[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-erosive-gastroesophageal-reflux-disease-nerd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-erosive-gastroesophageal-reflux-disease-nerd":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100653757","mirgeal-gel-as-add-on-therapy-to-esomeprazole-in-adults-with-non-erosive-gastroesophageal-reflux-disease-100653757",false,"NCT07790549","Mirgeal® Gel as Add-on Therapy to Esomeprazole in Adults With Non-Erosive Gastroesophageal Reflux Disease","Effect of the Use of Alginate Combined With Licorice and Blueberry in the Symptomatic Treatment of Adult Patients With Gastroesophageal Reflux Disease","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Males and females.\n* Diagnosis of non-erosive gastroesophageal reflux disease (NERD), based on the absence of macroscopic lesions of the distal esophageal mucosa on endoscopy performed within 6 months prior to enrollment.\n* Heartburn and\u002For acid regurgitation at least 3 times per week during the 2 weeks prior to enrollment.\n* Written informed consent for study participation obtained prior to the start of the study.\n\nExclusion Criteria:\n\n* Active gastric or duodenal ulcer within the previous 3 months.\n* Previous surgery involving the esophagus or treated upper gastrointestinal tract.\n* Absence of erosive esophagitis or Barrett's esophagus.\n* Severe renal or hepatic impairment.\n* Use of proton pump inhibitors (PPIs), H2-antagonists, or systemic glucocorticoids within 2 weeks prior to enrollment.\n* Pregnancy.\n* Breastfeeding.\n* Alcohol or drug abuse.\n* Hypersensitivity to any of the study product components.\n* Participation in another clinical trial within 30 days prior to enrollment.\n* Lack of acceptance of written informed consent.","ALL","18 Years","75 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","Gastroesophageal reflux disease (GERD) is a common condition that can cause symptoms including heartburn, acid regurgitation, sour taste and other upper gastrointestinal complaints. This prospective, multicenter, randomized, controlled, non-profit clinical trial will evaluate the clinical efficacy and safety of Mirgeal® Gel, a dietary supplement containing sodium alginate and standardized extracts of licorice (Glycyrrhiza glabra) and blueberry (Vaccinium myrtillus), when used as an add-on to esomeprazole in adults with non-erosive gastroesophageal reflux disease (NERD).\n\nA total of 140 participants will be randomly assigned in a 1:1 ratio to receive either esomeprazole 20 mg\u002Fday plus Mirgeal® Gel, 2 sticks per day (1 after lunch and 1 after dinner), or esomeprazole 20 mg\u002Fday alone for 4 continuous weeks. Clinical assessments will be performed at baseline and after 2 and 4 weeks of treatment. The study will assess whether adding Mirgeal® Gel to standard proton pump inhibitor therapy improves reflux-related symptoms and quality of life compared with esomeprazole alone.",[27],"Non-Erosive Gastroesophageal Reflux Disease (NERD)","NOT_YET_RECRUITING","2026-08-25",{"date":31,"type":32},"2026-08-27","ACTUAL",{"date":34,"type":21},"2026-09-07",{"date":36,"type":21},"2027-01-29",{"name":38,"class":39},"Liaquat University of Medical & Health Sciences","OTHER",2]