[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"molar-incisor-hypomineralisation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:molar-incisor-hypomineralisation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,62,87,118,139,161,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100649026","correlation-between-colour-and-hypersensitivity-of-first-permanent-molars-with-molar-incisor-hypomineralisation-mih-100649026",false,"NCT07727044","Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH)","Molar-Incisor Hypomineralisation (MIH): Correlation Between Colour of the Defect and Hypersensitivity in Young First Permanent Molars","MIH Study Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016)\n* Children with first molars in occlusion\n* Children fit and healthy\n\nExclusion Criteria:\n\n* MIH first permanent molars that have already received any kind of dental treatment\n* Children diagnosed with HSPM (hypomineralised second primary molars)\n* Children older than 8 years - Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study\n* Children with MIH teeth that show clinically visible enamel loss during the eruption\n* Children without the first molars in occlusion\n\nNon- MIH Control Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with no clinically affected molars\n* Children fit and healthy\n\nExclusion Criteria:\n\n* Children who have already received any kind of dental treatment on their permanent or primary teeth\n* Children diagnosed with MIH or any other disease of the teeth\n* Children older than 8 years\n* Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study",true,"ALL","5 Years","8 Years",{"count":21,"type":22},45,"ESTIMATED","OBSERVATIONAL","Cheese molars (MIH: molar incisor hypomineralisation) can be recognized not only by their colour abnormalities but also by their hypersensitivity. Clinical management of these teeth may become challenging by the chronic hypersensitivity, which makes various steps of a treatment, such as pain control or light curing of any type of composite restorations, difficult or even impossible, despite profound local anesthesia. Hypersensitivity can be detected by the clinician based on the patient's statements or reaction. On the other hand, colours and structural abnormalities can be easily assessed by visual inspection. The aim of this study is to determine the relationship between hypersensitivity and the colour of the enamel defect on young first permanent molars. A correlation between colour of the defect and hypersensitivity could enable early prognosis leading to preventive measures in order to delay, amplify or even avoid the onset of the symptoms. Children diagnosed with MIH on their first permanent molars of different severity are matched to children with sound molars. They are identified by the annual school dental check-up and are invited to take part in the study. The children will be invited to the university dental clinic via letter for the first appointment. Upon parental consent, the teeth will be photographed and scanned as well as investigated for hypersensitivity through a gentle air blast.",[26],"Molar Incisor Hypomineralisation",[28,29,30],"MIH","Hypersensitivity","colour of defect","RECRUITING","2026-07-21",{"date":34,"type":35},"2026-07-27","ACTUAL",{"date":37,"type":35},"2026-01-09",{"date":39,"type":22},"2026-10-31",{"name":41,"class":42},"University of Basel","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":28,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":59,"leadSponsor":61,"locationsCount":43},"100648903","correlation-between-colour-of-defect-and-enamel-breakdown-in-first-permanent-molars-with-molar-incisor-hypomineralisation-mih-100648903","NCT07727200","Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)","Molar-Incisor Hypomineralisation (MIH): Correlation Between Colour of Defect and Enamel Breakdown","MIH Study Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016)\n* Children with first molars in occlusion\n* Children fit and healthy\n\nExclusion Criteria:\n\n* MIH first permanent molars that have already received any kind of dental treatment\n* Children diagnosed with HSPM (hypomineralised second primary molars)\n* Children older than 8 years - Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study\n* Children with MIH teeth that show clinically visible enamel loss during the eruption\n* Children without the first molars in occlusion\n\nNon- MIH Control Group\n\nInclusion Criteria:\n\n* Children between 5 to 8 years with no clinically affected molars- Page 4 of 5\n* Children fit and healthy\n\nExclusion Criteria:\n\n* Children who have already received any kind of dental treatment on their permanent or primary teeth\n* Children diagnosed with MIH or any other disease of the teeth\n* Children older than 8 years\n* Children younger than 5 years\n* Children with any cranio-facial and\u002For other developmental dental defects\n* Children diagnosed with parafunctions (attrition\u002F erosion)\n* Children and\u002For parents who did not consent to the study",{"count":21,"type":22},"Cheese molars (MIH) can be recognized not only by their colour abnormalities but also by the enamel breakdown. Clinical management of those teeth may become challenging by the chronic hypersensitivity, that makes various steps during treatment, such as pain control or light curing of any type of composite restorations, difficult or even impossible, despite profound local anaesthesia. The aim of this study is to determine the relationship between colour of the defect and loss of ename in the affected teeth. A correlation between colour of the defect and risk of enamel breakdown could enable early prognosis leading to preventive measures in order to delay or even avoid completely any breakdown of the enamel. Children diagnosed with MIH on their first permanent molars of different severity are matched to children with sound molars. They are identified by the annual school dental check-up and are invited to take part in the study. The children will be invited to the university dental clinic via letter for the first appointment. Upon parental consent, the teeth will be photographed and scanned on the first appointment. Three follo-up appointments will be organised in order to take pictures and scan again the teeth. The baselne scan of the tetth will be compared to the scans of the subsequent appointments in order to measure the level of enamel breakdown and correlate it to the colour of the defect.",[26,54,55],"Enamel Breakdown","Colour of Defect",[28,55,54],{"date":34,"type":35},{"date":37,"type":35},{"date":60,"type":22},"2027-03-31",{"name":41,"class":42},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":16,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100620272","the-effect-of-salvadora-persica-miswak-compared-to-fluoridated-toothpaste-on-childrens-teeth-diagnosed-with-molar-incisor-hypomineralization-mih-a-randomized-clinical-trial-100620272","NCT07355465","The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy children with age ranged between 6-12 years old\n\n  * Presence of at least one first permanent molar and incisor diagnosed with MIH.\n  * The MIH-affected teeth will have a clinical presentation of white, creamy, yellow, or brown demarcated opacities\n\nExclusion Criteria:\n\n* Medically compromised children.\n* Unwillingness to participate or be randomly assigned to the study groups.\n* Receiving treatment for controlling MIH other than fluoride application","6 Years","12 Years",{"count":71,"type":22},30,"INTERVENTIONAL",[74],"NA","Molar-Incisor Hypo mineralization (MIH) was first described in 2001 as a developmental enamel defect . It is a condition in which the enamel of at least one first primary molar is affected with a qualitative defect causing abnormal translucency appearing as demarcated opacities; The permanent incisors and second primary molars can also be affected . MIH has adverse consequences on the oral health and child's quality of life. It increases the risk of caries, discomfort and teeth sensitivity .\n\nMIH management comprises a variety of treatment options ranging from total caries removal to the polar opposite treatment option of no caries removal and non-invasive methods used to prevent caries progression . Dental caries prediction and prevention are now more important than dental caries diagnosis and treatment. Recently, the reasons for repairing dental cavities have been narrowed, and caries prevention is being used to reduce caries . Salvadora persica, commonly known as Miswak was used as a toothbrush for many years among many countries . It was reported to have a significant effect on oral health and caries prevention .Other studies have found a consistent link between the use of Miswak and a reduction in oral bacteria. However, a comprehensive assessment of using Miswak in the treatment and control of MIH among young children has yet to be conducted.\n\nTherefore, the aim of this clinical trial is to assess the effect of SalvadoraPersica and fluoridated toothpaste on controlling hypersensitivity and preventing caries among children with MIH in primary schools. Additionally, this trial will evaluate the shade of the hypo-mineralized enamel before and after using SalvadoraPersica and fluoridated toothpaste",[26],"NOT_YET_RECRUITING","2026-01-20",{"date":80,"type":35},"2026-01-21",{"date":82,"type":22},"2026-01-29",{"date":84,"type":22},"2027-05-30",{"name":86,"class":42},"King Abdulaziz University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":95,"targetDuration":4,"studyType":72,"phases":97,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100606553","phase-2-hydroxyapatite-vs-fluoride-toothpaste-for-mih-remineralization-100606553","NCT07177053","Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization","Comparative Clinical Evaluation of Remineralization of Molar Incisor Hypomineralization Using Hydroxyapatite vs. Fluoride Toothpaste","MIH-CARE","Inclusion Criteria:\n\n* at least one affected permanent molar or incisor\n* good general health\n* parental informed consent, and the child's assent\n\nExclusion Criteria:\n\n* Patients with systemic conditions affecting enamel or recent use of desensitizing treatments.",{"count":96,"type":22},160,[98],"PHASE2","Molar Incisor Hypomineralization (MIH) is a common developmental enamel defect affecting children, particularly in Dubai, where it contributes to hypersensitivity, esthetic concerns, plaque accumulation, and increased caries risk. These complications often lead to premature tooth extraction and orthodontic issues, negatively impacting children's oral health-related quality of life.\n\nThis randomized, open-label clinical trial aims to compare the remineralization efficacy of a fluoride-free hydroxyapatite toothpaste with a conventional fluoride toothpaste in children aged 6-12 years diagnosed with mild to moderate MIH.\n\nParticipants will be recruited from Dubai Health pediatric dental clinics, with inclusion criteria requiring at least one affected permanent molar or incisor, good general health, parental informed consent, and the child's assent. Children with systemic conditions affecting enamel or recent use of desensitizing treatments will be excluded.\n\nPrimary outcome assessment will involve Quantitative Light-Induced Fluorescence-QLF at baseline, 3, 6, 9, and 12 months. The images were analyzed using a commercial software program (Inspektor QLF 1.97, Inspektor Research Systems, Amsterdam, The Netherlands) to determine the change in fluorescence (ΔF, %) and extension of the lesion (area; mm2).\n\nSecondary outcome measures will include enamel fluorescence readings using the DIAGNOdent Pen. After prophylaxis and air-drying, three readings per lesion will be recorded, with mean and peak values analyzed to monitor mineralization. Hypersensitivity in MIH-affected teeth will be assessed using air stimulus (Schiff scale) and Visual Analogue Scale (VAS) at baseline, 3, 6, 9, and 12 months. Oral health-related quality of life (OHRQoL) will be measured using age-appropriate validated questionnaires to evaluate the impact of MIH and treatment over time.\n\nThis study also responds to growing parental concerns about fluoride exposure and the demand for safer, fluoride-free alternatives. By evaluating the clinical effectiveness of hydroxyapatite toothpaste, the trial aims to inform evidence-based preventive strategies for MIH management. The findings may guide clinical practice and public health recommendations, ultimately improving oral health outcomes for affected children.",[26],[102,103,104,105,106,107],"Molar Incisor Hypomineralization (MIH)","Child","Remineralization","Hydroxyapatite Toothpaste","Fluoride Toothpaste","Quantitative Light-Induced Fluorescence(QLF)","2025-09-12",{"date":110,"type":35},"2025-09-16",{"date":112,"type":22},"2025-11",{"date":114,"type":22},"2026-11",{"name":116,"class":117},"Dubai Health","OTHER_GOV",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":72,"phases":127,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":43},"100605404","etch-bleach-seal-technique-in-managing-opacities-related-mih-using-icon-100605404","NCT07162077","Etch-bleach-seal Technique in Managing Opacities Related MIH Using Icon®","The Effectiveness of Sodium Hypochlorite Application in Managing Opacities of Molar-incisor Hypomineralization on Incisors Using Resin Infiltration","Inclusion Criteria:\n\n* Patients diagnosed with MIH-related opacities on the incisal and middle thirds of the buccal surface of their permanent incisors, ac- cording to EAPD diagnostic criteria of (MIH), only isolated lesions will be selected.\n\nExclusion Criteria:\n\n* Teeth with resin composite restorations, previously treated by exter- nal bleaching, micro-abrasion or re-mineralization(fluoride varnish or calcium-based products such asCPP-ACP) will be excluded.\n* Opacities present only on incisors without molar\n* WSLs caused by orthodomtic treatment\n* Teeth affected by dental fluorosis, Amelogenesis imperfecta and Tetracycline-pigmented teeth",{"count":126,"type":22},24,[74],"Objectives: to compare aesthetic effectiveness of resin infiltration with\u002Fwithout using sodium hypochlorite in managing opacities of MIH on incisors, and to compare parent's satisfaction with results of both application protocols.\n\nMethods: Twenty-four teeth with yellow\u002F brown opacities of MIH, will be diagnosed according to EAPD diagnostic criteria, will be randomly allocated to test or control group. In the test group, the investigators will be applied sodium hypochlorite 5.25% by using cotton wad before treatment, then after the first and second etching cycles (application of the Icon-Etch (ICON® -Etch; DMG, Hamburg, Germany) and Icon-dry (ICON® -Dry; DMG, Hamburg, Germany) according to the manufacturer's recommendations) as irrigation step and following the third -Etch etching cycle Icon-infiltrant (ICON® -Infiltrant; DMG, Hamburg, Germany) will be applied . In control group, the investigators will be applied the same protocol of test group but without using sodium hypochlorite. The masking efficacy will be analyzed using the Lab System to calculate the color difference (ΔE) between the opacity and the adjacent enamel in Adobe Photoshop 2024. The infiltration proportion of opacity will be measured using Image J software and the infiltrated area will be expressed as a percentage. The satisfaction of the parents with the results of both application protocols will be compared using Likert scale.",[26],"2025-09-07",{"date":132,"type":35},"2025-09-09",{"date":134,"type":35},"2025-08-25",{"date":136,"type":22},"2026-10",{"name":138,"class":42},"Tishreen University",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":72,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100584992","effect-of-nano-hydroxy-apatite-varnish-and-potassium-nitrate-gel-on-the-mih-affected-permanent-teeth-100584992","NCT06896565","Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth","Comparative Evaluation of Three Different Topically Applied Materials as Non-invasive Treatment of Permanent Teeth With Molar Incisor Hypo-mineralization: Randomized Clinical Trial","The research unit of this study will be the MIH-affected permanent tooth, in children aged from six to ten years, from either gender.\n\nInclusion criteria:\n\nParticipants related criteria:\n\n1. Children aged from six to ten years old.\n2. Medically free children according to the history taken from their parents.\n3. Children who are categorized as Class I or II according to the American Society of Anaesthesiologists (ASA).\n4. Children whom their parents accept to comply with the follow-up visits.\n5. Children who accept, and their guardians, to participate in the study by signing the informed consent.\n6. Children with no more than four cavitated primary teeth.\n\nTooth related criteria:\n\n1\\. The diagnosis of MIH will be done as per the Wurzburg concept, 2023 MIH diagnostic criteria:\n\nThe child will be confirmed to have MIH if any of the following characteristics are apparent:\n\n* affected teeth show a clearly defined opacity at the occlusal and buccal surfaces of a tooth,\n* defects vary in shape, size, and pattern,\n* white, cream-colored, or yellow-brown color deviations are recognizable,\n* defects variably vary in size,\n* teeth with hypersensitivity are present,\n* teeth have an atypical restoration,\n* permanent teeth for (suspected) MIH reasons are missing (extractions),\n* combinations of the above characteristics are present.\n\n  1. MIH-affected permanent teeth, suffering from dentin hypersensitivity, (MIH-TNI 3, 4a).\n  2. Positive Schiff Cold Airblasting Sensitivity score (score 1, 2, or 3).\n\n     * Exclusion criteria:\n\nParticipants related criteria:\n\n1. Children with severe behavioral or emotional disabilities.\n2. Children who received analgesics within the last 24 hours before the procedure.15\n3. Patients who are using chlorhexidine-based gels or mouthwashes.\n\nTooth related criteria:\n\n1. A tooth with signs and symptoms of irreversible pulpitis.\n2. A tooth with signs and symptoms of necrotic pulp.\n3. Sealing therapy or application of desensitizing agent on the MIH teeth within one month before participation in the study.\n4. Presence of dental caries on the MIH-affected permanent tooth.\n5. Presence of restoration(s) on MIH-affected permanent tooth.","10 Years",{"count":148,"type":22},48,[74],"This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing MIH-affected teeth.",[26],"2025-04-22",{"date":154,"type":35},"2025-04-24",{"date":156,"type":22},"2025-06-01",{"date":158,"type":22},"2026-08-01",{"name":160,"class":42},"Cairo University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":168,"maxAge":69,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100571998","prevalence-of-hypomineralized-second-primary-molars-and-its-association-with-molar-incisor-hypomineralization-100571998","NCT06727539","Prevalence of Hypomineralized Second Primary Molars and Its Association with Molar-Incisor Hypomineralization.","Prevalence of Hypomineralized Second Primary Molars in a Group of Egyptian Children and Its Association with Molar-Incisor Hypomineralization: a Cross-Sectional Study.","Inclusion Criteria:\n\n1. Both genders will be included\n2. Children and adolescents with age group from 6-12 years\n3. Participants who agreed to sign rhe informed consent\n\nExclusion Criteria:\n\n1. Patients having enamel defects like fluorosis, amelogenesis imperfecta and dentinogenesis imperfecta\n2. Special health care needs\n3. Non-Egyptian children","7 Years",{"count":170,"type":22},825,"The aim for thid study is to detect the prevalence of HSPM and the possible association between MIH and HSPM in a group of Egyptian children aged from 6-12 years. The study will also observe the possible etiological factors that might predispose hypomineralization of primary teeth.\n\nTo our knowledge, there are no relevant studies that considered the prevalence of HSPM and its possible etiology in Egypt or its association with MIH. So, this study will address this knowledge gap. The possible relationship between HSPM and MIH is highly significant in pediatric dentistry, since the early diagnosis of HSPM as soon as second primary molars erupt makes it possible to initiate more intensive supervision and preventive measures, as these patients are otherwise prone to developing MIH in permanent teeth within a few years.",[26,173,174,175],"Molar Incisor Hypomineralization","Hypomineralization Molar Incisor","Hypomineralization of Enamel","2024-12-11",{"date":178,"type":35},"2024-12-16",{"date":180,"type":22},"2025-01-01",{"date":182,"type":22},"2026-02",{"name":160,"class":42},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":16,"sex":17,"minAge":68,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":72,"phases":194,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":43},"100565348","this-study-aims-to-evaluate-the-effect-of-rinsing-off-or-blot-drying-silver-fluoride-on-the-retention-of-subsequently-applied-resin--and-glass-ionomer-based-fissure-sealants-in-permanent-molars-affected-by-molar-incisor-hypomineralization-100565348","NCT06641011","This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.","The Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.","Inclusion Criteria:\n\n* Patients and their parents who consent to participate and have signed the informed consent form.\n* Patients with at least one permanent molar diagnosed with molar incisor hypomineralization based on EAPD guidelines.\n* Fully erupted teeth with ICDAS I or II lesions that necessitate the application of fissure sealants.\n* Teeth displaying demarcated opacities on the occlusal surface and at least one additional surface.\n\nExclusion Criteria:\n\n* Teeth that have existing restorations or cavities.\n* Patients currently receiving orthodontic treatment.\n* Patients who are uncooperative during dental procedures.\n* Teeth affected by dental fluorosis or enamel defects associated with specific syndromes.\n* Children with systemic conditions requiring ongoing medication.","14 Years",{"count":193,"type":22},104,[74],"The aim of this study is three-fold: 1. To evaluate the clinical performance of glass ionomer fissure sealants and resin fissure sealants when placed immediately after or one week following the application of silver fluoride on permanent molars affected by Molar-Incisor Hypomineralization in high caries-risk children. 2. To compare the effects of rinsing off the silver fluoride or not rinsing it off (blot-drying with cotton pellet) on sealant retention when the sealant is placed immediately after silver fluoride application, and 3. To measure the desensitizing effect of fissure sealant application following silver fluoride treatment on hypersensitive MIH molars.",[26,197,198],"Children","Dental Caries",[26,197,200,201,202,203],"Silver Fluoride","Fissure Sealant","Glass ionomer","Silver-modified atraumatic restorative treatment","2024-10-11",{"date":206,"type":35},"2024-10-15",{"date":208,"type":35},"2023-07-31",{"date":210,"type":22},"2026-10-30",{"name":212,"class":42},"Hacettepe University"]