[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"overall-survival-all-cause-mortality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:overall-survival-all-cause-mortality":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100610213","exercise-and-mortality-in-middle-aged-and-older-adults-100610213",false,"NCT07224659","Exercise and Mortality in Middle-Aged and Older Adults","Exercise and Mortality in Middle-Aged and Older Adults: A Target Trial Emulation","* Adults enrolled into the PLCO screening trial.\n* Among participants reporting low exercise at Q0 (i.e., 0 or less than 1 day\u002Fweek, with each session \\\u003C15 minutes in duration), completion of an exercise survey at Q1 as part of PLCO standard trial procedures no later than 5 years after reporting non-exercising status \\[i.e., no exercise) at Q0.\n* No evidence of any of the following absolute contraindications to exercise: uncontrolled hypertension, symptomatic valvular disease; hypertrophic cardiomyopathy; unstable angina pectoris; primary pulmonary hypertension; heart failure; severe arrhythmia; diagnosed dementia; any form of cancer other than non-melanoma, and severe infectious disease.","ALL","55 Years","74 Years",{"count":20,"type":21},19000,"ESTIMATED","OBSERVATIONAL","This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).",[25],"Overall Survival (All-cause Mortality)","NOT_YET_RECRUITING","2026-08-18",{"date":29,"type":30},"2026-08-19","ACTUAL",{"date":32,"type":21},"2026-10-01",{"date":34,"type":21},"2026-12-01",{"name":36,"class":37},"City of Hope Medical Center","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":60,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":38},"100646291","phase-2-shuganhuazhuo-formula-for-advanced-hepatocellular-carcinoma-with-damp-heat-syndrome-100646291","NCT07691645","Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome","Shuganhuazhuo Formula (Chinese Herbal Medicine) in the Combined Treatment of Advanced Hepatocellular Carcinoma With Damp-Heat and Blood Stasis Syndrome: An Open-Label Randomized Controlled Trial","DAWNbreak-120","Inclusion Criteria:\n\n1. According to the National Health Commission(China)'s \"Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2026)\", clinically or pathologically diagnosed as primary liver cancer.\n2. Barcelona Clinic Liver Cancer (BCLC) stage is C.\n3. Planning to receive second-line or third-line anti-tumor therapies.\n4. The dominant syndrome in traditional Chinese medicine diagnosis is damp or heat.\n5. Age: ≥ 18 years and ≤ 75 years.\n\nExclusion Criteria:\n\n1. Expected survival is less than 3 months.\n2. Definitive pathological diagnosis of intrahepatic cholangiocarcinoma or combined hepatocellular-cholangiocarcinoma (cHCC-CCA).\n3. Comorbid severe heart, liver, kidney dysfunction:\n\n   1. heart\n\n      * New York Heart Association(NYHA) cardiac function \\> class II\n   2. liver\n\n      * aspartate aminotransferase \\> 3 times the upper limit of normal\n      * alanine aminotransferase \\> 3 times the upper limit of normal\n      * bilirubin \\> 3 times the upper limit of normal\n   3. kidney\n\n      * creatinine clearance (Cockcroft-Gault) \\\u003C 60 mL\u002Fmin)\n4. Concurrent with other malignant tumors.","18 Years","75 Years",{"count":50,"type":21},120,"INTERVENTIONAL",[53],"PHASE2","Primary liver cancer is a malignant tumor with a very poor prognosis. Hepatocellular carcinoma(HCC) accounts for approximately 80% of cases. Under the current targeted and immunotherapy-based treatment approaches, the overall survival of patients with advanced HCC has improved significantly compared to targeted therapy alone. However, there are still limitations in therapeutic effectiveness. In addition to the tumor burden, liver reserve function is associated with the prognosis of HCC. Cirrhosis, tumor burden, and anti-tumor treatment can all lead to damage to liver reserve function, which in turn leads to a decrease in patient survival. Currently, there are no specific treatments for deteriorating liver reserve function; only symptomatic treatments such as reducing transaminase levels, bilirubin levels, and blood ammonia levels, as well as diuretics, are available. The indocyanine green(ICG) clearance test allows for precise, dynamic, and quantitative measurement of liver clearance function, making it a commonly used method for assessing liver reserve function in clinical practice.Previous studies have confirmed that its test results are closely related to the prognosis of HCC.\n\nShuganhuazhuo Formula(SHF) is a Chinese herbal medicine used to treat advanced HCC with syndrome of Damp-Heat and Blood stasis. It can inhibit necrosis in the livers of mice in experimental models, reduce fibrosis scores, and demonstrate potential therapeutic effects in protecting the liver, reducing oxidative stress, and preventing fibrosis.\n\nThis study is an open-label randomized controlled trial. Patients with advanced HCC who are receiving second-line or third-line anti-tumor treatment are randomly assigned in a 1:1 ratio to either the control group or the traditional Chinese medicine (TCM) group. The control group receives anti-tumor treatment as recommended by guidelines, while the TCM group receives additional treatment with SHF. SHF involves decocting traditional Chinese medicine ingredients twice daily. Each time, 150 ml of the decoction is prepared and taken orally half an hour after breakfast and dinner. Treatment lasts for 6 months. During this period, the ICG clearance test is performed every 2 months to assess liver reserve function, and quality of life is also evaluated. After the treatment period, follow-ups on survival and safety are conducted every 3 months. This study aims to evaluate the benefits of the SHF in terms of liver reserve function, overall survival, and quality of life in patients with HCC of the syndrome of Damp-Heat and Blood stasis. It also includes exploratory analyses of differences in biomarker expression during treatment.",[56,57,58,25,59],"HCC - Hepatocellular Carcinoma","Chinese Herbal Medicine","ICG (Indocyanine Green)","Quality of Life",[61,62,63,64,65,66],"Hepatocellular Carcinoma(HCC)","Chinese herbal medicine","Shuganhuazhuo Formula(SHF)","Liver reserve function","Overall survival","Quality of life","2026-07-08",{"date":69,"type":30},"2026-07-09",{"date":71,"type":21},"2026-09-01",{"date":73,"type":21},"2031-08-31",{"name":75,"class":37},"Xiang-Qian"]