[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"occupational-lung-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:occupational-lung-diseases":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100650234","effect-of-aerobic-and-resistance-exercise-on-quarry-workers-100650234",false,"NCT07744334","Effect of Aerobic and Resistance Exercise on Quarry Workers","Aerobic Versus Resistance Exercise Training on Ventilatory Function in Quarry Workers","AE RE VF","Inclusion Criteria:\n\n* Male quarry workers.\n* The age range is between 30 and 40 years.\n* BMI values from 25 to 29.9 kg\u002Fm².\n* They work 5 to 6 times per weeks with mean exposure range (5-10 years) (Kumar et al., 2014). Exhibited chest manifestations (Respiratory symptoms) like cough, dyspnea, wheeze, and ventilatory impairment with significant reduction in (FEV1\u002FFVC\\\u003C70% and\u002For FVC\\\u003C80% and reduce Peak Expiratory flow 25- 75% (PEF25-75%)(Abdelwahaab et al., 2025).\n* Clinically stable (no exacerbation in past 4-6 weeks).\n* Low levels of physical activity (using the International Physical Activity Questionnaire-Short Version) (The Arabic version of the questionnaire will be used).\n\nExclusion criteria:\n\n* Patients with acute respiratory infections or recent exacerbation(4-6 weeks).\n* Asthmatic patient.\n* Chest cancer.\n* Musculoskeletal diseases and other disorders that could potentially impact the study's findings are excluded from the trial.\n* Other major lung diseases (e.g., TB, ILD, bronchiectasis, cancer).\n* Unstable cardiovascular disease.\n* Uncontrolled hypertension.\n* Severe musculoskeletal or neurological limitation to exercise.\n* Cognitive impairment.\n* Participation in PR in past 6 months.\n* Heavy smokers.","MALE","30 Years","40 Years",{"count":21,"type":22},75,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this randomized clinical trial is to compare the effects of aerobic exercise training and resistance exercise training on ventilatory function in quarry workers. It will also evaluate their effects on functional capacity and health-related quality of life (HRQOL).\n\nThe main questions it aims to answer are:\n\nDoes aerobic exercise training improve ventilatory function more effectively than resistance exercise training? How do aerobic and resistance exercise training affect functional capacity and health-related quality of life in quarry workers?\n\nResearchers will compare aerobic exercise training and resistance exercise training with a control group receiving routine treatment and breathing exercises to determine which intervention is more effective in improving ventilatory function, functional capacity, and health-related quality of life.\n\nParticipants will:\n\nBe randomly assigned to one of three groups: an aerobic exercise training group, a resistance exercise training group, or a control group.\n\nReceive the assigned intervention three times per week for eight consecutive weeks.\n\nUndergo ventilatory function assessment using spirometry. Complete assessments of functional capacity and health-related quality of life before and after the intervention.",[28,29,30],"Ventilatory Defect","Occupational Lung Diseases","Respiratory Disorders","RECRUITING","2026-08-03",{"date":34,"type":35},"2026-08-05","ACTUAL",{"date":37,"type":35},"2026-07-09",{"date":39,"type":22},"2027-01-25",{"name":41,"class":42},"Cairo University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100640455","clinical-utility-of-libs-multi-element-imaging-and-the-iff-algorithm-in-chronic-lung-diseases-100640455","NCT07597187","Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm in Chronic Lung Diseases","Evaluation of the Clinical Utility of LIBS Multi-Element Imaging and the IFF Algorithm for the Etiological and Medico-Legal Management of Chronic Lung Diseases","PNEUMO-LIBS","Inclusion Criteria:\n\n* Adult patient aged 18 years or older.\n* Diagnosis or documented clinical suspicion of chronic lung disease, including interstitial lung disease, pulmonary granulomatosis such as sarcoidosis, or pulmonary emphysema.\n* Availability of a lung tissue biopsy sample obtained during routine medical care and stored as a formalin-fixed paraffin-embedded sample.\n* Sufficient medical record information to document the clinical context, occupational or environmental exposure history, smoking status, imaging, pathology reports, and other relevant routine-care data.\n* No documented objection to the secondary use of health data and biological samples for this research.\n\nExclusion Criteria:\n\n* Documented objection to participation in the study or to the secondary use of health data or biological samples for research.\n* Missing, unavailable, degraded, or technically unusable biopsy sample.\n* Insufficient medical record information to document the clinical context or exposure history.\n* Lung condition outside the scope of the study, such as isolated acute infection, isolated cardiac disease, or primary lung cancer.\n* Patient under legal protection when the applicable legal conditions for non-opposition cannot be fulfilled.","ALL","18 Years",{"count":55,"type":22},70,"OBSERVATIONAL","PNEUMO-LIBS is a multicenter, non-interventional observational study designed to evaluate whether multi-element tissue imaging by Laser-Induced Breakdown Spectroscopy (LIBS), combined with an artificial intelligence-based analysis tool called Interesting Features Finder (IFF), may help physicians better understand the possible causes of chronic lung diseases.\n\nThe study focuses on adult patients with chronic lung diseases for which a lung biopsy has already been performed as part of routine medical care. These diseases include diffuse interstitial lung diseases, pulmonary granulomatoses such as sarcoidosis, and emphysema, especially when an environmental or occupational exposure is suspected but not clearly demonstrated.\n\nSome chronic lung diseases may be influenced by inhaled mineral or metallic particles, such as silica, aluminum, titanium, or other metals. However, these exposures are often difficult to document at the individual patient level. Standard clinical, radiological, and pathological investigations do not usually provide direct information on the presence and distribution of such elements within lung tissue.\n\nLIBS is an imaging technique that can detect and map chemical elements directly in tissue samples, including archived formalin-fixed paraffin-embedded biopsy blocks. In this study, lung biopsy samples will be analyzed with LIBS to search for elemental signatures that may be compatible with occupational or environmental exposures. The IFF algorithm will then be used to help interpret the LIBS data and identify rare or unexpected elemental signals.\n\nThe study does not require any additional biopsy, blood test, imaging examination, treatment, or hospital visit for participants. It uses tissue samples and medical data already collected during routine care. The results of LIBS and IFF analyses will be presented to the treating physician or investigator, who will complete standardized online questionnaires at three time points: before receiving the LIBS results, after receiving the LIBS report, and after receiving the IFF-assisted interpretation.\n\nThe main objective is to assess the perceived clinical utility of LIBS imaging for physicians, particularly regarding etiological understanding, possible occupational disease recognition, and prevention-oriented reasoning. Secondary objectives include assessing the added value of the IFF algorithm and evaluating the feasibility of a centralized multicenter workflow for sample transfer, LIBS analysis, IFF processing, result reporting, and questionnaire completion.\n\nThe study aims to include approximately 70 patients across several French hospital centers. Its results may support the development of future diagnostic, occupational health, and environmental medicine approaches, without modifying the medical care of participants during the study.",[59,60,61,29,62,63],"Interstitial Lung Diseases (ILD)","Pulmonary Emphysema","Chronic Lung Diseases","Environmental Exposure","Occupational Exposure","NOT_YET_RECRUITING","2026-05-12",{"date":67,"type":35},"2026-05-19",{"date":69,"type":22},"2026-07-01",{"date":71,"type":22},"2027-07-01",{"name":73,"class":42},"University Hospital, Grenoble"]