[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multidrug-resistant-organisms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multidrug-resistant-organisms":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100648300","enteral-nutrition-and-colonization-resistance-through-microbiota-modulation-in-critically-ill-patients-100648300",false,"NCT07719673","Enteral Nutrition and Colonization Resistance Through Microbiota Modulation in Critically Ill Patients","Enteral Nutrition to Enhance Colonization Resistance Through Gut Microbiota Modulation in Critically Ill Patients: A Randomized Controlled Pilot Trial","MICRON","Inclusion Criteria:\n\n* Patients with medical (non-surgical) conditions admitted to the ICU.\n* ICU admission within the previous 48 hours at the study site.\n* Initiation of enteral nutrition within the first 48 hours after ICU admission.\n* Written informed consent obtained for participation in the study.\n\nExclusion Criteria:\n\n* Surgical ICU patients.\n* Patients in whom enteral nutrition was not initiated within the first 48 hours after - ICU admission.\n* Patients with galactosemia.\n* Patients with major contraindications to enteral nutrition, including: intestinal obstruction, intestinal ischemia, intestinal perforation, severe hemodynamic instability, patients who refuse participation in the study.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether enteral nutrition enriched with fiber can influence gut microbiota and improve resistance to colonization with multidrug-resistant bacteria in critically ill patients. The study will also evaluate the safety and clinical outcomes associated with fiber-enriched enteral nutrition.\n\nThe main questions it aims to answer are:\n\n* Does fiber-enriched enteral nutrition reduce the acquisition of colonization with multidrug-resistant bacteria during intensive care unit (ICU) hospitalization?\n* Does fiber-enriched enteral nutrition modify the composition and diversity of the intestinal microbiota?\n* Are there differences in clinical outcomes, including adverse events, between patients receiving fiber-enriched and non-fiber enteral nutrition?\n\nResearchers will compare patients receiving fiber-enriched enteral nutrition with patients receiving standard enteral nutrition without added fiber to determine whether fiber supplementation influences gut microbiota and colonization resistance.\n\nParticipants will:\n\n* Receive enteral nutrition through a feeding tube according to their clinical needs.\n* Receive either a fiber-enriched enteral nutrition formula or a standard enteral nutrition formula.\n* Have stool samples collected during ICU hospitalization for analysis of intestinal microbiota and detection of multidrug-resistant bacteria.\n* Be monitored for clinical outcomes, infections, antibiotic exposure, and adverse events during their ICU stay and follow-up period.",[27,28,29,30],"Bacterial Colonization","Multidrug Resistant Organisms","Critical Illness","Gut Microbiota Dysbiosis",[32,33,34,35,36],"enteral nutrition","bacterial colonization","multidrug resistant organisms","gut microbiota","critical care","NOT_YET_RECRUITING","2026-07-20",{"date":40,"type":41},"2026-07-22","ACTUAL",{"date":43,"type":21},"2026-10",{"date":45,"type":21},"2027-12",{"name":47,"class":48},"Iuliu Hatieganu University of Medicine and Pharmacy","OTHER"]