[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:older-adults":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,54,0,25,[9,45,76,101,118,160,189,220,248,268,297,336,371,400,424,453,478,500,531,553,584,608,636,661,685],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100652857","wearable-sensor-for-early-detection-and-monitoring-of-cognitive-decline-100652857",false,"NCT07780162","Wearable Sensor for Early Detection and Monitoring of Cognitive Decline","A MULTI-MODAL WEARABLE SENSOR FOR EARLY DETECTION OF COGNITIVE DECLINE AND REMOTE MONITORING OF COGNITIVE-MOTOR DECLINE OVER TIME","Inclusion Criteria:\n\n* Adults age 55 years or older\n* Ambulatory (able to walk 40 feet with or without walking assistance)\n* Willing and able to provide informed consent.\n* Individuals in the cognitive impairment group, should either have a diagnosis of cognitive impairment, a MoCA score of 25 or lower, or be confirmation of cognitive impairment by the Principal Investigator or clinical collaborators based on self-reported memory problems and relevant patient history. Individuals in the non-cognitively impaired group must have a MoCA score of 26 or higher.\n\nExclusion Criteria:\n\n* Children and younger adults: We exclude children and younger adults (younger than 55 years old) as dementia and cognitive-motor impairment is anticipated to be lower among those younger than 55.\n* Immobility or major mobility disorder: We will exclude those who were bedbound or unable to stand or ambulate with or without walking assistance (e.g., cane, walker) that prohibit them from performing the 40-foot walking test needed for the Fried Frailty Criteria.\n* Pre-existing acute conditions: We will exclude those with acute or unstable conditions (e.g., fractures) that may significantly affect gait and balance, according to the judgement of clinical investigators. In addition, we will exclude those with any significant medical or psychiatric condition that, in the judgment of the investigators, would potentially interfere with the ability to participate in the study.\n* Medication: Changes in medication regime unrelated to dementia or those taken temporarily that may affect balance and\u002For gait (e.g., narcotic, anxiety medication) based on judgement of our clinical investigators.\n* Severe vision, aphasia, or healing problems: We will exclude those with major hearing, aphasia, or visual problems, which may limit their ability to complete patient-reported outcomes, complete the cognitive screening assessments, and may impact Dual Task physical activities. Those with corrected vision or hearing problems (e.g., using prescription glasses, hearing aids, etc.) will be included.\n* Ongoing treatment: We will exclude those receiving active therapy (e.g., undergoing active chemotherapy or radiotherapy).\n* Lack of capacity to consent.\n* Other exclusion criteria include the inability to use telemedicine (e.g., no internet at home, severe visual or hearing problem, lack of caregiver support, etc.); inability or unwillingness to participate in scheduled in clinic visits (e.g., living farther than 30 miles from the clinic, unavailability of caregivers). We will also exclude those with significant cognitive impairment (MoCA score\\\u003C16), severe dementia, severe apathy, severe aphasia or speaking problems, severe depression, those who are on hospice care or palliative care, those with severe pain, and with history of drug or alcohol abuse over the last six months. Finally, we will exclude those who are unable to communicate in English or are unlikely to fully comply with the follow-up protocol (e.g., long travel distance).","ALL","55 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","This observational study will enroll approximately 100 participants evenly split by cognitive status (Cognitively Impaired vs Non-Cognitively Impaired), and involves four clinic visits over one year (at baseline, 3, 6, and 12 months), each followed by 7 days of remote monitoring to assess the long-term feasibility of PAMSys+ (Physical Activity Monitoring System).",[25,26,27],"Mild Cognitive Impairment (MCI)","Older Adults With Cognitive Decline","Older Adults",[29,30,31],"digital health","wearable sensors","mild cognitive impairment","NOT_YET_RECRUITING","2026-08-19",{"date":35,"type":36},"2026-08-21","ACTUAL",{"date":38,"type":21},"2026-12-15",{"date":40,"type":21},"2030-03-30",{"name":42,"class":43},"BioSensics","INDUSTRY",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100640906","feasibility-and-effects-of-inspiratory-muscle-training-combined-with-blood-flow-restriction-for-frail-older-adults-100640906","NCT07573995","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years and older who are classified as at least \"vulnerable\" using the Clinical Frailty Scale (score ≥4).\n* Participants must have no cognitive impairment and be able to follow commands, as assessed by the Mini-Mental State Examination (MMSE).\n\nExclusion Criteria:\n\n* (1) are unable to participate in exercise (e.g., due to severe musculoskeletal disorders)\n* (2) have high-risk factors for exercise, such as uncontrolled hypertension (\\>150 mmHg systolic blood pressure (SBP) \u002F \\>90 mmHg diastolic blood pressure (DBP), coagulation disorders, and deep venous thrombosis\n* (3) have hematological disorders or are using hematology related-medications\n* (4) have significant comorbidities, including a history of stroke, diabetes with severe complications, or cardiovascular diseases\n* (5) chronic lung conditions (e.g., obstructive pulmonary disease, asthma), and\n* (6) have participated in a structured exercise training program within the past 3 months at a frequency exceeding three sessions per week.","65 Years",{"count":54,"type":21},30,"INTERVENTIONAL",[57],"NA","This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults. Outcomes of interest include feasibility, physical function, respiratory muscle strength, handgrip strength, five-times sit-to-stand performance, body composition, frailty level, fall efficacy, blood pressure, and adverse events.",[60,27,61,62],"Frailty Syndrome","Blood Flow Restriction (BFR) Training Effects","Inspiratory Muscle Training",[64,65,66,67],"frailty","older adults","blood flow restriction","inspiratory muscle training",{"date":35,"type":36},{"date":70,"type":21},"2026-07-30",{"date":72,"type":21},"2027-07-31",{"name":74,"class":75},"Taipei Medical University","OTHER",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":55,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100652530","the-effect-of-iot-based-smart-exercises-system-in-the-senior-adults-coordination-100652530","NCT07772726","The Effect of IoT-based Smart Exercises System in the Senior Adults: Coordination","Smart Health Care and Innovative Technology Service Model Plan: Development of Innovative Health Promotion System for Senior Adults","Inclusion Criteria:\n\n* Adult over 50 years old\n* No significant limb disability or joint deformation\n* No history of cardiovascular disease\n* Never lost balance due to dizziness in the past 12 months\n\nExclusion Criteria:\n\n* limb disability or joint deformation\n* history of cardiovascular disease\n* lost balance due to dizziness in the past 12 months\n* cognitive deficits",true,"50 Years",{"count":20,"type":21},[57],"Subjects are divided into two groups, (1) Control (Ctrl) and (2) Smart Exercise (SE) group. Participants in the Ctrl group are instructed to perform combined muscle strength and coordination exercises twice weekly, with each session lasting 30 minutes, following an exercise guide recommended by a physical therapist. Participants in the SE group perform combined muscle strength and coordination training using the Smart Exercise System twice weekly, with each session lasting 30 minutes, for 12 weeks. Physical fitness tests, coordination tests, and questionnaires are administered to participants in both groups before and after the 12-week exercise program.",[27],[27,90,91],"Smart Exercises System","Coordination","RECRUITING","2026-08-14",{"date":33,"type":36},{"date":96,"type":36},"2023-08-07",{"date":98,"type":21},"2027-08-31",{"name":100,"class":75},"National Cheng-Kung University Hospital",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":55,"phases":108,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":114,"startDateStruct":115,"completionDateStruct":116,"leadSponsor":117,"locationsCount":44},"100652365","the-effect-of-iot-based-smart-exercises-system-in-the-senior-adults-resistance-band-training-system-100652365","NCT07772713","The Effect of IoT-based Smart Exercises System in the Senior Adults: Resistance Band Training System",{"count":107,"type":21},80,[57],"Subjects are divided into two groups, (1) Control (Ctrl) and (2) Smart Exercise (SE) group. Participants in the Ctrl group are instructed to perform resistance band training twice weekly according to a paper-based exercise guide, whereas participants in the SE group are instructed to perform resistance band training twice weekly for 12 weeks using the Resistance Band Training System. The physical fitness tests and questionnaire of both groups are performed before and after the 12-week exercise program.",[27],[27,112,90,113],"Home-based Training","Physical Function",{"date":33,"type":36},{"date":96,"type":36},{"date":98,"type":21},{"name":100,"class":75},{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":55,"phases":129,"briefSummary":131,"conditions":132,"keywords":137,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":44},"100651334","phase-2-hmb-plus-vitamin-d-to-preserve-muscle-in-older-adults-starting-semaglutide-100651334","NCT07760948","HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide","Preserving the Metabolic Engine: HMB Supplementation to Combat Iatrogenic Sarcopenia and Metabolic Adaptation in Older Adults Initiating Semaglutide Therapy","PRESERVE-HMB","Inclusion Criteria:\n\n* Age 65 to 85 years, inclusive.\n* Type 2 diabetes mellitus, defined by HbA1c at or above 6.5% or current use of antihyperglycemic medication.\n* Body mass index at or above 27 kg\u002Fm2.\n* Newly initiating semaglutide as standard clinical care under the direction of a treating clinician.\n* Able to walk 400 meters without assistance; use of a cane is permitted.\n* Able to understand and provide legally effective informed consent.\n* English speaking for the initial study because the consent documents, questionnaires, study-product instructions, safety instructions, and procedure-specific materials are available only in English.\n\nExclusion Criteria:\n\n* Estimated glomerular filtration rate below 45 mL\u002Fmin\u002F1.73 m2.\n* Use of HMB, creatine, or high-dose whey protein supplements within the previous 3 months.\n* Weight change greater than 5% during the previous 3 months.\n* Recent fracture within the previous 6 months.\n* Neuromuscular disease, including Parkinson disease, or another condition that would interfere with study outcomes or safe participation.\n* Chronic corticosteroid use.\n* Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.\n* History of pancreatitis.\n* Smoking more than 7 cigarettes per day.\n* Previous malabsorptive or restrictive intestinal surgery or a malabsorptive syndrome.\n* Pregnancy or breastfeeding.\n* Recent history of neoplasia within the previous 5 years, as defined by the protocol.\n* Other active inflammatory conditions or neuromuscular disorders that could interfere with study outcomes or safety.\n* Serum 25-hydroxyvitamin D below 15 ng\u002FmL.\n* Any medical, functional, laboratory, medication-related, or safety condition that the investigator determines makes study participation unsafe or prevents completion of essential procedures.","85 Years",{"count":128,"type":21},90,[130],"PHASE2","This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults aged 65 to 85 years with type 2 diabetes who are newly starting semaglutide as part of usual clinical care. Participants will receive calcium-HMB plus vitamin D3 or matching placebo for approximately 6 months. The primary outcome is change in appendicular lean mass measured by dual-energy X-ray absorptiometry from baseline to month 6. Secondary assessments include body composition, muscle strength, physical performance, gait, physical activity, resting metabolic rate, metabolic measures, and whole-body quantitative computed tomography. An optional mechanistic substudy of up to 36 participants will include D3-creatine dilution, nonradioactive stable isotope infusions, repeated blood sampling, a standardized meal, breath sampling, and vastus lateralis muscle biopsies at baseline and month 6.",[133,134,135,136,27],"Type 2 Diabetes Mellitus (T2DM)","Sarcopenia","Obesity","Muscle Loss",[138,139,140,141,142,143,144,145,146,147,65,148,149,150],"semaglutide","GLP-1 receptor agonist","beta-hydroxy-beta-methylbutyrate","HMB","calcium-HMB","vitamin D3","appendicular lean mass","metabolic adaptation","resting metabolic rate","skeletal muscle","D3-creatine","muscle protein synthesis","muscle protein breakdown","2026-08-07",{"date":153,"type":36},"2026-08-12",{"date":155,"type":21},"2026-12-01",{"date":157,"type":21},"2030-11",{"name":159,"class":75},"Vanderbilt University Medical Center",{"id":161,"slug":162,"hasResults":12,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":83,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":55,"phases":169,"briefSummary":170,"conditions":171,"keywords":176,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":44},"100649604","perioperative-transcranial-photobiomodulation-and-delayed-neurocognitive-recovery-in-older-patients-100649604","NCT07736092","Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients","Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial","Inclusion Criteria:\n\n* Aged 65 years or older.\n* Preoperative Mini-Mental State Examination (MMSE) \\\u003C27.\n* Scheduled to undergo non-cardiac, non-neurosurgical surgery under general anesthesia, with an expected surgical duration \\>1 hour.\n* Planned hospital stay of at least 1 day before surgery and at least 2 days after surgery.\n\nExclusion Criteria:\n\n* Communication barriers before surgery due to coma, severe dementia, or language disorders.\n* History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or delirium before surgery.\n* History of brain injury, tumors, or surgery, or intracranial metal implants, or skin or soft tissue injuries on the head or face.\n* History of ischemic or hemorrhagic stroke within 3 months before surgery.\n* An American Society of Anesthesiologists class ≥ IV.\n* Enrolled in other interventional studies.\n* Other conditions deemed unsuitable for study participation.",{"count":168,"type":21},130,[57],"Delayed neurocognitive recovery is a common neurocognitive complication in older patients after surgery, especially those with preoperative neurocognitive decline. Transcranial photobiomodulation therapy is a novel neuromodulation technique using transcranial low-power light to modulate brain biological functions. This technique has been used to treat various neurological or psychiatric conditions, including ischemic stroke, traumatic brain injury, and major depression. This study is designed to explore whether using transcranial photobiomodulation therapy during the perioperative period can reduce the incidence of delayed neurocognitive recovery in older patients with pre-existing neurocognitive impairment.",[27,172,173,174,175],"Surgery","Transcranial Photobiomodulation","Delayed Neurocognitive Recovery","Postoperative Delirium",[177,172,178,179,180],"Older adults","Transcranial photobiomodulation","Delayed neurocognitive recovery","Postoperative delirium",{"date":182,"type":36},"2026-08-10",{"date":184,"type":36},"2026-08-05",{"date":186,"type":21},"2027-07",{"name":188,"class":75},"Peking University First Hospital",{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":55,"phases":197,"briefSummary":198,"conditions":199,"keywords":207,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":44},"100585459","geriatric-trauma-care-program-for-living-alone-older-adults-with-injuries-100585459","NCT06902636","Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Patient Experience of Older Adults Living Alone With Injuries and Long-Term Effects of Geriatric Trauma Care Program for Living Alone Older Adults With Injuries","Inclusion Criteria:\n\n1. willing to join this study for three months\n2. with limb injuries\n3. living alone in a household\n4. aged 65 years old or older\n5. independent before a traumatic injury\n6. having a smartphone.\n\nExclusion Criteria:\n\n1. with an ISS greater than 16 (severe injuries)\n2. having cognitive impairments\n3. diagnosed with psychiatric illness",{"count":128,"type":21},[57],"To examine the long-term effects of the Geriatric Trauma Care Program (GTCP) regarding pain, functional disability, depression, loneliness, and health-related quality of life among older adults with traumatic injuries who live alone.",[200,27,201,202,203,204,205,206],"Limb Injury","Geriatric","Pain","Geriatric Depression","Barthel Index","Quality of Life","Loneliness",[208,209,65,210],"Limb injury","geriatric trauma","loneliness","2026-08-04",{"date":213,"type":36},"2026-08-06",{"date":215,"type":36},"2025-03-27",{"date":217,"type":21},"2026-10-31",{"name":219,"class":75},"Kaohsiung Medical University",{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":12,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":55,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":247},"100561314","improving-needs-among-older-adults-100561314","NCT06588556","Improving Needs Among Older Adults","Improving Needs Among Older Adults: the ICUconnect 2 Primary Palliative Care RCT","ICUconnect 2","Inclusion Criteria:\n\nPatients (who are not interviewed but whose characteristics prompt enrollment of family members)\n\n1. Adult aged ≥18 years\n2. Managed in an adult medical, cardiac, trauma, surgical, or neurological ICU\n3. Serious acute illness associated with a need for invasive mechanical ventilation\n4. ICU team expect patient to require mechanical ventilation for 2 or more days\n\nFamily members\n\n1. Adult aged ≥18 years\n2. Family member: self-described as the individual (related or unrelated) who provides the most support and with whom the eligible patient has a significant relationship (Society of Critical Care Medicine definition of family; Davidson J, et al. Crit Care Med, 45:103-128; 2017)\n\nICU clinicians\n\n1. Adult aged ≥18 years\n2. ICU clinician: ICU attending caring for the eligible patient on the day of family member informed consent\n\nExclusion Criteria:\n\nPatients\n\n1. Death or full comfort care plan expected within 24 hours by ICU attending or fellow physician Rationale: measurable intervention effect unlikely\n2. Palliative care consultative team and\u002For palliative care specialists are currently involved in the patient's care.\n\n   Rationale: this would dilute the intervention's effect.\n3. ICU length of stay \\>4 days during current ICU admission. Rationale: this would dilute intervention effect by widening the timeframe of family-clinician interactions and limiting standardization.\n\n6\\. Imprisoned person. Rationale: this is a vulnerable population.\n\nFamily members\n\n1. Low palliative care need burden (i.e., NEST scale score \\\u003C15) at baseline. Rationale: if there are very low baseline needs, the intervention cannot impact the primary outcome measure (i.e., NEST).\n2. Lack of English or Spanish fluency, operationalized as need for a translator to understand medical forms or participate in medical discussions.\n\n   Rationale: the app has not been translated into other languages; also, many outcome measures aren't validated in languages other than English and Spanish.\n3. Endorsement of suicidal ideation (i.e., PHQ-9 suicidality item) at the time of baseline data collection.\n\n   Rationale: this indicates a serious level of distress that will require professional assistance beyond that provided by the intervention (or control).\n4. Patient regains decisional capacity after informed consent but before the first family meeting. Rationale: as in our past ICU-based studies, this circumstance (the entry of the patient as a decision maker), would substantially change the nature of the interactions of family members and clinicians.\n5. The ICU clinician changes from a consented clinician to a non-consented clinician before the first family meeting. Rationale: in this circumstance the intervention cannot be fully deployed.\n\nICU clinicians None","18 Years",{"count":230,"type":21},350,[57],"Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists' limited workforce and geographic inconsistency. To address these gaps, the investigators developed an innovative mobile app-based primary palliative care intervention called ICUconnect. ICUconnect facilitates families' and patients' self-report of actual palliative care needs across all core domains of palliative care quality, provides ICU clinicians with a scalable digital infrastructure for coordinating consistent and personalized needs-targeted care, and provides a variety of informational supports relevant to each user's role. In this RCT, the investigators will test ICUconnect vs. usual care control among 350 patient-family member dyads with elevated baseline levels of unmet palliative care need in a 4-site network serving a diverse population (Duke, Medical University of South Carolina, University of Alabama at Birmingham, Columbia).\n\nThe specific aims are to: (1) Test the efficacy of ICUconnect vs. usual care control in improving palliative care needs and other person-centered outcomes including psychological distress, (2) Determine participant characteristics associated with a greater treatment response using a heterogeneity of treatment effects approach, and (3) Ensure off-the-shelf intervention readiness for implementation using a mixed-methods integration of qualitative analysis of semi-structured trial participant interviews and quantitative RE-AIM implementation framework-informed trial data.",[234,235,27,236,237],"Critical Illness","Palliative Care","Informal Caregivers","Care Delivery Model","2026-07-22",{"date":240,"type":36},"2026-07-23",{"date":242,"type":36},"2025-09-16",{"date":244,"type":21},"2028-12-31",{"name":246,"class":75},"Duke University",4,{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":83,"sex":17,"minAge":52,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":55,"phases":258,"briefSummary":259,"conditions":260,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":266,"locationsCount":44},"100540984","tvns-during-motor-training-in-older-adults-100540984","NCT06323954","tVNS During Motor Training in Older Adults","Pairing tVNS With Motor Skill Training in Older Adults","Inclusion Criteria:\n\n* 65-84 years old across all races, genders, and ethnicities.\n* Physically and cognitively healthy\n\nExclusion Criteria:\n\n* Younger than 65 years old or older than 84 years old\n* Current or history of cardiac disease\n* Have an implanted device such as a neurostimulator or cochlear implant\n* Current or history of tympanic membrane perforation\n* Have a musculoskeletal issue that prevents hand function (e.g., arthritis)\n* Have a vision problem not corrected by glasses or contact lenses\n* Uncorrected auditory impairments\n* Had a stroke or lesion (including tumor) in the brain\n* Had a head injury or brain surgery\n* Suffer from frequent or severe headaches\n* Had a fainting spell or syncope\n* Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work\n* Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines\n* Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer)\n* Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor)\n* Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion\n* Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia)\n* Suspected of pregnancy\n* Pregnant\n* Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \\\u003C26)\n* Musculoskeletal condition or injury that would limit hand range of motion","84 Years",{"count":257,"type":21},34,[57],"The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning. Participants will be randomly assigned to tVNS or sham group and receive tVNS or sham, respectively, at the outer ear during finger control training sessions. Finger control performance will be tested before and after the training sessions without outer ear stimulation.",[27],"2026-07-20",{"date":238,"type":36},{"date":264,"type":36},"2025-05-27",{"date":72,"type":21},{"name":267,"class":75},"Georgia Institute of Technology",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":12,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":55,"phases":278,"briefSummary":279,"conditions":280,"keywords":282,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":296},"100588395","a-pilot-randomized-controlled-trial-of-the-hopeful-and-healthy-living-program-100588395","NCT06940843","A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program","Enhancing Social Connection, Health, and Aging in Older Persons: A Pilot Randomized Trial of the Hopeful and Healthy Living (HHL) Program","(HHL)","Inclusion Criteria:\n\n50 years or older, diagnosis of a serious mental illness, and a member of Center Club or Transitions of Boston\n\nExclusion Criteria:\n\nDiagnosis of dementia or other progressive neurological disorder",{"count":277,"type":21},60,[57],"The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle activities. The Hopeful and Healthy Living (HHL) intervention combines social skills training and training in cognitive self-management strategies in order to help older adults build healthy lifestyle and social routines. We predict that:\n\n* Individuals who participate in the HHL intervention will improve more in perceived social support (i.e., what people get from relationships such as reliance, reassurance of worth, attachment) and loneliness at the 4-, 8-, and 12-month follow-up assessments than those who receive treatment as usual (TAU).\n* Individuals who participate in the HHL intervention will improve more in overall psychosocial functioning at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n* Individuals who participate in the HHL intervention will improve more in cognitive functioning at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n* Individuals who participate in the HHL intervention will improve more in healthy behaviors (sleep, activity, diet) at the 4-, 8-, and 12-month follow-up assessments than those who receive TAU.\n\nIn this trial, participants will be either receive the HHL intervention or participate in their regular treatment activities (treatment as usual). HHL vs. TAU will be compared to see if there are any differences in social support, cognition, loneliness, psychosocial functioning, or healthy lifestyle activities including physical activity, sleep, and diet.\n\nParticipants will be asked to complete an interview-based assessment at baseline, 4-months, 8-months, and 12-months. After completing the baseline assessment, those who are in the experimental group will participate in the 16-week long HHL group intervention.",[281,27],"Serious Mental Illness",[283,284,285,286,287],"psychosocial interventions","cognitive interventions","social skills interventions","healthy lifestyle interventions","older adults with SMI","2026-07-17",{"date":261,"type":36},{"date":291,"type":36},"2025-03-12",{"date":293,"type":21},"2028-07-31",{"name":295,"class":75},"Boston University Charles River Campus",2,{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":55,"phases":307,"briefSummary":308,"conditions":309,"keywords":320,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":44},"100646109","evaluation-of-choose-to-move-replacement-ready-ctm-rr-100646109","NCT07696650","Evaluation of Choose to Move Replacement Ready (CTM-RR)","Choose to Move Replacement Ready: Implementation and Effectiveness of a Virtual Health-Promoting Intervention for People Awaiting Total Hip or Knee Replacement Surgery","CTM-RR","Inclusion Criteria:\n\n1. Activity coach hired by the Active Aging Society (activity coaches must speak English to participate in the evaluation);\n2. English-speaking older adults (aged \\>=50 years) who participate in CTM-RR will be invited to participate in the evaluation;\n3. Referral partner (People who work in a healthcare setting who refer patients into the program)\n\nExclusion Criteria:\n\n1. non-English speaking activity coach\n2. non-English speaking referral partner",{"count":306,"type":21},210,[57],"Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \\>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR\u002FTHR) for osteoarthritis (OA). The primary goals of this observational study are to describe how the adapted program, Choose to Move Replacement Ready (CTM-RR), is implemented in BC and determine if the adapted program improves health outcomes in people with hip and\u002For knee osteoarthritis who are on surgical waitlists for TKR\u002FTHR. The investigators will also evaluate whether any health benefits achieved by CTM-RR participants are maintained three months after they finish the program and also during the remaining time that they wait for their TKR\u002FTHR surgery.\n\nThe investigators will work with referral partners from hospitals and orthopaedic clinics in BC to recruit participants into CTM-RR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.",[310,311,312,313,314,315,316,27,317,202,318,319],"Osteoarthritis (OA)","Osteoarthritis (OA) of the Hip","Osteoarthritis (OA) of the Knee","Total Knee Anthroplasty","Total Hip Arthroplasty (THA)","Mobility Limitation","Physical Activity","Social Isolation or Loneliness","Implementation Science","Sedentary Behaviors",[321,322,323,324,177,325,326,206,202],"Osteoarthritis","Implementation science","Physical activity","Social isolation","Mobility","Joint replacement","2026-07-08",{"date":329,"type":36},"2026-07-10",{"date":331,"type":21},"2026-08",{"date":333,"type":21},"2028-08",{"name":335,"class":75},"University of British Columbia",{"id":337,"slug":338,"hasResults":12,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":83,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":346,"conditions":347,"keywords":351,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":370},"100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159","NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent",{"count":345,"type":21},400,"This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[348,349,27,350,175],"Frailty","Cognitive Impairment","Hip Arthroplasty",[352,353,354,355,356,357,358,359,360,361],"ALBA test","CAM-ICU","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Clinical Frailty Scale","Total Hip Replacement","Observational Study","Prospective Cohort",{"date":363,"type":36},"2026-07-09",{"date":365,"type":36},"2026-04-24",{"date":367,"type":21},"2030-03-31",{"name":369,"class":75},"Tomas Bata Hospital, Czech Republic",7,{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":55,"phases":380,"briefSummary":381,"conditions":382,"keywords":385,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":44},"100535061","healthy-aging-as-black-adults-in-it-together-a-comparative-effectiveness-study-of-chronic-pain-and-cognitive-decline-100535061","NCT06246929","Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline","Comorbidity of Chronic Pain and Early Cognitive Decline Among Older, Community-Based Black Adults: Comparative Effectiveness of Mindfulness-Based Cognitive Therapy With Walking (MBCT+w) vs Active Living Every Day (ALED)","HABIT","Inclusion Criteria:\n\n* Black adults, male and females, age 50 or older\n* Have nonmalignant musculoskeletal chronic pain for more than three months\n* Reports early cognitive decline (subjective and objective)\n* Telephone Interview for Cognitive Status-41 score greater than or equal to 31\n* Functional Activities Questionnaire score less than 9\n* English fluency\u002Fliteracy\n* Free of concurrent psychotropic or pain medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic or pain medication for a minimum of 6 weeks and willing to maintain stable dose\n* Cleared by medical doctor for study participation and no self-reported concerns about physical functioning on the revised Physical Activity Readiness Questionnaire (PAR-Q; score 0)\n\nExclusion Criteria:\n\n* Diagnosed with dementia or neurodegenerative disease\n* Regular use of nonpharmacological pain management\n* Diagnosed with serious mental illness or substance abuse\n* Current suicidal ideation on self-report\n* Engagement of regular exercise for more than 30 minutes daily\n* Unable to walk",{"count":345,"type":21},[57],"The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active Living Every Day (ALED). The investigators will assess how each program may help in improving physical, cognitive, and emotional function. The investigators will also assess whether improvements in outcomes from the two programs are maintained through a 6-month follow-up.",[383,316,27,384],"Chronic Pain","Mild Cognitive Impairment",[386,387,388,389,202,390],"Black Older Adults","African Americans","Subjective Cognitive Decline","Memory Related Problems","Cognition Disorders","2026-07-02",{"date":393,"type":36},"2026-07-07",{"date":395,"type":36},"2025-01-10",{"date":397,"type":21},"2028-12-15",{"name":399,"class":75},"Massachusetts General Hospital",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":17,"minAge":407,"maxAge":126,"enrollmentInfo":408,"targetDuration":410,"studyType":22,"phases":4,"briefSummary":411,"conditions":412,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":44},"100641165","an-ai-based-prediction-of-cognitive-capacity-in-older-adults-and-individuals-with-mild-cognitive-impairment-during-virtual-reality-driving-tasks-100641165","NCT07656389","An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks","From Eye Movements to Visuomotor Coupling: An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks","Inclusion Criteria:\n\n* (1) a score of 23 or higher on the Montreal Cognitive Assessment; (2) a Clinical Dementia Rating score of 0 for cognitively healthy participants or 0.5 for participants with mild cognitive impairment (MCI); (3) healthy young adults aged between 30 and 39 years, and cognitively healthy older adults and participants with MCI aged between 65 and 85 years; (4) right-hand dominance; and (5) adequate visual function to complete VR and eye-tracking tasks, defined as corrected binocular visual acuity of at least 0.5 without severe visual field deficits.\n\nExclusion Criteria:\n\n* (1) the presence or history of major psychiatric disorders or central nervous system diseases; (2) significant ocular diseases, such as untreated cataracts, active retinal diseases, moderate-to-severe or poorly controlled glaucoma, or marked visual field deficits beyond a specified level; (3) epilepsy; and (4) severe dizziness or VR-induced motion sickness.","30 Years",{"count":409,"type":21},192,"12 Months","Driving ability in older adults is essential for independent mobility and social participation, yet declines under high cognitive load or distraction often lead to visual attention failures such as \"look-but-fail-to-see,\" increasing crash risk. Older adults and individuals with mild cognitive impairment (MCI) show impairments in visual attention, executive control, and visuomotor integration, which are not adequately captured by conventional assessments. Virtual reality (VR) integrated with eye-tracking and upper-limb motion analysis enables ecologically valid simulation of driving scenarios and precise quantification of visuomotor behavior. However, current studies are limited by single-scenario designs, unimodal AI models, and insufficient integration of action-related data.\n\nThis study proposes a multi-phase framework: Year 1 develops an eye-movement-based AI model for MCI identification; Year 2 integrates multimodal data in VR driving tasks; and Year 3 establishes an explainable AI system with longitudinal validation. The study aims to advance cognitive assessment and develop a digital tool for early MCI detection and driving risk prediction.",[25,413,414,415,27],"Virtual Reality","Eye Movement Disorder","Multimodal Monitoring","2026-06-14",{"date":418,"type":36},"2026-06-18",{"date":420,"type":21},"2026-06-20",{"date":422,"type":21},"2029-12-31",{"name":100,"class":75},{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":55,"phases":432,"briefSummary":433,"conditions":434,"keywords":439,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":296},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors",{"count":431,"type":21},64,[57],"The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[26,27,435,436,437,316,438],"AI-Based Fitness","Wearables","Cognitive Decline","Physical Inactivity",[177,440,435,316,438,441,442,443],"Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults","2026-06-10",{"date":446,"type":36},"2026-06-15",{"date":448,"type":36},"2026-06-08",{"date":450,"type":21},"2028-06-08",{"name":452,"class":75},"The University of Tennessee, Knoxville",{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":17,"minAge":460,"maxAge":4,"enrollmentInfo":461,"targetDuration":4,"studyType":55,"phases":462,"briefSummary":464,"conditions":465,"keywords":469,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":44},"100638812","phase-4-intranasal-dexmedetomidine-esketamine-on-sleep-and-cognition-in-older-adults-with-mild-to-moderate-cognitive-impairment-100638812","NCT07610343","Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment","Impact of Intranasal Dexmedetomidine-esketamine on Sleep Quality and Cognitive Function in Older Adults With Mild-to-moderate Cognitive Impairment: a Randomized, Double-blind, and Placebo-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥ 60 years.\n2. Meeting the clinical diagnostic criteria for Alzheimer's disease, with mild cognitive impairment (MoCA score 18-25) or moderate cognitive impairment (MoCA score 10-17) due to Alzheimer's disease.\n3. Comorbid with sleep disorders (Pittsburgh Sleep Quality Index \\[PSQI\\] score ≥ 7).\n4. Signed informed consent.\n\nExclusion Criteria:\n\n1. Cognitive impairment\u002Fdementia due to other causes (e.g., vascular dementia, frontotemporal dementia, Parkinson's disease dementia).\n2. Unsuitable for intranasal administration due to nasal cavity diseases (e.g., rhinitis, nasal polyps, or nasal congestion of any cause).\n3. Inability to communicate due to visual, auditory, language, or other reasons, or Mini-Mental State Examination (MMSE) score ≤ 9 or MoCA score ≤ 9.\n4. History of schizophrenia, epilepsy, or Parkinson's disease, or confirmed diagnosis of glaucoma, hyperthyroidism, pheochromocytoma, or myasthenia gravis.\n5. Confirmed diagnosis of restless legs syndrome or sleep apnea, or judged to be at high risk of moderate-to-severe sleep apnea according to STOP-Bang score, or Body Mass Index (BMI) \\> 30 kg\u002Fm2.\n6. History of stroke or transient ischemic attack within 12 months prior to enrollment, confirmed intracranial aneurysm, or elevated intracranial pressure from any cause.\n7. Uncontrolled hypertension (e.g., hypertensive crisis or systolic blood pressure \\> 160 mmHg and\u002For diastolic blood pressure \\> 100 mmHg prior to enrollment), myocardial infarction, unstable angina, revascularization surgery within 12 months prior to enrollment, or NYHA class III.\n8. Sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C 50 beats\u002Fmin), atrioventricular block above degree II without a pacemaker, corrected QT interval (Fridericia-corrected QTcF) ≥ 450 ms, or other severe arrhythmias (e.g., frequent premature ventricular contractions).\n9. Uncontrolled diabetes (e.g., HbA1c \\> 9%, diabetic ketosis, hyperglycemic coma, or hypoglycemia).\n10. Severe hepatic dysfunction (Child-Pugh Class C), renal dysfunction (eGFR ≤ 30 ml\u002Fmin\u002F1.73m2), respiratory insufficiency (SpO2 \\\u003C 93% on room air), or other severe diseases (e.g., frailty with inability to walk independently, advanced-stage tumors).\n11. Alcohol or drug dependence (manifested as strong cravings, uncontrolled use, and withdrawal symptoms upon cessation), or use of contraindicated medications.\n12. Major surgery under general anesthesia within 12 weeks prior to enrollment, or planned surgery within 12 weeks.\n13. Allergy to dexmedetomidine and\u002For esketamine.\n14. Participation in other interventional clinical studies.\n15. Any other conditions deemed unsuitable for study inclusion by the investigator.","60 Years",{"count":277,"type":21},[463],"PHASE4","Patients with cognitive decline are frequently comorbid with sleep disorders which may in turn aggravate cognitive decline. Sedative dose dexmedetomidine improved sleep quality but incresed bradycardia and hypotension; low dose dexmedetomidine produce less side effects, but the sleep promoting effects are relatively weak. Low dose esketamine also has sleep-promoting effects but may produce neuropsychiatric side effects. Both dexmedetomidine and esketamine are approved for intranasal administration. We suppose that intranasal administration of dexmedetomidine-esketamine combination may improve sleep quality and therefore cognitive function in older ptients with Alzheimer's disease cognitive impairment and sleep disorders.",[27,349,466,467,468],"Sleep Disorders","Dexmedetomidine","Esketamine",[27,349,466,467,468],"2026-05-28",{"date":472,"type":36},"2026-06-01",{"date":474,"type":21},"2026-06",{"date":476,"type":21},"2027-12",{"name":188,"class":75},{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":83,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":55,"phases":487,"briefSummary":488,"conditions":489,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":498,"locationsCount":44},"100523024","motivational-interviewing-to-enhance-advance-care-planning-for-older-adults-and-caregivers-after-emergency-visits-100523024","NCT06090240","Motivational Interviewing to Enhance Advance Care Planning for Older Adults and Caregivers After Emergency Visits","Maximizing Teachable Moments: Motivational Interviewing (MI) to Enhance Advance Care Planning (ACP) for Older Adults and Caregivers After Emergency Visits - A Mixed-Method Randomized Controlled Trial","The target group will be dyads comprising older adults who have had ER visits within the previous six months and their family caregivers. A dyad is defined as one older adult and one primary family caregiver of the older adult.\n\nFor older adults:\n\nInclusion Criteria:\n\n* Aged 65 or older\n* At least one episode of ER visit in the last six months\n* Has a family caregiver to be present during the intervention\n* Able to communicate in Chinese\n\nExclusion Criteria:\n\n* Has completion of an AD\n* Moderate to severe cognitive impairment or diagnosis of dementia, as identified in health records\n* Communication problems (e.g., deafness or aphasia)\n\nFor family caregivers:\n\nInclusion Criteria:\n\n* Aged 18 or above\n* Immediate or extended family member or friend nominated by an eligible older adult participant as primary caregiver\n* Able to communicate in Chinese\n\nExclusion Criteria:\n\n* Moderate to severe cognitive impairment\n* Communication problems (e.g., deafness or aphasia)",{"count":486,"type":21},300,[57],"This study aims to evaluate the effectiveness of a motivational interviewing (MI) intervention in enhancing advance care planning (ACP) among older adults who have visited the Emergency Room (ER) in the past six months and their family caregivers. The main question it aims to answer is: The effectiveness of the MI-based ACP intervention implemented within six months of an ER visit on improving older adults' advance directives (AD) completion rate.\n\nCompared to participants in the control group who will only receive a self-education booklet, participants in the intervention group will receive a motivational interview educational intervention to see the effectiveness of an MI-based ACP intervention implemented within six months following an emergency room visit regarding the completion of AD for older adults.",[27,490,491,492],"Advance Care Planning","Advance Directives","Family Members",{"date":494,"type":36},"2026-06-02",{"date":496,"type":36},"2023-12-14",{"date":72,"type":21},{"name":499,"class":75},"The University of Hong Kong",{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":506,"eligibilityCriteria":507,"healthyVolunteers":12,"sex":17,"minAge":460,"maxAge":4,"enrollmentInfo":508,"targetDuration":4,"studyType":55,"phases":509,"briefSummary":510,"conditions":511,"keywords":514,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":530},"100637138","phase-2-vaccination-response-modulation-with-a-targeted-rapamycin-protocol-study-100637138","NCT07587801","Vaccination Response Modulation With a Targeted Rapamycin Protocol Study","Vaccination Response Modulation With a Targeted Rapamycin Protocol (VON TRAPP) Study","VON TRAPP","Inclusion Criteria:\n\n* End-stage kidney disease requiring in-centre haemodialysis three times per week as kidney replacement therapy\n* Aged \\>60 years\n\nExclusion Criteria:\n\n* Aged \\\u003C60 years\n* Alternative haemodialysis regimens (e.g. twice-weekly haemodialysis, second-daily home haemodialysis)\n* Recent infection (\\\u003C6 months) with proven Influenza A, Influenza B, or RSV\n* Current use of immunosuppressive medications, including:\n\n  * Oral steroid at a dose equivalent of 5 mg\u002Fday prednisolone or greater\n  * Mycophenolate mofetil\n  * Azathioprine\n  * Calcineurin inhibitors\n  * mTOR inhibitors\n* Recent use of intravenous immunosuppressive medications (\\\u003C6 months), including:\n\n  * T-cell depleting agents (e.g. anti-thymocyte globulin)\n  * B-cell depleting agents (e.g. rituximab)\n  * Cyclophosphamide\n* Has a history of problems with side-effects associated with sirolimus use including\n\n  * Angioedema\n  * Active\u002Frecent opportunistic infection\n  * Current or prior interstitial lung disease, non-infectious pneumonitis, organising pneumonia, or pulmonary fibrosis\n  * Clinically significant pleural effusion or pericardial effusion\n  * Active non-healing wounds, chronic skin ulcers, or planned major surgery\u002Fprocedures\n  * Current malignancy or recent malignancy with high recurrence risk\n  * Severe or uncontrolled hyperlipidaemia\n  * History of rhabdomyolysis\n  * Severe hepatic impairment\n* Ongoing use of strong CYP3A4\u002FP-gp inhibitors or inducers including\n\n  * Inhibitors: Ketoconazole, Voriconazole, Itraconazole, Telithromycin, Clarithromycin\n  * Inducers: Rifampicin, Rifabutin\n* Unable or unwilling to provide informed consent to participate in the trial\n* Known allergy to or intolerance of sirolimus (rapamycin) or the contents of the influenza or RSV vaccine",{"count":277,"type":21},[130],"This study will investigate dialysis recipients' responses to important vaccines.\n\nResearch suggests that a medication commonly used by transplant recipients may improve vaccine responses. The investigators will be conducting a clinical trial to see whether a short course of low-dose Sirolimus improves the response to vaccination against respiratory syncytial virus (RSV) and influenza (flu) in patient with kidney disease over 60 years old who receive haemodialysis.",[512,513,27],"Vaccine Immune Response","Haemodialysis Patients",[515,516,517,518,65,519],"influenza","RSV","vaccine","haemodialysis","immunosenescence","2026-05-11",{"date":522,"type":36},"2026-05-14",{"date":524,"type":21},"2026-05",{"date":526,"type":21},"2026-07",{"name":528,"class":529},"Central Adelaide Local Health Network Incorporated","OTHER_GOV",3,{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":538,"targetDuration":4,"studyType":55,"phases":540,"briefSummary":541,"conditions":542,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":44},"100601077","dance-intervention-to-improve-executive-function-and-physical-performance-in-older-adults-with-cognitive-impairment-100601077","NCT07105800","Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment","A Pilot Study of Dance Intervention for Enhancing Executive Function and Physical Performance in Cognitively Impaired Older Adults","Inclusion Criteria:\n\n* Subjective Cognitive Decline (SCD) with a score ≥5 on the SCD-Q9 questionnaire, or Mild Behavioral Impairment (MBI) with a score ≥7 on the MBI-Checklist, with symptoms persisting for more than three months.\n* Ability to follow instructions.\n* Ability to stand unsupported or with assistive devices for at least 10 minutes.\n* Ability to walk at least 10 meters, either unsupported or with assistive devices.\n\nExclusion Criteria:-Age below 55 years.\n\n* Severe visual or hearing impairment.\n* Score \\\u003C16 on the Montreal Cognitive Assessment (MoCA).\n* Emotional or anxiety symptoms caused by psychiatric medications that significantly impair the ability to perform study-related motor tasks.",{"count":539,"type":21},50,[57],"This pilot study investigates the effects of a music-based dance intervention on executive function and physical performance in middle-aged and older adults with cognitive impairment. Dance, as a form of dual-task training, integrates music, rhythmic movement, and cognitive-motor coordination. When combined with group interaction and partner-guided physical cues, it has the potential to enhance both cognitive and motor functions simultaneously.\n\nThe intervention features a simple, structured dance sequence designed to stimulate rhythm, attention, and coordination through music-based movement. This study aims to evaluate the feasibility and preliminary efficacy of this approach in improving executive function and lower limb physical performance among individuals with cognitive impairment.",[27,543],"Cognitive Impairment, Mild","2026-04-27",{"date":546,"type":36},"2026-04-28",{"date":548,"type":36},"2025-11-01",{"date":550,"type":21},"2026-06-30",{"name":552,"class":75},"Taipei Medical University Shuang Ho Hospital",{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":4,"eligibilityCriteria":559,"healthyVolunteers":83,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":55,"phases":562,"briefSummary":563,"conditions":564,"keywords":568,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":44},"100632279","a-multi-level-strategy-for-de-implementing-mammography-overuse-among-older-women-100632279","NCT07511621","A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women","De-implementation of Overuse of Mammography Screening in Older Racially and Ethnically Diverse Women","Patient level criteria\n\nInclusion criteria\n\n* English- or Spanish-speaking women based on preferred language in electronic health record\n* Aged 75 and older at the time of their scheduled primary care visit\n* Women who have a primary care visit scheduled within the next 2-4 weeks\n* Women who have not had a screening mammogram 6 months prior to their scheduled primary care visit but have had a screening mammogram 7-18 months prior to their scheduled primary care visit\n\nExclusion Criteria\n\n* Women with a history of atypical ductal hyperplasia (ADH) or non-invasive or invasive breast cancer (assessed via ICD 10 code)\n* Women with dementia (assessed via ICD 10 code)\n* ICD codes to use across exclusion criteria: F01-F03, Z85.3, G30-G31, N60, C50, or D05\n\nProvider level criteria\n\nInclusion Criteria\n\n• Primary care clinicians attributed to the 2 intervention clinics that serve adult patients, including those ≥75 years\n\nExclusion Criteria\n\n* Specialists\n* Primary care clinicians for patients \\\u003C 18 years old\n* Non-clinicians\n* Physician assistants",{"count":561,"type":21},500,[57],"This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75 years. Informed by an innovative participatory, stakeholder-driven innovation tournament and a discrete choice experiment, the research team identified, prioritized, and tailored a multilevel de-implementation strategy. The research team will conduct a cluster randomized controlled trial (at the provider level) to test the impact of the provider- and patient-level components of the multilevel strategy on screening mammography use, and secondarily, on provider referrals\u002Forders for screening mammography. The organizational level components of the multilevel strategy will be implemented among all participants, not via random assignment.",[565,566,567,27],"Mammography","Medical Overuse","Evidence-based Practice",[565,569,322,570,571,572,573,574],"Medical overuse","Aging","Women","Randomized controlled trial","Screening cessation","De-implementation","2026-03-30",{"date":577,"type":36},"2026-04-06",{"date":579,"type":36},"2026-03-11",{"date":581,"type":21},"2028-03",{"name":583,"class":75},"Columbia University",{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":589,"acronym":4,"eligibilityCriteria":590,"healthyVolunteers":83,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":55,"phases":593,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":606,"locationsCount":4},"100631106","dyadic-management-intervention-in-older-people-with-co-occurring-cognitive-impairment-and-diabetes-as-a-supplementary-approach-to-chronic-diseases-self-management-program-100631106","NCT07496359","Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program","Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program: A Hybrid Effectiveness-implementation Study","Inclusion Criteria:\n\n* Individuals with DM aged \\>= 55 years old;\n* Recent glycosylated haemoglobin (HbA1c) level of 6.5% or above without change in diabetes medication within the last 3 months based on centre's records;\n* Subjective cognitive decline (using SCDQ21) (separately reported by the patient and\u002For caregiver) and confirmed by MOCA (Chinese version) screened by the research nurses;\n* Subjects with nominated primary caregivers will be recruited in the intervention group;\n* For caregivers: they will be considered in the project if they have been the primary caregiver for the person for at least 1 year and are providing or involved in the patient's care on a daily basis.\n\nExclusion Criteria:\n\n* Medical diagnoses of dementia;\n* Those who have terminal illness;\n* For caregivers: those who are temporary caregivers and have only provided\u002Finvolved in care for less than a year.",{"count":592,"type":21},309,[57],"The goal of this study is to evaluate the effectiveness and implementation of a dyadic management of the Chronic Disease Self-Management Program (CDSMP) for older adults with co-occurring cognitive impairment and diabetes with the involvement of caregivers.\n\nThe main questions it aims to answer are:\n\n* Does the intervention improve diabetes self-management and cognitive function in older adults?\n* How is the implementation of the intervention in real-world settings?\n\nParticipants will:\n\n* Attend weekly CDSMP session over a 6-week period (2.5-hour per session).\n* Provide feedback on their experience with the intervention through interviews and surveys.",[596,597,598,599,384,27],"Choroid Disease","Caregiver","Self-management","Diabetes","2026-03-23",{"date":602,"type":36},"2026-03-27",{"date":604,"type":21},"2026-03",{"date":476,"type":21},{"name":607,"class":75},"The Hong Kong Polytechnic University",{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":4,"eligibilityCriteria":614,"healthyVolunteers":83,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":615,"targetDuration":4,"studyType":55,"phases":617,"briefSummary":618,"conditions":619,"keywords":621,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":634,"locationsCount":296},"100630936","group-based-exercise-intervention-to-prevent-cognitive-and-motor-decline-100630936","NCT07494149","Group-Based Exercise Intervention to Prevent Cognitive and Motor Decline","Effects of the Ideomotor Group Program Exercise on Cognitive Functioning, Motor Functioning and Overall Well-being in Community-Dwelling Older Adults","Inclusion Criteria:\n\n* At least 50 years old;\n* Able to move independently;\n* Live in the community;\n* Demonstrated ability to comprehend complex verbal instructions.\n\nExclusion Criteria:\n\n* Presence of severe neurological and psychological conditions;\n* Less than 9,36 score in the FAB15;\n* Lack of medical clearance to participate in an exercise program;\n* Less than 75% of attendance.",{"count":616,"type":21},158,[57],"The goal of this clinical trial is to evaluate the efficacy of the Ideomotor Program in healthy older adults living in the community. The main research questions are:\n\n1\\) Is the Ideomotor Program effective in improving cognitive function? 2) Is the Ideomotor Program effective in improving motor function? 3) Is the Ideomotor Program effective in improving overall well-being?\n\nResearchers will compare the Ideomotor Program to a community group cognitive training program to determine whether the effects are superior. Participants will: undergo assessments at baseline, at the mid-intervention point, and upon program completion; participate in a 16-week group exercise program in a community gym two times per week; keep a diary to monitor the number of falls and any adverse events.",[620,27],"Healthy",[622,623,624,625,626,627],"Exercise","Cognition","Psychological Well-Being","Primary Prevention","Physical Fitness","healthy longevity","2026-03-19",{"date":602,"type":36},{"date":631,"type":36},"2026-02-01",{"date":633,"type":21},"2026-08-01",{"name":635,"class":75},"University of Bergamo",{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":640,"acronym":4,"eligibilityCriteria":641,"healthyVolunteers":83,"sex":17,"minAge":642,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":55,"phases":645,"briefSummary":646,"conditions":647,"keywords":651,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":659,"locationsCount":44},"100224513","influenza-immunization-in-adults-over-age-75-100224513","NCT02200276","Influenza Immunization in Adults Over Age 75","Inclusion Criteria:\n\n* Adults over age 75 years\n\nExclusion Criteria:\n\n* Allergies to egg or vaccine\n* Active malignancies\n* On radiation or chemotherapy\n* Active systemic inflammatory diseases including rheumatoid arthritis, Crohn's disease, and ulcerative colitis\n* Acute exacerbation of chronic cardiopulmonary conditions including decompensated CHF or COPD\n* Taking oral steroids (such as prednisone) or immune modulating drugs (such as methotrexate).\n* Lacking the capacity to consent (individuals who do not understand what Flu shot is or need someone else to decide if s\u002Fhe should get the Flu shot)","75 Years",{"count":644,"type":21},1025,[57],"The immune system is the part of the body that protects against infection. The immune system often doesn't work as effectively as people get older. This research is being done to find out how the immune systems in older people who are over age 75 respond to influenza vaccine (flu shot). We also want to find out if chronic cytomegalovirus (CMV) infection, a common virus infection in older persons affects the immune response in people older than 75 years of age who receive a flu shot. The Flu Shot is a vaccine approved for the prevention of influenza (\"Flu\") infections and is recommended every year for all persons 50 years and older. People who are older than 75 years of age are considered healthy or frail may join. A total of 1025 persons will be participating in this study.\n\nIn order to determine if you are qualified for the study, we would ask you to answer a few questions over the phone that will take approximately 5 minutes. If you qualify and agree to proceed, you will be asked to come to Johns Hopkins Bayview Medical Center or, if you are unable to come to Bayview, one of our staff can visit you at your home. During that visit we obtain consent, review your medical history, and measure your vital signs, walking speed and grip strength. We will also administer a few brief questionnaires and collect urine and blood samples. We will then give you the Influenza vaccine for free. 7 days post receiving your Influenza Vaccine we will collect a small blood sample for further immune system testing. also, you will be asked to complete a 12-question survey which will assess your symptoms over the past 7 days (post receiving the Influenza vaccine). Also 4 weeks post receiving your Influenza vaccine you will be asked to complete a third visit that will include follow up health questionnaires and an influenza symptoms assessment questionnaire and vital signs. A third blood draw will be collected (approximately 10 teaspoons) to measure immune responses to the influenza vaccine. In addition, you will receive your test result (CBC\u002Fw\u002FDiff.) from visit #1. Throughout the influenza study season, we will call you once a week to ask about your general health and any Flu-like symptoms. These calls will be made throughout the Flu season which typically lasts through May. If you begin to have any influenza like symptoms at any time during the study, we ask that you call our office to report these symptoms so that we may perform vital signs, nasal swab to confirm influenza, and a fourth blood draw to look at the immune response and protection of influenza vaccine.",[648,649,27,650],"Influenza","Immunization","Over Age 75",[648],"2026-03-13",{"date":654,"type":36},"2026-03-16",{"date":656,"type":4},"2014-03",{"date":658,"type":21},"2027-11-30",{"name":660,"class":75},"Johns Hopkins University",{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":55,"phases":670,"briefSummary":671,"conditions":672,"keywords":674,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":683,"locationsCount":4},"100626822","the-count-me-in-program-in-support-of-social-participation-for-older-people-with-loss-of-autonomy-100626822","NCT07440628","The Count Me In Program in Support of Social Participation for Older People With Loss of Autonomy","The Count Me In Program in Support of Social Participation for Seniors Residing in Long-term Care Facilities and Seniors With Loss of Autonomy in Day Centres","Inclusion Criteria:\n\n* Must be over 55 years old\n* Must be able to understand and speak French fluently\n* Must be able to attend a group meeting lasting about 45 minutes\n* Must currently participate in at least one leisure activity in a day centre\n\nExclusion Criteria:\n\n* None",{"count":669,"type":21},8,[57],"The goal of this observational study is to determine whether the Count Me In Program (Participe-Présent in French), which focuses on the strengths and power to act of older adults, can improve social participation and psychosocial factors among older adults with loss of autonomy, as assessed by the following outcome measures: (1) loneliness; (2) depressive symptoms; (3) cognition; (4) frequency of participation in leisure activities; and (5) type of social participation.\n\nParticipants will attend seven weekly workshops in the Count Me In Program.",[27,673],"Loss of Autonomy",[177,675,676],"Loss of autonomy","Day centre","2026-02-25",{"date":679,"type":36},"2026-02-27",{"date":681,"type":21},"2026-04-01",{"date":472,"type":21},{"name":684,"class":75},"Université du Québec à Trois-Rivières",{"id":686,"slug":687,"hasResults":12,"nctId":688,"briefTitle":689,"officialTitle":689,"acronym":4,"eligibilityCriteria":690,"healthyVolunteers":83,"sex":17,"minAge":460,"maxAge":4,"enrollmentInfo":691,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":693,"conditions":694,"keywords":695,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":699,"lastUpdatePostDateStruct":700,"startDateStruct":702,"completionDateStruct":703,"leadSponsor":705,"locationsCount":707},"100620268","frailty-geriatric-syndromes-and-care-pathways-of-older-adults-living-with-hiv-in-west-africa-100620268","NCT07355413","Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa","Inclusion Criteria:\n\n* HIV+ Group\n\n  * Person 60 years of age and older\n  * Infected with HIV-1 and\u002For 2\n  * Able to move around the data collection site\n  * Having given free and informed consent\n* HIV- Group\n\n  * Person 60 years of age and older\n  * HIV-uninfected\n  * Able to move around the data collection site\n  * Having given free and informed consent\n\nExclusion Criteria:\n\nPerson deprived of liberty (guardianship, curatorship, judicial safeguard) Karnofsky Index 50≤50% Hospitalized\n\n\\-",{"count":692,"type":21},600,"With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, thus increasing the prevalence of premature frailty.\n\nThere are few data on the prevalence of frailty and geriatric syndromes among older people living with HIV (OpHIV) in sub-Saharan Africa (SSA) and the screening and diagnostic tools to identify them.\n\nThe initiation contract financed by the ANRS-MIE in 2021 whose objective was to 1) carry out an inventory and evaluate the feasibility of a project for monitoring OpHIV in Burkina-Faso in Côte d'Ivoire and Togo and 2) to select the collection tools adapted to the description of geriatric syndromes in these elderly people has allowed to highlight the following (i) The collection of data on geriatric conditions and syndromes is almost non-existent in the daily care and management practice (ii) there is a significant proportion (10,6%) of PLWHIV aged 60 years and over in the active files of the PLWHIV care centers that participated in the survey (iii) Adapted screening tools have been selected and will allow documentation of the above-mentioned syndromes. This research project, which follows on from this initiation contract, will therefore make it possible to obtain data from the geriatric evaluation, to identify the specificities of PLWHIV by comparing them to a population not infected with HIV and to propose geriatric management adapted to PLWHIV. Its innovative nature also lies in its mixed approach combining quantitative and qualitative methods, which will make it possible to document the needs and resources for the care of PLWHIV in a global and holistic manner.\n\n600 participants, aged 60 years and over (300 living with HIV and 300 not living with HIV), in three West African countries (Burkina Faso, Côte d'Ivoire, Togo) will be included in this study whose primary objective is to compare the prevalence of frailty among people aged 60 years and over (PA60) between HIV-infected and non-HIV-infected; the secondary objective is to estimate the prevalence of frailty among PA60 according to HIV status. A population-based matching will be performed on sex and age class (threshold 70 years), during the recruitment of HIV- PA60.\n\nThis will be a mixed study combining:\n\n* A \"clinical\" component comprising a stratified, comparative, international, multicenter cross-sectional study;\n* A \"health systems strengthening\" component combining a quantitative cross-sectional survey and a qualitative survey;\n* A qualitative socio-anthropological component including individual interviews and focus groups with people living with HIV60, their families and caregivers.\n\nThe 3 components will be conducted with a time lag between the different components due to the overlapping constitution of the source populations.\n\nMost research on aging with HIV in the context of SSA has been very clinically focused (e.g., frailty or cognitive impairment). This research will provide a more comprehensive approach that takes into account the different levels of factors influencing health (individual, health system, social environment).",[27],[696,348,697,698],"HIV","Geriatric syndromes","Care pathways","2026-01-14",{"date":701,"type":36},"2026-01-21",{"date":604,"type":21},{"date":704,"type":21},"2029-03",{"name":706,"class":529},"ANRS, Emerging Infectious Diseases",6]