[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"open-bite\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:open-bite":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,84,111,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100652802","clinical-comparison-of-clear-aligners-and-fixed-appliances-in-dental-anterior-open-bite-100652802",false,"NCT07778108","Clinical Comparison of Clear Aligners and Fixed Appliances in Dental Anterior Open Bite","Clinical Comparison of Clear Aligners and Fixed Orthodontic Appliances in the Treatment of Dental Anterior Open Bite in Adults: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nAdult patients aged 18 to 30 years with fully erupted permanent dentition. Anterior open bite equal to or greater than 2 mm. Angle Class I malocclusion. Good oral hygiene and healthy periodontal status.\n\n\\-\n\nExclusion Criteria:\n\n* Previous orthodontic treatment. Presence of craniofacial anomalies or cleft lip\u002Fpalate. Active periodontal disease or severe bone loss. History of temporomandibular joint disorders (TMD). Systemic conditions or medications affecting bone metabolism and tooth movement.","ALL","18 Years","30 Years",{"count":20,"type":21},46,"ESTIMATED","INTERVENTIONAL",[24],"NA","Dental anterior open bite is a challenging orthodontic condition with a high risk of relapse in adults. This randomized controlled clinical trial aims to compare the effectiveness and post-treatment stability of in-house clear aligners versus fixed orthodontic appliances in treating adult patients aged 18-30 years with dental anterior open bite (0 to -4 mm).\n\nA total of 46 eligible participants will be randomly allocated into two equal groups (23 treated with clear aligners and 23 with fixed appliances). Treatment outcomes, vertical dentoalveolar changes, and skeletal changes will be evaluated using digital intraoral scans, virtual model superimposition, and lateral cephalometric analysis. Following active treatment, an 8-month retention phase (bonded lingual retainer combined with a vacuum-formed retainer) and an 8-month post-retention follow-up phase will be implemented to comprehensively evaluate treatment stability and relapse tendency over a total observation period of 16 months.",[27,28],"Open Bite","Malocclusion Class I",[30,31,32,33,34],"Anterior Open Bite","Clear Aligners","Fixed Orthodontic Appliances","Randomized Controlled Clinical Trial","Orthodontic Stability","NOT_YET_RECRUITING","2026-08-20",{"date":38,"type":39},"2026-08-21","ACTUAL",{"date":41,"type":21},"2026-11",{"date":43,"type":21},"2029-07",{"name":45,"class":46},"Sana'a University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":66,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100600934","ioa-preventing-occlusal-changes-with-mad-use-100600934","NCT07103941","IOA Preventing Occlusal Changes With MAD Use","Effectiveness of Interocclusal Aligner (IOA) on Preventing Occlusal Changes in Patients Treated With a Mandibular Advancement Device (MAD): A Preliminary Study","Inclusion Criteria:\n\n* adult participants (≥18 years)\n* diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy\n* Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.\n\nExclusion Criteria:\n\n* pervious orthognathic surgery\n* anterior cross bite\n* posterior cross bite\n* existing open bite or implant supported restorations\n* tooth mobility\n* significant dental caries or periodontitis\n* severe bruxism\n* planned upcoming dental work including caps, crowns, implants, or braces\n* inadequate mandibular protrusion\n* severe micrognathia\n* large tori\n* significant claustrophobia\n* significant nasal obstruction\n* large oropharyngeal masses or large tonsils",true,{"count":56,"type":21},30,[24],"This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite.\n\nParticipants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes.\n\nThe study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.",[60,61,62,27,63,64,65],"Sleep Related Breathing Disorder","Snoring","Obstructive Sleep Apnea (OSA)","Occlusal Changes","Tooth Migration","Posterior Open Bite",[67,68,65,63,69,70,71,72],"Interocclusal Aligner","Mandibular advancement Device","Dental Changes","Protrusion","Sleep Appliance","Obstructive Sleep Apnea","RECRUITING","2026-05-14",{"date":76,"type":39},"2026-05-18",{"date":78,"type":39},"2025-11-17",{"date":80,"type":21},"2026-12-30",{"name":82,"class":46},"Isabel Moreno Hay",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":83},"100625295","investigate-the-effectiveness-of-3d-printed-shape-memory-aligners-in-the-treatment-of-anterior-open-bite-100625295","NCT07420777","Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open Bite","Evaluating the Effectiveness of 3D Directly Printed Shape Memory Aligners in the Management of Anterior Open Bite","Inclusion Criteria:\n\n1. Age 18-35 years,\n2. Both genders.\n3. The patient is well fitted with no systemic disease.\n4. Mild-moderate dental anterior open bite.\n5. Well-aligned or mildly crowded dentition.\n\nExclusion Criteria:\n\n1. Patient with a history of trauma to the molars or incisors.\n2. Patient with a history of endodontic treatment to the maxillary first molar or incisors.\n3. Patient with a systemic disease related to bone metabolism.\n4. Patient taking immunosuppressive drugs or drugs inhibiting or accelerating tooth movement; and\n5. Patient with neuromuscular deficiencies.","35 Years",{"count":93,"type":21},51,[24],"The goal of this randomised clinical trial study is to investigate 3D-printed shape memory aligners in the treatment of anterior dental open bite adult patients. The main questions it aims to answer are:\n\n1. Do 3D-direct-printed shape memory aligners demonstrate potentiality in the management of AOB?\n2. What is the effect of 3D-direct printed shape memory aligners on molar intrusion?\n3. Can the 3D-direct printed shape memory aligners extrude anterior teeth without the use of attachments?\n4. Do 3D-direct printed shape memory aligners generate greater\u002Fhigher stress distribution and initial teeth displacement compared to conventional clear aligners? Researchers will compare three groups: Group I: Patients treated with conventional clear aligners with attachments; Group II: Patients treated with 3D direct-printed shape-memory aligner without attachment; Group III: Patients treated with 3D direct-printed shape memory clear aligners with attachments and see its effect on anterior open bite treatment.\n\nParticipants will wear a clear aligner for about 6-8 months. Then",[27],[98,99,100,101],"open bite","clear aligner","memory shape","3D direct printed","2026-05-08",{"date":104,"type":39},"2026-05-11",{"date":106,"type":39},"2026-05-01",{"date":108,"type":21},"2027-03-27",{"name":110,"class":46},"Kufa University",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":83},"100636547","stability-of-orthodontic-treatment-of-anterior-open-bite-100636547","NCT07567105","Stability of Orthodontic Treatment of Anterior Open-bite","Orthodontic Correction of Anterior Open-bite, Treatment Outcome Stability and Impact of Anterior Open Bite Malocclusion","Inclusion Criteria:\n\n\\- Clinical diagnosis of anterior open bite malocclusion, past or present\n\nExclusion Criteria:\n\n* No malocclusion\n* craniofacial genetic anomaly",{"count":119,"type":21},80,"OBSERVATIONAL","The study aims to explore how an open bite malocclusion affects daily life of an individual, is its orthodontic treatment effective, and what kind of burden of care the treatment has caused.",[27],[124],"Anterior open bite","2026-04-27",{"date":127,"type":39},"2026-05-05",{"date":129,"type":39},"2025-12-01",{"date":131,"type":21},"2030-07-30",{"name":133,"class":46},"University of Helsinki",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":54,"sex":16,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":148,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":4},"100560234","myofunctional-therapy-in-open-bite---rct-100560234","NCT06574490","Myofunctional Therapy in Open Bite - RCT","Effectiveness of Myofunctional Therapy in Children With Open Bite - a Randomized Clinical Trial","Myofunctional","Inclusion Criteria:\n\n* generally healthy children aged 6-10 years,\n* infant swallowing type,\n* open anterior occlusion (i.e. no contact between the maxillary and mandibular medial incisors),\n* mixed dentition\n\nExclusion Criteria:\n\n* finger sucking habit (or similar) occurring within the last 6 months,\n* previous myofunctional therapy,\n* upper airway obstruction,\n* congenital craniofacial developmental disorder,\n* connective tissue or muscle disease,\n* macroglossia,\n* ankyloglossia,\n* mental retardation","6 Years","10 Years",{"count":119,"type":21},[24],"The goal of this clinical trial is to learn if myofunctional therapy in 6-10-year-old children with infant type of swallowing and open bite is effective.\n\nPrimary hypothesis: myofunctional therapy results in correction of open bite Researchers will compare a group in which myofunctional therapy is performed for 6 months to a group in which myoufunctional therapy will be delayed by 1 year.\n\nParticipants will exercise according to a pre-established regimen and schedule",[27],[98,149,150,151,152],"child","myofunctional","myotherapy","exercises","2024-08-25",{"date":155,"type":39},"2024-08-28",{"date":157,"type":21},"2024-10",{"date":159,"type":21},"2028-10",{"name":161,"class":46},"Piotr Fudalej"]