[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mins\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mins":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100645739","perioperative-medicine---metabolic-inflexibility-as-a-mechanism-for-myocardial-injury-after-non-cardiac-surgery-100645739",false,"NCT07694453","PeriOperative Medicine - Metabolic Inflexibility as a Mechanism for Myocardial Injury After Non-Cardiac Surgery","POM-MIMICS","Inclusion Criteria:\n\n* Adults aged 18 or over\n* Scheduled for major elective abdominal cancer surgery with planned overnight admission\n* Scheduled for pre-operative CPET\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Less than 18 years old\n* Emergency surgery\n* Unable or unwilling to undergo CPET\n* Pregnancy\n* Active sepsis\n* End-stage organ failure (e.g. on dialysis)\n* Participants without the mental capacity to consent\n* Diagnosis of Type 1 Myocardial Infarction meeting the 4th Universal Definition criteria during the immediate pre-operative period. (Note: Added based on MINS definition context)","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether metabolic inflexibility, which means reduced ability of the body to switch between using fats and sugars for energy, is associated with myocardial injury after non-cardiac surgery (MINS) in adults undergoing major elective abdominal cancer surgery.\n\nThe main question it aims to answer is:\n\nDoes pre-operative metabolic inflexibility predict myocardial injury after non-cardiac surgery (MINS) within the first 72 hours after surgery?\n\nParticipants will continue with their usual surgical care and pre-planned CPET (which can measure metabolic flexibility). As part of the study, participants will:\n\n* Have additional blood samples taken before and after surgery\n* Have an echocardiogram and, where possible, muscle ultrasound\n* Wear a wrist-worn activity monitor before surgery\n* Have routine clinical and surgical information collected from their medical records\n* Receive a follow-up phone call around 90 days after surgery",[24],"MINS",[24,26,27,28,29,30,31],"metabolic flexibility","CPET","Cardiopulmonary Exercise Testing","abdominal cancer surgery","Perioperative medicine","Troponin","NOT_YET_RECRUITING","2026-07-13",{"date":35,"type":36},"2026-07-14","ACTUAL",{"date":38,"type":20},"2026-10-01",{"date":40,"type":20},"2030-10-01",{"name":42,"class":43},"University College, London","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100588661","comparison-of-myocardial-injury-after-noncardiac-surgery-mins-incidence-in-supine-vs-prone-positioning-during-percutaneous-nephrolithotomy-pnl-100588661","NCT06944301","Comparison of Myocardial Injury After Noncardiac Surgery (MINS) Incidence in Supine vs. Prone Positioning During Percutaneous Nephrolithotomy (PNL)","Inclusion Criteria:\n\n* Age ≥40 years.\n* Patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Known coronary artery disease, heart failure, or other significant cardiovascular conditions.\n* Elevated preoperative troponin levels (≥0.03 ng\u002FmL).\n* Major intraoperative complications (e.g., severe bleeding requiring transfusion).\n* Inability to comply with study procedures.","40 Years",{"count":52,"type":20},400,"INTERVENTIONAL",[55],"NA","This prospective cohort study aims to compare the incidence of Myocardial Injury after Noncardiac Surgery (MINS) in patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones in supine versus prone positioning. MINS is defined as an elevated postoperative troponin level (≥0.03 ng\u002FmL) within 48 hours after surgery. Approximately 400 patients will be enrolled, with 200 patients in each positioning group (supine and prone). The primary outcome is the incidence of MINS, assessed through troponin measurements and electrocardiogram (ECG) findings. Secondary outcomes include intraoperative complications, duration of surgery, and postoperative recovery metrics. The study seeks to determine whether surgical positioning impacts MINS risk, potentially guiding safer surgical practices.",[24,58,59,60,61,62,63],"Myocardial Injury After Noncardiac Surgery","Myocardial Injury After Noncardiac Surgery (MINS)","Renal Calculi","Renal Stones","Percutaneous Nephrolithotomy (PNL)","Nephrolithiasis",[24,65,66,67,68,69],"PNL","percutaneous nephrolithotomy","Myocardial Injury after Noncardiac Surgery","prone","supine","2025-04-23",{"date":72,"type":36},"2025-04-25",{"date":74,"type":20},"2025-06-01",{"date":76,"type":20},"2026-08-01",{"name":78,"class":43},"Medipol University"]