[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neonate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neonate":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,79,110,153,176,201,233,259,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652456","point-of-care---sepsis-study-100652456",false,"NCT07774013","Point of Care - Sepsis Study","Diagnostic Accuracy of Inflammatory Parameters for the Diagnosis of Early Onset Neonatal Sepsis and Differentiation Between Viral and Bacterial Infections in Preterm Infants Using a Point-of-care Device - a Pilot Study (POCT Sepsis)","POCT Sepsis","Inclusion Criteria:\n\n* Preterm neonates born at \\\u003C37+0 weeks of gestation who are admitted to the Division of Neonatology, Department of Pediatrics, Medical University of Graz after birth.\n* Written parental informed consent before birth.\n\nExclusion Criteria:\n\n* Term and preterm neonates who are not admitted to the neonatal care unit.\n* No point-of-care measurement of IL-6 and PCT in neonatal blood for infants who do not require blood gas analysis within the first 12 hours of life.","ALL",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","This pilot study will evaluate whether a rapid point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. The study will include preterm infants born before 37 weeks of pregnancy who are admitted to the neonatal care unit and have a suspected infection.\n\nThe researchers will measure several substances in the blood that can increase during infection, including interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), and myxovirus resistance protein A (MxA). Results obtained with the point-of-care device will be compared with standard laboratory measurements. The researchers will also study whether measuring IL-6 and PCT during the first 12 hours of life may provide useful information about infection earlier than CRP testing and whether combined MxA and CRP measurements may help distinguish bacterial from viral infections.\n\nThis is an observational study and will not change the infants' standard medical care or treatment. Results from the point-of-care device will not be used to make treatment decisions during the study. Blood samples will be collected as part of, or together with, routine blood sampling whenever possible. The study is expected to include approximately 40 preterm infants, with a maximum of 80 infants enrolled.",[24,25,26,27,28],"Neonate","Sepsis","IL6","PCT","Point of Care",[30,31,26,27,32],"neonate","sepsis","Point of care","NOT_YET_RECRUITING","2026-08-12",{"date":36,"type":37},"2026-08-19","ACTUAL",{"date":39,"type":20},"2026-08-15",{"date":41,"type":20},"2028-08-31",{"name":43,"class":44},"Medical University of Graz","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100645456","multimodal-analysis-of-early-biomarkers-of-the-impacts-of-perinatal-asphyxia-100645456","NCT07702500","Multimodal Analysis of Early Biomarkers of the Impacts of Perinatal Asphyxia","Neurobiom","Inclusion Criteria:\n\n* Non-Perinatal Asphyxia Cohort:\n\nThe non-PA cohort includes:\n\n* Full-term infants (born between 36 and 42 weeks of gestation), clinically \"normal\" and without PA. Infants must have birth weights within the normal range for their gestational age.\n* Satisfactory Apgar scores at 1, 3, and 5 minutes, indicating good health.\n* Meet specific biochemical biomarker criteria as defined by the study protocols.\n* No major complications should occur during pregnancy or delivery.\n\n  * At-Risk Perinatal Asphyxia Cohort:\n\nThe at-risk PA cohort includes newborns who are:\n\n* Identified by healthcare professionals as being at risk based on criteria that do not exceed the diagnostic thresholds for PA but whose combined assessment of maternal, fetal, and neonatal medical criteria suggests risk factors and early signs of potential PA,\n* OR\n* Classified as such based on biochemical markers identified in WP1 (see WP1).\n\n  * Confirmed Perinatal Asphyxia Cohort:\n\nThe PA cohort includes:\n\n* Newborns diagnosed with PA and treated with hypothermia. The inclusion criteria for this group allow for various modes of delivery, complications during pregnancy and delivery, and a range of gestational ages, as long as they meet the criteria for PA.\n* Birth weight must be ≥ 1800 g.\n* Apgar scores at 1, 3, and 5 minutes must indicate potential complications or difficulties.\n* Specific biochemical markers indicative of PA must be present\n\nExclusion Criteria:\n\n* Full-term newborn not meeting inclusion criteria",true,"1 Day",{"count":56,"type":20},280,"INTERVENTIONAL",[59],"NA","Current diagnostic methods rely primarily on clinical symptoms, supplemented by brain imaging and physiological tests. However, these signs of injury only become apparent once significant damage has occurred, thus delaying intervention and compromising the effectiveness of treatments. Therefore, there is a need to develop new markers to develop preventive measures for the consequences of perinatal asphyxia.\n\nThe primary objective is to compare cognitive and motor development at 18 months in three populations (PA, at risk of PA, and Control) defined on the basis of clinical, biological, and neural criteria.",[24,62,63,64,65],"Asphyxia","EEG","Eye Tracking","Biomarkers",[24,67,68,63,69,65],"asphyxia","anoxo ischemia","Eye tracking","2026-07-09",{"date":72,"type":37},"2026-07-14",{"date":74,"type":20},"2026-07",{"date":76,"type":20},"2029-12",{"name":78,"class":44},"Centre Hospitalier Universitaire, Amiens",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":57,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100568620","sealion-study-on-supplemental-oxygenation-via-nasal-cannula-for-young-children-during-intubation-100568620","NCT06683599","SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation","SEALion: a Study on the Effectiveness of Additional Oxygenation in Little Children During Intubation Using Oxygenation Delivered by Nasal Cannula","SEALION","Inclusion Criteria:\n\n* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical procedures.\n* Neonates and infants up to 52 weeks post-conceptual age.\n* Written informed consent provided by legal guardians prior to the intervention.\n\nExclusion Criteria:\n\n* Prediction of difficult intubation based on physical examination or a history of previous difficult intubation.\n* Requirement for an alternative technique to direct laryngoscopy to secure the airway.\n* Specific conditions, such as congenital heart disease requiring FiO₂ \\\u003C 1.0, or cardiopulmonary collapse necessitating advanced life support and intubation for emergency surgical or non-surgical interventions.","1 Minute","52 Weeks",{"count":90,"type":20},240,[59],"Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety. Intubation, while life-saving for children with circulatory shock or respiratory failure, carries risks of severe desaturation that can lead to hypoxic encephalopathy, cardiac arrest, or death. Neonates, especially, are prone to hypoxemia due to high oxygen consumption, low functional residual capacity, small closing capacity, and increased risk of airway collapse, which is exacerbated under anesthesia and neuromuscular paralysis. Rapid desaturation occurs after cessation of ventilation, with neonates facing shorter apnea times before desaturation. Studies show that about two-thirds of neonates undergoing non-emergency nasotracheal intubation experience desaturation (SpO₂ \\\u003C80% for over 60 seconds), although low-flow oxygen supplementation (0.2 L\u002Fkg\u002Fmin) can extend safe apnea time.\n\nThis study aims to investigate apneic oxygenation with VL (using Miller or Macintosh blades size 0 or 1) in operating rooms or intensive care units. We hypothesize that supplemental oxygen and standardized VL use will improve first-pass success rates and reduce adverse events.",[94,95,24],"Difficult Airway","Difficult Airway Intubation",[97,98,24],"Difficult intubation","Apneic oxygenation","RECRUITING","2025-11-24",{"date":102,"type":37},"2025-11-25",{"date":104,"type":37},"2024-12-10",{"date":106,"type":20},"2026-12-01",{"name":108,"class":44},"Vinícius C Quintão, MD, MSc, PhD",3,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":53,"sex":17,"minAge":4,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":57,"phases":120,"briefSummary":121,"conditions":122,"keywords":137,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":152},"100609268","infant-microbiota-restoration-with-maternal-microbes-100609268","NCT07212361","Infant Microbiota Restoration With Maternal Microbes","MaMi","Inclusion Criteria:\n\n* Healthy mother and healthy pregnancy\n* Singleton pregnancy,\n* Mothers who speak Finnish or Swedish\n* Mothers who are planning to breastfeed or give breastmilk by bottle to the infant\n* Infants who are expected to be healthy and who will not require BCG vaccination.\n\nExclusion Criteria:\n\n* Participants who lives further than a 2-hour drive from Meilahti, Helsinki, Finland\n* Mothers who are not planning to breastfeed or feed breastmilk by bottle to the infant\n* Mothers who are diagnosed with gestational diabetes, pre-eclampsia or who have been receiving antibiotics during the pregnancy or delivery\n* Premature infants born before the pregnancy week 37\n* Infants, who are born by urgent cesarean section or emergency cesarean section\n* Infants, who receive antibiotics during the first week of life\n* Infants, who are diagnosed with a disease, congenital anomaly or who receive less than 9 Apgar points at 5 minutes.\n* Infants, who receive BCG-vaccine","50 Years",{"count":119,"type":20},100,[59],"The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants. The main question it aims to answer is:\n\nDo maternally derived strains of bacteria perform better than commercially available probiotic strains in restoring the gut microbiota of C-section born infants? Researchers will compare the gut microbiota of treated infants to that of untreated C-section born infants and untreated vaginally born infants to see if the bacterial treatments cause the microbiota to resemble that of vaginally born infants.\n\nParticipants will be given a bacterial product orally once daily for either one or four weeks and be asked to collect faecal, urine and saliva samples.",[123,124,125,126,127,128,129,130,131,132,133,134,135,136,24],"Infant, Newborn","Gut -Microbiota","Gut Dysbiosis","Cesarean Delivery Affecting Newborn","Cesarean Section","Vaginal Delivery","Gastrointestinal Microbiota","Microbiota, Cesarean Section, Probiotics, Dysbiosis","Feces","Delivery, Obstetric","Microbiota","Microbiology","Humans","Pregnancy",[138,139,140,30,141,142],"Infant","newborn","cesarean section","restore","gut microbiota","2025-09-30",{"date":145,"type":37},"2025-10-08",{"date":147,"type":37},"2025-07-17",{"date":149,"type":20},"2035-12-31",{"name":151,"class":44},"University of Helsinki",2,{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":160,"minAge":4,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":57,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":172,"leadSponsor":174,"locationsCount":45},"100598861","dilemma-of-neonatal-circumcision-in-egypt-100598861","NCT07076992","Dilemma of Neonatal Circumcision in Egypt","The Dilemma of Neonatal Circumcision in Egypt: A Comparative Randomized Study","Inclusion Criteria:\n\n* Male infants less than 3 months old.\n* Undergoing circumcision.\n\nExclusion Criteria:\n\n* Male infants more than 3 months old.\n* Infants with bleeding disorders.\n* Neonates with hypospadias, epispadias, micropenis, disorders of sex development (DSD)\n* Neonates with buried or webbed penis.","MALE","3 Months",{"count":163,"type":20},60,[59],"The study aims to compare wound healing, wound healing complications, cosmetic outcome, and level of parental satisfaction amongst four techniques of neonatal circumcision.",[24,167],"Circumcision","2025-07-22",{"date":170,"type":37},"2025-07-23",{"date":168,"type":37},{"date":173,"type":20},"2025-12-30",{"name":175,"class":44},"Tanta University",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":57,"phases":185,"briefSummary":186,"conditions":187,"keywords":191,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":45},"100503481","magnetoencephalography-by-optical-pumping-magnetometer-100503481","NCT05835817","Magnetoencephalography by Optical Pumping Magnetometer","MEG OPM","Inclusion Criteria:\n\n* For healthy adult volunteers\n* Age between 18 and 65\n* No pathology, no treatment\n* No toxicant intake\n* For term newborns\n* Child between 38 and 42 weeks gestational age on the day of registration\n* No pathology, no treatment\n* For children born prematurely\n* Child between 28 and 36 weeks gestational age on the day of registration\n* No pathology, no treatment apart from routine care related to prematurity\n* For pregnant women\n* Pregnant with between 28 to 40 weeks gestational age on the day of registration\n* No pathology, no treatment\n\nExclusion Criteria:\n\n* Subject and Patients \"not compatible\" MEG. Wearers of prosthesis or pacemaker likely to generate artefacts interfering with the measurement. There is no danger to the subject, but the measurement itself may be impossible.\n* Patients who cannot stand to stand still for a few minutes.\n* Newborn on ventilatory assistance or infusion\n* Newborn baby not meeting the age criteria",{"count":184,"type":20},70,[59],"MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG). The main limitation of MEG is its cost due to the sensors used, the Super Quantum Interference Devices (SQUID). These require a complex infrastructure from an instrumentation point of view to operate, requiring liquid helium, most often at a loss, at increasing cost. Optical Pumping Magnetometers (OPM) type sensors represent a promising alternative to SQUIDs sensors, especially since they do not require helium cooling.\n\nThe purpose of this project is to Identify biomarkers in Magnetoencephalography of normal brain development in healthy adults, premature and term newborns from \"a priori\" obtained by the classical technique of High Resolution EEG performed.",[188,189,24,190],"Magnetoencephalography","Optical Pump Magnetometer","Premature",[188,192,30,190],"optical pump magnetometer","2025-05-22",{"date":195,"type":37},"2025-05-28",{"date":197,"type":37},"2023-04-11",{"date":199,"type":20},"2026-04",{"name":78,"class":44},{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":57,"phases":212,"briefSummary":213,"conditions":214,"keywords":220,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":45},"100585164","an-educational-intervention-to-improve-the-success-of-intubation-in-newborns-using-a-video-laryngoscope-by-reducing-the-time-the-procedure-takes-100585164","NCT06898801","An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.","Neonatal INtubation After \"Just-in-time\" Audiovisual Training: a Randomised Controlled Trial","NINJA","Inclusion Criteria:\n\nNeonates of any age or gestation who require endotracheal intubation in the Neonatal Intensive Care Unit in the National Maternity Hospital during the study period.\n\nExclusion Criteria:\n\n* Neonates with an upper airway malformation.\n* If it is deemed by the treating clinical team that the clinical scenario does not allow time for the intervention e.g. cardiac arrest","1 Year",{"count":211,"type":20},140,[59],"This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital. When a baby has serious breathing difficulty, inserting a breathing tube to place them on a ventilator can be lifesaving. A breathing tube must be placed through the vocal cords into the windpipe (trachea). A device called a laryngoscope is placed in a patients mouth to allow the doctor to see the vocal cords and insert the tube correctly.\n\nThe skill of placing this breathing tube (intubation) is important for doctors and specialists to learn so that they can confidently perform it in an emergency.\n\nIn the past, doctors had more opportunities during their training to learn and practice this with supervision from seniors. In recent years, babies, thankfully, need to be intubated less frequently and doctors working hours are better regulated. As a result, junior doctors have less chances to perform this skill. There is a need to improve how we teach the procedure of intubating babies to doctors in training to meet the needs of trainees today.\n\nThe investigators want to perform a study to help teach doctors in training how to perform intubation of a newborn using a video laryngoscope. The team are looking to assess if showing a short educational video to the doctor and team just before performing an intubation using a video laryngoscope will reduce the time the procedure takes. This is called a \"Just-in-Time\" video. The investigators aim to demonstrate a benefit by performing a randomised control trial. This means that when a baby requires intubation as decided by their treating doctors, the team will be randomly allocated to view a \"Just-in-Time\" video before performing the intubation or not. The investigators will then compare the two groups to see if there is a difference in the total time the procedure takes.",[215,216,217,218,24,219],"Respiratory Distress Syndrome, Newborn","Endotracheal Intubation","Neonatal Intubation Performance","Prematurity","Education, Medical",[221,222,223],"Just-in-Time","Neonatal intubation","Teaching","2025-03-20",{"date":226,"type":37},"2025-03-27",{"date":228,"type":20},"2025-03",{"date":230,"type":20},"2027-05",{"name":232,"class":44},"University College Dublin",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":241,"maxAge":242,"enrollmentInfo":243,"targetDuration":54,"studyType":21,"phases":4,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":45},"100513466","comparing-electromyography-of-the-diaphragm-with-ultrasound-in-neonates-and-children-with-respiratory-support-100513466","NCT05965830","Comparing Electromyography of the Diaphragm With Ultrasound in Neonates and Children With Respiratory Support","PRospective Observational Study Comparing Electromyography of the Diaphragm With Ultrasound in Neonates and Children With REspiratory Support: the PROCEDURES Study","PROCEDURES","Inclusion Criteria:\n\n* Age between 0 - 12 months of age at the moment of inclusion and born ≥ 37 weeks gestational age.\n* Specific patients cohort PICU:\n\npediatric patients with invasive respiratory support comply with the extubation readiness test (ERT) criteria\n\n* No spontaneous breathing for the duration of the assessment\n* Written parenteral informed consent (IC)\n* A patient can only participate once\n\nExclusion Criteria:\n\n* Unilateral diaphragm paresis diagnosed by ultrasound\n* Congenital malformations not compatible with dEMG\n* Need of cardiac pacing\n* Congenital muscle atrophy disorder\n* Clinical instability requiring frequent interventions by the nursing staff that may interfere with the measurements\n* The attending physician considers the patient to be too vulnerable to participate in the study","0 Months","12 Months",{"count":244,"type":20},50,"Background of the study:\n\nIncreased work of breathing, potentially leading to respiratory insufficiency, resulting in the need of (non-) invasive respiratory support is the most common observed problem in the neonatal - and pediatric intensive care unit (NICU\u002FPICU). The diaphragm is the main respiratory muscle. Currently there is not an established technique accessible to observe the (clinical) function of the diaphragm and its role in respiratory insufficiency. New non-invasive modalities are promising, such as transcutaneous diaphragm electromyography (dEMG) and diaphragm ultrasound (dUS).\n\nObjective of the study:\n\nOur objective is to assess the association between transcutaneous diaphragm electromyography (dEMG) and diaphragm ultrasound (dUS) in the PICU population.\n\nStudy design:\n\nSingle center pilot study\n\nStudy population:\n\nThe study population consists of children between 0-12 months, admitted to the PICU of the Leiden University Medical Center, with invasive respiratory support.\n\nPrimary study parameters\u002Foutcome of the study:\n\nPrimary endpoint is to evaluate the association between dEMG and dUS measurements in the PICU population.",[247,248,249,24],"Ultrasound","Transcutaneous EMG","Diaphragm","2025-03-17",{"date":252,"type":37},"2025-03-18",{"date":254,"type":37},"2023-11-25",{"date":256,"type":20},"2025-11",{"name":258,"class":44},"Leiden University Medical Center",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":53,"sex":17,"minAge":4,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":268,"conditions":269,"keywords":275,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":152},"100577805","investigation-of-the-mechanisms-of-the-tendency-to-hypothermia-in-newborns-and-premature-neonates-100577805","NCT06803069","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates","Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Infants During Surgical Interventions and in the Intensive Care Unit (Non-Interventional, Single-Center, Prospective Clinical Research)","Inclusion Criteria:\n\n* For Substudy 1: Patients admitted to the Neonatal Intensive Care Unit at the University of Pécs, Department of Obstetrics and Gynaecology (premature infants or those in neonatal intensive care).\n* For Substudy 2: Patients under 2 years of age undergoing elective surgery lasting more than 30 minutes at the University of Pécs, Department of Paediatrics.\n* For both substudies: Written consent for participation in the study has been provided by the patient's parent, guardian, or legal representative.\n\nExclusion Criteria:\n\n* For both substudies: If the patient cannot be mobilized (e.g., during the post-operative phase of abdominal or thoracic surgery; presence of chest tubes for pneumothorax or other reasons; hemodynamic instability; need for continuous electrocardiogram (ECG) monitoring; or use of an external pacemaker).\n* The patient's parent, guardian, or legal representative does not consent to the study or withdraws their consent at any point.\n* For Substudy 2: if the patient is older than 2 years.","2 Years",{"count":119,"type":20},"Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue. The development of this thermogenic tissue starts around the 26th gestational week and continues until shortly before birth, after which no further growth occurs. As a result, premature infants, who have less developed brown fat, are more prone to reduced heat production and are at higher risk for hypothermia. There are few human studies examining the thermoregulatory differences and mechanisms between full-term and premature neonates, and the findings remain inconclusive.\n\nIn this study, the investigators aim to conduct a prospective, observational research. Researchers will compare body temperature, brown adipose tissue activity, and specific plasma markers between full-term and premature neonates in insensive care units and during elective surgeries.",[270,271,272,24,273,274],"Neonatal Hypothermia","Brown Adipose Tissue","Preterm and Term Infants","Thermogenesis","Blood Markers",[276,30,277,278,279,280,139],"brown adipose tissue","neonatal hypothermia","preterm","nonshivering thermogenesis","infant","2025-02-18",{"date":283,"type":37},"2025-02-19",{"date":285,"type":37},"2024-07-01",{"date":287,"type":20},"2029-07-01",{"name":289,"class":44},"University of Pecs",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":45},"100511072","latin-american-surgical-outcomes-study-in-pediatric-patients-100511072","NCT05934682","Latin American Surgical Outcomes Study in Pediatric Patients","LASOS-Peds","Inclusion Criteria:\n\n* All of the consecutive patients under 18-years-old who were admitted to participating hospitals during the study period and who underwent elective and nonelective surgeries will be included in the study.\n\nExclusion Criteria:\n\n1. patients undergoing radiological or other procedures that do not require general anesthesia or in which general anesthesia is performed but no procedure is performed (e.g., general anesthesia during MRI);\n2. patients undergoing obstetric surgery.","18 Years",{"count":299,"type":20},10000,"This prospective, international, multicenter observational study will include hospitals performing pediatric surgery in participating Latin American countries.\n\nWe aim to assess the incidence of hospital postoperative complications in pediatric surgical patients \\\u003C 18-years-old in Latin America. We will recruit all consecutive pediatric patients under the age of 18 years who were admitted to participating hospitals undergoing elective and nonelective surgery. The primary outcome is in-hospital postoperative complications up to 30 days after surgery.",[302,303,24,138,304],"Postoperative Complications","Children","Anesthesia","2024-12-05",{"date":307,"type":37},"2024-12-09",{"date":309,"type":37},"2023-12-20",{"date":311,"type":20},"2025-03-30",{"name":313,"class":44},"University of Sao Paulo"]