[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurocognitive-deficit\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurocognitive-deficit":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100368181","mri-biomarkers-for-radiation-induced-neurocognitive-decline-following-srs-of-newly-diagnosed-brain-mets-100368181",false,"NCT04073966","MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets","Magnetic Resonance Imaging Biomarkers for Radiation-Induced Neurocognitive Decline Following Stereotactic Radiosurgery of Newly Diagnosed Brain Metastases: An Observational Pilot Study","Inclusion Criteria:\n\n* Histologic diagnosis of cancer\n* Newly diagnosed brain metastasis being treated with SRS. Any extent of cranial disease permitted. Subsequent courses of SRS while on study permitted when clinically indicated.\n* Patients are permitted to have undergone craniotomy and resection of metastasis\u002Fmetastases if at least 1 other intact metastasis planned for definitive SRS is present. Receiving or previously received systemic therapy also permitted.\n* Anticipated life expectancy at least 1 year\n* Age ≥ 18 years\n* Ability to read and comprehend written English and follow instructions in English\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous radiation to the brain or head\n* Previous malignancy - other than non-melanomatous skin cancer or cervical carcinoma in situ - and not disease-free for at least 3 years\n* Previous severe head or brain injury\n* History of a neurological disorder such as Epilepsy, Parkinson's, Alzheimer's, or Dementia\n* Prisoners","ALL","18 Years",{"count":19,"type":20},20,"ESTIMATED","OBSERVATIONAL","Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration, patients with brain metastases are at increasing risk of developing and experiencing long-term side effects from treatment of brain metastases. The overarching goal of this study is to better understand the determinants of RT-associated changes in white and gray matter function and associated neurocognitive decline.",[24,25,26,27],"Brain Metastases","Neurocognitive Deficit","White Matter Alterations","Radiation Exposure","RECRUITING","2026-08-12",{"date":31,"type":32},"2026-08-14","ACTUAL",{"date":34,"type":32},"2019-12-04",{"date":36,"type":20},"2029-05-31",{"name":38,"class":39},"UNC Lineberger Comprehensive Cancer Center","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":58,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":72,"locationsCount":40},"100573684","the-gut-microbiome---source-of-sepsis-and-novel-target-in-intensive-care-units-100573684","NCT06749483","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? Research on Human Tissue, Body Fluids, Neuropsychological Assessment and Brain Imaging","MS-ICU","Inclusion Criteria:\n\n* Age ≥ 18 years\n* One of the following criteria\n\n  1. Critically ill patients treated with meropenem or piperacillin\u002Ftazobactam started within the last 72 h\n  2. Critically ill patients without systemic antimicrobial therapy within the last 72 hours and an expected ICU length of stay of more than 3 days\n  3. Long-term survivors of sepsis, e.g. from pre-existing sepsis cohorts\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Major bowel resection\n* Selective decontamination of the oral and digestive tract\n* Oral vancomycin therapy\n* Immunocompromised patients\n* History of chemotherapy during the last 6 months.\n* Known travel history to countries to areas of high antimicrobial resistance (\\>5% according to the report of the European Centre for Disease Prevention and Control and all countries except USA and Canada) within the last 4 weeks\n* Acute neurological diseases (e.g., brain ischemia, hemorrhage, meningoencephalitis, tumor)\n* Manifest dementia, pre-existing psychiatric diseases (schizophrenia, psychosis)\n* Acute brain surgery\n* MRI contraindications: pacemakers, hearing aids, neurostimulation, insulin pumps, other potentially ferromagnetic implants, screws, clips, prostheses, metal splinters, etc., pregnancy, claustrophobia, extensive tattoos.",{"count":50,"type":20},100,"Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.",[53,54,25,55,56,57],"Critical Illness","Intensive Care Unit Delirium","Microbiome,immune Function, Critically Ill","Infection in ICU","Sepsis",[59,60,61,62,63,64,65],"sepsis","broad-spectrum antibiotics","stool","neuropsychological assessment","delirium","neurocognitive impairment","microbiome","2024-12-27",{"date":68,"type":32},"2024-12-30",{"date":66,"type":32},{"date":71,"type":20},"2026-12-31",{"name":73,"class":39},"Jena University Hospital"]