[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mental-health-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mental-health-depression":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,83,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100652087","ai-based-personalized-exercise-prescription-through-mobile-health-on-physical-activity-and-health-outcomes-in-older-adults-a-feasibility-study-100652087",false,"NCT07768670","AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Artificial Intelligence-based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Inclusion Criteria:\n\n* Be aged 65 years or older.\n* Own a smartphone (Android or iOS) compatible with study applications.\n* Have reliable access to the internet or Wi-Fi.\n* Demonstrate basic digital literacy sufficient to operate a smartphone (e.g., ability to open applications, navigate simple interfaces, and follow on-screen instructions), with or without initial guidance from the research staff.\n* Be able to safely engage in physical activity, as determined by the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) or physician approval if indicated.\n* Report engaging in less than 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Be able to communicate in English sufficiently to complete study procedures and assessments.\n\nExclusion Criteria:\n\n* Are younger than 65 years of age.\n* Do not own a compatible smartphone (Android or iOS) or do not have reliable internet\u002FWi-Fi access.\n* Are deemed unable to safely participate in physical activity based on the screening process (including PAR-Q+, STEADI, and research staff assessment), or do not obtain required physician clearance when indicated.\n* Currently meet or exceed 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Are unable to communicate in English sufficiently to understand study procedures, provide informed consent, or complete study-related assessments.\n* Have any medical, physical, or cognitive condition that, in the judgment of the research team, would make participation unsafe or prevent completion of study procedures.",true,"ALL","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research is to investigate the feasibility, acceptability, appropriateness, and preliminary efficacy of a wearable and artificial intelligence-driven mobile application-based exercise prescription grounded in self-determination theory (SDT) and behavioral change techniques (BCTs) among older adults. As no data exists on the feasibility of AI-driven exercise programs grounded in SDT and multiple BCTs specifically for older adults, this will be a pioneering study to explore the feasibility of wearable and AI-driven exercise program protocols and the rates of acceptance and appropriateness of the exercise prescription intervention among older adults. In addition, this study will test the preliminary efficacy of the intervention on physical activity (PA), mental health, and quality of life. This study follows the National Institute of Health (NIH) stage model, and it represents stage 1b of the NIH stage model, which emphasizes the feasibility and actionable processes for delivering a new health intervention. Specifically, this study will: 1.Evaluate the research protocol feasibility of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs (of goal setting, self-monitoring, graded task, and demonstration) on older adults over 8 weeks 2. Evaluate the acceptability and appropriateness of a wearable, AI-driven, mobile application-based exercise prescription grounded in SDT and BCTs among older adults over 8 weeks. 3. Evaluate the preliminary impact of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs on older adult PA (steps per day and daily duration of light PA and Moderate-vigorous PA), sedentary time, sleep, mental health (depression and anxiety), and quality of life.",[27,28,29,30,31],"Feasibility Studies","Physical Activity","Mental Health (Depression)","Anxiety","Quality of Life",[33,34,35,36,37,38,39,40,41],"AI-based intervention","mobile health technology","wearable","fitness app","feasibility study","study acceptability and appropriateness","older adult","age 65 years","60 years","RECRUITING","2026-08-18",{"date":45,"type":46},"2026-08-20","ACTUAL",{"date":48,"type":21},"2026-10-01",{"date":50,"type":21},"2026-12-31",{"name":52,"class":53},"The University of Tennessee, Knoxville","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100638186","stress-management-and-meditative-movements-for-asian-americans-with-depression-and-physical-symptoms-100638186","NCT07610928","Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms","Integrating the Stress Management and Resiliency Training (SMART) With Qigong\u002FTai Chi (QTC) to Develop a Holistic Treatment for Asian Americans With Depression and Distressing Somatic Symptoms","Inclusion Criteria:\n\n* Self-identify as being of Asian ethnicity\n* English language proficiency\n* Be ≥18 years of age\n* Satisfy DSM-5 criteria for MDD prior to the initiation of the study intervention, as determined by a clinical interview conducted by the Principal Investigator (PI) during screening using DSM-5 diagnostic criteria.\n* A baseline of the Patient-Reported Outcomes Measurement Information System (PROMIS) Depression score ≥ 16\n* A baseline score of PHQ-15 ≥10\n* Have not had Tai Chi\u002FQigong training\u002Fpractice or other forms of mind-body intervention (e.g. yoga, mindfulness training, muscle relaxation training, etc) more than once a week in the past 3 months\n* A total score 24 or higher in Mini-Mental Status Examination for cognitive ability (if the participant endorses a history of cognitive impairment).\n* Willing to keep any psychiatric medications and psychotherapy stable throughout the course of the study (from Week 0 baseline to Week 12 Follow-up)\n* Have access to a device (i.e., smartphone, iPad, personal computer) and a stable network to attend the online group sessions\n* Ability to perform daily physical activity\n\nExclusion Criteria:\n\n* Have a primary psychiatric diagnosis other than MDD\n* Any history of psychosis, mania, or impulsivity and difficulty relating to people and judged by the clinician not appropriate for group intervention\n* Active eating disorder or substance use disorder within the last 6 months\n* Any relevant medical conditions that may be the medical basis of depression including thyroid diseases, epilepsy, history of an abnormal EEG, severe head trauma, or stroke\n* Have serious uncontrolled medical conditions (e.g. poorly controlled diabetes, severe congestive heart failure), or other medical conditions that in the opinion of the investigators represents a risk to the subject, including presence of a pacemaker, cardiac arrhythmia, fever, weakness and hypotension, or vagal nerve stimulator\n* current active suicidal or self-injurious potential (i.e., PHQ-9 item 9 ≥1 and\u002For a positive response to C-SSRS screener items 3, 4, 5, or 6), and assessed by the clinician necessitating immediate treatment\n* Participant who are or who plan to receive confounding treatments (including treatment of endocrinopathies): use of antidepressants, complementary and alternative medical (CAM) treatments thought to have beneficial effects on mood, including St. John's Wort, S-Adenosyl methionine (SAMe), omega-3 fatty acids, light therapy, conventional psychotherapy, mind-body interventions (e.g. Qigong, mindfulness training, muscle relaxation training, etc.)\n* Electroconvulsive therapy (ECT) during the last year as these patients are often among the more refractory and are not optimal candidates for CAM\n* History of refractory to treatment with ≥3 failed antidepressant trials in current depressive episode\n* Participated in other depression-related clinical trials within the past 3 months\n* Antidepressant or psychiatric medications that are initiated less than 8 weeks or a dose change less than 4 weeks prior to screening visit\n* Psychotherapy that has been initiated within the past 3 months","18 Years",{"count":64,"type":21},70,[24],"Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time. Right now, there is no proven treatment that effectively addresses both the depression and these physical symptoms together. This study will test whether it is practical, acceptable, and safe to combine the Stress Management and Resiliency Training (SMART) program with meditative movements for people who have both major depression and these distressing physical symptoms.",[68,29],"Depression \u002F Major Depressive Disorder",[70,71,72],"Depression","Asian American","Somatic symptoms","NOT_YET_RECRUITING","2026-07-10",{"date":76,"type":46},"2026-07-13",{"date":78,"type":21},"2026-08-15",{"date":80,"type":21},"2027-08-31",{"name":82,"class":53},"Massachusetts General Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":16,"sex":17,"minAge":62,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":54},"100634401","precarity-and-reduction-of-its-impact-on-the-mental-health-of-health-students-100634401","NCT07539207","Precarity and Reduction of Its Impact on the Mental Health of Health Students","PRISMES","Inclusion Criteria:\n\n* Enrollment as a health student at the Faculty of Health, Université de Rouen Normandie (any program or discipline).\n\nAge between 18 and 30 years.\n\nMeet at least one of the following three financial vulnerability criteria:\n\nInsufficient monthly funds to cover basic living expenses. Recurrent monthly bank overdraft. Frequent omission of food purchases due to financial constraints. Affiliation with a social security scheme or beneficiary of such a scheme\n\nExclusion Criteria:\n\n* Participants meeting any of the following criteria will be excluded:\n\nCurrently receiving, or having received in the past 12 months, psychological or sophrology follow-up.\n\nCurrently treated for, or having been treated in the past 12 months for, anxiety or depression.","30 Years",{"count":92,"type":21},110,[24],"Student financial insecurity has become a major public health and societal issue affecting a growing proportion of young adults in higher education, exacerbated by the COVID-19 pandemic and more recently by inflation. Health students may be particularly exposed because of the demanding and lengthy nature of their training, often combined with limited opportunities for paid work due to hospital placements and academic workload. A national study conducted in 2024 by the Unit Institut national de la santé et de la recherche médicale U1073 under the supervision of the Conférence Nationale des Doyens de Médecine among more than 12,000 health students showed that 12% experienced severe financial insecurity, characterized by insufficient monthly resources, recurrent bank overdrafts, and frequent food deprivation, while 20% reported moderate insecurity. Financial insecurity was strongly associated with anxiety, depression, and emotional exhaustion, while vulnerable students were also more likely to forgo healthcare, including psychological consultations, for financial reasons. This vicious circle between financial hardship and mental health may compromise academic success and justifies targeted intervention.\n\nAlthough support systems such as Santé Psy Étudiant and free psychological consultations at the faculty already exist, they remain underused because of stigma, insufficient information, or perceived barriers to access. The PRISMES project proposes a participatory, adaptive, and real-world intervention designed to improve mental health support for financially vulnerable health students.\n\nStudents directly participate in the co-construction of interventions together with researchers, student associations, health professionals, academic representatives, and a sociologist involved in understanding social determinants, mental health representations, and barriers to participation. Three intervention formats will initially be proposed, Three types of interventions are offered to students. Intervention I consists of four individual psychological consultations. Intervention II includes two collective workshops focused on stress and budget management, combined with two sophrology sessions. Intervention III comprises one psychological consultation and two collective workshops on stress and budget management.. This non-randomized design reflects real-life implementation conditions and improves future transferability.\n\nThe main objective is to provide concrete support to financially vulnerable students by improving well-being, mental health, and knowledge of available support systems. Secondary objectives are to evaluate intervention effects on anxiety, depression, stress, quality of life, and emotional exhaustion, to adapt interventions according to feedback, and to improve awareness and use of social and health support services.\n\nA mixed-method design will combine quantitative and qualitative data. Quantitative assessments will be conducted monthly during the three months following the first intervention and again three months after the final intervention. Validated questionnaires will assess perceived stress (Cohen scale), anxiety and depression (HAD score), quality of life, and emotional exhaustion (MBI-SS). Qualitative interviews and focus groups conducted at the end of the intervention will explore perceived benefits, barriers, and implementation factors among students and professionals.\n\nThe adaptive design allows continuous adjustment according to interim findings. For example, if attendance is limited by timetable constraints, sessions may be rescheduled. Feedback loops involving participants and stakeholders will guide iterative improvement.\n\nEligible participants are health students aged 18-30 enrolled at Université de Rouen Normandie presenting at least one indicator of financial insecurity: insufficient monthly resources, recurrent overdraft, or frequent food deprivation. Students currently receiving psychological follow-up are excluded.\n\nAssuming a reduction in anxiety prevalence from 55% to 45%, 88 participants are required; with 20% loss to follow-up, 110 students will be included. Among approximately 4,500 health students in Rouen, about 540 are estimated to experience severe insecurity and 900 moderate insecurity, ensuring strong feasibility. PRISMES aims to generate directly transferable recommendations for university support policies and improve resilience, well-being, and academic success.",[29,96,97],"Mental Health","Quality of Lifte",[99,100,101],"university student","economic precarity","mental health","2026-06-09",{"date":104,"type":46},"2026-06-11",{"date":106,"type":21},"2026-09-15",{"date":108,"type":21},"2027-09-30",{"name":110,"class":111},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":16,"sex":120,"minAge":62,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":129,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100605332","developing-an-immersive-virtual-reality-platform-100605332","NCT07161141","Developing an Immersive Virtual Reality Platform","Developing an Immersive Virtual Reality Platform to Support Birth Preparedness and Mental Wellbeing in Pregnant Women","VR Support","Inclusion Criteria:\n\n* The pregnant women between the ages of 18-49\n* Primiparous\n* At least 20 weeks of gestation\n* Single pregnancy\n* Without any visual and hearing problems andcan communicate verbally are included to this study.\n\nExclusion Criteria:\n\n* Pregnant women with multiple pregnancies were multiparous\n* Risky pregnancy, and did not accept participation in the study will excluded from the study.\n* Individuals with a history of any psychiatric disorder (eg, mood disorder or anxiety disorder) will excluded from this study.","FEMALE","49 Years",{"count":123,"type":21},68,[24],"This study is a two-stage, mixed-method, pre-test post-test design aimed at developing and testing an immersive VR intervention for new mothers. This research is 2-arm a 4-week prospective randomized clinical trial",[127,29,128],"Pregnancy","Childbirth Preparation Program",[130,131,132,101,133],"Virtual reality","immersive","childbirth","pregnancy","2025-09-15",{"date":136,"type":46},"2025-09-16",{"date":138,"type":21},"2026-01-01",{"date":140,"type":21},"2026-12-30",{"name":142,"class":53},"Necmettin Erbakan University"]