[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mitochondria-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mitochondria-health":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":4},"100652393","mitochondrial-intervention-for-resilience-in-older-adults-with-coenzyme-q10-100652393",false,"NCT07772336","MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10","Mitochondrial Intervention for Resilience in Older Adults With Coenzyme Q10","MIRO-Q","Inclusion Criteria\n\n* Age 65 years or older.\n* Community-dwelling older adult.\n* Presence of signs of reduced biological resilience or prefrailty, defined by meeting at least one of the following criteria:\n\n  * Prefrailty according to the Fried frailty phenotype, defined as the presence of 1-2 of the following criteria: unintentional weight loss, self-reported exhaustion, reduced physical activity, slow walking speed, or reduced handgrip strength; or\n  * Reduced physical performance, defined as a Short Physical Performance Battery (SPPB) score of ≤9; or\n  * Increased functional vulnerability, defined as a Clinical Frailty Scale (CFS) score of ≥4.\n* Ability to understand the study procedures and comply with the study protocol.\n* Ability and willingness to provide written informed consent before participation.\n\nExclusion Criteria\n\n* Established frailty with severe functional impairment that would interfere with study participation or outcome assessment.\n* Advanced dementia or cognitive impairment preventing informed consent or reliable participation in study assessments.\n* Active malignant disease or ongoing cancer treatment.\n* Acute inflammatory disease or acute infection at the time of enrollment.\n* Acute or unstable medical condition that could substantially affect functional performance, cognitive assessment, or the safety of the intervention.\n* Any medical condition considered by the investigator to make participation inappropriate or unsafe.\n* Current use of CoQ10 supplementation at a dose that could interfere with assessment of the study intervention, unless discontinued for the predefined washout period.\n* Known hypersensitivity or intolerance to CoQ10 or any component of the study product.\n* Participation in another interventional clinical trial that could affect the outcomes of the present study.",true,"ALL","65 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, double-blind, placebo-controlled clinical trial will investigate whether 10 weeks of CoQ10 supplementation can improve biological resilience and functional health in community-dwelling adults aged 65 years or older with signs of reduced biological resilience or prefrailty.\n\nParticipants will be randomly assigned in a 1:1 ratio to receive either 200 mg of CoQ10 daily or matching placebo for 10 weeks. The study will assess the effects of CoQ10 supplementation on mitochondrial functional resilience, chronic low-grade inflammation, metabolic health, physical performance, cognitive function, and objective measures of skin aging.\n\nThe study will also investigate whether baseline biological and functional characteristics can identify individuals who are more likely to benefit from CoQ10 supplementation. An exploratory aim is to develop a multidimensional composite index of biological resilience integrating molecular, biochemical, functional, and clinical measures of aging.\n\nThe study will provide evidence on whether a mitochondria-targeted intervention with CoQ10 may represent a potential strategy for improving functional resilience and reducing features of prefrailty in older adults.",[28,29,30,31,32],"Frailty","Aging","Mitochondria Health","Skin Aging","Mitochondrial Dysfunction",[34,35,36,37,38,39,40],"frailty","aging","older adults","Coenzyme Q10","mitochondrial dysfunction","geroscience","functional aging","NOT_YET_RECRUITING","2026-08-13",{"date":44,"type":45},"2026-08-19","ACTUAL",{"date":47,"type":22},"2026-09",{"date":49,"type":22},"2027-02",{"name":51,"class":52},"University Medical Centre Ljubljana","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":17,"sex":18,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100617729","kaempferol-absorption-and-pharmacokinetics-evaluation-100617729","NCT07322406","Kaempferol Absorption and Pharmacokinetics Evaluation","Kaempferol Absorption and Pharmacokinetics Evaluation (K.A.P.E.)","KAPE","Inclusion Criteria:\n\nAdults aged 18 to 70 years\n\n* Healthy volunteers as determined by medical history and screening assessment\n* Ability to understand the study procedures and provide informed consent\n* Willingness and ability to comply with all study procedures, including dietary restrictions, clinic visits, blood draws, urine collection, and follow-up assessments\n* Willingness to abstain from restricted foods, beverages, and supplements as specified in the study protocol during the study period\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to Kaempferol or related flavonoids\n* Pregnancy or breastfeeding\n* Presence of significant acute or chronic medical conditions that could increase risk or interfere with study outcomes, including but not limited to:\n* Active or chronic infections\n* Cancer\n* Cardiovascular disease\n* Neurological or neurodegenerative disorders\n* Metabolic or systemic inflammatory conditions\n* Use of prescription medications or supplements known to interfere with Kaempferol metabolism or pharmacokinetic assessment\n* Blood donation within 8 weeks prior to study enrollment\n* Participation in another interventional clinical study within a timeframe that could interfere with study results or participant safety\n* Any condition or circumstance that, in the judgment of the study investigator, would make participation unsafe or compromise data integrity","18 Years","70 Years",{"count":64,"type":22},120,[25],"This study is a multi-site clinical trial designed to evaluate how the body absorbs and processes Kaempferol, a naturally occurring compound found in many plant-based foods. The primary purpose of the study is to measure the pharmacokinetics and biological absorption of Kaempferol in healthy adults.\n\nParticipants will receive Kaempferol and undergo scheduled blood and urine collections over a short study period. These samples will be used to measure Kaempferol levels in the body and to assess safety and tolerability. In addition, selected biological samples will be analyzed to explore molecular changes associated with Kaempferol exposure using advanced laboratory methods.\n\nThe study will be conducted at multiple research centers in the United States using a standardized protocol to ensure consistency across sites. The information collected will help improve understanding of how Kaempferol is absorbed and metabolized in humans and will support future research and regulatory evaluation.",[68,30,69,70,71],"No Disease","Longevity","Pharmacokinetics and Biological Absorption of Kaempferol in Healthy Adult","Healthy Volunteers",[73,74,75,76,77,78,79,80,81],"Mitochondria","Kaempferol","KMP","Pharmacokinetics","Bioavailability","Absorption","Dietary supplement","Healthy volunteers","Multi-omics","RECRUITING","2026-03-19",{"date":85,"type":45},"2026-03-23",{"date":87,"type":45},"2025-12-09",{"date":89,"type":22},"2027-12-22",{"name":91,"class":52},"University of Pittsburgh",3]