[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lichen-sclerosus-lesion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lichen-sclerosus-lesion":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100648195","identification-of-genetic-variants-associated-with-lichen-sclerosus-100648195",false,"NCT07720830","Identification of Genetic Variants Associated With Lichen Sclerosus","GENITALS","Inclusion Criteria:\n\n* Individual with clinical or \u002Fand histological Lichen sclerosus\n* Family member of an individual with lichen sclerosus\n\nExclusion Criteria:\n\n* No Family member with lichen sclerosus",true,"ALL","1 Year",{"count":20,"type":21},100,"ESTIMATED","1 Day","OBSERVATIONAL","Lichen Sclerosus (LS) is a common genital skin condition that severely impacts on daily living. LS occurs worldwide but may be more common in the white population. The extragenital skin is involved in about 10% of reported patients, exact numbers are not known. LS is estimated to affect 0.1-0.3% of new patients in a general hospital patient population and 1.7% of patients referred to general gynaecological practice, however, the exact prevalence and incidence is not known. LS has a major impact on the quality of life, as symptoms of itching, pain and discomfort can make it difficult to sit, walk and go to the toilet. Having sex becomes painful because of erosions and fissures (break down of the skin), sometimes impossible because of irreversible fusion (sticking together) and sclerosis (hardening) of the genital skin. There is an increased risk of genital cancer in individuals with LS, this seems higher in familial cases. Next to a genetic background leading to a dysregulation of the immune system, certain external trigger mechanisms seem to play an important role in the development of LS.\n\nIn this project the investigators propose to identify pathogenic variants in novel protein-coding genes that may be involved in Lichen sclerosus using samples from families with members manifesting LS. Through elucidating underlying pathomechanims which have not yet been fully explored the development of novel treatments may be possible.",[26],"Lichen Sclerosus Lesion",[28,29,30],"lichen sclerosus","family","genetic","RECRUITING","2026-07-17",{"date":34,"type":35},"2026-07-22","ACTUAL",{"date":37,"type":35},"2025-12-13",{"date":39,"type":21},"2027-12-31",{"name":41,"class":42},"Gudula Kirtschig","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100545987","laser-treatment-for-lichen-sclerosus-100545987","NCT06389071","Laser Treatment for Lichen Sclerosus","Safety and Efficacy of Ablative Fractional 2940 nm Laser Treatment for Lichen Sclerosus Lesion","Inclusion Criteria:\n\n* Female aged 18 years or older\n* Biopsy-proven vulvar lichen sclerosus lesion\n* Experiencing one or more of the following symptoms of LS:\n\n  1. Dryness\n  2. Itching\n  3. Burning\n  4. Bleeding\n  5. Blistering\n  6. Soreness\n  7. Easily bruises\n  8. Easily tears\n  9. Ulcerated lesions\n  10. Painful intercourse\n* Negative urine pregnancy test if subject is of childbearing potential before enrollment\n* Absence of vulvovaginal infection i.e. fungi, bacterial vaginosis, and STI\n* Ability to understand and sign informed consent, questionnaires, and all investigation requirements\n* Willing to consent to clinical photographs of the treatment area\n* Willing to consent to ultrasound images of the treatment area\n* Willing and able to logistically follow schedule of treatments and follow-up visits\n\nExclusion Criteria:\n\n* Pregnancy, less than 3 months postpartum, or planning to become pregnant during the investigation to protect integrity of the data\n* Is a nursing mother\n* History of uncontrolled malignant disease\n* Active urogenital infection or chronic infection (i.e., candida, herpes, herpes simplex, bacterial vaginosis, trichomoniasis, or other infection)\n* Immunocompromised (e.g., lymphoma, AIDS, Wiskott-Aldrich syndrome)\n* Subjects with genital skin disease, psoriasis due to risk of koeberizing\n* Subjects on immunosuppressants: mycophenolate, retinoids, azathioprine, cyclosporin\n* Known allergy or intolerance to local anesthesia\n* Known history of connective tissue disease\n* Known propensity for keloid formations\n* Known medical condition that may affect wound healing\n* Any reason that the investigator deems prohibits participation in the investigation","FEMALE","18 Years",{"count":54,"type":21},50,"INTERVENTIONAL",[57],"NA","Fractional ablative laser treatment for Lichen Sclerosus lesion",[26],"2026-04-21",{"date":62,"type":35},"2026-04-23",{"date":64,"type":35},"2024-03-01",{"date":66,"type":21},"2027-12-30",{"name":68,"class":69},"Sciton","INDUSTRY"]