[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"outpatients-with-chronic-heart-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:outpatients-with-chronic-heart-failure":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100657480","biomarker-panel-development-for-early-identification-of-worsening-heart-failure-and-improved-post-acute-care-100657480",false,"NCT07838766","Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care","Integration of Metabolic Assessment on Phenylalanine Axis and Clinical Databank-based Artificial Intelligence Computation in Heart Failure: Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care","Inclusion Criteria:\n\n* Adult men and women aged 18 to 85 years\n* Patients with chronic heart failure diagnosed as stage C or D in outpatient settings. Stage definitions are based on the American Heart Association Heart Failure Classification System.\n* Patients with a recorded left ventricular ejection fraction (LVEF) ≤ 40% in their medical history, but LVEF is not restricted at the time of admission to include patients with heart failure with reduced ejection fraction (HFrEF), heart failure with improved ejection fraction (HFimpEF), and those potentially progressing to heart failure with mildly reduced ejection fraction (HFmrEF)\u002F heart failure with preserved ejection fraction (HFpEF).\n* Patients who have recently been hospitalized for acute heart failure must be discharged and have been clinically stable for at least three months before inclusion.\n\nExclusion Criteria:\n\n* Patients with other serious comorbidities that significantly impact life expectancy or survival within three months based on clinical assessment, such as terminal cancer or severe multiple organ failure.\n* Patients with New York Heart Association (NYHA) class IV and unstable clinical condition requiring frequent intravenous therapy or hospitalization.\n* Patients currently receiving maintenance hemodialysis or peritoneal dialysis.\n* Patients who are unable to complete basic follow-up, lack key clinical data, or do not consent to the use of the specimen and data.","ALL","18 Years","85 Years",{"count":20,"type":21},800,"ESTIMATED","OBSERVATIONAL","Heart failure is a complex clinical syndrome with high hospitalization rates and high mortality risks. While N-terminal-pro B-type natriuretic peptide (NT-proBNP) is widely used in clinical practice to assist in diagnosis and assessment, its ability to detect prognosis in heart failure remains insufficient. Recent scientific research has found that phenylalanine in the blood and its endogenous toxic substance phenylpyruvate are closely related to impaired energy synthesis in heart muscle cells, making them highly promising next-generation long-term biomarkers. Our research team has previously developed a \"risk score\" prediction model that combines phenylpyruvate levels in the blood with clinical data; this project aims to further confirm its clinical value.\n\nTherefore, the investigators cordially invite heart failure patients who are being followed up in the cardiology outpatient clinic to have their \"phenylalanine\" and \"phenylpyruvic acid\" concentrations measured in a small amount of blood. This data, combined with clinical data, will be used to calculate a \"Risk Score\" to identify high-risk heart failure patients earlier.",[25,26],"Outpatients With Chronic Heart Failure","Heart Failure Chronic",[28,29,30,31,32],"outpatients","chronic heart failure","biomarker","phenylalanine","phenylpyruvate","NOT_YET_RECRUITING","2026-09-25",{"date":36,"type":37},"2026-09-29","ACTUAL",{"date":39,"type":21},"2026-09-18",{"date":41,"type":21},"2030-10-31",{"name":43,"class":44},"Chang Gung Memorial Hospital","OTHER"]