[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obesity-bmi--35\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obesity-bmi--35":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,82,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100651397","preserving-muscle-mass-during-incretin-induced-weight-loss-100651397",false,"NCT07761923","Preserving Muscle Mass During Incretin-Induced Weight Loss","Resistance Exercise Training to Preserve Muscle Mass and Physical Function During Incretin-Based Weight Loss","INCRETraIN","Inclusion Criteria:\n\n* Adults aged 18-64 years with obesity.\n* Planned initiation of incretin-based obesity pharmacotherapy as part of routine clinical care.\n* Able to participate in supervised unilateral resistance training.\n* Able to complete physical function tests.\n* Able to attend study visits at the study center.\n* Able to provide written informed consent in the Swedish language.\n\nExclusion Criteria:\n\n* Contraindication to magnetic resonance imaging.\n* Medical condition preventing resistance training or physical function testing.\n* Medical condition preventing skeletal muscle or adipose tissue biopsy.\n* Inability to understand study information in Swedish or provide informed consent.","ALL","18 Years","64 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Treatment with appetite suppressant drugs, including incretin-based receptor agonists, generally leads to clinically meaningful weight loss and reduced cardiometabolic risk. However, weight loss may include not only loss of adipose tissue but also loss of skeletal muscle mass, which ultimately may impair physical function and metabolic health.\n\nResistance training is an effective strategy to maintain or increase skeletal muscle mass during weight loss, but its effects during treatment with appetite suppressant obesity medications have been studied insufficiently. This study will investigate whether unilateral resistance training during incretin-based receptor agonist treatment can preserve or improve skeletal muscle mass. Additionally, the study will determine whether preservation of muscle is accompanied by the preservation of muscle function and\u002For molecular adaptations in skeletal muscle, adipose tissue and blood.\n\nParticipants will be adults with obesity who are about to start treatment with an incretin-based receptor agonist as part of routine clinical care. During the 13-week intervention, participants will perform supervised unilateral resistance training two times per week, training one leg while the other leg serves as an internal control. Data and tissue collection will take place before treatment start and after 13 weeks. Assessments include whole-body magnetic resonance imaging, blood sampling, skeletal muscle and adipose tissue biopsies, physical function tests, questionnaires, and monitoring of physical activity.",[28],"Obesity (BMI > 35)",[30,31,32,33,34],"Obesity","Incretins","Skeletal muscle","Resistance training","Exercise training","NOT_YET_RECRUITING","2026-08-10",{"date":38,"type":39},"2026-08-12","ACTUAL",{"date":41,"type":22},"2026-09-01",{"date":43,"type":22},"2029-01-01",{"name":45,"class":46},"Karolinska Institutet","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100628084","digital-follow-up-and-nursing-education-in-bariatric-surgery-patients-100628084","NCT07457034","Digital Follow-Up and Nursing Education in Bariatric Surgery Patients","The Effect of the Use of a PHP-MySQL Database-Based Follow-Up System and Nursing Education on Quality of Life in Patients Undergoing Bariatric Surgery","DigiBarQoL","Inclusion Criteria:\n\n* Adults aged 18-65 years Undergoing bariatric surgery Eligible for physical activity participation according to the International Physical Activity Questionnaire (IPAQ) Able to use the PHP-MySQL based digital follow-up system Willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Severe cardiopulmonary disease or any medical condition that contraindicates exercise Uncontrolled hypertension or uncontrolled diabetes Severe musculoskeletal limitations preventing participation in the exercise program Severe psychiatric disorder impairing compliance or follow-up Participation in another interventional study during the study period Refusal or inability to provide informed consent","65 Years",{"count":58,"type":22},52,[25],"This randomized controlled experimental study aims to evaluate the effect of a PHP-MySQL database-based digital follow-up system combined with structured nursing education on quality of life, body mass index (BMI), and exercise habits in patients undergoing bariatric surgery. Although bariatric surgery is an effective treatment for morbid obesity, long-term success depends largely on adherence to lifestyle modifications, including regular physical activity and sustained behavioral change.\n\nParticipants will be randomly assigned to either an intervention group or a control group. The intervention group will receive structured nursing education along with an 8-week digitally monitored exercise program starting at postoperative month four. The control group will receive standard postoperative care. Outcomes will be assessed using the Moorehead-Ardelt Quality of Life Questionnaire II (MA-II), BMI measurements, and the International Physical Activity Questionnaire (IPAQ). The study aims to provide evidence for integrating digital health technologies and structured nursing interventions into postoperative bariatric care.",[28,62],"Bariatric Surgery",[64,65,66,67,68,69,70,71],"bariatric surgery","obesity","nursing education","digital health","exercise program","Quality of Life","Physical Activity","Randomized Controlled Trial","RECRUITING","2026-07-26",{"date":75,"type":39},"2026-07-28",{"date":77,"type":39},"2026-03-07",{"date":79,"type":22},"2026-12-31",{"name":81,"class":46},"Okan University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":47},"100633591","ultrasound-vs-clinical-parameters-for-difficult-airway-prediction-in-obesity-100633591","NCT07528677","Ultrasound vs Clinical Parameters for Difficult Airway Prediction in Obesity","Comparison of Airway Ultrasonography and Conventional Difficult Airway Parameters for Predicting Difficult Airway in Obese Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18-65 years\n* BMI \\>30 kg\u002Fm2\n* ASA physical status I, II, or III\n* Scheduled for elective surgery requiring orotracheal intubation under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Emergency surgery\n* History of previous head and neck surgery or radiotherapy\n* Known or anticipated difficult airway (history of difficult intubation)\n* Presence of cervical spine pathology or limited neck mobility\n* Presence of oropharyngeal or laryngeal pathology\n* Pregnancy\n* Patients with tracheostomy\n* Refusal to participate",{"count":90,"type":22},70,"OBSERVATIONAL","Obesity is associated with anatomical changes in the upper airway that increase the risk of difficult laryngoscopy and difficult mask ventilation during anesthesia. Conventional airway assessment parameters such as Mallampati score, neck circumference, and STOP-BANG scale are widely used but have limited predictive accuracy in obese patients. Airway ultrasonography has emerged as a promising non-invasive tool for difficult airway prediction; however, ultrasonographic criteria have not yet been standardized.\n\nThis prospective observational study aims to evaluate the utility of airway ultrasonography in predicting difficult airway in adult obese patients (BMI \\>30 kg\u002Fm²) scheduled for elective surgery under general anesthesia. Ultrasonographic measurements will include the distance from skin to hyoid bone (DSHB) at the level of the hyoid bone, the anterior neck soft tissue thickness at the thyrohyoid membrane level, and the hyomental distance ratio (HMDR). These parameters will be compared with conventional airway assessment tools and correlated with intraoperative Cormack-Lehane laryngoscopy grade and Han Scale mask ventilation score to determine their predictive value for difficult airway.",[28,94,95,96],"Difficult Airway","Difficult Airway Intubation","Difficult Mask Ventilation",[98,99,100,101,102,103,104,105,106,107,108,109],"Airway ultrasonography","Difficult airway prediction","Obese patients","Cormack-Lehane classification","Han Scale","Hyomental distance ratio","Distance from skin to hyoid bone","Neck circumference","Mallampati score","STOP-BANG scale","General anesthesia","Orotracheal intubation","2026-04-09",{"date":112,"type":39},"2026-04-14",{"date":114,"type":22},"2026-04-10",{"date":116,"type":22},"2026-11",{"name":118,"class":46},"Fatih Sultan Mehmet Training and Research Hospital",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":47},"100629586","the-ob-well-project-a-randomized-controlled-trial-of-an-internet-based-self-help-system-for-psychological-support-in-obesity-100629586","NCT07476599","The OB-WELL Project, a Randomized Controlled Trial of an Internet-Based Self-Help System for Psychological Support in Obesity","The OB-WELL Project: Study Protocol for a Three-Arm Randomized Controlled Trial of an Internet-Based Self-Help System for Psychological Support in Obesity","Inclusion Criteria:\n\n* Adults aged 18 years or older;\n* Body Mass Index (BMI) ≥ 30 kg\u002Fm²; 3. Internet access;\n* Sufficient computer and internet literacy;\n* Fluent knowledge of the Italian language;\n* Provision of informed consent via the digital platform;\n* Presence of mild or subthreshold psychological or eating-related symptoms, as identified by the Web Screening Questionnaire (WSQ);\n* Presence of a score \\\u003C 27 on the Binge Eating Scale (BES).\n\nExclusion Criteria:\n\n* Visual, auditory, or cognitive impairments that could limit effective interaction with the digital interface;\n* Diagnosis of severe psychiatric disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);\n* Insufficient digital literacy or lack of stable internet connectivity;\n* Concurrent psychopharmacological treatment or ongoing psychological\u002Fpsychotherapeutic intervention during the study period.",{"count":127,"type":22},224,[25],"Objective: This study aims to evaluate the feasibility and effectiveness of the OB-WELL program, an internet-based self-help intervention grounded in the principles of Cognitive Behavioral Therapy (CBT) and Brief Strategic Therapy (BST), designed to promote psychological well-being among individuals with obesity from the general Italian population. Methods: A three-arm randomized controlled trial with individual-level random allocation will be conducted to compare two active intervention formats - CBT and BST - with a waiting list (WL) control condition. The intervention will last six weeks and will consist of five online self-help modules followed by one individual synchronous session. Selected psychological outcomes will be assessed at baseline and immediately post-intervention (after 6 weeks). Participants in the experimental groups will also complete follow-up assessments at 3, 6, and 12 months after treatment termination.\n\nExpected results and conclusions: Both active interventions are expected to show greater improvements immediately post-treatment compared to the waitlist (WL) condition, and these effects are anticipated to be maintained over time. It is further hypothesized that the BST condition will demonstrate greater stability of psychological outcomes at follow-up compared to CBT.",[28],[132,30,133,134,135,136,137],"Internet-based interventions","Mental health","Cognitive Behavioral Therapy","Brief Strategic Therapy","Randomized controlled trial","Clinical psychology","2026-03-12",{"date":140,"type":39},"2026-03-17",{"date":142,"type":22},"2026-06-15",{"date":144,"type":22},"2027-06-30",{"name":146,"class":46},"Catholic University of the Sacred Heart"]