[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"molar-incisor-hypomineralization-mih\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:molar-incisor-hypomineralization-mih":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,69,92,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100649286","comparison-of-computer-assisted-and-conventional-local-anesthesia-in-children-with-molar-incisor-hypomineralization-100649286",false,"NCT07733011","Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization","Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization: A Split-Mouth Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Children aged 8-12 years\n* Children with no systemic disease\n* Children with no pathology involving the oral region, such as trauma, cysts, or tumors\n* Children who have not used antibiotics within the past month\n* Children who have not used nonsteroidal anti-inflammatory drugs (NSAIDs) within the past month\n* Children with at least two homologous permanent molars affected by molar-incisor hypomineralization (MIH) and indicated for restorative treatment due to dentin caries\n* Children with a Frankl Behavior Rating Scale score of 3 or higher will be included in the study\n\nExclusion Criteria:\n\n* Children in whom local anesthesia cannot be administered due to lack of cooperation\n* Children who require pulp treatment after enrollment in the study will be withdrawn from the study.",true,"ALL","8 Years","12 Years",{"count":21,"type":22},54,"ESTIMATED","INTERVENTIONAL",[25],"NA","The main questions this study aims to answer are:\n\nDoes computer-controlled local anesthesia cause less pain and anxiety than conventional local anesthesia in children with molar-incisor hypomineralization (MIH)?\n\nIs there a difference between the two methods in anesthesia onset time, injection duration, physiological responses, and the need for additional anesthesia?\n\nResearchers will compare computer-controlled and conventional local anesthesia in children aged 8-12 years with MIH. Each child will receive both anesthesia methods during separate dental visits, on comparable permanent molar teeth, to determine which method is more comfortable, effective, and preferred by children.",[28,29,30],"Molar-Incisor Hypomineralization","Molar-Incisor Hypomineralization (MIH)","Computer-Controlled Local Anesthesia","NOT_YET_RECRUITING","2026-07-28",{"date":34,"type":35},"2026-07-29","ACTUAL",{"date":37,"type":22},"2026-08-11",{"date":39,"type":22},"2027-11-01",{"name":41,"class":42},"Marmara University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100648146","direct-composite-versus-indirect-hybrid-resin-restorations-in-hypomineralized-first-permanent-molars-100648146","NCT07718191","Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars","Clinical Evaluation of Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Participants aged from 7 years to 11 years\n2. MIH-TNI 2 or 4\n3. No past dental treatment for the hypomineralized first permanent mandibular molars.\n4. Caries lesions that include the occlusal surface.\n\nExclusion Criteria:\n\n1. The presence of systemic disease, physical or mental disability.\n2. Any potential confounding enamel defects i.e., amelogenesis imperfecta.\n3. Uncooperative children.\n4. A history of allergic reactions to local anesthetics or some components of restorative materials\n5. History of spontaneous pain.\n6. Presence of clinical or radiographic signs of pulp necrosis (Fistula\u002Fabscess, internal or external root resorption, mobility of the tooth, and swelling).","7 Years","11 Years",{"count":54,"type":22},40,[25],"The aim of this clinical trial is to evaluate the clinical success of 3D printed Indirect hybrid resin restorations in the hypomineralized first permanent molars.",[29],[59],"MIH","2026-07-17",{"date":62,"type":35},"2026-07-21",{"date":64,"type":22},"2026-10-01",{"date":66,"type":22},"2027-12",{"name":68,"class":42},"Cairo University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":91,"locationsCount":43},"100645520","assessment-of-peridontal-inflamatuar-markers-in-mih-100645520","NCT07701642","Assessment of Peridontal Inflamatuar Markers in MIH","Investigation of Periodontal Inflammatory Mediators in Permanent Molars Affected by Molar-incisor Hypomineralization","Inclusion Criteria:\n\n* Systemically healthy children aged 8-13 years (both sexes).\n* Children who demonstrate adequate cooperation for dental treatment and study procedures (Frankl Behavior Rating Scale score ≥3).\n* Study group: Children with molar-incisor hypomineralization (MIH) affecting at least three permanent first molars and requiring initial periodontal treatment for gingivitis.\n* Control group: Children without molar-incisor hypomineralization who require initial periodontal treatment for gingivitis.\n* Presence of gingivitis requiring initial periodontal therapy.\n\nExclusion Criteria:\n\n* Use of antibiotics within the previous 1 month.\n* Radiographic evidence of periodontal destruction.\n* History of periodontal treatment within the previous 3 months.\n* Presence of systemic, chronic, or metabolic diseases.\n* Ongoing active orthodontic treatment.\n* Developmental enamel defects other than molar-incisor hypomineralization.\n* History of premature birth.","13 Years",{"count":78,"type":22},76,"OBSERVATIONAL","The goal of this observational study is to investigate periodontal inflammatory mediators in systemically healthy children aged 8-13 years with and without molar-incisor hypomineralization (MIH) who require initial periodontal treatment due to gingivitis.\n\nThe main questions it aims to answer are:\n\nAre the levels of periodontal inflammatory mediators in gingival crevicular fluid different between children with MIH and those without MIH? Is the presence and severity of MIH associated with clinical periodontal parameters and dentin hypersensitivity?\n\nResearchers will compare children with MIH to children without MIH to determine whether MIH is associated with changes in periodontal inflammatory mediator levels and periodontal clinical findings.",[29],[83,84],"periodontal inflammatory markers","first permenant molars","2026-07-08",{"date":87,"type":35},"2026-07-14",{"date":89,"type":22},"2026-07-16",{"date":39,"type":22},{"name":41,"class":42},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":76,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100640792","evaluation-of-occlusal-force-and-masticatory-function-in-children-with-molar-incisor-hypomineralization-100640792","NCT07589179","Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization","Evaluation of Occlusal Force Distribution and Masticatory Function Before and After Restorative Treatment in Children With Molar-Incisor Hypomineralization","Inclusion Criteria:\n\n* Children aged 7 to 12 years\n* Presence of bilateral molar-incisor hypomineralization (MIH) affecting first permanent molars\n* Need for restorative treatment in MIH-affected molars\n* Cooperative children with sufficient cognitive ability to complete functional assessments\n* Presence of healthy control participants without MIH for comparison\n* Mixed dentition period\n* Signed informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Temporomandibular disorders or orofacial pain\n* Systemic diseases or regular medication use affecting mastication\n* History of orthodontic treatment or parafunctional habits\n* Craniofacial anomalies or developmental dental anomalies\n* Extensive prosthetic restorations affecting chewing function\n* Uncooperative children unable to complete examination procedures\n* Acute dental infection or pain requiring emergency treatment",{"count":100,"type":22},68,[25],"This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment. MIH is a developmental enamel defect that may cause tooth sensitivity, discomfort during chewing, and functional asymmetry.\n\nChildren aged 7 to 12 years with bilateral MIH affecting the first permanent molars will receive glass hybrid restorative treatment. Right-left occlusal force distribution will be assessed using a digital occlusal analysis system. In addition, chewing side preference and chewing balance will be evaluated using a standardized chewing gum protocol. These two assessment methods will be used together to provide complementary information about masticatory function.\n\nMeasurements will be performed before treatment and during follow-up visits after treatment. The findings obtained from children with MIH will also be compared with healthy children without MIH. The study aims to determine whether restorative treatment improves chewing balance and functional oral performance in children with MIH.",[29,104,105,106],"Masticatory Performance","Occlusal Analysis","Chewing Function","2026-06-02",{"date":109,"type":35},"2026-06-04",{"date":111,"type":22},"2026-05-11",{"date":113,"type":22},"2026-12-20",{"name":41,"class":42},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":121,"maxAge":19,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":43},"100626469","color-change-and-desensitization-of-molar-incisor-hypomineralization-affected-enamel-using-biomimetic-nano-hydroxyapatite-toothpaste-100626469","NCT07436039","Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste","Inclusion Criteria:\n\n\\- Children aged 6-12 years.\n\n* Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM).\n* Presence of white, creamy, yellow, or brown demarcated opacities\n* Indexed teeth include permanent first molars and permanent maxillary incisors.\n\nExclusion Criteria:\n\n* • Decayed permanent molars.\n\n  * Diabetes, hypertension, sleeping disorders, or allergic reactions to medications.\n  * Children on medication\n  * Presence of other enamel defects (e.g., fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions).\n  * Previous treatment with liquid enamel or other remineralizing agents on affected teeth.","6 Years",{"count":123,"type":22},60,[25],"This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are:\n\n* Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity?\n* How does Nano-HA compare to fluoridated toothpaste in terms of outcomes?\n\nParticipants will:\n\n* Use Nano-HA or fluoridated toothpaste daily for 12 months.\n* Visit the clinic for checkups and evaluations every 1 to 3 months.\n* Record symptoms, brushing compliance, and sensitivity.\n\nThe study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .",[29],"RECRUITING","2026-02-21",{"date":130,"type":35},"2026-02-27",{"date":132,"type":35},"2025-10-01",{"date":134,"type":22},"2027-07-01",{"name":136,"class":42},"King Abdulaziz University"]