[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"myalgic-encephalomyelitischronic-fatigue-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:myalgic-encephalomyelitischronic-fatigue-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,74,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100614890","phase-2-low-dose-naltrexone-for-mecfs-dose-finding-100614890",false,"NCT07285473","Low-Dose Naltrexone For ME\u002FCFS: Dose-Finding","Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome (ME\u002FCFS): Dose-Finding","Inclusion Criteria:\n\n* Between ages of 18 and 65\n* Living in Alabama\n* Meets ME-ICC criteria\n\nExclusion Criteria:\n\n* Abnormal hepatic function\n* Abnormal renal function\n* Abnormal complete blood count\n* Evidence of active or chronic systemic infection\n* A1C \\> 9.0%\n* Current opioid analgesic use\n* Pregnant or plans to become pregnant during the study participation period\n* Auto-immune disorder\n* Enrolled in other experimental treatment study","ALL","18 Years","65 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome (ME\u002FCFS). A remote trial approach is used, with eligibility open to the state of Alabama.",[27],"Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome",[27,29],"ME\u002FCFS","NOT_YET_RECRUITING","2026-08-19",{"date":33,"type":34},"2026-08-21","ACTUAL",{"date":36,"type":21},"2026-10-01",{"date":38,"type":21},"2028-04-01",{"name":40,"class":41},"University of Alabama at Birmingham","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100587806","rct-of-mind-body-in-long-covid-and-myalgic-encephalomyelitis-100587806","NCT06933173","RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis","Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT","MILES","Inclusion Criteria:\n\n* Age 18 years or older;\n* Individuals diagnosed with ME\u002FCFS, according to the Institute of Medicine (2015) criteria, for more than six months.\n\nExclusion Criteria:\n\nIndividuals who: 1) are too ill to participate; 2) lack reliable internet; 3) cannot communicate in English; 4) Presently have or ever had inflammatory bowel disease; and\u002For 5) Have been prescribed or used an oral or systemic (infusion) antibiotic in the past one month-;; 6) are participating in a concurrent study; 7) are participating in a concurrent mind-body intervention during the study period including\n\n* Art Therapy\n* Autogenic training\n* Biofeedback\u002Fneurofeedback\n* Breathing exercise\n* Cognitive restructuring\n* Dynamic Neural Retraining System\n* Emotional Freedom Techniques (EFT)\n* Eye movement desensitization and reprocessing (EMDR)\n* Guided imagery\n* Hypnotherapy\u002Fself-hypnosis\n* Meditation (mindfulness, mantra, guided, transcendental)\n* Mindfulness-based cognitive therapy (MBCT)\n* Mindfulness-based Stress Reduction (MBSR)\n* Music therapy\n* Neurolinguistic programming\n* Psychological flexibility\n* Qigong\n* Relaxation therapy (relaxation response, progressive muscle relaxation)\n* Tai Chi\n* Visualization\n* Yoga and\u002For starting any other new treatment during the study period, including any mind-body therapy, psychotherapy, prescription medication, over-the-counter medication, etc; 8) have any active medical condition (untreated\u002Funcontrolled) that may explain the presence of fatigue including:\n* untreated hypothyroidism (including Hashimoto's disease)\n* hyperthyroidism\n* diabetes mellitus\n* iron deficiency anemia\n* other treatable anemia\n* iron overload syndrome\n* adrenal insufficiency\n* Cushing's syndrome\n* anorexia nervosa\n* iatrogenic conditions such as side effects or interactions of medication(s) or supplements\n\n  • Rheumatological disorders:\n* rheumatoid arthritis\n* lupus\n* polymyositis\n* polymyalgia rheumatica\n* Sjogren's Syndrome\n* Ehlers Danlos Syndromes \\[Hypermobility type\\]\n\n  • Other heritable disorders of connective tissue:\n* Marfan syndrome\n* Stickler syndrome etc.\n\n  * Multiple sclerosis\n  * Celiac disease\n* Note: Patients with celiac disease can present without gastrointestinal symptoms\n\n  • Immune disorders\n* such as HIV\u002FAIDS\n\n  • Sleep disorders\n* including obstructive sleep apnea\n\n  • Prior illnesses may relapse or may not have completely resolved during treatment.\n* Examples are certain malignancies\n* leukemia\n* infectious diseases such as tuberculosis and chronic hepatitis\n\n  • Active primary psychiatric disorders\n* eating disorders\n* alcohol\n* substance use disorder",{"count":52,"type":21},200,[54],"NA","We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome (ME\u002FCFS) with or without Long COVID (LC). Our team recognizes that ME\u002FCFS and Long COVID are serious, debilitating, biomedical conditions.\n\nME\u002FCFS can affect many different parts of the body, such as the nervous system, immune system, and metabolism. It is hypothesized that central sensitization (i.e., when nerves get too excited) may influence these complex conditions and may make symptoms worse.\n\nThis study explores a mind-body program called the Dynamic Neural Retraining System™, or DNRS™.\n\nMind-body interventions (MBIs) focus on how the brain, mind, body, and behaviour interact to improve health and well-being. These techniques help people become more aware of themselves, take better care of their health, and boost mood, quality of life, and coping skills. MBIs use the brain's ability to change (neuroplasticity) by reinforcing certain thoughts, feelings, or behaviours that support changes in biology and function. MBIs may influence physical health by affecting how the brain and body communicate through chemicals such as hormones and neurotransmitters. Objective fMRI evidence shows that practising MBIs can change brain structure and function. This makes MBIs a potential good fit for people with chronic illnesses like ME\u002FCFS and LC, which involve complex interactions between the brain, immune system, and hormones.\n\nThere is no rigorous peer-reviewed evidence that DNRS is effective. Our study will address this question using subjective and objective measurements in a multiple-methods wait-list randomized controlled trial.\n\nThe objectives of this study are to: 1) examine the effectiveness of the DNRS program for individuals diagnosed with ME\u002FCFS with and without Long COVID, compared to a treatment-as-usual wait-list control group on a range of patient-reported outcomes including health-related quality of life, fatigue, pain, anxiety and depression and objective measures including daily steps, heart rate variability, and sleep; 2) quantify metabolic changes through untargeted serum metabolomics profiling, 3) determine if metabolomics screening can predict treatment responsiveness to DNRS; and 4) identify the microbial signatures of large bowel microbiota in Long COVID patients pre and post MBI.\n\nA descriptive qualitative study will also be conducted in a sample of participants to learn more about their experiences during the trial.",[27],[58,59,60,61,62],"Myalgic encephalomyelitis\u002FChronic fatigue syndrome","Mind-body intervention","Long COVID","RCT","Patient engagement","RECRUITING","2026-05-05",{"date":66,"type":34},"2026-05-07",{"date":68,"type":34},"2025-07-10",{"date":70,"type":21},"2028-03",{"name":72,"class":41},"University of Alberta",3,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":42},"100610427","chronic-infections-and-inflammation-in-mecfs-an-observational-study-100610427","NCT07227441","Chronic Infections and Inflammation in ME\u002FCFS: An Observational Study","CHIIME","Inclusion Criteria:\n\n* Willing and able to provide written informed consent\n* At least 18 years of age\n* Either: (1) a reported diagnosis of ME\u002FCFS or (2) no history of ME\u002FCFS or other infection-associated chronic conditions (healthy control)\n\nExclusion Criteria:\n\n* Self reported or documented chronic anemia with hemoglobin \\\u003C9 g\u002FdL\n* Known HIV, hepatitis B, or hepatitis C infection\n* Diagnosis of an infection-associated chronic condition other than ME\u002FCFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)\n* Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent\n* Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent",true,{"count":52,"type":21},"OBSERVATIONAL","CHIIME is a study of people who have myalgic encephalomyelitis\u002Fchronic fatigue syndrome (ME\u002FCFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.",[27],[29,87,88],"myalgic encephalomyelitis","chronic fatigue syndrome","2026-03-04",{"date":91,"type":34},"2026-03-06",{"date":93,"type":34},"2026-01-01",{"date":95,"type":21},"2030-09",{"name":97,"class":41},"University of California, San Francisco",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100620443","the-effect-of-acupuncture-therapy-on-cognitive-function-in-post-covid-19-myalgic-encephalomyelitischronic-fatigue-syndrome-100620443","NCT07357688","The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome","The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis\u002FChronic Fatigue Syndrome: A Study With Multimodal Magnetic Resonance Imaging","Inclusion Criteria:\n\n* 18-60 years old\n* Fatigue occurred during or after initial recovery of COVID-19 confirmed by nasopharyngeal swab reverse transcription-polymerase chain reaction(RT-PCR) or antigen testing lasts for at least 6 months\n* Fulfilling US National Academy of Medicine(NAM) criteria for ME\u002FCFS\n* Chinese native speaker\n* Right handedness\n* Voluntary to participate in the study and signing the informed consent form.\n\nExclusion Criteria:\n\n* Persistent fatigue occurs prior to COVID-19\n* Previous or current diagnosis of severe chronic diseases such as heart, kidney or liver failure, tumor\n* Previous or current diagnosis of neurological or psychiatric disorder such as neurodegenerative disease, stroke, epilepsy, bipolar disorder, schizophrenia\n* Previous or current diagnosis of endocrine or metabolic disease such as hypothyroidism, adrenocortical hypofunction, type 2 diabetes\n* Previous or current diagnosis of autoimmune disease such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis\n* Chronic infection or inflammatory disease such as acquired immune deficiency syndrome(AIDS), chronic hepatitis, irritable bowel syndrome\n* Substance or alcohol abuse\n* Obesity (Body Mass Index≥28)\n* Long-term use of immunosuppressant or glucocorticoid\n* Within one year after major surgery\n* Metal or electronic device implants\n* Claustrophobia\n* Pregnancy or lactation\n* Previous acupuncture treatment in the latest 3 months\n* Participating in another clinical research within a month","60 Years",{"count":107,"type":21},99,[54],"Background of study:\n\nMyalgic encephalomyelitis\u002Fchronic fatigue syndrome (ME\u002FCFS) is a common sequela after SARS-CoV-2 infection(COVID-19). Cognitive dysfunction is one of the most common debilitating symptoms in ME\u002FCFS. Currently, standardized therapy for ME\u002FCFS has not been established. Some treatments, such as cognitive behavioral therapy (CBT) and graded exercise therapy (GET), mainly exert effects on physical symptoms, whereas the influence on cognitive problems is not significant. Acupuncture is an important complementary and alternative therapy for ME\u002FCFS. However, However, research focused on the impact of acupuncture on cognitive functions in ME\u002FCFS is rare. Additionally, no study has evaluated the efficacy and mechanism of acupuncture treatment in improving cognitive functions for post-COVID-19 ME\u002FCFS.\n\nObjective of the study:\n\nThe first objective of this study is to assess the efficacy of acupuncture treatment in improving cognitive function for post-COVID-19 ME\u002FCFS. The second objective is to explore whether acupuncture improves cognitive ability in patients with post-COVID-19 ME\u002FCFS through modulating hippocampal connectivity and metabolites using multimodal magnetic resonance imaging(MRI).\n\nStudy design:\n\nA prospective, three-armed, randomized controlled trial with resting-state functional MRI(rs-fMRI) and magnetic resonance spectroscopy(MRS). Adults with post-COVID-19 ME\u002FCFS will be randomly assigned to acupuncture, sham acupuncture, or waitlist control group in a 1:1:1 ratio, receiving 8-week intervention or waiting. Cognitive functions and resting-state functional connectivity(RSFC) and the levels of metabolites for each hippocampus will be examined at baseline and 8th week.\n\nStudy population:\n\nPatients fulfilling 2015 National Academy of Medicine (NAM) criteria for ME\u002FCFS following COVID-19.",[27],[112,113,114,115,116,117,118,119],"Post-COVID-19","myalgic encephalomyelitis\u002Fchronic fatigue syndrome","hippocampus","cognitive function","neurochemical","functional connectivity","multimodal MRI","acupuncture","2026-01-13",{"date":122,"type":34},"2026-01-22",{"date":124,"type":21},"2026-05",{"date":126,"type":21},"2027-12",{"name":128,"class":41},"Xi Wu",2]