[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"motor-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:motor-symptoms":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100632792","remotely-supervised-home-based-transcranial-temporal-interference-stimulation-on-motor-symptoms-in-parkinsons-disease-100632792",false,"NCT07518290","Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease","Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease: Protocol For a Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of Parkinson's disease according to established clinical criteria\n* Mild-to-moderate disease severity, defined as Hoehn and Yahr stage 1.5-3;\n* Age between 40 and 80 years;\n* Stable anti-parkinsonian medication regimen;\n* Ability to walk unaided for at least 2 minutes.\n\nExclusion Criteria:\n\n* contraindications to TIs (e.g., metal implantation, pacemakers, etc.);\n* the use of DBS;\n* significant cognitive impairment as defined by the diagnosis of Alzheimer's disease or dementia, or Montreal Cognitive Assessment (MoCA) total score\\\u003C21, a recommended threshold for dementia in PD;\n* diagnosis of other neurological conditions such as multiple sclerosis, previous stroke;\n* report of severe lower-extremity arthritis, pain, or orthopedic problems significantly affecting gait;\n* physician-diagnosis of schizophrenia or other psychiatric illness;\n* an unwillingness to cooperate or participate in the study protocol. Eligible and interested participants will then be enrolled and complete baseline assessments before the randomization.","ALL","40 Years","80 Years",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment. The main questions it aims to answer are:\n\n1. Does home-based TIS improve movement problems such as slow movement, stiffness, and walking difficulty?\n2. Are the effects maintained after the treatment ends?\n3. What medical problems (adverse events) occur during treatment? Researchers will compare active TIS to a sham treatment (a look-alike procedure that does not deliver active stimulation) to see if TIS works.\n\nParticipants will:\n\n1. Receive active TIS or sham stimulation once a day for 4 weeks at home under remote supervision\n2. Visit the clinic at specific time points for movement assessments\n3. Complete online questionnaires about symptoms and quality of life",[27,28],"PARKINSON DISEASE (Disorder)","Motor Symptoms",[30,31,32,33,34],"Parkinson disease","Transcranial temporal interference stimulation","Home-based intervention","Motor symptom","Randomized controlled trial","RECRUITING","2026-08-11",{"date":38,"type":39},"2026-08-13","ACTUAL",{"date":41,"type":39},"2026-04-04",{"date":43,"type":21},"2028-03-30",{"name":45,"class":46},"Shanghai University of Sport","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100647604","investigating-the-neurophysiology-of-the-motor-system-and-the-feasibility-of-vagus-nerve-stimulation-in-functional-neurological-disorder-fnd-100647604","NCT07710677","Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)","Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND): a Randomized, Sham-controlled Study","TMS-VNS","Inclusion Criteria for FND patients:\n\n* Over 18 years of age.\n* Capable of judgement.\n* Willing to participate in the study (by signing the informed consent form).\n* FND diagnosis by a certified neurologist or psychiatrist.\n* Motor FND symptoms in the upper limb in the form of tremor or weakness.\n* Participating in physiotherapy for FND.\n\nExclusion Criteria for FND patients:\n\n* Severe neuropsychiatric comorbidities.\n* Pregnancy or breastfeeding.\n* Prior knowledge on the effects of attention on the motor system.\n* Prior history of epilepsy or epileptic seizures in the person and their family.\n* Severe claustrophobia.\n* Implanted medical devices.\n* Ear anatomy incompatible with the taVNS device (e.g. cauliflower ear).\n* Previous use of taVNS.\n* Substance abuse.\n* Simultaneous participation in another investigation involving an investigational drug or a MD.\n* Enrolment of the PI and their dependent persons.\n\nInclusion Criteria for healthy volunteers:\n\n* Over 18 years of age.\n* Capable of judgement.\n* Willing to participate in the study (by signing the informed consent form).\n\nExclusion Criteria for healthy volunteers:\n\n* Neurological or neuropsychiatric or movement disorders.\n* Pregnancy or breastfeeding.\n* Prior knowledge on the effects of attention on the motor system.\n* Prior history of epilepsy or epileptic seizures in the person and their family.\n* Substance abuse.\n* Simultaneous participation in another investigation involving an investigational drug or a MD.\n* Enrolment of the PI and their dependent persons.",true,"18 Years",{"count":20,"type":21},[24],"This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.\n\nFirst, the investigators will test the normal functioning of the motor regions of the brain in FND patients and in healthy volunteers for comparison, using a painless method called TMS (Transcranial Magnetic Stimulation). Then, the investigators will further test how brain regions communicate with each other in FND patients, using fMRI (functional Magnetic Resonance Imaging, also painless). Additionally, the investigators will ask both FND patients and healthy volunteers to answer questions about their health and wellbeing, and will assess the exact symptoms of FND patients. The FND patients will then be assigned to two groups randomly, and neither they nor the researchers will know in which group they are. Both groups will do 5 sessions of their usual physiotherapy - one group with a real stimulation of the vagus nerve, and the other group with a fake stimulation. This is important to obtain reliable results. At the end, both groups of patients will be tested again to see if the way brain regions communicate with each other has changed. They will also answer again questions about their health and wellbeing, and their symptoms will be assessed again, to see if any changes happen. The results of the two groups of patients will be compared to isolate the effects of vagus nerve stimulation from the effects of physiotherapy alone.",[62,28],"Functional Neurological Disorder",[62,64,65,66,67,68,69],"FND","vagus nerve stimulation","VNS","TMS","fMRI","motor","NOT_YET_RECRUITING","2026-07-16",{"date":73,"type":39},"2026-07-17",{"date":75,"type":21},"2026-07-01",{"date":77,"type":21},"2028-12-01",{"name":79,"class":46},"University of Fribourg",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100641633","hf-rtms-primed-balance-training-on-corticomotor-excitability-balance-and-gait-in-parkinsons-100641633","NCT07653256","HF-rTMS Primed Balance Training on Corticomotor Excitability, Balance, and Gait in Parkinson's","Effects of High-frequency Repetitive Transcranial Magnetic Stimulation-primed Balance Training on Corticomotor Excitability, Balance, and Gait Performance in Parkinson's Disease","Inclusion Criteria:\n\n* Diagnosed with idiopathic PD\n* Aged between 40-80 years\n* Stable on antiparkinsonian medication ( \\> 3 months)\n* H\\&Y I-III\n* Able to walk continuously for at least 10 minutes\n* The ability to follow commands and instructions\n\nExclusion Criteria:\n\n* Neurological diseases other than PD\n* Severe musculoskeletal, cardiopulmonary disorders\n* MMSE \\\u003C 24\n* Contraindications for TMS\n* Have undergone or are scheduled to undergo neurological surgery during the study participation period",{"count":89,"type":21},20,[24],"This study aims to investigate the effects of repeated transcranial magnetic stimulation combined with modified otago exercise program balance training intervention on motor cortex excitability, balance, and gait performance in patients with Parkinson's disease.",[93,94,95,96,28],"Parkinson's Disease","Corticomotor Excitability","Balance Control","Gait Performance","2026-06-11",{"date":99,"type":39},"2026-06-17",{"date":75,"type":21},{"date":102,"type":21},"2028-04-01",{"name":104,"class":46},"Chung Shan Medical University"]