[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-acute-carotid-artery-occlusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-acute-carotid-artery-occlusion":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100654566","endovascular-treatment-for-symptomatic-non-acute-carotid-occlusion-100654566",false,"NCT07803419","Endovascular Treatment for Symptomatic Non-acute Carotid Occlusion","Endovascular Treatment for Symptomatic Non-acute Carotid Occlusion - A Multicenter, Prospective, Blind Endpoint, Pilot， Randomized Controlled Trial","ASCENT","Inclusion Criteria:\n\n1. The age ranged from 18 to 80 years\n2. Unilateral carotid artery occlusion confirmed by CTA or DSA (excluding anterior and middle cerebral artery occlusion)\n3. Complete 3T-MRI within 1-3 days before operation\n4. The time of carotid artery occlusion was more than 24h (confirmed by imaging or according to the patient's condition), and not more than 3 months\n5. Ischemic stroke or TIA related to occluded vessels existed in the past 3 months, and the last ischemic event was \\> 2 weeks; and there was cognitive impairment, MoCA score ≤ 25 after education correction\n6. Imaging confirmed that there was hypoperfusion in the ipsilateral cerebral hemisphere of carotid artery occlusion, which met at least any of the following requirements:\n\n   ①Head CT perfusion imaging showed low perfusion in the lesion vascular area (CBF decreased by 30% compared with contralateral perfusion)\n\n   ②ASITN\u002FSIR collateral circulation score based on DSA \\\u003C 3 points\n\n   ③Cerebral infarction with hemodynamic abnormalities confirmed by head MRI (such as watershed infarction)\n7. Sign the informed consent form\n\nExclusion Criteria:\n\n1. There was severe neurological dysfunction (mRS ≥ 4) before enrollment\n2. The ipsilateral common carotid artery was occluded, or the ipsilateral middle cerebral artery was severely stenosed or occluded\n3. Non atherosclerotic occlusion (such as vasculitis, moyamoya disease, etc.)\n4. Patients with massive cerebral infarction (infarction volume based on MRI-DWI\u002FADC is more than 70ml)\n5. Untreated intracranial aneurysms, intracranial tumors (except meningiomas) or any intracranial vascular malformations\n6. Evidence of cardiogenic embolism\n7. Allergic to heparin, aspirin, clopidogrel, statins, metals, anesthetics, contrast agents, or unable to tolerate general anesthesia surgery\n8. Any history of intracranial hemorrhage within 30 days (including cerebral parenchyma, ventricle, subarachnoid hemorrhage, subdural or epidural)\n9. History of primary cerebral parenchymal hemorrhage\n10. There are contraindications to antiplatelet drugs\n11. There are coagulation disorders and systemic bleeding\n12. Thrombocytopenia (\\\u003C100 × 10⁹\u002FL)\n13. Uncontrolled severe hypertension (systolic blood pressure\\>180mmHg or diastolic blood pressure\\>110mmHg)\n14. Severe coronary heart disease, severe liver injury (AST or ALT more than 3 times the normal value), liver cirrhosis and severe renal insufficiency (creatinine\\>177 μmol\u002FL) were observed\n15. Major surgical operations within 30 days or in the next 90 days\n16. It is known that patients with dementia, cognitive impairment caused by other reasons or mental diseases cannot complete the assessment of neurological and cognitive functions\n17. There are cerebral infarction that clearly involves the key brain areas of cognition, or there are neurological deficits that affect the accuracy of cognitive function assessment, such as severe aphasia, neglect, and audiovisual impairment. According to the judgment of the researchers, the decline of cognitive function is mainly caused by irreversible brain tissue injury\n18. The expected survival time of patients with other diseases was less than 2 years\n19. Pregnancy or lactation\n20. Patients have been included in other studies, which is in conflict with this study","ALL","18 Years","80 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a multicenter, prospective, randomized, open-label, blinded-endpoint clinical trial designed to evaluate the safety and potential efficacy of endovascular recanalization strategies in patients with symptomatic non-acute carotid artery occlusion and cognitive impairment. Eligible participants will be randomly assigned to best medical treatment alone, endovascular recanalization without proximal protection plus best medical treatment, or endovascular recanalization with proximal balloon protection plus best medical treatment. The study will assess whether endovascular recanalization improves cognitive function and whether proximal protection reduces procedure-related new ischemic lesions on diffusion-weighted magnetic resonance imaging.",[28,29],"Non-acute Carotid Artery Occlusion","Cognitive Impairment",[28,31,32,33,34,29],"Chronic Carotid Artery Occlusion","Symptomatic Carotid Artery Occlusion","Endovascular Recanalization","Balloon Guide Catheter","NOT_YET_RECRUITING","2026-08-31",{"date":38,"type":39},"2026-09-03","ACTUAL",{"date":41,"type":22},"2026-09-01",{"date":43,"type":22},"2028-12-01",{"name":45,"class":46},"Dapeng Mo","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":5},"100539405","revascularization-for-symptomatic-non-acute-carotid-artery-occlusion-100539405","NCT06303414","Revascularization for Symptomatic Non-acute Carotid Artery Occlusion","RESCO","Inclusion Criteria:\n\n1. Older than 18 years old;\n2. Sign the informed consent form;\n3. Carotid occlusion at least 24h;\n4. Patients with clinical localization symptoms: ipsilateral hemisphere ischemia symptoms or ipsilateral eye ischemia symptoms or cognition impairment, with or without anterior circulation blood supply area infarction;\n5. DSA confirmed common carotid artery or internal carotid artery (mTICI=0) occlusion;\n6. Perfusion imaging confirms the presence of hypoperfusion in the corresponding area(CBF decrease);\n7. The optimal medical treatment for patients who still have ischemic symptoms;\n8. Routine DWI and ADC sequence examinations are performed before surgery no new infarction;\n\nExclusion Criteria:\n\n1. Intracranial arteriovenous malformation or aneurysm;\n2. Unstable angina, myocardial infarction (MI), or congestive heart failure in the last 6 months;\n3. Uncontrolled diabetes mellitus defined as glucose \\> 300 mg\u002FdL (16.67 mmol\u002FL);\n4. Patient is expected to have the ADP antagonist therapy interruption within 3 months after the procedure;\n5. Pregnant or in the perinatal period;\n6. Severe concomitant disease with poor prognosis (life expectancy \\\u003C 3 years);\n7. Intolerance or allergies to any of the study medications, such as aspirin or clopidogrel;\n8. Allergy to iodine or radiographic contrast media;\n9. Concomitant vascular conditions precluding endovascular;\n10. Patients with large cerebral infarction within 2 weeks;\n11. History of ipsilateral vocal cord paralysis;\n12. Those with severe skin diseases who are expected to have difficulty healing the incision;\n13. Poor functional status before onset (mRS score 4-5 points).\n14. The area of infarction in the occluded vascular area exceeds half of the vascular supply area;\n15. Already have dementia or psychiatric illness and are unable to complete neurological and cognitive assessments.\n16. Any condition that in the surgeon's judgment suggests the patient an unsuitable surgical candidate.",{"count":56,"type":22},1000,"12 Months","OBSERVATIONAL","The short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies. The comparison of success rate, complication rate and efficacy among the three recanalization modalities also needs to be further explored. The purpose of this cohort study is to observe the success rate, efficacy and safety of recanalization treatment for non-acute occlusion, and to further compare the advantages and disadvantages of CEA, endovascular intervention and hybrid surgery.",[28],"RECRUITING","2024-03-04",{"date":64,"type":39},"2024-03-12",{"date":66,"type":39},"2016-06-17",{"date":68,"type":22},"2028-12-30",{"name":70,"class":46},"Xuanwu Hospital, Beijing"]