[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"memory-consolidation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:memory-consolidation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100648608","early-phase-1-human-cognition-during-surgery-stimulation-based-and-cholinergic-modulation-100648608",false,"NCT07721272","Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation","Studying Human Cognition During Deep Brain Stimulation Surgery Using High-Density Neural Probes and Pharmacological Interventions","Study Population\n\nInclusion Criteria for Essential Tremor Patients:\n\n* Diagnosis of Essential Tremor\n* Recommended to undergo deep brain stimulation implantation surgery for surgical management of medication-resistant tremor based on clinical indications\n\nExclusion Criteria for Essential Tremor Patients:\n\n* Patients with recent use (within one week) of anticoagulant or antiplatelet agent\n* Contraindication to use of cholinergic modulation\n\nInclusion Criteria for Epilepsy Patients\n\n* Diagnosis of intractable epilepsy\n* Undergoing neuromodulation procedure that utilizes insertion of electrodes into subcortical structures, including the thalamus or hippocampus\n* Undergoing neuromodulation procedure that utilizes frame-based insertion of electrodes into the thalamus (ANT or CM)\n\nExclusion Criteria for Epilepsy Patients:\n\n* Patients with recent use (within one week) of anticoagulant or antiplatelet agent\n* Contraindication to use of cholinergic modulation\n\nContraindication for cholinergic modulation in both patient sets will be assessed by members of the treatment team (e.g. epileptologist), as well as a neuroanesthesiologist. Multiple medications and conditions are singular disqualifiers; however some medications are eliminated only in combination following neuroanesthesiologist evaluation. Patients at risk of reaction to the treatment arm based on concurrent or recent medications or other health conditions will be excluded from participation.\n\nInclusion Criteria for Study Participation\n\n* Is patient between 18-70?\n* In general good health, aside from history of epilepsy or essential tremor, as ascertained by medical history, physical exam, clinical labs, and ECG?\n* Candidate for surgery as determined independently by the patient's treating physician\u002Fclinical team as part of the patient's routine medical care?\n* Able to read, understand, and provide written, dated informed consent, and participate in cognitive tasks?\n\nExclusion Criteria for Study Participation\n\n* Female that is pregnant, breastfeeding, or has a positive pregnancy test?\n* Under 18, over 70, or currently a prisoner on medical release?\n* Hepatic impairment (moderate or severe)?\n* Renal impairment (moderate or severe)?\n* Untreated narrow angle glaucoma?\n* Bladder obstruction, prostatic hyperplasia (BPH), diabetic cystopathy, pre-existing urinary retention?\n* History of hypersensitivity to COBENFY or trospium chloride?\n* Biliary disease, including symptomatic gallstones, gallbladder disorders, pancreatitis?\n* Fluoxetine, paroxetine, bupropion, terbinafine?\n* Buspirone or eletriptan?\n* Digoxin, colchicine, apixaban?\n* Diphenhydramine, beztropine, oxybutynin?\n* Benztropine, trihexyphenidyl, tolterodine, solifenacin, darifenacin, fesoterodine, hyoscyamine, dicyclomine, scopolamine?","ALL","18 Years","70 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic system.\n\nThis study aims to answer: 1) how cholinergic circuitries act during task performance in humans, and 2) develop a better understanding of how cognitive control interacts with learning, memory and decision making in the setting of cholinergic manipulation.\n\nParticipants will complete a single treatment arm, regardless of which surgical procedure they are to receive. An anesthesiologist or other clinical staff will administer either the drug or the saline at a critical point which addresses the research questions, prior to patient surgery. This will be either with the drug, or the placebo pill. Half of the participants will be randomized to receive the drug, and the other half of these the placebo. Participants will be unaware whether the actual drug has been received.\n\nEssential tremor patients who participate will complete a cognitive task during an awake surgery. Epilepsy patients who participate will have a resting state recording during the procedure from the deep cortical layers of the brain. A probe will be used during the surgery to measure the effects of this drug and other procedures of the study on the cholinergic system. This probe is the clinical probe known as the AlphaOmega, which is FDA approved for standard of care procedures.\n\nResearchers will compare the brain activity between treatment arms to determine what brain activity changes based on the cholinergic manipulation.",[27,28,29,30,31,32,33,34,35],"Epilepsy","Essential Tremor","Seizures","Memory Consolidation","Memory Disorders","Memory Replay","Memory Encoding","Cognitive Control","Motor Abilities",[37,38,39,40,41,42,43],"interoperative","oscillatory changes","neuronal spiking","time cell","place cell","cholinergic agonist","cholinergic modulation","NOT_YET_RECRUITING","2026-07-17",{"date":47,"type":48},"2026-07-23","ACTUAL",{"date":50,"type":21},"2026-10",{"date":52,"type":21},"2030-09",{"name":54,"class":55},"University of Texas Southwestern Medical Center","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":71,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":56},"100590478","sleep-and-rehearsal-driven-memory-in-epilepsy-100590478","NCT06967935","Sleep and Rehearsal-Driven Memory in Epilepsy","Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy","CORESOM-EPI","Inclusion Criteria:\n\n* Patient with epilepsy (any type of epilepsy)\n* Hospitalized for video-EEG recording lasting at least 4 days\n* Aged 18-65 years\n\nExclusion Criteria:\n\n* Major cognitive impairment other than memory deficit\n* Refusal to participate\n* Pregnant women, women in labor or nursing mothers\n* Persons deprived of their liberty by judicial or administrative decision\n* Persons under psychiatric care\n* Persons admitted to a health or social institution for purposes other than research\n* Adults under legal protection (guardianship, curatorship)","65 Years",{"count":67,"type":21},20,"OBSERVATIONAL","Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn \"object-place\" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with \"wake\" and \"sleep\" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.",[27,30],[27,72,73,74,75],"Memory consolidation","Sleep","Reharsal","Reactivation","RECRUITING","2026-06-19",{"date":79,"type":48},"2026-06-23",{"date":81,"type":48},"2025-06-30",{"date":83,"type":21},"2027-07",{"name":85,"class":55},"Hospices Civils de Lyon",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100589477","the-effect-of-memory-based-exercise-and-planned-training-applied-to-epilepsy-patients-on-quality-of-life-100589477","NCT06954922","The Effect of Memory-Based Exercise and Planned Training Applied to Epilepsy Patients on Quality of Life","Inclusion Criteria:\n\n1. Being literate,\n2. Being over the age of 18,\n3. Having sufficient communication skills to answer oral and written questions and follow instructions,\n4. Being at a cognitive level to be able to use a mobile phone and perform the memory exercise.\n5. Not having severe vision problems,\n6. Having been diagnosed with epilepsy for at least 6 months\n\nExclusion Criteria:\n\n1. Being under 18 years of age\n2. Residing outside Bilecik Province\n3. Having psychiatric diagnoses such as Bipolar Disorder and Schizophrenia",{"count":93,"type":21},50,[95],"NA","Epilepsy; It is a chronic, neurological disease that can occur regardless of social class, race and age. Every year, approximately 5 million people worldwide are diagnosed with epilepsy and 50 million people are affected by this disease, constituting a significant part of the disease burden in the world. When we look at the rate of patients in the population who actively experience symptoms of the disease and need treatment, this rate is approximately 4 to 10 people per 1000 people. According to estimates, 700,000 people in Turkey are actively diagnosed with epilepsy. It is accepted that this disease occurs as a result of sudden, abnormal discharge of neurons in some parts of the central nervous system, and the disease generally progresses with recurrent changes in consciousness. The symptoms accompanying epilepsy are perceived negatively by patients and significantly affect their lives. Epilepsy treatment; It consists of several options such as medical drugs, ketogenic diet and surgical intervention. The ultimate goal of treatment is to achieve seizure control, reduce the frequency of seizures, minimize drug side effects that may occur due to long-term treatment, and improve the patient's quality of life. Along with pharmacological treatment, non-pharmacological treatment is also a valuable approach in the treatment of epilepsy. One of the non-pharmacological approaches is rehabilitation interventions with mind and memory exercises. Epilepsy is a disease that requires a complex psychological adaptation for the patient and affects the whole family. In this disease, it is very important for the patient to comply with the treatment requirements, to have self-control over his\u002Fher behavior, as well as to cope with the difficulties of living with epilepsy. Increasing the quality of life and preventing possible behavioral problems is possible by keeping mental functions at an optimal level on the one hand, and providing psychological counseling to the patient and his family on the other. Nowadays, epileptic seizures are often more easily controlled with developing pharmacological treatment options. Therefore, the fight against epilepsy should be expanded to include other educational, mental, psychotherapeutic and behavioral interventions besides drug therapy. In a study conducted by the National Center for Health and Care Research (NIHR), electrical activity scans in the brain of 25 epilepsy patients were examined. Some images in different categories were presented to epilepsy patients for a certain period of time. Later, when asked to remember the images shown in the previous step, it was noted that slow waves occurred in the brain during sleep. As a result of the research, it was revealed that the effect of epileptic spikes on brain activity decreased with the emergence of slow waves. This study has demonstrated for the first time a potential protective mechanism used by the brain to counteract epileptic activity. Patients diagnosed with epilepsy who are admitted to the neurology outpatient clinic or admitted to the neurology clinic will be introduced and informed about the study. Patients who want to participate in the study and meet the inclusion criteria will be determined. After patient consent is obtained, groups will be determined according to the randomization list.\n\nThe patient introduction form and the Quality of Life in Epilepsy Scale will be administered to the patients in both groups by the researcher using the face-to-face interview technique (pre-test). Patients in the experimental group will be informed about memory-based exercise and planned training.\n\nPatients in the control group will only be informed about the planned training to be given.\n\nThe experimental group will be given memory-based exercises that will last approximately 15-20 minutes every day for 2 months. Four sessions of epilepsy training will be given, one session per week.\n\nThe control group will receive 4 sessions of epilepsy training, one session per week.\n\nAt the end of two months, the Quality of Life in Epilepsy Scale (posttest) will be applied to both groups.",[27,30,98,99],"Education of Patients","Quality of Life (QOL)",[101,102,103,104],"quality of life","epilepsy","education of patiens","memory","2025-04-30",{"date":107,"type":48},"2025-05-02",{"date":109,"type":21},"2025-05",{"date":111,"type":21},"2026-01",{"name":113,"class":55},"Ataturk University"]