[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-induced-respiratory-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-induced-respiratory-depression":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100610423","timing-of-opioid-administration-and-postoperative-respiratory-depression-100610423",false,"NCT07227389","Timing of Opioid Administration and Postoperative Respiratory Depression.","The Relationship Between Timing of Opioid Administration and Postoperative Respiratory Depression.","Inclusion Criteria:\n\n* Written informed consent\n* Adults ≥18 years of age and ≤85 years of age\n* Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours\n* Patients expected to receive postoperative opioid analgesia\n\nExclusion Criteria:\n\n* Non-operative procedure (imaging)\n* Patients not admitted to the PACU postoperatively\n* Use of patient-controlled analgesia systems\n* Female patients who are pregnant or breastfeeding\n* Patients with asymmetric lung disease\n* American Society of Anesthesiologists (ASA) classification V\n* Emergency surgery (ASA E Modifier)",true,"ALL","18 Years","85 Years",{"count":21,"type":22},52,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids.\n\nThe primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation.\n\nA secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation.\n\nThe investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.",[27,28,29],"Respiratory Complications","Opioid Induced Respiratory Depression","Postoperative Respiratory Complications",[31,32,33,34,35],"opioids","bio-impedance","hypoxia","hypercapnia","minute ventilation","RECRUITING","2026-07-14",{"date":39,"type":40},"2026-07-16","ACTUAL",{"date":42,"type":40},"2026-02-01",{"date":44,"type":22},"2029-02-01",{"name":46,"class":47},"Wayne State University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":5},"100637012","pupillometry-in-identifying-risk-of-postoperative-opioid-induced-respiratory-depression-in-children-undergoing-tonsillectomy-100637012","NCT07573150","Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy","Pupillometry in Identifying Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy","Inclusion Criteria:\n\n* Age 3 to less than 18 years\n* Scheduled to undergo tonsillectomy with or without adenoidectomy\n* Planned postoperative recovery in a monitored clinical setting (e.g., post-anesthesia care unit)\n* Ability to obtain informed consent from parent or legal guardian and assent from the participant when developmentally appropriate\n\nExclusion Criteria:\n\n* Known neurologic or ophthalmologic conditions that may affect pupillary function\n* Use of medications known to significantly alter pupillary response outside of standard perioperative care\n* Inability to obtain adequate pupillometry measurements (e.g., due to eye injury or inability to safely perform measurement)\n* Patients not receiving opioids as part of perioperative care\n* Any condition that, in the opinion of the investigator, would interfere with study participation or data interpretation","3 Years","17 Years",{"count":59,"type":22},300,"This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy. Opioid-induced respiratory depression is a serious and potentially life-threatening complication that can occur after surgery, and current monitoring approaches are limited in their ability to predict which patients are at highest risk.\n\nIn this prospective observational cohort study, approximately 300 pediatric patients undergoing tonsillectomy will undergo non-invasive pupillometry measurements at defined perioperative time points, including preoperative, intraoperative, and postoperative periods. Pupillometry measurements will be collected using a commercially available, FDA-regulated infrared pupillometer. These measurements will include pupil size, constriction and dilation velocities, and latency in response to light stimulation.\n\nPupillometry data will be collected for research purposes only and will not be used to guide clinical care or treatment decisions. Standard clinical care will not be altered as part of this study. Clinical outcomes, including the occurrence of postoperative opioid-induced respiratory depression, opioid use, sedation levels, pain scores, and other postoperative events, will be recorded from the medical record.\n\nThe goal of this study is to evaluate the relationship between pupillary response patterns and the occurrence of postoperative respiratory depression, and to support the development of predictive models that may improve early identification of patients at risk for opioid-related adverse events.",[62,63,64],"Opioid-Induced Respiratory Depression","Postoperative Complications (Cardiopulmonary)","Respiratory Complications Due to Anesthesia",[66,67,68,69,70,71,72,73,74,75,76,62,77],"Sedation","Postoperative Period","Perioperative Monitoring","Pediatrics","Pupillary Light Reflex","Pupillometry","Analgesia","Anesthesia","Opioids","Hypoventilation","Oxygen Desaturation","Respiratory Depression","2026-05-06",{"date":80,"type":40},"2026-05-08",{"date":82,"type":40},"2026-05-04",{"date":84,"type":22},"2027-04-30",{"name":86,"class":87},"NeurOptics Inc","INDUSTRY"]