[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mixed-pain-nociceptive-and-neuropathic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mixed-pain-nociceptive-and-neuropathic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100652081","early-phase-1-s1r-imaging-based-cryoneurolysis-in-chronic-pain-100652081",false,"NCT07768501","S1R Imaging-Based Cryoneurolysis in Chronic Pain","Molecular Imaging-Based Cryoneurolysis: Targeting Upregulated Sigma-1 Receptor Positive Nerves in Chronic Pain","Inclusion Criteria:\n\n1. Chronic nociceptive, neuropathic, or mixed pain for ≥2 months\n2. Pain originating from a region amenable to cryoneurolysis (celiac plexus, intercostal nerves, pudendal nerve, peripheral nerve block\n3. Chronic pain ≥2 months\n4. Pain score ≥4\u002F10\n5. Pain location amenable to cryoneurolysis\n6. Willing and able to provide consent.\n\nExclusion Criteria:\n\n1. Pregnancy or nursing.\n2. Non-English speaking individuals\n3. Contraindication to MRI scanning which includes, but is not limited to, incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ.\n4. Weight \\>350 pounds or a large body habitus, which the MR scanner cannot accommodate.\n5. Claustrophobia or feeling that he or she will be unable to lie still in the scanner for a period of 2 hours or fit in the PET\u002FMR scanner due to body size.","ALL","18 Years",{"count":19,"type":20},6,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The goal of this clinical trial is to determine whether a sigma-1 receptor PET\u002FMRI scan can help identify the specific nerves responsible for chronic pain.\n\nResearchers will use an investigational imaging agent called \\[18F\\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests.\n\nParticipants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.",[26,27],"Chronic Pain","Mixed Pain (Nociceptive and Neuropathic)",[29,30,31],"chronic pain","PET\u002FMRI","cryoneurolysis","NOT_YET_RECRUITING","2026-08-12",{"date":35,"type":36},"2026-08-17","ACTUAL",{"date":38,"type":20},"2026-09",{"date":40,"type":20},"2030-09",{"name":42,"class":43},"Davidzon, Guido, M.D.","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100562129","phase-1-petmri-for-chronic-pain-from-spinal-or-peripheral-nerve-origin-100562129","NCT06599151","PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin","Use of (18F)FTC-146 PET_MRI for Characterizing Chronic Pain Phenotypes in Chronic Pain Patients with Spinal or Peripheral Nerve Origin","Inclusion Criteria:\n\n* Healthy Volunteers\n\n  1\\. At least 18 years old.\n* Pain Subjects\n\n  1. At least 18 years old.\n  2. Chronic Pain is of Spinal or Peripheral Nerve Origin\n  3. Subject's Chronic pain lasting greater than 2 months.\n  4. Pain level of at least 4\u002F10 on a 0-10 Comparative Pain Scale.\n\nExclusion Criteria:\n\n* Healthy Volunteers\n\n  1. Any chronic Pain\n  2. Use of pain medication.\n  3. MRI incompatibility.\n  4. Kidney problems.\n  5. Pregnant or nursing.\n  6. Non-English speaker.\n  7. Presence of vasculopathy or Raynaud's.\n  8. Inability to tolerate cessation of anticoagulant medication during the study.\n* Pain Subjects\n\n  1. MRI incompatibility.\n  2. Kidney problems.\n  3. Pregnant or nursing.\n  4. Non-English speaker.",true,{"count":53,"type":20},200,[55],"PHASE1","The purpose of this study is to compare the uptake of \\[18F\\]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.\n\nPrimary Objectives:\n\nA) To quantify the bio-distribution of \\[18F\\] FTC-146 uptake in subjects with Spinal or Peripheral Nerve Origin pain and compare it with healthy controls.\n\nB) To determine whether painful schwannomas can be differentiated from non-painful schwannomas based on imaging.\n\nSecondary Objectives:\n\nA) To assess the reproducibility of \\[18F\\]FTC-146 PET imaging within the same healthy volunteer subjects using Test-Retest analysis.\n\nB) To investigate whether post-treatment \\[18F\\]FTC-146 uptake differs from pre-treatment uptake and correlate the imaging with subject reported pain level after treatment",[58,59,60,61],"Nerve Pain","Neuropathic Pain","Nociceptive Pain","MIxed Pain (Nociceptive and Neuropathic)",[30,26,58],"2024-09-12",{"date":65,"type":36},"2024-09-19",{"date":67,"type":20},"2024-10-01",{"date":69,"type":20},"2030-10-01",{"name":71,"class":43},"Stanford University"]