[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mobility-limitations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mobility-limitations":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,87,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100651414","smart-nursing-ai-agent-for-health-self-management-100651414",false,"NCT07761663","Smart Nursing AI Agent for Health Self-Management","Smart Nursing AI Agent for Health Self-Management Among Middle-aged and Older Adults","Inclusion Criteria:\n\n1. Patients aged 50 years or older who present with mobility limitations such as gait instability, sarcopenia, joint degeneration, chronic pain, or functional decline\n2. Able to ambulate\n3. Alert and oriented\n\nExclusion Criteria:\n\n1. Terminal cancer or major illness with a prognosis of left 6 months\n2. Moderate to severe dementia or language expression disorders\n3. Individuals with significant audiovisual impairments that prevent AI conversation\n4. Unable to complete walking tests on their own","ALL","50 Years",{"count":19,"type":20},102,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to develop and evaluate a smart nursing AI agent to support health self-management among middle-aged and older patients, and further to examine its effectiveness in home care and health self-management. The goal is to propose innovative strategies for middle-aged and older care that enhance the quality of home care and strengthen patients' health self-management abilities. A randomized controlled trial design will be adopted, with a planned enrollment of 102 participants. Participants will be randomly assigned to either the experimental group or the control group. Regardless of group assignment, their routine medical care will remain unchanged. Both groups will participate in the study for 12 weeks (8 weeks of intervention and 4 weeks of follow-up), with identical frequency and number of follow-ups, interviews, and evaluations. The experimental group will receive an 8 week intervention using the smart nursing AI agent care model, which provides daily interaction, reminder systems, personalized recommendations, activity monitoring, goal setting, motivational support, and health self-management education. The control group will continue with the existing standard health education approach. Data collection will include demographic information, medical history, physiological indicators, functional activity measures (e.g., steps, distance, exercise duration), sarcopenia screening, nutritional assessment, physical activity levels, health self-management ability, health literacy, quality of life, and digital usage behaviors. Statistical analyses will be conducted to evaluate the effectiveness, feasibility, and acceptability of the intervention.",[26,27,28],"Mobility Limitations","Community-dwelling Older Adults","Middle-aged and Older Adults",[30,31,32,33,34,35],"Health Self-Management","Smart Nursing AI Agent","eHealth Literacy","community-dwelling older adults","Middle-aged and older adults","mobility limitations","NOT_YET_RECRUITING","2026-08-09",{"date":39,"type":40},"2026-08-12","ACTUAL",{"date":42,"type":20},"2026-08-05",{"date":44,"type":20},"2028-08-05",{"name":46,"class":47},"National Yang Ming Chiao Tung University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":48},"100647149","dual-task-balance-training-in-traumatic-lower-limb-prosthesis-users-100647149","NCT07706452","Dual-Task Balance Training in Traumatic Lower-Limb Prosthesis Users","Effectiveness of Dual-Task Balance Training on Balance, Mobility, and Mental Health Among Traumatic Lower-Limb Prosthesis Users in the Gaza Strip: A Randomized Controlled Trial","DTBT-LLA","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Traumatic unilateral lower-limb amputation.\n* Transtibial or transfemoral amputation level.\n* Current lower-limb prosthesis user.\n* Able to stand and walk with the prosthesis, with or without an assistive device.\n* Medically stable and able to participate in a rehabilitation training program.\n* Able to understand and follow study instructions.\n* Provides written informed consent.\n\nExclusion Criteria:\n\n* Lower-limb amputation due to dysvascular, congenital, or non-traumatic causes.\n* Bilateral lower-limb amputation.\n* Severe cognitive impairment that prevents understanding or following study instructions.\n* Severe visual, vestibular, neurological, or musculoskeletal condition that significantly affects balance or walking independent of the amputation.\n* Unhealed residual limb wounds, severe pain, or skin problems that prevent safe prosthesis use.\n* Uncontrolled medical condition that makes participation unsafe.\n* Participation in another structured balance training program during the study period.","18 Years",{"count":59,"type":20},63,[23],"This randomized controlled trial will evaluate the effectiveness of dual-task balance training on balance, mobility, and mental health among traumatic lower-limb prosthesis users in the Gaza Strip. Participants will be randomly assigned to either an experimental group receiving dual-task balance training in addition to standard rehabilitation or a control group receiving standard rehabilitation only. The intervention will be delivered over 6 weeks, with three sessions per week. Balance and mobility will be assessed using the Berg Balance Scale and the Amputee Mobility Predictor with Prosthesis, while mental health will be assessed using the Depression, Anxiety, and Stress Scale-21.",[63,64,65,26],"Lower Limb Amputation","Prosthesis Users","Balance Impairment",[67,68,69,70,71,72,73,74,75,76],"Dual-task training","Balance training","Lower-limb prosthesis","Traumatic amputation","Amputee rehabilitation","Berg Balance Scale","Amputee Mobility Predictor","DASS-21","Gaza Strip","Mental health","RECRUITING","2026-07-22",{"date":80,"type":40},"2026-07-23",{"date":82,"type":40},"2026-07-08",{"date":84,"type":20},"2026-10-30",{"name":86,"class":47},"Al-Azhar University - Gaza",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":21,"phases":98,"briefSummary":99,"conditions":100,"keywords":112,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":48},"100531998","the-fit-with-us-study-100531998","NCT06207084","The Fit With Us Study","Precision-based Teleexercise Trial to Increase Adherence in People With Disabilities","FITWITHUS","Eligible participants must meet the following criteria to be included: (1) live with a permanent physical disability that limits their mobility; (2) be 18 to 89 years of age; (3) have broadband internet access; (4) be able to speak and read English; and (5) be able to attend coaching and training sessions during the weekdays.\n\nParticipants are excluded from participation if they (1) possess significant visual acuity that prevents seeing a computer screen to follow a home exercise program; (2) have been regularly engaging in exercise for the previous 3 months; (3) are unable to use their arms and their legs at all to exercise; (4) are unsafe to exercise; (5) self-report that they are currently pregnant","89 Years",{"count":97,"type":20},257,[23],"The purpose of this 32-week study is to use an innovative experimental design known as SMART (Sequential Multiple Assignment Randomized Trial), which will allow us to determine the best way to sequence the delivery of teleexercise (referred to as an adaptive intervention), combined with predictive analytics on participant adherence in a stepped program of physical activity interventions. All 257 participants will have access to a library of recorded video exercise content, and a weekly wellness article. Some participants will receive health coaching calls (1st randomization). Analytic data will be used to determine which participants are responding or not responding to the intervention. Participants not responding after 4 weeks will receive either live one-on-one or group exercise training (2nd randomization). After 8 weeks, the participant will receive only pre-recorded exercise content and articles for a 24-week maintenance phase (weeks 9-32). The study outcomes are: The effectiveness of the adaptive interventions; Exploring mediating and moderating variables; Sensitivity analysis of the predictive analytics.",[26,101,102,103,104,105,106,107,108,109,110,111],"Disability Physical","Telehealth","Health Coaching","Physical Activity","Behavior, Health","eHealth","Health Literacy","Self Efficacy","Fatigue","Usability","Predictive Model",[113,114,115],"telehealth","health coaching","disability","2026-01-07",{"date":118,"type":40},"2026-01-09",{"date":120,"type":40},"2024-09-01",{"date":122,"type":20},"2029-02-01",{"name":124,"class":47},"University of Alabama at Birmingham",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":132,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":141,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100617764","virtual-reality-based-vs-traditional-physiotherapy-for-balance-frailty-and-fall-prevention-in-adults-aged-45-years-and-older-100617764","NCT07322861","Virtual Reality-Based vs Traditional Physiotherapy for Balance, Frailty, and Fall Prevention in Adults Aged 45 Years and Older","A Controlled Trial Comparing Virtual Reality-Based PABLO Training With Traditional Otago Physiotherapy for Balance, Frailty, and Fall Risk in Adults Aged 45 Years and Older","Inclusion Criteria:\n\n* Adults aged 40 years and older\n* History of at least one fall in the past 12 months OR clinical evidence of balance dysfunction\n* Ability to walk at least 10 meters, with or without an assistive device\n* Adequate cognitive function, defined as Mini-Mental State Examination (MMSE) score ≥ 24\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (MMSE \\\u003C 24)\n* Unstable cardiovascular, musculoskeletal, or neurological conditions that contraindicate exercise participation\n* Severe uncorrected visual or auditory impairment that interferes with training or assessments\n* Current participation in another structured exercise or rehabilitation program\n* Any medical condition deemed unsafe for participation by the treating physiotherapist","40 Years",{"count":134,"type":20},80,[23],"This study will compare two exercise-based rehabilitation programs to improve balance and reduce fall risk in adults aged 45 years and older who have had at least one fall in the past year or have balance problems. Participants will be assigned to one of two groups: (1) a virtual reality (VR) exercise program using the PABLO system, or (2) a traditional physiotherapy program based on the Otago approach. Both programs will include balance training, strength\u002Fpower exercises, aerobic activity, and flexibility. The program will last 12 weeks, with two supervised sessions per week (about 30 minutes each). Assessments will be completed at the start of the study and again after 12 weeks. The main outcomes include frailty status, number of falls, mobility (Timed Up and Go test), and balance (Berg Balance Scale). Additional outcomes include grip strength, quality of life (SF-12), and program adherence and safety. The study will help determine whether VR-based rehabilitation improves participation and outcomes compared with traditional physiotherapy.",[138,139,140,26],"Frailty","Falls","Balance Deficits",[142,143,144,138,145],"Virtual Reality Rehabilitation","Balance Training","Fall Prevention","Exergaming","2025-12-29",{"date":116,"type":40},{"date":149,"type":20},"2026-01-01",{"date":151,"type":20},"2026-06-01",{"name":153,"class":47},"Umm Al-Qura University"]