[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nutritional-supplementation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nutritional-supplementation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":5},"100658817","effects-of-pre-run-nutritional-supplements-during-a-fixed-pace-5-km-treadmill-run-100658817",false,"NCT07854223","Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run","Fueling the Kilometers: Effects of Pre-Run Nutritional Supplements on Physiological Responses During a Fixed-Pace 5 km Treadmill Run","Inclusion Criteria:\n\n* Age 18-35 years\n* Healthy adult\n* Able to provide written informed consent\n* Regularly engaged in running-based aerobic training at least 3 times per week for at least 30 minutes per session during the past 3 months\n* Able to complete a 5 km run in under 30 minutes\n* Able and willing to comply with treadmill testing, fingerstick testing, dietary standardization, supplement restrictions, and pre-visit instructions\n* Participants randomly selected for the continuous glucose monitoring subgroup must also be willing to undergo Dexcom Stelo continuous glucose monitor placement and wear\n\nExclusion Criteria:\n\n* Known cardiovascular, metabolic, pulmonary, or neurological disease that may increase the risk associated with exercise testing or materially influence study outcomes\n* Uncontrolled hypertension or another cardiovascular condition that, in the investigator's judgment, makes vigorous treadmill exercise unsafe\n* Diagnosed type 1 or type 2 diabetes mellitus or another known metabolic disease that may materially influence study outcomes\n* Pregnant, breastfeeding, or planning pregnancy during the study period\n* Current use of nitrate medications or phosphodiesterase type 5 (PDE5) inhibitors, including sildenafil, tadalafil, or vardenafil\n* Known sensitivity or allergy to caffeine, L-citrulline, exogenous ketone\u002FBHB salt products, or any study beverage ingredient\n* Current use of stimulant medications or other medications that may significantly influence cardiovascular, blood pressure, or metabolic responses to exercise, as determined by the investigator\n* Musculoskeletal injury or condition that limits safe treadmill running\n* Smoking or regular use of nicotine products\n* Recent illness, surgery, or hospitalization that, in the opinion of the investigators, may interfere with safe participation or study outcomes\n* Unable or unwilling to comply with study procedures or pre-visit standardization requirements\n* Running fewer than 3 times per week or otherwise not meeting the running-training inclusion criterion",true,"ALL","18 Years","35 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will examine how three commonly used pre-run nutritional supplements-caffeine, L-citrulline, and an exogenous ketone supplement-affect physiological and perceptual responses during a fixed-pace 5 km treadmill run in healthy, physically active runners.\n\nParticipants will complete one screening and baseline visit followed by four experimental visits in a randomized order. At each experimental visit, participants will receive caffeine, L-citrulline, an exogenous ketone supplement, or placebo before completing a fixed-pace 5 km treadmill run. Each participant will receive all four conditions and will therefore serve as their own control.\n\nThe study will evaluate measures including running economy, heart-rate responses, oxygen consumption, respiratory measures, blood lactate and ketone concentrations, perceived exertion, gastrointestinal symptoms, fatigue, energy, and focus. A randomly selected subgroup will also wear a continuous glucose monitor to explore glucose responses during the experimental visits. The study will also assess the feasibility and tolerability of completing repeated treadmill trials under the four supplement conditions.",[28,29],"Exercise Physiology","Nutritional Supplementation",[31,32,33,34,35,36,37,38,39,40,41,42,43],"Running Economy","Heart Rate Drift","Caffeine","L-Citrulline","Exogenous Ketones","Beta-Hydroxybutyrate","5 km Running","Endurance Exercise","Nutritional Supplements","Indirect Calorimetry","Blood Lactate","Blood Ketones","Continuous Glucose Monitoring","RECRUITING","2026-09-26",{"date":47,"type":48},"2026-10-02","ACTUAL",{"date":50,"type":22},"2026-10",{"date":52,"type":22},"2027-08",{"name":54,"class":55},"St. Louis University","OTHER"]