[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"osteosarcoma-recurrent-refractory\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:osteosarcoma-recurrent-refractory":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100652525","early-phase-1-68ga-b7-h3-nanobody-immunopet-in-osteosarcoma-100652525",false,"NCT07774533","68Ga-B7-H3 Nanobody ImmunoPET in Osteosarcoma","Clinical Evaluation of a 68Ga-Labeled B7-H3 Nanobody for ImmunoPET Imaging in Patients With Osteosarcoma","Inclusion Criteria:\n\n* Age ≥10 years.\n* Histologically confirmed osteosarcoma.\n* Relapsed or refractory disease following failure of first- or second-line systemic therapy.\n* Ability to understand the study procedures and provide written informed consent (or assent with parental\u002Flegal guardian consent, where applicable).\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Severe uncontrolled systemic disease or medical condition that, in the investigator's judgment, may interfere with study participation or image interpretation.\n* Unable to undergo PET\u002FCT examination.\n* Any condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.","ALL","10 Years","80 Years",{"count":20,"type":21},16,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This study aims to evaluate the safety, feasibility, and imaging performance of a novel 68Ga-labeled B7-H3 nanobody for immunoPET imaging in patients with osteosarcoma. Participants with suspected or histologically confirmed osteosarcoma will undergo 68Ga-B7-H3 nanobody PET\u002FCT imaging according to the study protocol. Imaging findings will be compared with conventional imaging and, when available, histopathological results. The study will assess tracer biodistribution, tumor uptake, lesion detectability, and safety to determine the potential clinical value of B7-H3-targeted immunoPET for the diagnosis and evaluation of osteosarcoma.",[27,28],"Osteosarcoma","Osteosarcoma, Recurrent, Refractory",[27,30,31,32,33,34,35,36],"B7-H3","CD276","ImmunoPET","Gallium-68","Nanobody","PET\u002FCT","Molecular Imaging","RECRUITING","2026-08-17",{"date":40,"type":41},"2026-08-19","ACTUAL",{"date":43,"type":41},"2026-04-01",{"date":45,"type":21},"2026-09-30",{"name":47,"class":48},"Peking University First Hospital","OTHER"]