[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lyme-borreliosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lyme-borreliosis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100645620","flow-cytometric-immune-monitoring-of-b-afzelii-specific-t-lymphocytes-100645620",false,"NCT07703787","Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes","LyTLymICS-AIM","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Subject informed of the results of the prior medical examination\n* Subject informed about the objectives, procedures, and potential risks of the study\n* Subject affiliated with a health insurance\u002Fsocial security scheme (beneficiary or dependent)\n* Subject having provided dated and signed informed consent\n* Lyme borreliosis\u002Facrordermatitis chronica atrophicans (ACA) group:\n\nSubject presenting clinical and biological criteria or Borrelia identification confirming chronic atrophic acrodermatitis, with appropriate antibiotic treatment initiated less than 18 months ago or untreated\n\n• Control group: Healthy subject with no history of Lyme disease and negative Lyme serology\n\nExclusion Criteria:\n\n* Body weight \\\u003C 50 kg\n* Pregnancy or breastfeeding\n* Diabetes mellitus\n* Immunodeficiency or ongoing immunosuppressive treatment (including oral corticosteroids)\n* Contraindication to local anesthesia with lidocaine, with or without adrenaline\n* Inability to provide informed consent (emergency situation, inability to understand study information, …)\n* Participation in another clinical trial\n* Legal protection measures (guardianship, curatorship, or legal safeguard)",true,"ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","Lyme borreliosis diagnosis currently relies on clinical assessment and detection of Borrelia-specific antibodies. However, serology does not allow reliable assessment of active infection. Evaluation of the cellular immune response through Borrelia-specific T lymphocyte monitoring may provide complementary diagnostic and prognostic information.\n\nThis study aims to assess Borrelia afzelii-specific T-cell responses using multiparameter flow cytometry after stimulation with standardized peptide pools. This approach enables the characterization of CD4+ and CD8+ T cells, including polyfunctional immune responses.\n\nThe diagnostic and prognostic value of this immunomonitoring strategy will be evaluated in patients with acrodermatitis chronica atrophicans, a late manifestation of Lyme borreliosis associated with B. afzelii.",[25,26],"Lyme Borreliosis","Lyme Disease","NOT_YET_RECRUITING","2026-07-09",{"date":30,"type":31},"2026-07-14","ACTUAL",{"date":33,"type":21},"2026-09",{"date":35,"type":21},"2029-03",{"name":37,"class":38},"University Hospital, Strasbourg, France","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100488515","effectiveness-of-an-intervention-combining-adapted-physical-activity-and-therapeutic-education-in-patients-with-chronic-symptoms-attributed-to-lyme-borreliosis-100488515","NCT05641116","Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.","Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis. Multicenter, Controlled, Randomized Pilot Study","LyMouv'","Inclusion Criteria:\n\n* Patient referred to the reference center for tick-borne diseases by his attending physician\n* Duration of symptoms \\>6 months\n* At the end of the initial assessment, the diagnosis of functional somatic disorders is retained after consensus between the physicians\n* Patient practicing less than 150 minutes of regular physical activity per week (WHO recommendations)\n\nExclusion Criteria:\n\n* Patients with cardiac or respiratory pathologies that contraindicate the practice of physical activity physical activity\n* Important comorbidities contraindicating the practice of physical activity: associated cardiac pathologies associated cardiac pathologies (severe rhythm disorders such as rapid atrial fibrillation), respiratory pathologies respiratory pathologies (obstructive or severe restrictive respiratory insufficiency), disabling joint pathologies joint pathologies (gonarthrosis or coxarthrosis limiting training on a treadmill or on a high-intensity bicycle). intensity cycling).\n* Patients under guardianship or curatorship",{"count":49,"type":21},62,"INTERVENTIONAL",[52],"NA","Lyme borreliosis, commonly known as Lyme disease, has been clinically described for more than a century, but has been officially recognized for 40 years, with the detection of the Borrelia bacterium by W. Burgdorfer, in ticks of the Ixodes ricinus complex, identified a few years before.",[25,55,56],"Physical Activity","Lyme Borreliosis, Nervous System",[58,59,60,61],"sedentary time","therapeutic education of the patient","adapted physical activity","training program","RECRUITING","2025-07-02",{"date":65,"type":31},"2025-07-03",{"date":67,"type":31},"2023-09-14",{"date":69,"type":21},"2027-12",{"name":71,"class":38},"Centre Hospitalier Universitaire de Saint Etienne",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":39},"100553944","risk-of-exposure-and-prevention-of-ticks-and-tick-borne-diseases-among-foresters-in-alsace-100553944","NCT06492668","Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in Alsace","Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in Alsace (France)","PREFORTIC","Inclusion Criteria:\n\n* Major forester (≥18 years old)\n* Male or female gender\n* ONF (National Forestry Office) staff\n* Regularly exposed to ticks in Alsace (exclusively)\n* Practicing regular forestry activities in a group\n* Agreeing to participate in the study.\n\nExclusion criteria:\n\n* Refusal to participate in the study",{"count":20,"type":21},"Ticks are blood-sucking arthropods that feed on vertebrate hosts. Although wild and domestic animals are the primary source of tick blood meals, humans can be an accidental host. During a blood meal, a microorganism can be transmitted to the host who can develop a disease. All infectious diseases transmitted by ticks are referred to as tick-borne diseases (TBDs). They are the most prevalent vector-borne diseases in the Northern Hemisphere. Among these diseases, Lyme borreliosis is the most common.\n\nIn Europe, Lyme borreliosis does not cause high fevers (\\> 38°C). Therefore, when a patient presents with a high fever with the notion of exposure to ticks, another etiology must be suspected. Anaplasma phagocytophilum and the tick-borne encephalitis virus are classically described as causing febrile syndromes.\n\nIn France, ticks and tick-borne diseases are increasing, particularly those associated with the Ixodes ricinus tick. This tick is mainly present in forest ecosystems with a peak of activity in May. Foresters represent a population with biting ticks and tick-borne diseases, notably Lyme borreliosis.",[25],[85,86,87,88],"Tick-Borne Diseases","Lyme borreliosis","Febrile syndromes","Ixodes ricinus tick","2024-07-11",{"date":91,"type":31},"2024-07-15",{"date":93,"type":31},"2024-01-01",{"date":95,"type":21},"2025-07-08",{"name":37,"class":38}]