[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-spondylolisthesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-spondylolisthesis":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,93,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100651966","early-phase-1-evaluation-of-an-online-peri-operative-health-education-platform-for-patients-undergoing-spine-surgery-ready-set-recover-100651966",false,"NCT07766824","Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover","Inclusion Criteria:\n\n* Patients deemed candidates for medium-\u002Flong-segment spinal fusion\n* Patients who score a \\> 4 on a 0-10 NRS for the question \"How motivated are you to participate in this research study?\"\n* At least 18 years of age and not older than 80 at the time of study enrollment •Ability to read and understand English\n* Daily access to the internet via cell phone, tablet, or computer\n\nExclusion Criteria:\n\n* Have received epidural steroid injection for low back pain, lumbosacral radiculopathy, or scoliosis in the prior 3 months\n* Have received a surgical intervention for low back pain, lumbosacral radiculopathy, or scoliosis in the previous 6 months\n* Concurrent diagnosis of cancer\n* Cognitive impairment\n* Severe comorbidities (e.g., terminal illness, severe organ failure)\n* Non-elective\u002Femergency surgery in the past","ALL","18 Years","80 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","Chronic back pain is the world's leading cause of disability, with spine surgery being a common yet costly intervention. However, many patients experience suboptimal recovery, with persistent pain and functional limitations contributing to high healthcare utilization and costs. Traditional surgical pathways often overlook the role of mental well-being and patient engagement in recovery. However, research indicates that interventions promoting self-management and stress reduction can lead to improvements in pain, faster recovery, and reduced hospital readmissions.\n\nEvidence shows that preoperative psychosocial factors, such as anxiety and depression, significantly predict post-surgical outcomes, yet structured perioperative support is lacking. To address this gap, Ready Set Recover (RSR), a mobile health (mHealth) intervention, provides education, behavioral strategies, and psychosocial support to enhance surgical preparedness and optimize post-surgical recovery. By addressing both psychological and behavioral factors, RSR has the potential to fill a critical gap in perioperative care. As a scalable digital platform, RSR offers an accessible, cost-effective solution that can be easily integrated into existing surgical care models, reducing the burden on healthcare providers while empowering patients to take an active role in their healing process.\n\nRSR aims to accomplish this by integrating evidence-based components such as cognitive behavioral therapy, mindfulness, gratitude practices, and guided movement to foster patient empowerment and sustainable health practices in the pre- and post-surgical periods. The platform provides patients with a structured and flexible tool to improve self-efficacy, adherence to post-surgical recommendations, and the overall surgical recovery experience.\n\nThis study aims to evaluate the feasibility and acceptability of RSR through an explanatory mixed-methods pilot randomized controlled trial (RCT) in patients undergoing medium-to-long segment spinal fusion at Oregon Health \\& Science University.\n\nAim 1 assesses feasibility and acceptability by measuring patient engagement, intervention completion rates, and satisfaction.\n\nAim 2 qualitatively evaluate barriers and facilitators to implementation of RSR within the clinic setting via provider, patient, and clinic stakeholder semi-structured interviews.\n\nAim 3 establishes a patient community advisory board (CAB) to guide future research and the development of a Phase II Small Business Technology Transfer (STTR) efficacy trial.\n\nFindings from this study will inform the refinement and scalability of RSR as a low-burden, cost-effective solution to improve surgical outcomes. Insights gained from this research may extend beyond spine surgery, informing the development of digital health interventions for other surgical populations, ultimately advancing patient-centered, technology-driven approaches to perioperative care.",[26,27,28,29,30,31,32,33,34],"Medium-\u002FLong-segment Spinal Fusion Patients","Spine Surgeons","Chronic Low Back Pain","Scoliosis Patients","Lumbar Spondylosis","Lumbar Spondylolisthesis","Cervical Spondylosis and Spondylolisthesis","Post Laminectomy Cervical Syndrome","Cervical Myelopathy",[36,37,38,39,40,41,42,43],"back surgery","medium-\u002Flong-segment spinal fusion","mindfulness","Perioperative Care","Whole Person Care","Chronic low back pain","Feasibility","Qualitative","NOT_YET_RECRUITING","2026-08-10",{"date":47,"type":48},"2026-08-17","ACTUAL",{"date":50,"type":20},"2026-09-30",{"date":52,"type":20},"2027-09-30",{"name":54,"class":55},"National University of Natural Medicine","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":64,"targetDuration":4,"studyType":21,"phases":66,"briefSummary":68,"conditions":69,"keywords":78,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":56},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation",{"count":65,"type":20},125,[67],"PHASE4","Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[70,71,31,30,72,73,74,75,76,77],"Lumbar Spinal Stenosis","Lumbar Disc Herniation","Lumbar Radiculopathy","Lumbar Spine Instability","Synovial Cyst","Degenerative Disc Disease","Degenerative Spondylolisthesis","Degenerative Intervertebral Discs",[79,80,81,82],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","RECRUITING","2026-02-11",{"date":86,"type":48},"2026-02-17",{"date":88,"type":48},"2022-02-01",{"date":90,"type":20},"2027-04-30",{"name":92,"class":55},"John O'Toole",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":15,"minAge":100,"maxAge":17,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100595103","a-study-on-the-clinical-use-of-a-new-expandable-olif-cage-with-posterior-bone-grafting-in-lumbar-spine-surgery-100595103","NCT07028099","A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery","Multi-Center Randomized Controlled Clinical Study on the Application of a Novel Expandable Posterior Bone Grafting OLIF Cage","Inclusion Criteria:1: Age between 40 and 80 years (inclusive)\n\n2: Clinically diagnosed with lumbar spondylolisthesis or lumbar spinal stenosis\n\n3: Confirmed single-level lumbar degenerative disease\n\n4: Affected level located at L2\u002F3, L3\u002F4, or L4\u002F5\n\n5: Failure of conservative treatment for at least 6 months\n\nExclusion Criteria:1: Patients requiring direct decompression of the spinal canal\n\n2: History of prior lumbar or retroperitoneal surgery\n\n3: Abnormal anatomy between the iliac vascular sheath and the psoas major muscle\n\n4: Presence of active infection or other significant systemic diseases\n\n5: Inability to complete surgical treatment or comply with follow-up due to various limitations\n\n\\-","40 Years",{"count":102,"type":20},340,[104],"NA","This clinical trial aims to evaluate the safety and effectiveness of a novel expandable OLIF (Oblique Lateral Interbody Fusion) cage with posterior bone grafting in patients with lumbar degenerative diseases. OLIF is a minimally invasive spinal surgery technique that restores intervertebral height and relieves nerve compression by placing a cage into the disc space.\n\nThe new device allows surgeons to adjust the height of the cage during surgery and deliver bone grafts through a special channel after expansion. This study compares the outcomes of patients receiving the new cage versus those treated with a conventional OLIF cage.\n\nThe trial will assess pain relief, functional improvement, spinal stability, fusion success, and potential complications. Radiological images and patient-reported scores (like VAS and ODI) will be collected over 12 months. The study includes patients aged 40 to 80 with single-level lumbar spine disease who have not improved after at least 6 months of conservative treatment.\n\nThis study will help determine whether the new expandable cage offers clinical advantages and better long-term outcomes for patients undergoing OLIF surgery.",[31,107,71,70],"Degenerative Lumbar Scoliosis",[109,110,111,112],"Expandable OLIF Cage","Minimally Invasive Spine Surgery","Prospective Multicenter Randomized Controlled Trial","Degenerative Lumbar Disease","2025-06-17",{"date":115,"type":48},"2025-06-19",{"date":117,"type":20},"2025-06-10",{"date":119,"type":20},"2027-05-31",{"name":121,"class":55},"The Affiliated Hospital of Qingdao University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":15,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":56},"100479758","spinal-stenosis-and-listhesis-treated-with-percutaneous-interspinous-spacer-a-non-surgical-trial-100479758","NCT05527145","Spinal Stenosis and Listhesis Treated With Percutaneous Interspinous Spacer: a Non-surgical Trial","Treatment of Spinal Stenosis and Spolilolisthesis With Percutaneous Interspinous Spacers. A Phase III Trial","Inclusion Criteria:\n\n1. Age 50-85 years.\n2. Clinical symptoms of lumbar spinal stenosis (pseudoclaudication) indicating and motivating surgery. Numeric Rating Scale in lower limbs ≥3.\n3. MRI with finding of lumbar spinal stenosis at 1-3 lumbar levels. Dural sac area ≤75 mm2 or degree of stenosis C or D according to Schizas's classification.34\n4. The patient has given oral and written informed consent to participate.\n\nExclusion Criteria:\n\n1. Degenerative deformity with Cobb angle \\>20°.\n2. Symptomatic osteoarthritis in the lower limbs that affects and limits the patient's function.\n3. Arterial insufficiency (claudication intermittent).\n4. Former lumbar surgery other than disc hernia.\n5. Conditions that affect the spine, such as ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis, spondylodiscitis\u002Finfections, malignancy and neurological diseases.\n6. Heart and lung diseases presenting a significant risk for surgery or making it impossible for the patient to take part in a percutaneous arm of treatment (American Society of Anesthesiologists (ASA) score \\>3).\n7. Polyneuropathies.\n8. Psychological factors rendering the patient incapable of inclusion in the trial (eg, drug addiction, dementia).","50 Years","85 Years",{"count":132,"type":20},200,[104],"Symptomatic lumbar spinal stenosis is the most common indication for spinal surgery. However, more than one-third of the patients undergoing surgery for lumbar stenosis report dissatisfaction with the results. On the other hand, conservative treatment has shown positive results in some cases. This trial will compare the outcomes of surgical versus non-surgical treatment for lumbar stenosis.",[136,73,31,70],"Lumbar Spine Degeneration",[138,139],"spondylolisthesis","lumbar spine stenosis","2024-02-09",{"date":142,"type":48},"2024-02-12",{"date":144,"type":20},"2024-09",{"date":146,"type":20},"2026-07",{"name":148,"class":55},"University of Roma La Sapienza"]