[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"microplastic-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:microplastic-exposure":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100650685","micro-nanoplastic-exposure-and-coronary-microcirculatory-dysfunction-as-well-as-cardiovascular-outcomes-100650685",false,"NCT07748767","Micro-nanoplastic Exposure and Coronary Microcirculatory Dysfunction as Well as Cardiovascular Outcomes","Association of Micro-Nanoplastic Exposure With Coronary Microvascular Dysfunction and Subsequent Cardiovascular Outcomes: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥ 18;\n* Patients with clinical indications for undergoing invasive coronary angiography and coronary functional assessment (including fractional flow reserve \\[FFR\\], CFR, and IMR);\n* Voluntarily sign the written informed consent form.\n\nExclusion Criteria:\n\n* The surgeon (or attending physician) determines that the patient is not suitable for or cannot tolerate a coronary physiological examination;\n* Intraoperative coronary angiography reveals a stenosis of\\>90% in any non-left main coronary artery lumen or a stenosis of\\>50% in the left main coronary artery lumen;\n* Left ventricular ejection fraction \\\u003C35% or cardiogenic shock or cardiac arrest;\n* Previous history of invasive procedures\u002Ftreatments;\n* Active inflammatory diseases;\n* Connective tissue disease;\n* History of malignant tumors;\n* Expected lifespan \\\u003C2 years;\n* Pregnancy or lactation;\n* Subjects who refuse to comply with the pollution control measures set in this study;\n* Currently participating in other interventional clinical trials.","ALL","18 Years",{"count":19,"type":20},184,"ESTIMATED","2 Years","OBSERVATIONAL","With strict quality control procedures applied throughout microplastic testing, this study will assess the association between baseline circulating micro-nanoplastic exposure and coronary microvascular dysfunction, as well as subsequent long-term cardiovascular outcomes.",[25,26,27,28],"Coronary Microvascular Dysfunction (CMD)","Microplastic Exposure","Nanoplastics","MACE","NOT_YET_RECRUITING","2026-08-19",{"date":32,"type":33},"2026-08-21","ACTUAL",{"date":35,"type":20},"2027-01-01",{"date":37,"type":20},"2029-12-31",{"name":39,"class":40},"Beijing Anzhen Hospital","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100646555","impact-of-chronic-microplastic-exposure-on-radiotherapy-of-head-and-neck-cancer-patients-clinical-and-translational-oncology-study-100646555","NCT07690631","Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:","MICRORAD","Inclusion Criteria:\n\n* Any stage head and neck cancer patients\n* Eastern Cooperative Oncology Group performance status 0-2\n* Undergoing radiotherapy with\u002Fwithout cisplatin chemopotentiation\n* Signed informed consent\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Mental illness\n* Prior or concurrent malignancies\n* Immunotherapy or immunosuppressive therapy\n* Immune diseases",{"count":49,"type":20},500,"MICRORAD is a pioneering 48-month translational research project that investigates the potential health and environmental impacts of micro- and nanoplastics (MNPs) released from medical devices when exposed to ionizing radiation. In radiation oncology, thermoplastic masks (TPMs) are standard immobilization tools, particularly for head and neck (HN) cancer patients. Globally, approximately 2.65 million TPMs are used annually in the radiotherapy of HN cancer patients and with an additional 8 to 10 million for other tumor types. TPMs are repeatedly subjected to high-energy X-rays and frequent handling, raising concerns about polymer degradation and the release of MNPs, which may interfere with treatment efficacy or contribute to radiation toxicity.\n\nMICRORAD is the first translational study to explore this phenomenon by integrating clinical oncology, materials science, radiobiology, and data science. The project will analyze radiation-induced changes in TPMs, quantify MNP release, and assess their biological effects through in vitro, in vivo, and clinical studies.\n\nUsing advanced detection techniques, the project will characterize MNPs and trace their biodistribution, while a clinical pilot will correlate MNP exposure with treatment outcomes. Data integration, biostatistics, and AI-based modeling will support the translation of findings into clinical guidelines, policy briefs, and public communication.\n\nA multidisciplinary team will collaborate to ensure real-world impact. By bridging oncology and environmental health, MICRORAD aims to establish eco-oncology as a new field, contributing to patient safety and sustainable innovation.",[52,26],"Head and Neck Cancer",[54,55,56,46,57],"Head and neck cancer","Microplastics","thermoplastics mask","MNPs","2026-07-13",{"date":60,"type":33},"2026-07-15",{"date":62,"type":20},"2026-09",{"date":64,"type":20},"2030-10",{"name":66,"class":40},"University of Kragujevac",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100587916","microplastic-exposure-from-clear-aligner-wear-mpe-100587916","NCT06934603","Microplastic Exposure From Clear Aligner Wear (MPE)","Microplastic Exposure From Clear Aligner Wear: An In Vivo, Longitudinal Study of Orthodontic Patients","MPE","Inclusion Criteria:\n\n* Individuals (all sexes, genders, races, and ethnicities) aged at least 10 years (in adult dentition) and at most 75 years\n* Receiving comprehensive, Phase II orthodontic treatment with clear aligner therapy\n* Stable physical health (ASA I or II), as determined by study coordinator or PI\n* Able to comprehend and follow requirements of study (including availability on scheduled visit dates)\n* Patient and parental consent (and assent for minors) for participation in the study\n\nExclusion Criteria:\n\n* Receiving orthodontic treatment with fixed appliances\n* Receiving hybrid treatment with fixed appliances and aligners\n* Receiving Phase I orthodontic treatment with fixed appliances\n* Established history of severe xerostomia (dry mouth), severe periodontal disease with actively bleeding gums, significant oral abrasions\u002Fulcers or growths, current alcohol abuse, and\u002For recreational drug abuse\n* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase risk associated with participation\n* Drinking, eating, or brushing teeth within 1 hour of study visit\n* Removing aligners within 1 hour of study visit\n* Developmental or cognitive disability such that the patient cannot self-consent, comprehend, and follow the requirements of the study based on research site personnel's assessment","10 Years","75 Years",{"count":78,"type":20},150,"An observational longitudinal study measuring microplastic exposure and physiologic uptake in orthodontic patients receiving clear aligner treatment.",[26],"RECRUITING","2025-09-17",{"date":84,"type":33},"2025-09-19",{"date":86,"type":33},"2025-08-08",{"date":88,"type":20},"2035-07-01",{"name":90,"class":40},"University of North Carolina, Chapel Hill",1]