[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-cancer--oral-squamous-cell-carcinoma-oral-cavity-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-cancer--oral-squamous-cell-carcinoma-oral-cavity-cancer":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100647853","effects-of-a-perma-h-model-mobile-based-rehabilitation-support-program-on-hope-self-efficacy-perceived-social-support-and-rehabilitation-outcomes-in-post--tracheostomy-oral-cancer-patients-100647853",false,"NCT07714967","Effects of a Perma-h Model Mobile-based Rehabilitation Support Program on Hope, Self-efficacy, Perceived Social Support and Rehabilitation Outcomes in Post- Tracheostomy Oral Cancer Patients","Inclusion Criteria:\n\n* Aged ≥18 years\n* Pathologically diagnosed with oral squamous cell carcinoma and undergoing, or scheduled to undergo, tracheostomy followed by decannulation\n* Fully conscious, with a Glasgow Coma Scale score of 15, and able to successfully complete the Three-Step Command Test, indicating intact comprehension ability\n* Able to communicate effectively through verbal speech or alternative methods, including writing, gestures, electronic device input, or voice-assisted tools\n* Able to use WeChat independently or after brief guidance, without communication barriers\n* Has at least one regular family caregiver; both the patient and caregiver fully understand the study content and voluntarily provide written informed consent\n* Free from severe cardiovascular, cerebrovascular, hepatic, renal, or pulmonary disease\n\nExclusion Criteria:\n\n* Presence of other serious malignancies or extensive tumor metastasis\n* Previous or current diagnosis of severe mental illness, such as schizophrenia or severe bipolar disorder\n* Significant cognitive impairment, severe depressive symptoms, or suicide risk that precludes effective participation in psychological interventions\n* Inability to complete assessments or interventions due to severe hearing, visual, or language impairments\n* Inability to communicate effectively through any available alternative means\n* Lack of access to a smartphone and absence of a designated caregiver\n* Explicit unwillingness or inability to use a mobile-based rehabilitation support program\n* Unexpected inability to complete the full intervention cycle, including planned hospital transfer or prolonged loss to follow-up\n* Concurrent participation in other clinical studies primarily focused on psychological or mobile health interventions that could confound study outcomes","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this study (exploratory sequential design; mixed-methods study) is to evaluate whether a PERMA-H model mobile-based rehabilitation support program delivered to post-tracheostomy oral cancer patients can improve psychological and rehabilitation outcomes, compared with a control group receiving usual care\u002Fstandard support. The study will focus on post-tracheostomy oral squamous cell carcinoma (OSCC) patients (aged ≥18 years) who are undergoing or scheduled to undergo tracheostomy followed by decannulation, and who have adequate communication ability and caregiver support.\n\nThe main questions it aims to answer are:\n\nDoes the PERMA-H model mobile-based rehabilitation support program improve patients' hope? (primary hypothesis\u002Foutcome measure 1) Does the PERMA-H model mobile-based rehabilitation support program improve patients' self-efficacy, perceived social support, and rehabilitation outcomes? (primary hypothesis\u002Foutcome measure 2) If there is a comparison group, researchers will compare the PERMA-H model mobile-based rehabilitation support program (intervention group) to a control group receiving standard\u002Fusual care (control group) to determine differences in outcomes between groups.\n\nParticipants will be asked to complete the main study tasks, including:\n\nparticipating in qualitative interviews to explore their digital needs, expectations, and experiences regarding psychosocial care (Phase I); using the WeChat mini-program platform that incorporates a PERMA-H evidence-based module set and a chatbot (Decannulationbot \u002F Digital rehabilitation Assistant, DDA) as part of the rehabilitation support program; completing validated assessments at study endpoints to measure hope (Herth Hope Index), self-efficacy (General Self-Efficacy Scale), and perceived social support (Perceived Social Support Scale), as well as rehabilitation-related outcomes (including rehabilitation willingness\u002Fparticipation and functional measures such as swallowing function and speech intelligibility as rated by speech-language pathologists).\n\nExpected outcomes include: comprehensive qualitative findings to inform the content and delivery of digital psychosocial support; a functional mobile intervention platform with evidence-based modules validated through expert appraisal and pilot testing; and statistically significant improvements in hope, self-efficacy, perceived social support, and rehabilitation outcomes in the intervention group compared with the control group.",[25,26,27,28,29,30,31,32,33,34],"Tracheostomized Patients","Decanulation","Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer","Rehabilitation Outcome","Mental Health","Hope","Self Efficacy","Perceived Social Support","Swallowing Function","Speech Intelligibility",[36,37,38,39],"PERMA-H","chatbot","Digital Rehabilitation Support","MODEL MOBILE","NOT_YET_RECRUITING","2026-07-15",{"date":43,"type":44},"2026-07-20","ACTUAL",{"date":46,"type":19},"2026-08-01",{"date":48,"type":19},"2027-02-01",{"name":50,"class":51},"Hainan Medical College","OTHER",2,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":20,"phases":63,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100568535","enhancing-oral-cancer-awareness-100568535","NCT06682494","Enhancing Oral Cancer Awareness","Comparative Study on Enhancing Oral Cancer Awareness: Classical Educational Materials vs. AI-Powered Chatbot","Inclusion Criteria:\n\n* Identify as African American as defined by the US Census\n* Participants must be able to read, speak, and write in English\n\nExclusion Criteria:\n\n* Individuals who cannot physically or mentally participate in the research project will be excluded\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Prisoners",true,{"count":62,"type":19},60,[22],"To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention",[66,67,68,69,27,70],"Oral Cancer","Chatbot","Patient Education","Prevention","Oropharyngeal Cancers",[72,73,74],"AI-powered Chatbox","Oral cancer prevention","Socio-economic barriers","RECRUITING","2026-05-07",{"date":78,"type":44},"2026-05-08",{"date":80,"type":44},"2025-09-24",{"date":82,"type":19},"2027-10-31",{"name":84,"class":51},"Virginia Commonwealth University",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":20,"phases":96,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":85},"100606849","proactive-risk-based-optimization--notifications-for-treatment--outcomes-in-head--neck-cancer-100606849","NCT07180901","Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck Cancer","Proactive Risk-based Optimization & Notifications for Treatment & Outcomes (PRONTO) in Head & Neck Cancer: A Strategy to Reduce Delays From Surgery to Post-Operative Adjuvant Therapy in Head and Neck Cancer","PRONTO-HN","Inclusion Criteria:\n\n* All adult patients (age 18 or older).\n* Pathologically confirmed oral cavity or laryngeal squamous cell carcinoma.\n* Diagnosed from July 2024 to September 2026.\n* With planned primary intention surgical resection.\n* With or without adjuvant therapy.\n* Treated at the Centre Hospitalier de l'Université de Montréal.\n\nExclusion Criteria:\n\n* Patients who do not end up receiving surgery.\n* S-PORT \\> 180 days",{"count":95,"type":19},85,[22],"Delays between surgery and the initiation of post-operative radiotherapy (S-PORT) in head and neck cancer (HNC) patients are prevalent and associated with worse oncologic outcomes. This pilot study evaluates whether a proactive, automated care coordination system (PRONTO-HN) can improve adherence to recommended S-PORT intervals of ≤42 days at the Centre hospitalier de l'Université de Montréal (CHUM).\n\nThe study is a single-center, quasi-experimental, interrupted time-series design with two phases. Group A (control) includes patients treated before the intervention (using a prospectively maintained database from August 2024 to August 2025). Group B (intervention) includes patients treated with the new coordination system from September 2025 to September 2026.\n\nThe intervention includes automated alerts, multidisciplinary task coordination, and risk stratification based on a predictive model developed and published by our team. This model uses only pre-operative data to estimate the likelihood that a patient will require adjuvant therapy after surgery, stratifying patients into high- and low-risk categories. High-risk patients receive intensified coordination protocols, including early oncology and dental consultations and shorter target times for pathology results.\n\nPrimary objective: Reduce the proportion of patients with S-PORT \\> 42 days. Secondary\u002Ftertiary objectives: Reduce mean S-PORT time. Evaluate impacts on overall, locoregional, and disease-free survival in a 2- and 3-year follow up study.\n\nPatients are identified at the time the operating room request is submitted. Demographic, clinical, and oncologic data are collected and stored securely in REDCap. As the intervention is administrative in nature and does not modify patient care, consent is waived.\n\nStatistical analysis will evaluate the intervention's effect and identify predictors of delays. A sample of 38 patients per group provides adequate power to detect a drop in S-PORT \\> 42 days from 80% to 50%.",[27,99,100],"Head &Amp;Amp; Neck Squamous Cell Carcinoma","Larynx Squamous Cell Carcinoma",[102,103,104],"Surgery to post-operative radiation therapy interval","Treatment delays","Oral cavity cancer","2025-09-11",{"date":107,"type":44},"2025-09-18",{"date":109,"type":44},"2025-08-21",{"date":111,"type":19},"2029-10-21",{"name":113,"class":51},"Centre hospitalier de l'Université de Montréal (CHUM)"]