[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolically-unhealty-obese\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolically-unhealty-obese":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100647733","plasma-taurine-in-older-women-with-obesity-impact-of-metabolic-phenotype-and-combined-exercise-100647733",false,"NCT07711899","Plasma Taurine in Older Women With Obesity: Impact of Metabolic Phenotype and Combined Exercise","Plasma Taurine Concentrations in Older Women With Obesity: The Influence of Metabolic Phenotype and Combined Exercise Training","non applicable","Inclusion Criteria\n\n* Women aged 60 to 75 years.\n* Residents of the city or region of Ribeirão Preto, São Paulo, Brazil.\n* Physically inactive for at least 3 months.\n* Body mass index (BMI) ≥ 30 kg\u002Fm² (PAHO, 2002).\n* Body fat percentage ≥ 35%, according to obesity diagnostic criteria (Batsis et al., 2016; Rubino et al., 2025).\n\nClassified into one of two obesity phenotypes based on Zembic et al. (2021):\n\nMetabolically Healthy Obesity (MHO\u002FOMS): all of the following criteria must be met:\n\n* Systolic blood pressure (SBP) \\\u003C 130 mmHg;\n* Waist-to-hip ratio \\\u003C 0.95;\n* Fasting blood glucose \\\u003C 126 mg\u002FdL.\n\nMetabolically Unhealthy Obesity (MUO\u002FOMNS): meets two or fewer of the above criteria.\n\nExclusion Criteria\n\nClinical conditions\n\n* Contraindication to physical exercise.\n* Current or previous diagnosis of:\n\n  * Neoplasms;\n  * Autoimmune diseases;\n  * Hepatic diseases;\n  * Coronary diseases;\n  * Renal diseases;\n  * Neurodegenerative diseases;\n  * Infectious diseases.\n\nPrevious or ongoing treatments\n\n* Use of medication for thyroid disorders.\n* Participation in exercise training programs, nutritional counseling, or weight loss treatment within the 3 months preceding the intervention.\n\nLifestyle habits\n\n* Current smoking.\n* Alcohol consumption.\n\nFor MHO Group:\n\n* Medication use\n\n  * Hypoglycemic agents\n  * Insulin (Bell, Kivimäki, \\& Hamer, 2014).\n* Protocol adherence \\*Attendance at less than 80% of the training sessions (De Carvalho et al., 2021).",true,"FEMALE","60 Years","75 Years",{"count":22,"type":23},36,"ESTIMATED","INTERVENTIONAL",[26],"NA","Population aging has been accompanied by a rise in obesity and other chronic diseases, increasing cardiovascular risk particularly among women, who exhibit a higher prevalence in older age groups compared to men. Aging and obesity share pathophysiological mechanisms, such as chronic inflammation and oxidative stress. However, distinct obesity phenotypes exist, such as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). Consequently, therapeutic interventions involving nutritional strategies and physical training are highly relevant, especially for older women. Taurine, a sulfur-containing amino acid, plays a role in modulating oxidative stress, inflammation, osmoregulation, and mitochondrial function. Rationale: Plasma taurine concentrations are lower in women with obesity compared to healthy individuals. However, studies investigating these concentrations across different phenotypes-particularly in older women, a group susceptible to functional and metabolic changes-remain limited. Understanding these variations could clarify taurine's role in the pathophysiology of obesity and aging and inform personalized therapeutic strategies. Combined physical training stands out as an effective strategy for modulating inflammatory, oxidative, and metabolic pathways, in addition to improving psychosocial aspects. Given that taurine levels can be influenced by these pathways, investigating the taurine response to physical training across different metabolic phenotypes may contribute to developing low-cost interventions aimed at improving the quality of life for older women with obesity.",[29,30,31],"Obesity (BMI>30)","Metabolically Healthy Obesity","Metabolically Unhealty Obese",[33,34,35,36,37],"Taurine","Metabolically unhealthy obesity.","Metabolically healthy obesity.","Physical training","Aging","NOT_YET_RECRUITING","2026-07-16",{"date":41,"type":42},"2026-07-20","ACTUAL",{"date":44,"type":23},"2026-10-01",{"date":46,"type":23},"2030-03-01",{"name":48,"class":49},"University of Sao Paulo","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100625534","effect-of-a-low-calorie-mct-rich-traditional-minangkabau-diet-on-obese-individuals-100625534","NCT07423884","Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals","The Effect of a Low-Calorie Diet Rich in Medium-Chain Triglycerides Based on Traditional Minangkabau Foods on Lipid Profile, Leptin Levels, and DNA Methylation of the Leptin Gene Promoter in Individuals With Obesity","Inclusion Criteria:\n\n* Administrative staff of the Faculty of Medicine and the Faculty of Public Health, Andalas University, Padang, with obesity defined as a body mass index (BMI) ≥ 25 kg\u002Fm².\n* Willing to participate in the study by providing written informed consent.\n* Participants with obesity classified as Metabolically Unhealthy Obese (MUHO)\n\nExclusion Criteria:\n\n* Did not come and could not be found at the time of research data collection\n* Unable to follow the dietary arrangements as set\n* Taking anti-diabetic or anti-lipid drugs\n* Use of contraceptives or hormonal drugs\n* In the treatment of radiotherapy or chemotherapyi\n* Participants with obesity classified as Metabolically Healthy Obese (MHO)","ALL","18 Years",{"count":60,"type":23},40,[26],"This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity. The traditional Minangkabau foods used in this study consist primarily of coconut milk-based dishes, which contain coconut oil as a natural source of MCTs. The metabolic biomarkers assessed include body mass index (BMI), waist circumference, systolic and diastolic blood pressure, body fat percentage, fasting blood glucose levels, lipid profile, leptin concentrations, and DNA methylation of the leptin gene promoter. Based on these metabolic biomarker measurements, participants will be classified into metabolic obesity phenotypes, namely metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The researchers hypothesize that the provision of a low-calorie, MCT-rich diet based on traditional Minangkabau foods will have a significant effect on metabolic biomarkers and metabolic status in individuals with obesity.",[31,64,65,66,67],"Dyslipidemia","Diabetes (DM)","Resistance, Insulin","Obesity",[69,70,71,72,73],"Low-calorie diet rich in medium-chain triglycerides","Traditional Minangkabau foods","Coconut oil","Metabolic biomarkers","Anthropometric parameters","2026-04-08",{"date":76,"type":42},"2026-04-13",{"date":78,"type":23},"2026-04",{"date":80,"type":23},"2026-07",{"name":82,"class":49},"Andalas University",1]