[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obesity-impaired-glucose-regulation-prediabetes-type-2-diabetes-mellitus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obesity-impaired-glucose-regulation-prediabetes-type-2-diabetes-mellitus":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100648774","time-restricted-eating-and-staple-food-reduction-combined-with-app-supported-exercise-for-weight-and-glycemic-control-100648774",false,"NCT07726615","Time-Restricted Eating and Staple Food Reduction Combined With App-Supported Exercise for Weight and Glycemic Control","A Multicenter Randomized Controlled Trial of Time-Restricted Eating, Staple Food Reduction, and App-Supported Exercise for Weight Loss and Glycemic Improvement in Adults With Obesity and Abnormal Glucose Metabolism","TRE-SFR-EX","Inclusion Criteria:\n\n* Age 18 to 50 years, all sexes.\n* Body mass index (BMI) \\>=28 kg\u002Fm2.\n* Willing and able to comply with study procedures and provide written informed consent.\n* Resident living near a participating study site and able to complete scheduled visits.\n* No habitual time-restricted eating or other fasting regimen, such as alternate-day fasting or fasting-mimicking diet.\n* Abnormal glucose metabolism or diabetes, defined as fasting plasma glucose \\>5.6 mmol\u002FL or HbA1c \\>5.7%.\n\nExclusion Criteria:\n\n* Secondary obesity, such as hypothyroidism or Cushing syndrome.\n* Use of weight-loss medication within 90 days before screening, or body weight change \\>5 kg within 90 days before screening.\n* Pregnant, lactating, or planning pregnancy during the study period.\n* Severe cardiac, hepatic, or renal dysfunction.\n* Severe psychiatric disease or cognitive impairment that prevents cooperation with the study.\n* Contraindication to exercise, such as severe osteoarthritis.\n* Unable or unwilling to follow the study diet and exercise intervention.\n* Long-term use of medications that may significantly affect body weight.\n* Active malignancy in any organ system.\n* Any other condition that, in the investigator's judgment, may affect efficacy or safety evaluation or make the participant unsuitable for the study.","ALL","18 Years","50 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","This multicenter, three-arm randomized controlled trial will evaluate the effects of early time-restricted eating and staple food reduction, each combined with an app-supported exercise intervention, on body weight and glycemic control among adults with obesity and abnormal glucose metabolism. A total of 300 participants aged 18 to 50 years with BMI \\>=28 kg\u002Fm2 and impaired glucose regulation or diabetes will be enrolled at five centers in China and randomized 1:1:1 to app-supported exercise alone, staple food reduction plus app-supported exercise, or early time-restricted eating plus app-supported exercise. The intervention lasts 12 weeks, followed by a 12-week post-intervention follow-up.",[28],"Obesity; Impaired Glucose Regulation; Prediabetes; Type 2 Diabetes Mellitus",[30],"time-restricted eating; staple food reduction; app-supported exercise; obesity; abnormal glucose metabolism; continuous glucose monitoring","NOT_YET_RECRUITING","2026-07-21",{"date":34,"type":35},"2026-07-24","ACTUAL",{"date":37,"type":22},"2026-07",{"date":39,"type":22},"2027-04",{"name":41,"class":42},"Peking University","OTHER"]