count":62,"type":20},90,"INTERVENTIONAL",[65],"NA","This study evaluates a new surgical device - the Metallic Anastomotic Clip (MAC) - for performing a laparoscopic bypass gastroenteroanastomosis with entero-enteric anastomosis (transit bipartition \u002F \"dual-path\" procedure) in patients with type 2 diabetes mellitus (T2DM) who have overweight or Class I obesity (BMI 25-34.9 kg\u002Fm²).\n\nCurrently, most bariatric and metabolic surgery procedures are only approved for patients with a BMI above 35 kg\u002Fm². However, many T2DM patients have BMI less 34.9 kg\u002Fm2 and cannot access surgical treatment under existing national guidelines. The transit bipartition procedure addresses this gap by creating a second food pathway from the stomach to the ileum while preserving normal duodenal digestion - producing a strong incretin (GLP-1) effect similar to GLP-1 receptor agonists (e.g., semaglutide), without causing excessive weight loss or requiring lifelong vitamin supplementation.\n\nThe MAC is a novel compression anastomotic device designed to replace conventional hand-sewn or stapled anastomoses, potentially reducing complications such as anastomotic leak, bleeding, marginal ulcers, and strictures, while also lowering operative costs.\n\nParticipants will be randomised into three groups. The study will assess metabolic outcomes (T2DM remission, glycaemic control), surgical safety, quality of life, and cost-effectiveness over a follow-up period of 2026-2027.",[68,69,70,24],"Type 2 Diabetes Mellitus (T2DM)","Obesity & Overweight","Marginal Ulcer (Peptic) or Erosion",[72,73,74,75],"Metallic Anastomotic Clip","Metabolic bariatric surgery","obesity","Type 2 diabetes mellitus","RECRUITING","2026-05-02",{"date":79,"type":44},"2026-05-07",{"date":81,"type":44},"2026-04-30",{"date":83,"type":20},"2028-05-30",{"name":85,"class":51},"The Society of Bariatric and Metabolic Surgeons of Kazakhstan",1]