[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nasal-surgical-procedures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nasal-surgical-procedures":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100649728","phase-4-low-dose-versus-standard-dose-remimazolam-for-prevention-of-emergence-agitation-after-nasal-surgery-100649728",false,"NCT07740655","Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery","Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery Under Sevoflurane Anesthesia: A Randomized Double-blind Non-inferiority Trial","Inclusion Criteria:\n\n* Adults aged 18 to 79 years.\n* Scheduled to undergo elective nasal surgery under sevoflurane-based general anesthesia at Jeju National University Hospital.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to remimazolam.\n* History of allergy or hypersensitivity to benzodiazepines.\n* Inability to provide informed consent due to cognitive impairment.\n* Preexisting psychiatric disorders.\n* History of alcohol or substance abuse.\n* Inability to assess the Riker Sedation-Agitation Scale (SAS).\n* Body mass index (BMI) \\> 40 kg\u002Fm².","ALL","18 Years","79 Years",{"count":20,"type":21},138,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Emergence agitation (EA) is a common complication during recovery from sevoflurane anesthesia, particularly after nasal surgery. Although remimazolam 0.1 mg\u002Fkg has been shown to reduce the incidence of EA, this dose may produce excessive sedation and increase the risk of intraoperative burst suppression.\n\nThis randomized, double-blind, non-inferiority trial will compare low-dose remimazolam (0.03 mg\u002Fkg) with the standard dose (0.1 mg\u002Fkg) administered at the end of surgery in adult patients undergoing nasal surgery under sevoflurane anesthesia. The primary objective is to determine whether low-dose remimazolam is non-inferior to the standard dose in preventing emergence agitation. Secondary outcomes include burst suppression, recovery profiles, and safety outcomes.",[27,28,29],"Emergence Agitation","General Anesthesia","Nasal Surgical Procedures",[31,32,33,34],"Remimazolam","Emergence Agitation Sevoflurane","Nasal Surgery","Non-inferiority Trial","NOT_YET_RECRUITING","2026-07-28",{"date":38,"type":39},"2026-07-31","ACTUAL",{"date":41,"type":21},"2026-07-24",{"date":43,"type":21},"2027-07-31",{"name":45,"class":46},"Jeju National University School of Medicine","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100584166","phase-2-evaluation-of-a-novel-nasal-conformer-in-pediatric-patients-100584166","NCT06885801","Evaluation of a Novel Nasal Conformer in Pediatric Patients","Inclusion Criteria:\n\n* Patient's undergoing primary cleft lip repair or release of nasal scarring\n\nExclusion Criteria:\n\n* patient or parents declined participation postoperative nasal stenting is judged clinically inappropriate",{"count":55,"type":21},20,[57],"PHASE2","This study compares the current commercially available nasal conformer available for use in cleft lip repair and nasal scar release to a novel, anatomically shaped conformer based upon typical nasal airspace shape. This will follow patients using both of these types of splints during the post-operative healing process with one group starting with the standard splint and then moving to the anatomic conformer and the second group beginning with the anatomic and them moving to the standard conformer. This study will evaluate the patient experience and outcomes of the 2 types of conformers, looking at the discomfort, device dislodgements, ease of use and occurrence of complications such as skin irritation and rashes or skin breakdown.",[60,29],"Cleft Lip","2025-03-13",{"date":63,"type":39},"2025-03-20",{"date":65,"type":21},"2025-06-01",{"date":67,"type":21},"2030-12-01",{"name":69,"class":46},"East Tennessee Children's Hospital"]