[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromyelitis-optica-spectrum-disease-nmosd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromyelitis-optica-spectrum-disease-nmosd":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100646971","phase-1-riptylimab-for-the-treatment-of-optic-neuritis-and-myelitis-spectrum-diseases-100646971",false,"NCT07685678","Riptylimab for the Treatment of Optic Neuritis and Myelitis Spectrum Diseases","Safety and Efficacy of Riptylimab in Optic Neuritis and Myelitis Spectrum Diseases","RIPERT-NMOSD","Inclusion Criteria:\n\n\\- 1. Age ≥ 18 and ≤ 75 years at screening. 2. Definite diagnosis of NMOSD. 3. Expanded Disability Status Scale (EDSS) score ≤ 7.0. 4. At least 1 NMOSD relapse requiring rescue treatment within 1 year prior to screening; or at least 2 NMOSD relapses requiring rescue treatment within 2 years prior to screening (including the initial episode).\n\n5\\. Voluntarily sign the informed consent form. 6. Female patients of childbearing potential must have a negative pregnancy test (serum β-HCG). Effective contraception shall be used during the study period and for 6 months after treatment discontinuation.\n\nExclusion Criteria:\n\n* 1\\. Any condition that, in the investigator's opinion, may interfere with the evaluation or administration of the study drug, assessment of patient safety, or interpretation of study results.\n\n  2\\. Presence of any uncontrolled active infection or severe infection within 8 weeks prior to the screening period.\n\n  3\\. Treatment with rituximab or any B-cell depleting agents within 6 months before screening (subjects with CD19+ or CD20+ B-cell counts above the lower limit of normal are eligible for enrollment).\n\n  4\\. Use of tocilizumab, eculizumab, mitoxantrone, or alkylating agents such as cyclophosphamide within 3 months prior to the first dose administration.\n\n  5\\. Use of immunosuppressants other than glucocorticoids within 1 month prior to the first dose administration, including but not limited to azathioprine, mycophenolate mofetil, tacrolimus, cyclosporine, methotrexate.\n\n  6\\. Receipt of plasma exchange (PE), moderate-volume blood transfusion, or immunomodulatory agents such as interferon beta, interferon gamma, or intravenous immunoglobulin (IVIG) within 1 month prior to the first dose administration.\n\n  7\\. Coexisting other chronic active immune system diseases requiring treatment with glucocorticoids, biologics or immunosuppressants (e.g., rheumatoid arthritis, scleroderma).\n\n  8\\. Vaccination with live or attenuated vaccines within 1 month prior to the first dose administration.\n\n  9\\. Prior history of bone marrow transplantation, hematopoietic stem cell transplantation, total lymphoid irradiation, or T-cell vaccine therapy.\n\n  10\\. Participation in any clinical trial with investigational products within 28 days prior to the first dose or within 5 half-lives of the investigational product, whichever is shorter.\n\n  11\\. Positive hepatitis B surface antigen (HBsAg) and\u002For hepatitis B core antibody (HBcAb) with HBV DNA exceeding the upper limit of normal; positive hepatitis C virus (HCV) antibody with HCV RNA exceeding the upper limit of normal; positive human immunodeficiency virus (HIV) serology; positive treponema pallidum antibody (TP-Ab).\n\n  12\\. Known hypersensitivity to any component of ripeltumab. 13. History of malignant tumors including malignant thymoma, myeloproliferative or lymphoproliferative disorders, unless the disease is considered cured with adequate treatment and there is no evidence of relapse for ≥3 years before screening. Patients with completely resected non-melanoma skin cancer (e.g., basal cell carcinoma or squamous cell carcinoma) or carcinoma in situ of the cervix are allowed to be enrolled at any time.\n\n  14\\. Patients with clinical evidence of other serious major illnesses or those who have recently undergone major surgery, which may confound trial results or expose patients to undue risks. This includes patients with severe renal or hepatic impairment.\n\n  15\\. For male subjects without sterilization: refusal to use barrier contraception from screening until 6 months after the end of treatment, and refusal to ask their partners to adopt alternative contraceptive measures including oral contraceptives, intrauterine devices, barrier methods or spermicides.","ALL","18 Years","75 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This clinical trial aims to evaluate the safety and efficacy of ripertamab in patients with neuromyelitis optica spectrum disorders (NMOSD). The key research objectives are as follows:\n\n1. To assess the efficacy of ripertamab for the treatment of neuromyelitis optica spectrum disorders.\n2. To assess the safety of ripertamab for the treatment of neuromyelitis optica spectrum disorders.\n\nStudy participants are required to:\n\nReceive a single intravenous infusion of ripertamab. Attend follow-up examinations and laboratory tests at the study site at Week 1, Week 9, Week 17, Week 25, Week 33, Week 41, Week 49, Week 57, Week 65, Week 73, Week 81, Week 89, Week 97.\n\nMaintain a daily symptom diary and record the number of rescue treatments.",[29,30],"Neuromyelitis Optica Spectrum Disease (NMOSD)","Ripertamab","NOT_YET_RECRUITING","2026-06-29",{"date":34,"type":35},"2026-07-06","ACTUAL",{"date":37,"type":22},"2026-07-15",{"date":39,"type":22},"2030-06-30",{"name":41,"class":42},"Zhongming Qiu","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100639236","early-phase-1-the-safety-and-efficacy-of-ksvcbd-injection-in-neuromyelitis-optica-spectrum-disorder-100639236","NCT07592754","The Safety and Efficacy of KSVCBD Injection in Neuromyelitis Optica Spectrum Disorder.","An Early Exploratory Clinical Study on the Safety and Efficacy of KSVCBD Injection in the Treatment of Relapsed\u002FRefractory AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder.","Key Inclusion Criteria:\n\n1. Patients must meet the 2015 International Consensus Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorder (NMOSD) and test positive for AQP4 antibodies.\n2. Documented evidence of at least 1 relapse within 12 months before signing the informed consent form.\n3. The Expanded Disability Status Scale (EDSS) score ≤ 8.\n4. Female participants of childbearing potential must present a negative pregnancy test at screening and agree to use effective contraception throughout the study period.\n5. Informed consent must be obtained from the patient or their legal representative, with a signed consent form must be provided.\n\nKey Exclusion Criteria:\n\n1. Viral infections: Known HIV, active HBV, or active HCV.\n2. Pregnant or breastfeeding women.\n3. History of other autoimmune diseases requiring immunosuppressive therapy.\n4. Use of any live vaccines against infectious disease within 6 weeks before enrollment.\n5. History of bone marrow\u002Fhematopoietic stem cell or solid organ transplantation.\n6. Patients deemed unsuitable for participation by the investigator.","65 Years",{"count":52,"type":22},18,[54],"EARLY_PHASE1","KSVCBD injection is an in vivo Chimeric Antigen Receptor T-Cell (CAR-T cell) therapy product. This is a multi-center, single-arm, open-label, early exploratory clinical study. The objective of this study is to evaluate the safety and preliminary efficacy of KSVCBD injection in AQP4-positive Neuromyelitis Optica Spectrum Disorder",[29],[58],"Neuromyelitis Optica Spectrum Disorders","2026-05-12",{"date":61,"type":35},"2026-05-18",{"date":63,"type":22},"2026-05-15",{"date":65,"type":22},"2029-03-31",{"name":67,"class":42},"Chinese PLA General Hospital",1]