[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"older-adults-with-cognitive-decline\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:older-adults-with-cognitive-decline":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100652857","wearable-sensor-for-early-detection-and-monitoring-of-cognitive-decline-100652857",false,"NCT07780162","Wearable Sensor for Early Detection and Monitoring of Cognitive Decline","A MULTI-MODAL WEARABLE SENSOR FOR EARLY DETECTION OF COGNITIVE DECLINE AND REMOTE MONITORING OF COGNITIVE-MOTOR DECLINE OVER TIME","Inclusion Criteria:\n\n* Adults age 55 years or older\n* Ambulatory (able to walk 40 feet with or without walking assistance)\n* Willing and able to provide informed consent.\n* Individuals in the cognitive impairment group, should either have a diagnosis of cognitive impairment, a MoCA score of 25 or lower, or be confirmation of cognitive impairment by the Principal Investigator or clinical collaborators based on self-reported memory problems and relevant patient history. Individuals in the non-cognitively impaired group must have a MoCA score of 26 or higher.\n\nExclusion Criteria:\n\n* Children and younger adults: We exclude children and younger adults (younger than 55 years old) as dementia and cognitive-motor impairment is anticipated to be lower among those younger than 55.\n* Immobility or major mobility disorder: We will exclude those who were bedbound or unable to stand or ambulate with or without walking assistance (e.g., cane, walker) that prohibit them from performing the 40-foot walking test needed for the Fried Frailty Criteria.\n* Pre-existing acute conditions: We will exclude those with acute or unstable conditions (e.g., fractures) that may significantly affect gait and balance, according to the judgement of clinical investigators. In addition, we will exclude those with any significant medical or psychiatric condition that, in the judgment of the investigators, would potentially interfere with the ability to participate in the study.\n* Medication: Changes in medication regime unrelated to dementia or those taken temporarily that may affect balance and\u002For gait (e.g., narcotic, anxiety medication) based on judgement of our clinical investigators.\n* Severe vision, aphasia, or healing problems: We will exclude those with major hearing, aphasia, or visual problems, which may limit their ability to complete patient-reported outcomes, complete the cognitive screening assessments, and may impact Dual Task physical activities. Those with corrected vision or hearing problems (e.g., using prescription glasses, hearing aids, etc.) will be included.\n* Ongoing treatment: We will exclude those receiving active therapy (e.g., undergoing active chemotherapy or radiotherapy).\n* Lack of capacity to consent.\n* Other exclusion criteria include the inability to use telemedicine (e.g., no internet at home, severe visual or hearing problem, lack of caregiver support, etc.); inability or unwillingness to participate in scheduled in clinic visits (e.g., living farther than 30 miles from the clinic, unavailability of caregivers). We will also exclude those with significant cognitive impairment (MoCA score\\\u003C16), severe dementia, severe apathy, severe aphasia or speaking problems, severe depression, those who are on hospice care or palliative care, those with severe pain, and with history of drug or alcohol abuse over the last six months. Finally, we will exclude those who are unable to communicate in English or are unlikely to fully comply with the follow-up protocol (e.g., long travel distance).","ALL","55 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","This observational study will enroll approximately 100 participants evenly split by cognitive status (Cognitively Impaired vs Non-Cognitively Impaired), and involves four clinic visits over one year (at baseline, 3, 6, and 12 months), each followed by 7 days of remote monitoring to assess the long-term feasibility of PAMSys+ (Physical Activity Monitoring System).",[24,25,26],"Mild Cognitive Impairment (MCI)","Older Adults With Cognitive Decline","Older Adults",[28,29,30],"digital health","wearable sensors","mild cognitive impairment","NOT_YET_RECRUITING","2026-08-19",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":20},"2026-12-15",{"date":39,"type":20},"2030-03-30",{"name":41,"class":42},"BioSensics","INDUSTRY",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":5},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors","65 Years",{"count":52,"type":20},64,"INTERVENTIONAL",[55],"NA","The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[25,26,58,59,60,61,62],"AI-Based Fitness","Wearables","Cognitive Decline","Physical Activity","Physical Inactivity",[64,65,58,61,62,66,67,68],"Older adults","Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults","RECRUITING","2026-06-10",{"date":72,"type":35},"2026-06-15",{"date":74,"type":35},"2026-06-08",{"date":76,"type":20},"2028-06-08",{"name":78,"class":79},"The University of Tennessee, Knoxville","OTHER"]