[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nature-human\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nature-human":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,75,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652899","nurture-by-nature-feasibility-study-100652899",false,"NCT07780123","Nurture by Nature Feasibility Study","A Feasibility Study of a Cluster Randomized Controlled Trial of a Nature-based Intervention Enhancing Mental and Physical Well-being Among Kindergarten Children From Deprived Areas: Nurture by Nature","Inclusion Criteria:\n\nA kindergarten cluster will be eligible for study participation if the cluster meets the following criteria:\n\n1. The kindergarten should geographically be located within or near by a social housing area or serve children from such an area.\n2. At least 11 children in the cluster, each:\n\n   1. aged 4-7 years due to the primary outcome cutoff age, and\n   2. have a parent who is able to understand and communicate in Danish, and\n   3. have consented to participate\n\nInclusion criteria of children and parents:\n\nA child and parent will be eligible for study participation if they meet the following criteria:\n\n1. the child is aged 4-7 years due to the primary outcome cutoff age, and\n2. the parent is able to understand and communicate in Danish, and\n3. have consented to participate\n\nInclusion criteria of kindergarten personnel:\n\nKindergarten personnel will be eligible for study participation if they meet the following criteria:\n\n1. if they have \\>80% of their working hours in the eligible kindergarten cluster\n2. have consented to participate\n\nExclusion Criteria:\n\nA kindergarten cluster will not be eligible for the study if the cluster meets any of the following criteria:\n\n1. the kindergarten is currently spending \\> two days per week in nature (green outdoor),\n2. the kindergarten is already using the ''Green Sprouts'' program,\n3. the kindergarten is exclusively for children with special needs All exclusion criteria are at cluster level. There are no individual exclusion criteria.",true,"ALL","4 Years",{"count":20,"type":21},127,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this feasibility cluster randomized trial is to determine whether a future large pragmatic cluster randomized controlled trial can be conducted to evaluate the effects of a nature-based intervention on children's mental and physical health. The intervention will be delivered in preschools located in or near public housing areas and compared with usual activities in similar preschools.\n\nThe main questions it aims to answer are:\n\n* Are parents willing to participate in follow-up assessment using the Strengths and Dif-ficulties Questionnaire (SDQ)?\n* Can participants be successfully recruited, and can the nature-based intervention be delivered as intended?\n* Is it possible to gather data on children's motor development, physical activity, sleep, absenteeism, and stress, and on stress and absenteeism among educators and parents?\n* Is the intervention safe and acceptable for children, parents, and educators?\n\nResearchers will compare a 14-week nature-based intervention with usual preschool activities.\n\nThe nature-based intervention is based on the Danish Outdoor Council's Green Sprouts (\"Grønne Spirer\") programme and focuses on using nature for play and learning. The intervention is being developed together with educators and children and includes nature-based activities designed to support motor development, physical activity, and positive interactions between children.\n\nParticipants will:\n\n* Take part in either the nature-based intervention or usual preschool activities.\n* Complete questionnaires about child well-being, quality of life, and parental stress.\n* Participate in assessments of fine and gross motor skills.\n* Wear an activity monitor to measure physical activity and sleep.\n* Provide hair samples for measurement of stress-related hormones.\n* Take part in interviews and observations.\n\nThe study will include approximately 56 children aged 4 to 6 years, their parents, and approx-imately 15 educators.\n\nThe results will help determine whether the intervention can be implemented in preschools as currently designed and will inform the planning of a future large cluster-randomized controlled trial. No major risks are expected. Participants may experience minor discomfort when a small hair sample is collected for stress measurement.",[27,28,29],"Nature, Human","Pediatric ALL","Well-Being, Psychological","NOT_YET_RECRUITING","2026-08-18",{"date":33,"type":34},"2026-08-21","ACTUAL",{"date":36,"type":21},"2026-10-01",{"date":38,"type":21},"2027-12-31",{"name":40,"class":41},"Ina Olmer Specht","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":62,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100562918","the-effect-of-nature-and-game-based-activities-on-older-people-100562918","NCT06609408","The Effect of Nature and Game Based Activities on Older People","The Effect of Nature and Game Based Activities on Happiness, Spiritual Well-Being, Frailty and Cognitive Status of Older People in Nursing Home","Inclusion Criteria:\n\n* Older people who have been in a nursing home for at least 6 months,\n* Older people aged 65 years and over,\n* Older people with a Mini Mental State score of 24 and above,\n* Older people who are open to communication and co-operation will be included in the study.\n\nExclusion Criteria:\n\n* Older people with physical problems that may prevent them from participating in nature and game based activities (such as stroke, Parkinson\\'s),\n* Older people with visual and hearing loss that may pose an obstacle to nature and game based activities,\n* Older people with mental problems (such as dementia) that would prevent participation in nature and game based activities were excluded from the study.","65 Years",{"count":52,"type":21},52,[24],"The purpose of this study is determine the effect of nature and game based activities on happiness, spiritual well-being, frailty and cognitive status of older people in nursing home.\n\nHypotheses of the Research H0: Nature and game-based activities don't affect the happiness, spiritual well-being, cognitive function and frailty of older people in nursing home.\n\nH1a: Happiness levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1b: Spiritual well-being levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1c: Cognitive function levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1d: Frailty status of older people in nursing home will be a decrease after nature and game-based activities.",[27,56,57,58,59,60,61],"Older People","Nursing Home","Happiness","Spiritual Well-being","Frailty","Cognitive Ability, General",[63,56,57,58,64,60,65],"Nature","Spiritual Well-Being","Cognition","2025-06-11",{"date":68,"type":34},"2025-06-12",{"date":70,"type":21},"2025-07-01",{"date":72,"type":21},"2026-05-01",{"name":74,"class":41},"Ondokuz Mayıs University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":96,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":113},"100546126","nationwide-research-on-the-rewilding-of-kindergarten-yards-100546126","NCT06390878","Nationwide Research on the Rewilding of Kindergarten Yards","Nationwide Research on the Rewilding of Kindergarten Yards - Vahvistu","Vahvistu","Inclusion Criteria:\n\n* Attendance in kindergarten\n\nExclusion Criteria:\n\n* Use of antibiotics in the year before sampling","1 Year","5 Years",{"count":86,"type":21},320,[24],"Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.\n\nThe investigators will estimate how rewilding of kindergarten yards affects commensal microbiome, prevalence of allergies, asthma, atopic dermatitis and infections, cortisol levels, cognitive skills and plasma cytokine levels of children.\n\nOur specific aims are:\n\nTo assess if rewilding diversifies health-associated skin, saliva and gut microbiota and reduces infectious diseases and atopic or allergic symptoms.\n\nAssess whether the rewilding has positive effects on cognitive skills. Assess whether the rewilding changes cortisol and plasma cytokine levels. The investigators will recruit altogether 320 (160 per treatment) study subjects aged between 1-5 to questionnaire study (Task 2), from which 120 study subjects will be analyzed more detailed using microbiological and blood samples (Task 1).",[90,91,92,93,94,95,27],"Microbial Colonization","Atopic Dermatitis","Asthma in Children","Allergy","Cognitive Change","Respiratory Infection",[97,98,99,100,101],"Commensal microbiome","Atopy","Planetary health","Biodiversity","Cognitive skills","RECRUITING","2024-06-20",{"date":105,"type":34},"2024-06-24",{"date":107,"type":34},"2024-05-15",{"date":109,"type":21},"2027-08-30",{"name":111,"class":112},"Natural Resources Institute Finland","OTHER_GOV",2,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":17,"minAge":122,"maxAge":84,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":113},"100546112","sand-play---the-effect-of-biodiversity-exposure-on-atopic-dermatitis-100546112","NCT06390696","Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis","Biodiversity Interventions for Well-being - the Effect of Biodiversity Exposure on Atopic Dermatitis","BIWE","Inclusion Criteria:\n\n* Eczema Area and Severity Index ≥ 2\n\nExclusion Criteria:\n\n* Eczema Area and Severity Index \\\u003C 2\n* Immune deficiencies, i.e., antibody deficiency\n* Immunosuppressive systematic medications\n* A disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes)\n* Cancer diagnosis\n* Topical medication for the treatment of atopic dermatitis during the trial\n* Disability affecting the immune response (e.g. Down's syndrome)\n* Non-participation in the national vaccine program\n* Participation in another intervention or follow-up study","2 Years",{"count":124,"type":21},80,[24],"The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood.\n\nSand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.",[91,27,90,128],"Immune System and Related Disorders",[98,100,130,131],"Commensal microbiota","Microbial exposure","2024-04-25",{"date":134,"type":34},"2024-04-30",{"date":136,"type":34},"2023-05-26",{"date":138,"type":21},"2027-09-30",{"name":111,"class":112}]