[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"otolaryngological-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:otolaryngological-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100535977","treatment-of-obstructive-sleep-apnea-with-personalized-surgery-in-children-with-small-tonsils-100535977",false,"NCT06258837","Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils","TOPS-ST","To be in the study:\n\n* Child has a diagnosis of moderate to severe OSA diagnosed by PSG (oAHI ≥ 5).\n* Child age is 2.00 to 17.99 years of age.\n* Child has small tonsils (Brodsky 1+ or 2+) noted during routine physical exam.\n* Caregiver can provide signed and dated consent and is 18 years of age or older at the time of consent.\n* Caregiver can speak, read, and write in English or Spanish.\n* Caregiver is primary caretaker of the child.\n* Child is not expecting their own child.\n* Child is eligible for surgical treatment\n\nCannot be in the study if:\n\n* Child has history of previous tonsillectomy, tonsillotomy, or partial tonsillectomy.\n* Child has any contraindication to surgery (e.g. bleeding disorders).\n* Child has significant cardiopulmonary comorbidity besides OSA requiring supplemental oxygen, subglottic or tracheal stenosis, tracheostomy dependence.\n* Child has a genetic abnormality, Down syndrome, neuromuscular disorder, craniofacial anomaly.\n* Caregiver is unwilling or unable to comply with study procedures.\n* Child is or plans to become a parent themselves.","ALL","2 Years","17 Years",{"count":20,"type":21},175,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to compare the effectiveness of a novel personalized surgical approach to the standard AT in children with small tonsils (ST). This will be accomplished by randomizing children with ST and OSA to one of these two treatments and comparing outcomes after 6 months. It is the investigators' central hypothesis that a personalized drug-induced sleep endoscopy (DISE)-directed surgical approach that uses existing procedures to address the specific fixed and dynamic anatomic features causing obstruction (ie, anatomic endotypes) in each child with ST will perform better than the currently recommended standard first line approach of AT. This novel approach may improve OSA outcomes and reduce the burden of unnecessary AT or secondary surgery for persistent OSA after an ineffective AT. To test this hypothesis, the investigators propose to study children aged 2-17 years with small tonsils and OSA.",[27,28],"Otolaryngological Disease","Obstructive Sleep Apnea","RECRUITING","2026-07-02",{"date":32,"type":33},"2026-07-06","ACTUAL",{"date":35,"type":33},"2024-10-04",{"date":37,"type":21},"2028-09-30",{"name":39,"class":40},"Oregon Health and Science University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":4,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100404539","to-develop-and-validate-a-nasoendoscopic-intelligent-diagnostic-system-for-nasopharyngeal-carcinoma-100404539","NCT04547673","To Develop and Validate a Nasoendoscopic Intelligent Diagnostic System for Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n* Older than 18 years of age\n\nExclusion Criteria:\n\n* Refuse to sign the informed consent statement\n* Patients who have contraindications, e.g. coagulation dysfunction, drug allergy.","18 Years",{"count":49,"type":21},1000,"OBSERVATIONAL","Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province. Endoscopic examination and biopsy are the main methods used for detection and diagnosis of NPC. Early NPC patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced NPC patients.\n\nHere, the investigators focused on the utility of artificial intelligence to detect early NPC, which based on white light imaging (WLI) and Narrow-band imaging (NBI) nasoendoscopic examination. Having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel Computer-Aided Diagnosis System.",[27,53],"Artificial Intelligence",[55,56,57,58],"Nasopharyngeal Carcinoma","Endoscopy","Narrow-Band Imaging","White-Light Imaging","2024-02-16",{"date":61,"type":33},"2024-02-20",{"date":63,"type":33},"2020-06-20",{"date":65,"type":21},"2026-12-31",{"name":67,"class":40},"First Affiliated Hospital, Sun Yat-Sen University",3]