[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"major-non-cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:major-non-cardiac-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100533410","individualized-versus-conventional-perioperative-blood-pressure-management-100533410",false,"NCT06225453","Individualized Versus Conventional Perioperative Blood Pressure Management","Effect of Individualized Versus Conventional Blood Pressure Management on Major Adverse Cardiac, Cerebrovascular, and Renal Events After Major Non-cardiac Surgery: Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged ≥65 or,\n* those aged ≥45 with a history of coronary artery disease, peripheral vascular disease, transient ischemic attack\u002Fstroke, or congestive heart failure,\n* undergoing non-cardiac surgery under general anesthesia with an anticipated duration of ≥2 hours.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Organ transplantation surgery\n* Brain\u002Fcarotid artery surgery\n* American Society of Anesthesiologists physical status 5 or 6\n* Pregnancy\n* Uncontrolled preoperative hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg)\n* Estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2\n* Renal replacement therapy\n* Acute decompensated heart failure\n* Sepsis\n* Shock\n* Use of inotropes\u002Fvasopressor infusion (dopamine, norepinephrine, vasopressin, etc.)","ALL","45 Years",{"count":19,"type":20},1896,"ESTIMATED","INTERVENTIONAL",[23],"NA","Study objective: To compare the effect of different perioperative blood pressure management strategies on major postoperative adverse outcomes \u002F Study design: a multicenter, randomized controlled trial \u002F Participants: 1896 patients undergoing major non-cardiac surgery \u002F Methods: Patients are randomized into two groups, the individualized strategy (maintaining perioperative mean arterial pressure and systolic blood pressure more than -20% of their baseline values) or the conventional strategy (maintaining perioperative mean arterial pressure ≥65 mmHg and systolic blood pressure ≥90 mmHg in all patients). Then, the frequency of major postoperative adverse outcomes occurring within 7 postoperative days or before discharge (whichever occurs first). \u002F Primary outcome: a composite of all-cause death, stroke, myocardial infarction, new or worsening congestive heart failure, unplanned coronary revascularization, and acute kidney injury, occuring within 7 postoperative days or before discharge (whichever occurs first).",[26],"Major Non-cardiac Surgery","RECRUITING","2026-07-05",{"date":30,"type":31},"2026-07-07","ACTUAL",{"date":33,"type":31},"2024-01-29",{"date":35,"type":20},"2026-12-31",{"name":37,"class":38},"Seoul National University Hospital","OTHER",5]