[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-fatigue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-fatigue":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,50,77,100,121,142,172,200,223,247,278,324,353,381],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100652957","mental-fatigue-attentional-focus-and-countermovement-jump-performance-100652957",false,"NCT07779304","Mental Fatigue, Attentional Focus, and Countermovement Jump Performance","The Effects of Acute Mental Fatigue and Attentional Focus Instructions on Countermovement Jump Performance","Inclusion Criteria:\n\n* Age 18-30 years\n* Third- or fourth-year undergraduate student in the Faculty of Sport Sciences, İnönü University\n* Engaged in structured physical activity on at least 2 days per week\n* Normal or corrected-to-normal vision and normal color vision\n* Able to safely perform maximal vertical jumps\n\nExclusion Criteria:\n\n* Major lower-extremity surgery or injury\n* Musculoskeletal injury during the preceding 6 months that could affect jumping\n* Diagnosed neurological, psychiatric, or cardiovascular disorder\n* Regular use of medication that could influence alertness, fatigue, cardiovascular responses, or neuromuscular performance\n* Any health condition compromising safety or measurement validity",true,"ALL","18 Years","30 Years",{"count":21,"type":22},32,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study examines whether short-term mental fatigue and different jump instructions affect how high people can jump. Thirty-two physically active university students will complete two testing sessions in random order: one after a 30-minute mentally tiring computer task and one after a 30-minute relaxing video. In both sessions, participants will perform vertical jumps while receiving one of three types of instructions: no special instruction, focusing on their own body movements, or focusing on pushing the ground away. The study will compare jump height across these conditions to better understand how mental tiredness and coaching cues affect jumping performance, which may help coaches and athletes design better training and competition preparation.",[28,29],"Mental Fatigue","Athletic Performance",[31,32,33,34,35,36],"Countermovement Jump","Attentional Focus","Stroop Task","Crossover Design","Vertical Jump Performance","Cognitive Fatigue","NOT_YET_RECRUITING","2026-08-19",{"date":40,"type":41},"2026-08-21","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2026-11-01",{"name":47,"class":48},"Inonu University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100617837","monitoring-the-effect-of-mental-fatigue-on-physical-performance-using-wearable-sensors-and-physiological-parameters-100617837","NCT07323810","Monitoring the Effect of Mental Fatigue on Physical Performance Using Wearable Sensors and Physiological Parameters","Inclusion Criteria:\n\n* Healthy (no neurological, cardiovascular or musculoskeletal disorders of any kind)\n* Male or female\n* No prior knowledge of the concept of MF\n* No medication\n* Non-smoker\n* 18-35 years of age\n* Experienced runners: (≥15km\u002Fweek and\u002For ≥2u\u002Fweek during the last 6 months)\n\nExclusion Criteria:\n\n* Injuries in the past 6 months, affecting running performance\n* Suffering from a chronic health condition (could be neurological, cardiovascular, internal or musculoskeletal)\n* Participating in any concomitant care or research trials\n* History of suffering from any mental\u002Fpsychiatric disorders\n* Use of medication\n* Use of caffeine and heavy efforts 24 hours prior each trial\n* Suffering from colour vision deficiencies\n* Not eating a standardized meal, the morning of each trial and the evening before each trial","35 Years",{"count":58,"type":22},30,[25],"Mental fatigue (MF) negatively affects both cognitive and physical performance, increasing the risk of errors in high-stakes environments such as sports and surgery. Traditional methods to assess MF rely on subjective self-report scales, which are prone to bias, or on complex brain measurements (e.g. EEG) that are impractical outside laboratory settings. This study aims to develop a real-time, objective monitoring method for MF using wearable physiological sensors. The study will recruit healthy, trained runners (18-35 years old) who will complete both an MF-inducing cognitive task (Stroop test) and a control condition (watching a documentary) in a randomized, counterbalanced, crossover design. Heart rate variability, respiration rate, and pupil metrics will be continuously recorded using wearable devices. Machine learning models will be used to predict MF-level as well as the effect of MF on physical performance (5-km time trial on a treadmill) using the physiological data as input.",[28],[63,64,65,66],"Fatigue","Performance","Physiology","Wearables","RECRUITING","2026-08-17",{"date":70,"type":41},"2026-08-18",{"date":72,"type":41},"2025-12-03",{"date":74,"type":22},"2026-09",{"name":76,"class":48},"Vrije Universiteit Brussel",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":83,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100650408","the-effect-of-brain-endurance-training-on-motor-skill-learning-in-adolescents-with-mild-mental-fatigue-100650408","NCT07746557","The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental Fatigue","Inclusion Criteria:\n\n* Participants assessed as having mild mental fatigue using the Mental Fatigue VAS scale\n* No prior experience in learning specific motor skills\n* In good physical health, with no history of central nervous system disorders, musculoskeletal injuries, or mental health conditions\n\nExclusion Criteria:\n\n* Individuals with moderate to severe mental fatigue or no mental fatigue\n* Individuals with moderate to severe mental fatigue or no mental fatigue\n* Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression - Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines\n* Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment - Individuals with persistent sleep disorders\n* Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression\n* Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines\n* Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment\n* Individuals with persistent sleep disorders - Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.","FEMALE","19 Years",{"count":86,"type":22},58,[25],"Objective: To investigate the effects of brain endurance training on improving motor skill learning in adolescents with mild mental fatigue. Methods: Fifty-eight adolescents experiencing mild mental fatigue were recruited. A 6-week training program was conducted using a 2 (BET group, control group) × 2 (pre- and post-Stroop task) × 3 (0, 3, 6 weeks) mixed-design experimental design. Assessments included basketball free throws, the Visual Analog Scale (VAS-MF), the 3-minute Psychomotor Vigilance Test (PVT-B), the Borg Rating of Perceived Exertion (RPE) to assess performance before and after a 30-minute Stroop task.",[28,90],"Motor Skill Learning","2026-08-03",{"date":93,"type":41},"2026-08-05",{"date":95,"type":22},"2026-08-02",{"date":97,"type":22},"2026-09-19",{"name":99,"class":48},"Yunliang Zhang",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":83,"minAge":18,"maxAge":84,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100648776","the-effects-of-caffeine-and-vitamin-c-on-maximum-strength-and-strength-endurance-in-adolescents-with-mild-mental-fatigue-100648776","NCT07726745","The Effects of Caffeine and Vitamin C on Maximum Strength and Strength Endurance in Adolescents With Mild Mental Fatigue","Inclusion Criteria:\n\n1. Aged between 18and 19years (adolescent)\n2. Able to complete standardized 1RM maximal strength test and muscular endurance protocol for back squat and bench press\n3. Meet criteria for mild mental fatigue verified by validated scale (PVT + VAS Mental Fatigue ≥4\u002F10 or Brief Fatigue Inventory) prior to experimental session\n4. Habitual daily caffeine intake ≤ 150 mg\u002Fday (low-to-moderate habitual consumption)\n5. Non-smoker; no regular alcohol consumption\n6. Consistent strength training status: No physical training for the past 3 months, or maintenance of a consistent daily activity routine throughout the study\n7. Able to attend all scheduled testing visits, comply with pre-test restrictions (diet, sleep, exercise, supplements)\n8. Participant provides written assent; parent\u002Flegal guardian provides written informed consent\n9. Able to understand and follow verbal and written study instructions\n\nExclusion Criteria:\n\n1. History of cardiovascular disease, arrhythmia, hypertension, asthma requiring regular medication\n2. Known hypersensitivity or adverse reaction to caffeine, vitamin C\n3. Chronic neurological disorders: epilepsy, migraine disorder, ADHD with stimulant medication\n4. Current psychiatric diagnosis (anxiety, depression) receiving psychotropic medication\n5. Musculoskeletal injury in the past 3 months limiting lower\u002Fupper body maximal strength testing\n6. Regular intake of ergogenic supplements (creatine, beta-alanine, energy drinks) within 4 weeks before screening\n7. Use of any stimulants, anti-fatigue drugs, corticosteroids within 30 days prior to enrollment\n8. Chronic gastrointestinal disease, kidney stone history (vitamin C related risk)\n9. Irregular sleep-wake cycle, diagnosed sleep disorder\n10. Females: current pregnancy; regular oral contraceptive use\n11. Participated in other human intervention trials within past 8 weeks\n12. Investigator judges any condition that compromises participant safety or interferes with outcome measurements",{"count":107,"type":22},40,[25],"Objective To investigate the independent and combined effects of caffeine and vitamin C on maximal strength and strength endurance in female adolescents with mild mental fatigue.\n\nMethods A randomised, double-blind, crossover experimental design was adopted. Forty female college students presenting mild mental fatigue were recruited as participants. Each participant completed five laboratory sessions in total. The first session determined their one-repetition maximum (1RM) for bench press and back squat. The remaining four experimental sessions involved four supplement interventions administered in random order: placebo control, vitamin C (VC) alone, caffeine (CAF) alone, and combined caffeine plus vitamin C (CAF+VC). A one-week washout interval was arranged between every two supplementation trials.\n\nIn each test session, participants completed a 45-min Stroop task to induce mental fatigue prior to exercise assessments. Measurements included the Visual Analogue Scale for Mental Fatigue (VAS-MF), 1RM bench press and squat performance, as well as the maximal number of repetitions at 65% 1RM for both movements. Immediately after the strength endurance test, perceived exertion and muscle pain were rated. Blood glucose and blood lactate concentrations were sampled before and after all exercise protocols.\n\nSupplementation was administered 1 hour prior to testing: a standard caffeine dosage of 3.0 mg per kg body mass and a single 500 mg dose of vitamin C were provided for the corresponding intervention groups.",[111,112,28],"Maximum Force","Strength Endurance","2026-07-23",{"date":115,"type":41},"2026-07-27",{"date":117,"type":22},"2026-07-25",{"date":119,"type":22},"2026-09-22",{"name":99,"class":48},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":129,"briefSummary":130,"conditions":131,"keywords":132,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100647580","effects-of-cognitive-fatigue-on-gait-100647580","NCT07710755","Effects of Cognitive Fatigue on Gait","Inclusion Criteria:\n\n* Adults aged 18-60 years.\n* Neurotypical individuals with no self-reported history of neurological or cognitive disorders.\n* Able to walk independently, without an assistive device.\n* Fluent in English.\n* Recruitment will aim for gender balance across the sample.\n* For Day 2, participants must arrive with clean, dry hair, free of styling products (e.g., gels, oils), to ensure adequate EEG electrode contact.\n\nExclusion Criteria:\n\n* Outside the age range of 18-60 years.\n* Self-reported history of neurological or cognitive disorders (e.g., epilepsy, multiple sclerosis, stroke\u002Ftraumatic brain injury).\n* Any musculoskeletal condition or injury affecting normal gait.\n* Use of an assistive device for walking (e.g., cane, walker, brace).\n* Self-reported photosensitive epilepsy or seizure disorder triggered by screen\u002Fvisual stimuli.\n* Non-English speaking.\n* Day 2 restrictions: less than 6 hours of sleep the night before; caffeine within 2 hours of the session; alcohol within 24 hours of the session.","60 Years",{"count":58,"type":22},[25],"The goal of this study is to comprehend how mental fatigue could affect human gait. The main questions to answer are:\n\n* Does mental fatigue change how people walk?\n* How long does it take for walking patterns to return to normal after mental fatigue sets in?\n* What role do constructs like boredom, sleepiness, and motivation play in this relationship?\n\nTo achieve this, participants will take part in the experiment, split into two sessions:\n\nDay 1 (online, about 25 minutes): Practice session. Participants will practice a computer task that will be used to induce mental fatigue in the next session.\n\nDay 2 (in-person, about 1.5 to 2 hours): Participants will wear several wearable sensors: motion sensors on their legs, feet, and back, sensor insoles in their shoes, a cap that measures brain activity, and glasses that track eye movement. After sensor placement, participants will walk in a straight line for 10 meters to measure their normal walking pattern. They will then complete a 32-minute computer task designed to induce mental fatigue. Afterward, participants will walk in a straight line for 10 meters again, rest for 3 minutes, and repeat this walk-and-rest cycle 3 more times. Participants will also answer short questions about how tired, bored, and alert they feel throughout the session.",[28],[133,63,36],"Mental fatigue","2026-07-13",{"date":136,"type":41},"2026-07-17",{"date":74,"type":22},{"date":139,"type":22},"2026-11",{"name":141,"class":48},"State University of New York at Buffalo",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":16,"sex":17,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":170,"locationsCount":49},"100643936","cognitive-reserve-and-post-fatigue-recovery-in-older-adults-100643936","NCT07667985","Cognitive Reserve and Post-Fatigue Recovery in Older Adults","Determining the Post-Physical and Mental Fatigue Recovery Perspectives of Older Adults Based on Their Cognitive Reserves","Inclusion Criteria:\n\n* being 65 years of age or older,\n* not having any neurological, psychiatric, or systemic disease that would affect one's mental state, and not using any medication for these conditions.\n\nExclusion Criteria:\n\n* Being younger than 65 years old,\n* having an illness or taking medication that affects mental health, or being\n* unable to complete the questionnaires.","65 Years","90 Years",{"count":152,"type":22},400,"OBSERVATIONAL","As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life.\n\n\"Cognitive reserve\" is a term that describes the brain's built-in resilience. Built over a lifetime through education, work, and social activities, a higher cognitive reserve acts like a buffer, helping the brain adapt to stress and aging. While research shows that a high cognitive reserve protects against conditions like dementia, we still do not fully understand how it helps older adults bounce back from normal, everyday physical and mental exhaustion.\n\nThe goal of this study is to investigate how cognitive reserve levels influence how individuals aged 65 and older perceive their recovery after experiencing physical and mental fatigue.\n\nWhat the Study Involves\n\nThe researchers will evaluate participants aged 65 and older to measure their baseline cognitive reserve levels. The study will look closely at how these levels affect the participants':\n\nAbility to cope with daily physical and mental fatigue. Need for rest and rest patterns. Time and ability to return to normal daily activities. Overall perception of their mental and physical recovery. Expected Outcome By understanding this relationship, the study aims to fill a gap in medical literature and help healthcare providers design better, more personalized rehabilitation and lifestyle support programs to improve the quality of life for older adults.",[156,157,28,63,158],"Cognitive Reserve","Aging","Recovery of Function",[160,161,162,163],"aging","cognitive reserve","fatigue","Post-Fatigue Recovery","2026-06-19",{"date":166,"type":41},"2026-06-25",{"date":168,"type":41},"2026-06-20",{"date":119,"type":22},{"name":171,"class":48},"Uşak University",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":49},"100642588","mental-fatigue-effects-on-posture-and-spinal-reflexes-100642588","NCT07650903","Mental Fatigue Effects on Posture and Spinal Reflexes","Effects of Mental Fatigue on Posture and Spinal Reflexes Modulations","Inclusion Criteria:\n\n* Healthy participants aged between 18 and 35 years\n* Recreational active\n\nExclusion Criteria:\n\n* Previous major lower limb injury (last 6 months)\n* Present neurological or musculoskeletal disorders\n* Involvement in another concurrent physical or cognitive intervention study",{"count":180,"type":22},26,[25],"This randomized crossover study investigates the effects of mental fatigue on postural control and spinal reflex excitability in healthy physically active adults aged 18-35 years. Participants will complete two experimental conditions: a mentally fatiguing Stroop task and a control condition involving passive documentary watching, separated by at least 48 hours. Postural control will be assessed using force plate measures of center of pressure displacement during bipedal and unipedal stance, with and without concurrent cognitive dual-tasking. In parallel, spinal reflex excitability will be evaluated using H-reflex recordings from the triceps surae muscles across sitting and standing postures.\n\nThe primary aim is to determine whether mental fatigue increases postural sway, particularly in more challenging balance conditions such as single-leg stance. The secondary aim is to examine whether mental fatigue alters the normal modulation of spinal reflex excitability across progressively demanding postural tasks. Additional biomechanical and neuromuscular measures, including EMG activity and hip kinematics, will be recorded to provide insight into underlying control mechanisms.\n\nThe study will include approximately 26 participants, with each serving as their own control. Data will contribute to understanding how cognitive fatigue influences balance control and spinal-level neuromuscular regulation.",[28],[185,186,187,188,189,190],"Postural control","Center of pressure","Spinal reflex excitability","H-reflex","Stroop task","Electromyography","2026-06-15",{"date":193,"type":41},"2026-06-16",{"date":195,"type":22},"2026-07-01",{"date":197,"type":22},"2026-12-01",{"name":199,"class":48},"Izmir Bakircay University",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":219,"leadSponsor":221,"locationsCount":49},"100641954","sleep-mental-fatigue-and-performance-in-students-100641954","NCT07644611","Sleep, Mental Fatigue, and Performance in Students","Sleep, Mental Fatigue, and Performance: Psychobiological Insights for Optimizing Learning in Physiotherapy and Psychology Students","Inclusion Criteria:\n\n* Enrolled as a physiotherapy or psychology student at LUDES Institute.\n* Age 18 years or older at the time of consent.\n* No self-reported major neurological disorders or conditions that would impair cognitive or physical testing.\n* Self-reported clinical sleep disorders.\n\nExclusion Criteria:\n\n* Use of psychostimulants (e.g., caffeine, energy drinks) before or during scheduled study sessions.\n* Vigorous exercise prior to testing sessions.\n* Melatonin intake.\n* Recent travel involving more than 3 time zones or shift\u002Fpart-time shift work.\n* Absence from more than 25% of total scheduled lesson time",{"count":58,"type":22},"This observational, prospective, within-subject study will examine how the volume and timing of physiotherapy and psychology classes and exams at LUDES Institute influence mental fatigue, sleepiness, motivation, executive function, and physical performance in university students. Approximately 30 students aged 18 years or older will complete repeated assessments at baseline (no formal academic activities), during a regular theoretical class, and, when feasible, during an exam session.\n\nAt each time point, participants will undergo non-invasive measurements including self-reported mental fatigue (visual analogue scale), sleepiness (Karolinska Sleepiness Scale), motivation (Motivational States Scale), cognitive performance (Encephalapp Stroop task), and handgrip strength and endurance with perceived exertion ratings, alongside sleep diaries and wrist actigraphy. The primary endpoint is the pre-to post-session change in mental fatigue and cognitive performance, with secondary endpoints capturing sleep and circadian metrics, physical performance, motivation, and exam grades. Mixed-effects models will be used to test how class\u002Fexam duration, time of day, sleep quantity and quality, and chronotype relate to psychobiological responses, with the goal of informing evidence-based scheduling and workload policies in health-profession education.",[28,210],"Sleep and Circadian Problems",[212,213,214,215],"sleep","mental fatigue","performance","learning",{"date":217,"type":41},"2026-06-17",{"date":195,"type":22},{"date":220,"type":22},"2027-02-20",{"name":222,"class":48},"L.U.de.S. Sagl",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":229,"targetDuration":4,"studyType":23,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":246,"locationsCount":49},"100642911","the-effect-of-mental-fatigue-on-upper-extremity-functional-performance-100642911","NCT07645404","The Effect of Mental Fatigue on Upper Extremity Functional Performance","Inclusion Criteria:\n\n* Age between 18 and 35 years\n* Healthy (no neurological, cardiovascular or musculoskeletal disorders of any kind)\n* Male or female\n* No prior knowledge of the concept of mental fatigue\n* Not currently taking medications that affect cognition or neuromuscular performance\n* According to the International Physical Activity Questionnaire, being physically active at a minimum level of 1500 MET-min\u002Fweek\n\nExclusion Criteria:\n\n* Previous major upper limb injury (last 6 months)\n* Involvement in another concurrent physical or cognitive intervention study\n* Use of caffeine and heavy efforts 24 hours prior each trial\n* Suffering from colour vision deficiencies\n* Not eating a standardized meal, the morning of each trial and the evening before each trial",{"count":230,"type":22},16,[25],"Mental fatigue (MF) is known to impair cognitive performance and may negatively affect physical performance. While its effects on lower-extremity functional performance have been investigated, little is known about the influence of MF on upper-extremity physical performance tests commonly used in sports and rehabilitation settings. This randomized crossover study will investigate the effects of experimentally induced mental fatigue on upper-extremity physical performance in 16 healthy physically active adults. Participants will complete both a mental fatigue condition, involving a prolonged Stroop task, and a control condition consisting of watching an emotionally neutral documentary. Before and after each condition, participants will perform the Upper Quarter Y Balance Test, Reactive Upper Quarter Y Balance Test, Closed Kinetic Chain Upper Extremity Stability Test, and Seated Single-Arm Shot Put Test. Subjective mental fatigue, cognitive performance, motivation, and perceived exertion will also be assessed. The findings will improve understanding of whether mental fatigue influences upper-extremity physical performance test outcomes and may assist clinicians and researchers in interpreting these assessments in sports medicine and rehabilitation contexts.",[28],[28,235,236,237,238,239,240,241],"Upper Extremity","Physical Performance","Functional Testing","Sports Medicine","Cognitive Performance","Visuomotor Reaction Time","Upper Quarter Y Balance Test","2026-06-12",{"date":191,"type":41},{"date":195,"type":22},{"date":197,"type":22},{"name":199,"class":48},{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":23,"phases":255,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":49},"100601350","tan-for-first-responders-100601350","NCT07109349","tAN for First Responders","Effect of Transcutaneous Auricular Neurostimulation on Mental Wellness and Resiliency for First Responders: A Pilot Trial","Inclusion Criteria:\n\n1. Participant is currently employed in a first responder position\n2. Age ≥ 18 years\n3. Reliable access to an internet-enabled device to complete required questionnaires\n4. GAD-7 score ≥ 5\n\nExclusion Criteria:\n\n1. Participant has a history of epileptic seizures\n2. Participant has a history of neurologic diseases or traumatic brain injury\n3. Participant has presence of devices (e.g., pacemakers, cochlear prostheses or implants, neurostimulators)\n4. Participant has abnormal left ear anatomy or ear infection present\n5. Participant has auditory impairment of the left ear (ruptured eardrum, deafness, tinnitus, etc.)\n6. Participant is currently enrolled in another interventional trial\n7. Women of childbearing potential, not using adequate contraception as per the investigator's judgement\n8. Females who are pregnant or lactating\n9. Participant has any other significant disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial",{"count":58,"type":22},[25],"This study is designed as an open label, single arm, decentralized clinical study in which first responders will receive transcutaneous auricular neurostimulation (tAN), which targets the auricular branch of the vagus nerve (ABVN) via the mastoid and the auriculotemporal nerve (ATN) anterior to the tragus. Participants will be enrolled in the study over the course of eight weeks (56 days).\n\nParticipants will respond to daily and weekly questionnaires regarding mood, stress, sleep, energy\u002Ffatigue, and burnout. Each week, participants will complete consolidated online questionnaires (intended to last no longer than 15 minutes) comprised of the Perceived Stress Short-Form (PSS-4), Well-Being Index (WHO-5), Mini-Z Burnout (5-item), PROMS Sleep Disturbance (PROMIS-SD), GAD-7 (every 2 weeks), and Perceived Stress (PSS-10; monthly). The PSS-10 will replace the PSS-4 on Days 0, 28, and 56.\n\nNo tAN treatment will be delivered during the Baseline Period (days between Study Introduction and Day 0). Participants will complete the weekly set of questionnaires (\"Weekly Questionnaires\") on Day 0. Participants will be recommended to complete the daily set of questionnaires (\"Daily Questionnaires \") on the other days of the Baseline Period.\n\nOn Days 1 - 28, participants will self-administer one session of one to two hours of tAN therapy each day. Participants will be recommended to complete the daily tAN session post-shift prior to sleep. Weekly Questionnaires will be completed by participants on Study Days 0, 7, 14, 21, 28, 35, 42, 49, and 56. Participants will be recommended to complete Daily Questionnaires on all other study days, up to Day 28. Daily Questionnaires will not be required to be completed by participants. Daily tAN sessions and Daily Questionnaires will cease after Day 28. Participants will complete a Study Satisfaction Questionnaire with the Weekly Questionnaires on Day 56.\n\nFollowing Day 56, participants will schedule a Study Exit Interview with the Research Coordinator.",[28,258],"Mental Stress",[260,261,262,263,264,265,266,267],"Mental resilience","tAN","Transcutaneous Auricular Neurostimulation","Vagus nerve stimulation","Neurostimulation","First responders","taVNS","Police officer","2026-06-01",{"date":270,"type":41},"2026-06-02",{"date":272,"type":41},"2025-09-10",{"date":274,"type":22},"2026-07-20",{"name":276,"class":277},"Spark Biomedical, Inc.","INDUSTRY",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":16,"sex":83,"minAge":285,"maxAge":127,"enrollmentInfo":286,"targetDuration":4,"studyType":23,"phases":287,"briefSummary":288,"conditions":289,"keywords":306,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":49},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.","40 Years",{"count":107,"type":22},[25],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[290,291,292,293,294,295,296,297,298,299,300,301,302,28,303,304,305],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Physical Fatigue","Productivity","Effort",[239,307,308,309,310,311,312,313,314],"Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":317,"type":41},"2026-01-06",{"date":319,"type":22},"2025-12-15",{"date":321,"type":22},"2026-08-31",{"name":323,"class":48},"Leeds Beckett University",{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":16,"sex":83,"minAge":18,"maxAge":331,"enrollmentInfo":332,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":334,"conditions":335,"keywords":340,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":49},"100491380","exploring-immunological-markers-associated-with-mental-fatigue-in-graves-disease-100491380","NCT05678374","Exploring Immunological Markers Associated With Mental Fatigue in Graves' Disease","Exploring Immunological Markers in Blood and Cerebrospinal Fluid Associated With Mental Fatigue in Euthyroidism After Graves' Disease- a Cross Sectional Study","Inclusion Criteria\n\n* If patient: Graves' disease with positive TSH-receptor antibodies and thyroid hormones above the upper reference limit at diagnosis\n* Diagnosis15 to 60 months ago. If recidive both episodes must have occurred within 15 months to 60 months.\n* Thyroid hormones within normal range without anti thyroid drugs\n* If control: No thyroid disease\n* Patient and control without mental fatigue: Mental Fatigue Score ≤8 (cut off 10.5)\n* Patient with mental fatigue: Mental Fatigue Score \\>13 and debut of symptoms of mental fatigue in parallel with debut of Graves' disease, without other obvious cause\n\nExclusion Criteria\n\n* Person unable to follow protocol\n* Multiple sclerosis, myalgic encephalomyelitis\u002Fchronic fatigue syndrome, any other neurological disease\n* Traumatic brain injury with unconsciousness\n* Other disease strongly associated with fatigue\n* Pregnancy and breast-feeding\n* On-going or recent systemic treatment with steroids\n* Radioiodine therapy within the last 18 months","72 Years",{"count":333,"type":22},180,"Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored hyperthyroidism in Graves' disease is an autoimmune complication. The aim of this study is to explore immunological markers possibly associated with mental fatigue in Graves' disease, which the investigators plan to validate in another study (ImmunoGraves wp 2).\n\nUsing a cross-sectional study design, mental fatigue is scored using a questionnaire to find 60 patients with and 60 without mental fatigue 15-60 months after diagnosis of Graves disease. The patients and 60 thyroid healthy controls without mental fatigue are assessed for thyroid hormones, quality of life, anxiety and depression, self-evaluated stress, coping strategies, eye symptoms and background variables. SciLifeLab in Stockholm, the national facility for autoimmune profiling, has pre-set large arrays including 42000 human proteins. Serum and cerebrospinal fluid will be separately pooled and analysed for a subgroup of patients with or without mental fatigue and for a subgroup of the control group. Proteins that preferably bind to antibodies in sera and\u002For cerebrospinal fluid from Graves' patients with mental fatigue in comparison to non-mental fatigue patients, will be screened against the Human Protein Atlas and the Allen brain map to identify those proteins that are expressed in the brain. Antibodies at higher concentration in the mental fatigue pools compared to the group without mental fatigue will be selected for further analyses on an individual level in the whole cohort together with antibodies targeting g-protein coupled receptors, thyroid autoantibodies, cytokines and biomarkers indicating organic and structural nerve damage.",[336,337,28,338,339],"Graves Disease","Graves Ophthalmopathy","Autoimmune Diseases","Thyroid Diseases",[341,342],"Biomarkers","Cerebrospinal fluid in Graves' disease","2025-09-23",{"date":345,"type":41},"2025-09-29",{"date":347,"type":41},"2019-10-01",{"date":349,"type":22},"2028-12-20",{"name":351,"class":352},"Vastra Gotaland Region","OTHER_GOV",{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":366,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":49},"100589274","music-intervention-on-golfers-under-mental-fatigue-100589274","NCT06952283","Music Intervention on Golfers Under Mental Fatigue","Effects of Music Intervention on Golf-Specific Skill Performance of Chinese Golfers Under Mental Fatigue","Inclusion Criteria:\n\n* Athletes must be between 18 and 24 years old.\n* Be registered golfers in the National Colleges and Universities Golf Championship.\n* Have at least three years of specialised golf training.\n* Engage in at least five weekly training sessions.\n\nExclusion Criteria:\n\n* Colour blindness.\n* Hearing loss.\n* Insomnia.\n* Physical injuries.\n* Ongoing mental health issues.\n* The use of any medication that might influence cognitive.\n* The use of any medication that might influence physical performance.","24 Years",{"count":362,"type":22},60,[25],"This study aims to evaluate the effects of music intervention on golf-specific skill performance under mental fatigue. It is a randomised, controlled, double-blind design. The study consists of three main phases: familiarisation with the experimental procedure, baseline testing, and the formal experiment. During the formal experiment, participants will be randomly assigned to one of the following three groups: (MF-Mu Group) Participants undergo a mental fatigue induction task followed by a music intervention; (MF-nMu Group) Participants undergo a mental fatigue induction task but do not receive a music intervention; (CON Group) Participants neither undergo a mental fatigue induction task nor receive a music intervention. The total intervention duration is 45 minutes, consisting of 30 minutes of mental fatigue induction and 15 minutes of music intervention. In conditions where mental fatigue induction or music intervention is not conducted, participants will remain in the same experimental environment and rest quietly for the same duration to control for external confounding factors and ensure experimental consistency. Immediately after the intervention, participants will complete golf skill testing, with the testing site located within a 2 minutes walking distance from the intervention area. Performance outcomes include driving performance, iron shot performance, chipping performance, and putting performance.",[28],[367,368,369,370,371],"lack of energy","feelings of tiredness","decreased attention","impaired cognitive","impaired behavioral performance","2025-04-27",{"date":374,"type":41},"2025-04-30",{"date":376,"type":22},"2025-09-01",{"date":378,"type":22},"2025-12-01",{"name":380,"class":48},"Pan Xiaoyang",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":331,"enrollmentInfo":388,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":390,"conditions":391,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":49},"100522347","validating-immunological-markers-associated-with-mental-fatigue-in-graves-disease-100522347","NCT06081439","Validating Immunological Markers Associated With Mental Fatigue in Graves' Disease","Validating Immunological Markers in Blood and Cerebrospinal Fluid Associated With Mental Fatigue in Graves' Disease and Their Association With Functional Changes in Neuronal Activation","Inclusion Criteria:\n\n* Recently diagnosed Graves' disease\n* Positive thyroid stimulating hormone (TSH)-receptor antibodies (TRAb)\n* Thyroid hormones above the upper reference limit\n* Inclusion within three weeks after start of antithyroid drugs\n\nControls: Matched for gender and age\n\nExclusion Criteria:\n\n* Person unable to follow protocol as with psychosis, dementia or not able to answer questionnaires in Swedish.\n* Recidive of Graves' disease\n* Pregnancy\n\nControls: -Thyroid disease\n\n* Neurological disease",{"count":389,"type":22},430,"Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored euthyroidism in Graves' disease is an autoimmune complication. This is a confirmatory study of the biomarkers from ImmunoGraves WP1 in which immunological markers with possible association with mental fatigue in Graves' disease are explored.\n\nIn ImmunoGraves WP2, 310 patients with Graves' disease are assessed for symptoms of mental fatigue, quality of life, anxiety and depression, self-evaluated stress, coping strategies, personality traits, eye symptoms and background variables. Participants are examined in hyperthyroidism at inclusion, within three weeks from diagnosis, and in euthyroidism after 15 months. Serum and cerebrospinal fluid (in a subsample of participants) is collected at both visits and will be evaluated for the immunological markers identified in WP1 as well as for thyroid hormones, thyroid autoantibodies and biomarkers indicating organic and structural nerve damage. Significant predictors for mental fatigue will be identified by logistic regression.\n\nTo assess functional changes in the brain, magnetoencephalography will be performed in a subset of patients and in healthy controls at inclusion and after 15 to 18 months. Combined with magneto resonance imaging (MRI), magnetoencephalography gives information on neuronal activation during attention testing.",[336,28],"2024-11-13",{"date":394,"type":41},"2024-11-18",{"date":396,"type":41},"2019-09-12",{"date":398,"type":22},"2025-12-20",{"name":351,"class":352}]