[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-limb-amputees\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-limb-amputees":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100646024","pns-to-improve-vascular-function-and-limb-health-in-veterans-100646024",false,"NCT07696988","PNS to Improve Vascular Function and Limb Health in Veterans","Peripheral Neural Stimulation to Improve Microvascular Function and Limb Health in Veterans With Diabetic Peripheral Neuropathy","Inclusion Criteria:\n\nInclusion Criteria - All Participants:\n\n* English-speaking\n* Veteran\n\nInclusion Criteria - Diabetic Peripheral Neuropathy (DPN) Participants:\n\n* Confirmed diagnosis of type 1 or type 2 diabetes mellitus for at least 5 years\n* Clinical signs and\u002For symptoms consistent with diabetic peripheral neuropathy Or confirmation of neuropathy via physical exam\n\nInclusion Criteria - Lower Limb Amputees:\n\n* Unilateral transtibial or transfemoral amputation\n* Medically stable for at least 3 months\n* For the designated subset of the limb-loss cohort (n = 6): implanted with C-FINEs on the sciatic and\u002For tibial nerves\n\nExclusion Criteria:\n\nExclusion Criteria - All Participants:\n\n* Severe neurological disorders impairing ambulation\n* Visual or hearing impairments interfering with study participation\n* Cardiovascular or respiratory conditions posing risk during participation\n* Cognitive or psychiatric conditions compromising informed consent\n* Participation in other clinical trials interfering with outcomes\n* Pregnancy\n* History of photosensitivity or known sensitivity to laser light\n\nAdditional Exclusion Criteria - Amputees:\n\n* Active skin breakdown or infection at residual limb\n* Significant phantom or residual limb pain interfering with study procedures\n* Bilateral lower-limb amputation",true,"ALL","18 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"NA","Establishing a sensitive, scalable physiological test for neurovascular reflex integrity and investigating whether targeted peripheral neural stimulation can enhance perfusion and vasodilatory responsiveness.",[27,28],"Lower Limb Amputees","Diabetes",[30,28],"lower extremity limb loss","NOT_YET_RECRUITING","2026-08-19",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":21},"2026-11-02",{"date":39,"type":21},"2030-05-30",{"name":41,"class":42},"VA Office of Research and Development","FED"]