[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"locoregional-anaesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:locoregional-anaesthesia":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100652223","continuous-interscalene-blocks-and-rebound-pain-100652223",false,"NCT07770165","Continuous Interscalene Blocks and Rebound Pain","Evaluation of the Effect of Continuous Interscalene Blocks on Rebound Pain Compared to Single-Shot Interscalene Blocks in Total Shoulder Arthroplasty : A Randomized-Controlled Trial","Inclusion Criteria:\n\n* Adults aged \\>18 years of age\n* ASA I-III\n* Scheduled for elective ambulatory total shoulder arthroplasty.\n\nExclusion Criteria:\n\n* ASA IV\n* Revision surgery\n* Contraindication to regional anesthesia (such as allergy to local anesthetics, systemic anticoagulation, local infection)\n* Preoperative chronic pain or opioid use\n* Preoperative drug dependency\n* Severe respiratory disease or contralateral diaphragmatic paralysis\n* Patient refusal.","ALL","18 Years",{"count":19,"type":20},154,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objectives of this present study are to examine whether a continuous interscalene block of a total duration of 48 hours reduces the incidence of rebound pain comparatively to single-shot interscalene block, through the evaluation of the NRS scores at rest and on movement in the postoperative period at 24, 48, 72 and 96 hours as well as the total opioid consumption in the same timeframe for patients undergoing total shoulder arthroplasty.\n\nRebound pain has been defined in some studies as the \"the transition from well-controlled pain (numerical rating scale \\[NRS\\] ≤3) while the block is working to severe pain (NRS ≥7) within 24 h of block performance.\"",[26,27,28,29,30,31,32,33],"Total Shoulder Arthroplasty","Reverse Total Shoulder Arthroplasty","Interscalene Analgesia","Interscalene Blocks","Interscalene Nerve Block","Orthopedic Surgery Patients","Locoregional Anaesthesia","Rebound Pain",[35,36,37,38,26,27,33],"Interscalene","Nerve Block","Catheter","Continuous Interscalene Block","NOT_YET_RECRUITING","2026-08-17",{"date":42,"type":43},"2026-08-19","ACTUAL",{"date":45,"type":20},"2026-10",{"date":47,"type":20},"2027-05",{"name":49,"class":50},"University of Calgary","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":51},"100520200","optimal-postoperative-chest-tube-and-pain-management-in-patients-surgically-treated-for-primary-spontaneous-pneumothorax-pneumotrial-100520200","NCT06053476","Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial)","Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial); a Randomized Controlled Trial","Inclusion Criteria:\n\n* All patients operated for PSP\n* Age ≥ 16 years\n* Able to read and understand the Dutch language\n* Mentally able to provide informed consent\n* Patients should have a preoperative chest CT scan in order to exclude evident secondary pneumothorax. Previously made CT scans, within a time range of maximum 5 years, are accepted. The identification of blebs or bullae on CT scan is not defined as secondary pneumothorax.\n\nExclusion Criteria:\n\n* Previous ipsilateral thoracic surgery (except diagnostic thoracoscopy only) or ipsilateral thoracic radiotherapy\n* Underlying lung disease that provoked the pneumothorax (secondary pneumothorax): genetically proven Birt-Hogg-Dubé syndrome, periodic pneumothorax in female patients in reproductive age with known endometriosis (or known catamenial pneumothorax), pulmonary cystic fibrosis, active pneumonia, lung fibrosis, chronic obstructive pulmonary disease (COPD), pulmonary ipsilateral malignancy\n* Contra-indications for TEA (infection at skin site, increased intracranial pressure, non-correctable coagulopathy, sepsis and mechanical spine obstruction)\n* Patients chronically (\\>3 months) using opioids will be excluded since postoperative baseline opioid requirement will be higher and TEA remains the preferred technique for these patients\n* Allergic reactions to analgesics used in the study","16 Years",{"count":61,"type":20},366,[23],"Guidelines lack high quality evidence on optimal postoperative chest tube and pain management after surgery for primary spontaneous pneumothorax (PSP). This results in great variability in postoperative care and length of hospital stay (LOS). Chest tube and pain management are prominent factors regarding enhanced recovery after thoracic surgery, and in standardised care they are crucial to improve quality of recovery and decrease LOS.\n\nHistorically, postoperative chest tubes are left in place for at least a fixed number of 3-5 days, irrespective of absence of air leakage. This period was deemed necessary for adequate pleurodesis and prevention of recurrence. However, it is suggested that removal on the same day of surgery is safe and associated with a reduced LOS.\n\nRegarding postoperative pain management, thoracic epidural analgesia (TEA) is the gold standard for postoperative pain management following video-assisted thoracic surgery (VATS). Although the analgesic effect of TEA is clear, it is associated with hypotension and urinary retention. Therefore, unilateral regional techniques, such as paravertebral blockade (PVB), are developed.\n\nThe investigators hypothesize that early chest tube removal accompanied by a single-shot paravertebral blockade (PVB) for analgesia is safe regarding pneumothorax recurrence and non-inferior regarding pain, but superior regarding LOS when compared to standard conservative treatment.",[65,66,67,32,68,69],"Pneumothorax, Primary Spontaneous","VATS","Pain, Postoperative","Thoracic Epidural","Chest Tube Drainage","RECRUITING","2025-05-06",{"date":73,"type":43},"2025-05-09",{"date":75,"type":43},"2023-11-08",{"date":77,"type":20},"2028-11-01",{"name":79,"class":50},"Maxima Medical Center"]