[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"optic-nerve-sheath-diameter-measurement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:optic-nerve-sheath-diameter-measurement":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100653313","comparison-of-hyperosmolar-agent-in-reduction-of-increased-intracranial-pressure-in-patients-with-traumatic-brain-injury-using-ultrasonography-100653313",false,"NCT07786324","Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography","Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''","MHTS-ONSD","Inclusion Criteria:\n\n* • Age ≥18 years.\n\n  * Acute severe traumatic brain injury (TBI) (GCS 3-8) confirmed by CT brain.\n  * Elevated ONSD suggestive of raised ICP (ONSD cutoff value ≥5.6 mm ).(14)\n  * Initiation of hyperosmolar therapy within 24 hours of injury.\n\nExclusion Criteria:\n\n* • Penetrating head injury.\n\n  * Hypotension.\n  * Previous ocular trauma or orbital surgery.\n  * Glaucoma or optic nerve pathology.\n  * Bilateral ocular injuries preventing ultrasound assessment.\n  * Pregnancy.\n  * Chronic renal failure requiring dialysis.\n  * Initial serum sodium \\>150mmol\u002FL or Patients reaching a sodium level \\>160mmol\u002FL during hypertonic administration.\n  * Previous hyperosmolar therapy before enrollment.\n  * Refusal of consent by legal surrogate.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain injury.",[27,28,29],"TBI (Traumatic Brain Injury)","ICP (Intracranial Pressure) Increase","Optic Nerve Sheath Diameter Measurement",[31,32,33,34,35],"mannitol","hypertonic saline","ICP","ONSD","TBI","NOT_YET_RECRUITING","2026-08-21",{"date":39,"type":40},"2026-08-25","ACTUAL",{"date":42,"type":21},"2026-10-01",{"date":44,"type":21},"2029-09-30",{"name":46,"class":47},"Assiut University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100653247","assessment-of-optic-sheat-diameter-onsd-and-eyeball-transverse-diameter-etd-ratio-measurement-from-ocular-ultrasound-100653247","NCT07784361","Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound","Assessment of Increased Intracranial Pressure by Optic Nerve Sheath Diameter (ONSD), Eyeball Transverse Diameter (ETD) and ONSD\u002FETD Ratio Measurement From Ocular Ultrasound","ONSD ETD","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Patients scheduled for laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I or II.\n\nExclusion Criteria:\n\n* History of intracranial space-occupying lesion or high intracranial pressure (ICP).\n* History of abdominal trauma.\n* History of orbital\u002Focular trauma.","80 Years",{"count":59,"type":21},68,"OBSERVATIONAL","The aim of this study is to evaluate the effects of different carbon dioxide gas insufflation pressures on the ultrasound-guided optic nerve sheath diameter in patients undergoing laparoscopic cholecystectomy and to determine the possible relationship between these changes and intracranial pressure. The study aims to gain a better understanding of the neurophysiological effects of gas pressures used during laparoscopic surgery and to obtain scientific data aimed at improving patient safety.",[29,63,64],"Intracranial Pressure Increase","Laparoscopic Cholecystectomy Surgery",[34,66,67,68],"ETD","Laparoscopic Cholecystectomy","intracranial pressure increase","2026-08-20",{"date":39,"type":40},{"date":72,"type":21},"2026-08-30",{"date":74,"type":21},"2026-10-30",{"name":76,"class":47},"Gaziantep City Hospital"]