[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"milk-allergy-cows\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:milk-allergy-cows":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100652017","oral-immunotherapy-for-children-with-cows-milk-allergy-100652017",false,"NCT07768696","Oral Immunotherapy for Children With Cow's Milk Allergy","Oral Immunotherapy for Children With Cow's Milk Allergy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 6 to 18 months\n* Cow's milk allergy confirmed at an oral food challenge\n* Reaction threshold below 300 mg of cow's milk protein at the oral food challenge\n* Specific IgE to cow's milk \\> 0.35 kU\u002FL\n* High risk of persistent allergy to cow's milk (based on defined criteria)\n* Family motivated for oral immunotherapy following shared decision-making using a decision aid\n\nExclusion Criteria:\n\n* Uncontrolled asthma, eczema, rhino-conjunctivitis, urticaria, or eosinophilic esophagitis\n* Treatment with biologic or immunosuppressive medication\n* Non-Danish-speaking families\n* Anticipated non-adherent families","ALL","6 Months","18 Months",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial aims to investigate if oral immunotherapy can help children with cow's milk allergy tolerate cow's milk.\n\nChildren aged 6-18 months can take part in the trial.\n\nMain question: What percentage of children can tolerate cow's milk after oral immunotherapy, compared with children who avoid cow's milk?\n\nChildren are assigned to these two groups by chance.\n\nChildren receiving oral immunotherapy will:\n\n* Take a small, increasing amount of cow's milk daily for 1-1.5 years\n* Attend clinic or online visits each time the dose is increased\n* Record missed doses\n\nAll children will:\n\n* Provide blood samples to measure allergy-related markers\n* Undergo an oral food challenge with cow's milk after 1-1.5 years to assess how much they can tolerate\n* Report allergic reactions (parent-reported)\n* Complete questionnaires (parent-reported)\n* Participate in an end-of-study telephone interview with an allergy nurse (parent-reported)",[27,28,29],"Milk Allergy, Cow's","Food Allergy in Children","Food Allergies",[31,32,33],"Oral immunotherapy","OIT","Desensitization","NOT_YET_RECRUITING","2026-08-12",{"date":37,"type":38},"2026-08-17","ACTUAL",{"date":40,"type":21},"2026-09",{"date":42,"type":21},"2031-09",{"name":44,"class":45},"Laura Ozer Kettner","OTHER",5,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100535770","investigating-modified-protocols-of-oral-immunotherapy-to-validate-efficacy-and-safety-100535770","NCT06256146","Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety","IMPROVES","Inclusion Criteria:\n\n* A history suggestive of immediate allergy to the food. A convincing clinical history of an IgE mediated reaction to a specific food will be defined as a minimum of 2 mild signs\u002Fsymptoms or 1 moderate or 1 severe sign\u002Fsymptom that was likely IgE mediated and occurred within 120 minutes after ingestion or contact\n* The presence of at least one of the following confirmatory tests:\n\n  * Positive SPT to the culprit food allergen (weal diameter 3 mm larger than that of the normal saline control). The allergens used will be commercial extracts of the foods (Omega Labs, Toronto, Ontario).\n  * Detection of serum specific IgE (\\>0.35 kU\u002FL) to the culprit food or any of its proteins, measured by fluorescence enzyme immunoassay (Phadia, CAP System, Uppsala, Sweden).\n\nExclusion Criteria:\n\n* Patients who have uncontrolled respiratory disease (asthma, cystic fibrosis, etc.)\n* Patients who present with intercurrent disease active at the time of starting desensitization.\n* Non IgE mediated or non-immunological adverse reactions to milk or peanuts.\n* Malignant or immunopathological diseases and\u002For severe primary or secondary immune deficiencies.\n* Patients receiving oral immunosuppressor therapy.\n* Patients receiving β-blockers (including topical formulations), or who receive daily doses of NSAIDs, aspirin or ACE inhibitors for cardiac issues.\n* Associated diseases contraindicating the use of epinephrine: cardiovascular disease, severe hypertension or hypotension.\n* Patients diagnosed with eosinophilic gastrointestinal disorders, including patients with a history of antacid use for reflux related to food impaction or with a history of esophageal spasm.\n* Patients already tolerating processed\u002Fcooked forms of the food (e.g.,baked goods with milk).","2 Years","40 Years",{"count":57,"type":21},360,[24],"Protocols for Oral Immunotherapy (OIT) for the main food allergens have been recently incorporated in clinical practice for food allergies and their clinical benefits have been acknowledged in European and Canadian official guidelines. There has been some reluctance in both clinicians and patients to implement these therapies, primarily because of the risk of allergic reactions during the desensitization process. This study will investigate if protocols using low doses of a food allergen or processed versions of the allergen can be both effective in conferring desensitization while inducing fewer allergic symptoms during the desensitization process.",[61,27,62],"Peanut Allergy","Egg Allergy","RECRUITING","2026-05-01",{"date":66,"type":38},"2026-05-07",{"date":68,"type":38},"2022-03-01",{"date":70,"type":21},"2030-02-28",{"name":72,"class":45},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",1]