[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lymphadenopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lymphadenopathy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100653938","new-approaches-for-the-diagnosis-of-lymphoma-and-multicentric-castleman-disease-100653938",false,"NCT07793006","New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease","Inclusion Criteria:\n\n* Age ≥1 year old and body weight of ≥ 10 kg.\n* HIV-infected.\n* Unexplained lymphadenopathy with at least one lymph node ≥2 cm that is amenable to biopsy.\n* Willing and able to give informed consent if the subject is 18 years of age or older, adolescent assent and legal guardian consent for subjects 15-17 years of age, pediatric assent and legal guardian consent for subjects 7-14 years of age, or legal guardian consent for pediatric subjects less than 7 years of age.\n\nExclusion Criteria:\n\n* Cannot or is not willing to follow study procedures.\n* Subjects with a previous history of cancer in the last five years with the exception of subjects with Kaposi sarcoma (i.e. history of Kaposi sarcoma is allowed in the study).","ALL","1 Year",{"count":18,"type":19},500,"ESTIMATED","INTERVENTIONAL",[22],"NA","Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.",[25,26,27,28,29,30],"HIV","Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease","Hodgkin Lymphoma","Non-Hodgkin Lymphoma","Tiny Isothermal Nucleic Acid Amplification System","Lymphadenopathy",[32],"Sub-Saharan Africa","RECRUITING","2026-08-25",{"date":36,"type":37},"2026-08-28","ACTUAL",{"date":39,"type":37},"2025-03-17",{"date":41,"type":19},"2028-12",{"name":43,"class":44},"Indiana University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100604933","value-of-super-resolution-ultrasonography-in-differentiating-benign-and-malignant-lymph-nodes-100604933","NCT07155954","Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes","Value of Super-resolution Ultrasound Microvascular Imaging in Distinguishing Benign and Malignant Superficial Lymph Nodes: a Prospective Multi-center Study","Inclusion Criteria:\n\n* (1)suggested abnormal lymph nodes indicated by ultrasonography; (2) Patients scheduled for lymph nodes puncture or fine needle aspiration or surgery; (3) Age greater than or equal to 18 years old.\n\nExclusion Criteria:\n\n* (1) Pregnant and lactating women; (2)pathological results not indicating benign or malignant lymph nodes; (3) history of chemotherapy or radiotherapy ; (4) History of allergies to eggs, milk, and ultrasound contrast agents; (5) Patients with acute coronary syndrome, severe pulmonary hypertension, or acute respiratory distress syndrome.","18 Years",{"count":55,"type":19},779,"OBSERVATIONAL","Lymph nodes are one of the most important components of the human immune system, and superficial lymph node enlargement lacks specificity.\n\nUltrasound examination has been widely used in the diagnosis of lymph node lesions and is of great significance in distinguishing between benign and malignant. However, the two-dimensional and Doppler ultrasound features of different types of lymph node lesions overlap and intersect, and the blood flow perfusion information of lymph nodes can provide more information for differentiation.\n\nAt present, the widely used contrast-enhanced ultrasound is easier to evaluate blood flow perfusion and can display small blood vessels smaller than 100 microns. The diagnostic accuracy of cervical lymph nodes using contrast-enhanced ultrasound is 80-90%.\n\nHowever, current contrast-enhanced ultrasound is limited by physical diffraction, with a resolution ranging from sub-millimeter to millimeter. This limitation hinders the visualization of small blood vessels or microcirculation by ultrasound, and parameters such as vascular size, spatial vascular pattern, and velocity of microcirculation are crucial for disease diagnosis and prognosis evaluation. Super resolution ultrasound (SRUS) is a new blood flow imaging technique. By tracking the movement trajectory of micro-bubbles instead of imaging the micro-bubbles themselves, the ultrasound diffraction limit can be exceeded to improve the sensitivity and image resolution of blood flow.\n\nThus the study aim to evaluate the feasibility of SRUS technology in distinguishing between benign and malignant lymph nodes, and compare the differences in blood flow distribution and perfusion index between benign and malignant lymph nodes under SRUS imaging.",[30,59,60,61],"Lymphnode Metastasis","Lymphoma","Lymphatic Tuberculosis","2025-08-27",{"date":64,"type":37},"2025-09-04",{"date":66,"type":37},"2024-10-23",{"date":68,"type":19},"2027-10-22",{"name":70,"class":44},"Peking University Third Hospital",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":20,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":5},"100586299","ebus-ttfb-vs-ebus-tbna-for-diagnosing-inadequate-lymph-node-specimens-based-on-mose-100586299","NCT06913569","EBUS-TTFB vs EBUS-TBNA for Diagnosing Inadequate Lymph Node Specimens Based on MOSE","Endobronchial Ultrasound-Guided Transtunnel Forceps Biopsy vs. Transbronchial Needle Aspiration for Diagnosing Inadequate Lymph Node Specimens Based on Macroscopic On-site Evaluation: A Prospective, Randomized, Multicenter Study","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. Chest imaging shows mediastinal or hilar lymphadenopathy (short axis ≥10 mm), requiring EBUS-TBNA for definitive diagnosis;\n3. EBUS-TBNA can be performed on these lymph nodes, and the specimens obtained from conventional EBUS-TBNA with three needle passes are inadequate (macroscopic visible core \\\u003C 30 mm);\n4. Willing to participate in this clinical study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Enlarged lymph nodes are identified as cystic or abscesses;\n2. Severe coagulopathy, insufficient anticoagulants\u002Fantiplatelets withdraw time or bleeding diathesis (platelets\\\u003C50\\*109\u002FL, INR\\>1.3) that do not meet bronchoscopy requirements;\n3. Other contraindications to bronchoscopy or transbronchial biopsy, such as severe cardiopulmonary insufficiency, intolerance to anesthesia, or endoscopic procedures;\n4. Patients who have participated in another clinical trial within the past three months;\n5. Vulnerable groups, such as pregnant women\n6. Any other condition that the investigator considers inappropriate for participation in this study.",{"count":79,"type":19},162,[22],"The study aims to compare the efficacy and safety of endobronchial ultrasound-guided transtunnel forceps biopsy to transbronchial needle aspiration in diagnosing inadequate lymph node specimens based on macroscopic on-site evaluation.",[30],"2025-04-15",{"date":85,"type":37},"2025-04-18",{"date":87,"type":37},"2025-04-01",{"date":89,"type":19},"2026-01-01",{"name":91,"class":44},"Shanghai Chest Hospital"]