[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-extremity-lymphedema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-extremity-lymphedema":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100638302","early-phase-1-evaluate-advanced-pneumatic-compression-device-with-revised-compression-programming-for-lymphedema-treatment-100638302",false,"NCT07613931","Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment","A Pilot Study to Evaluate and Compare Lymphatic Transport in Patients With Lower Extremity Lymphedema Between Flexitouch Plus® and Flexitouch Plus® With Novel Multi-Chamber Firmware","Inclusion Criteria:\n\n1. 18 years of age or older\n2. A diagnosis of active lower extremity lymphedema, as assessed by medical history\n3. Participant is a candidate for APCD treatment per the Flexitouch Plus indications for use\n4. Must be able to provide informed consent prior to study participation\n5. Willing and able to comply with the study protocol requirements and all study-related visit requirements\n\nExclusion Criteria:\n\n1. Heart failure (acute pulmonary edema, decompensated acute heart failure)\n2. Acute venous disease (acute thrombophlebitis, acute deep venous thrombosis, acute pulmonary embolism)\n3. Severe peripheral artery disease (critical limb ischemia, including ischemic rest pain, arterial wounds or gangrene)\n4. Active skin or limb infection\u002Finflammatory disease (acute cellulitis, other uncontrolled skin or untreated inflammatory skin disease) on the trunk or lower extremities\n5. Active cancer or metastasis in the lower extremity lymphatic watersheds\n6. Eczema, rash, scarring, or extensive tattoos at imaging sites\n7. Participant is pregnant or trying to become pregnant\n8. Participants with a history of allergy to iodides, who may be susceptible to iodine present in ICG formulation\n9. Patients exhibiting Grade 3 or higher on the CTCAE v6.0 superficial soft tissue fibrosis scale\n10. Body Mass Index (BMI) ≥40\n11. Participants unable to recline on their backs for up to 60 consecutive minutes and walk in place or tolerate assisted lower extremity movement for 5 minutes","ALL","18 Years",{"count":19,"type":20},5,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The goal of this pilot study is to learn if a revised method of compression improves lymphatic function compared to the current method of compression. The main questions:\n\n• Does the revised method of compression improve lymph movement and lymphatic propulsion?",[26],"Lower Extremity Lymphedema",[28,29],"lymphedema","lower extremity","RECRUITING","2026-08-09",{"date":33,"type":34},"2026-08-11","ACTUAL",{"date":36,"type":34},"2026-07-09",{"date":38,"type":20},"2026-09",{"name":40,"class":41},"Tactile Medical","INDUSTRY",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100648643","aerobic-exercise-effects-in-lower-extremity-lymphedema-100648643","NCT07726277","Aerobic Exercise Effects in Lower Extremity Lymphedema","Effects of Aerobic Exercise on Ultrasonographic Parameters, Functional Status, Balance, and Quality of Life in Patients With Lower Extremity Lymphedema","Inclusion Criteria:\n\n* Diagnosis of lower extremity lymphedema (unilateral or bilateral)\n* Age ≥18 years\n* Absence of cognitive impairment\n* Provision of written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Cognitive impairment\n* Presence of general contraindications to exercise (e.g., hemodynamic instability, uncontrolled hypertension, decompensated heart failure, recent myocardial infarction, or unstable angina pectoris)\n* Presence of neurological diseases affecting the lower extremities that would preclude participation in the exercise program\n* Presence of unhealed fractures in the lower extremities preventing exercise therapy\n* Active systemic infection or local infection in the treatment area, such as cellulitis, erysipelas, or thrombophlebitis in the lower extremities\n* Acute venous thromboembolic events involving the lower extremities\n* Heart failure or renal failure that may cause lower extremity edema\n* Presence of concomitant lipedema\n* Presence of venous insufficiency\n* Ongoing chemotherapy or radiotherapy (among patients with malignancy-related lymphedema)\n* Pregnancy",{"count":51,"type":20},50,[53],"NA","Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients with lymphedema. CDT consists of manual lymph drainage (MLD), skin care, compression bandaging, and exercise. Several studies have demonstrated the effectiveness of CDT in patients with lower extremity lymphedema. However, the results of studies investigating the effectiveness of different types of exercise are inconsistent. Moreover, most of these studies have been conducted in patients with upper extremity lymphedema, and the outcome measures have generally been limited to limb circumference measurements and quality of life assessments.\n\nTo the best of our knowledge, no previous study has comprehensively evaluated the effects of aerobic exercise on both ultrasonographic parameters (quantitative data) and functional outcomes in patients with lower extremity lymphedema, as planned in the present study. Therefore, this study was designed to contribute to the existing literature by investigating these effects.",[26],"NOT_YET_RECRUITING","2026-07-22",{"date":59,"type":34},"2026-07-24",{"date":61,"type":20},"2026-08-01",{"date":63,"type":20},"2027-03-15",{"name":65,"class":66},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":42},"100645896","respiratory-and-relaxation-training-in-lower-extremity-lymphedema-100645896","NCT07697482","Respiratory and Relaxation Training in Lower Extremity Lymphedema","Effect of Respiratory and Relaxation Training Added to Complex Decongestive Therapy on Functional Capacity and Muscle Oxygenation in Patients With Lower Extremity Lymphedema: A Single-Center Randomized Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 18 years or older.\n* Clinically diagnosed with secondary lower extremity lymphedema.\n* Presence of lower extremity lymphedema for at least 3 months.\n* Able to stand and walk independently to complete the Six-Minute Walk Test.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Acute cellulitis or other active infection within the previous 2-4 weeks.\n* Current or recent deep vein thrombosis (DVT) or uncontrolled peripheral vascular disease.\n* Severe cardiovascular, pulmonary, orthopedic, or neurological conditions that could interfere with participation or outcome assessments.\n* Pregnancy.\n* Skin lesions or irritation preventing placement of the near-infrared spectroscopy (MOXY) sensor.\n* Inability to comply with the study protocol or follow-up assessments.","FEMALE","65 Years",{"count":77,"type":20},60,[53],"This randomized controlled trial aims to investigate the effectiveness of respiratory and relaxation training added to standard complex decongestive therapy (CDT) on muscle oxygenation, functional capacity, and limb volume in patients with lower extremity lymphedema. Participants will be randomly assigned to receive either standard CDT alone or CDT combined with respiratory and relaxation exercises. Outcomes will be assessed before treatment, immediately after treatment, and two months after completion.",[26],[26,82,83,84,85],"Complex Decongestive Therapy","Respiratory Training","Relaxation Training","Muscle Oxygenation","2026-07-10",{"date":88,"type":34},"2026-07-13",{"date":90,"type":34},"2026-03-01",{"date":92,"type":20},"2027-03",{"name":94,"class":95},"Toros University","OTHER"]