[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pain-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pain-postoperative":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,139,0,25,[9,44,71,94,121,149,178,207,236,260,291,317,341,362,387,427,452,480,503,529,558,583,605,632,666],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100609979","phase-4-oral-methadone-in-cardiac-surgery-100609979",false,"NCT07221617","Oral Methadone in Cardiac Surgery","Oral Methadone In Cardiac Surgery","OMICS","Inclusion Criteria:\n\n• Undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n* Chronic pain requiring opioid medications as an outpatient\n* Opioid use disorder on medication assistance treatment\n* Prolonged QTc \\>500ms\n* Chronic kidney disease with eGFR \\\u003C 30mL\u002Fmin\n* Documented cirrhosis\n* Intolerance to methadone\n* Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery\n* Pregnancy at the time of surgery\n* Subsequent surgeries after index surgery","ALL","18 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.",[28,29,30],"Pain, Postoperative","Anesthesia","Cardiac Surgery","RECRUITING","2026-08-20",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2026-01-13",{"date":39,"type":22},"2026-08-31",{"name":41,"class":42},"Mayo Clinic","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100646026","phase-2-liposomal-bupivacaine-vs-standard-bupivacaine-for-post-rhinoplasty-analgesia-100646026","NCT07689162","Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia","Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years) undergoing open rhinoplasty of any indication or complexity (e.g., primary, revision, functional, or cosmetic), including autologous grafting of any type (e.g., septal or costal cartilage) or cadaveric grafting.\n\nExclusion Criteria:\n\n* Chronic pain condition requiring ongoing or scheduled analgesic therapy, or any diagnosis associated with chronic pain (e.g., fibromyalgia, chronic headache\u002Fmigraine, neuropathic pain, complex regional pain syndrome), long-term opioid use (≥3 months, any agent), allergy or contraindication to local anesthetics, acetaminophen, ibuprofen \u002F NSAIDs, tramadol, ketamine, Medrol (methylprednisolone) dose pack\n* Concurrent non-nasal surgery planned",{"count":52,"type":22},45,[54],"PHASE2","The purpose of this study is to find out which pain medication is more effective in reducing pain after nose surgery (rhinoplasty). The investigators are looking to find the best treatment to reduce discomfort and improve the healing process for patients having nose surgery.",[28],[58,59,60,61],"Otolaryngology","Rhinoplasty","Bupivacaine","Liposomal Bupivacaine","2026-08-17",{"date":64,"type":35},"2026-08-18",{"date":66,"type":35},"2026-08-01",{"date":68,"type":22},"2027-07",{"name":70,"class":42},"Washington University School of Medicine",{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100619225","dexamethasone-palmitate-for-postoperative-pain-100619225","NCT07341854","Dexamethasone Palmitate for Postoperative Pain","Effect of Intravenous Dexamethasone Palmitate on Postoperative Pain Prevention","Inclusion Criteria:\n\n1. Age 18-65 years.\n2. Scheduled for a range of surgeries under general anesthesia, including both minimally invasive procedures (such as video-assisted thoracoscopic surgery and laparoscopy) and open surgeries (such as thoracotomy, laparotomy, spinal surgery, total joint replacement, and mastectomy).\n3. Capacity to comprehend the study procedures and assessment scales, and communicate effectively with research staff.\n\n4）Classified as American Society of Anesthesiologists (ASA) physical status I, II, or III.\n\n5\\) Willingness to participate voluntarily and provide written informed consent.\n\nExclusion Criteria:\n\n1. Known hypersensitivity to dexamethasone or its excipients.\n2. Systemic glucocorticoid therapy within 3 months prior to enrolment.\n3. History of severe cardiovascular disease, hepatic or renal failure, or systemic rheumatic disease (e.g., rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus).\n4. Coexisting chronic pain at enrolment.\n5. Uncontrolled diabetes mellitus or active systemic infection.\n6. Use of any systemic or topical analgesics within 48 hours prior to surgery.\n7. Significant cognitive impairment or severe psychiatric disorder.\n8. Pregnancy or lactation.","65 Years",{"count":80,"type":22},446,[82],"NA","Postoperative pain remains highly prevalent and inadequately managed in a significant proportion of surgical patients, often leading to delayed recovery, increased opioid consumption, and potential progression to chronic pain. While perioperative systemic dexamethasone is used for its anti-inflammatory and opioid-sparing effects, its efficacy is inconsistent, and concerns regarding systemic side effects persist. Dexamethasone palmitate, a novel lipophilic prodrug formulated as nanoparticle emulsion, leverages the enhanced permeability and retention effect to target inflammatory sites selectively, potentially offering superior anti-inflammatory and analgesic efficacy with reduced systemic exposure. This trial aims to evaluate whether preoperative intravenous dexamethasone palmitate is more effective than conventional dexamethasone in preventing moderate-to-severe postoperative pain.",[28,85],"Dexamethasone Palmitate",{"date":87,"type":35},"2026-08-19",{"date":89,"type":35},"2026-04-06",{"date":91,"type":22},"2027-12-30",{"name":93,"class":42},"Beijing Tiantan Hospital",{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":23,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100624637","phase-4-effect-of-tegileridine-on-postoperative-bowel-function-recovery-in-abdominal-surgery-100624637","NCT07412223","Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery","Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery: A Multicenter, Randomized, Controlled Trial","Inclusion Criteria:\n\n1. Scheduled to undergo elective abdominal surgery under general anesthesia.\n2. Age ≥ 18 years.\n3. Body Mass Index (BMI) between 18 and 30 kg\u002Fm².\n4. American Society of Anesthesiologists (ASA) physical status classification of I to III.\n5. Requires postoperative analgesia and is capable of correctly using a patient-controlled intravenous analgesia (PCIA) pump.\n6. Understands the trial objectives and voluntarily participates, providing written informed consent.\n\nExclusion Criteria:\n\n1. Undergoing gastrointestinal tract surgery.\n2. Has advanced cancer with ascites or extensive metastasis, or is receiving systemic chemotherapy\u002Fradiotherapy, or requires postoperative hyperthermic intraperitoneal chemotherapy (HIPEC).\n3. Diagnosed or suspected gastrointestinal obstruction or emptying disorder.\n4. History of severe cardiovascular or cerebrovascular disease (e.g., severe sinus bradycardia, myocardial infarction, unstable angina, grade II or higher atrioventricular block, history of arrhythmia, NYHA class II or higher heart failure, ischemic stroke) or abnormal QTcF interval at screening ( \\>450 ms for males, \\>470 ms for females).\n5. Comorbid psychiatric or neurological disorders (e.g., schizophrenia, depression, epilepsy) or cognitive dysfunction.\n6. Known allergy to opioid drugs or any component of the trial medications.\n7. Current acute or chronic pain conditions, or presence of hyperalgesia or other sensory disorders.\n8. Long-term opioid therapy (defined as receiving \\>15 mg morphine milligram equivalents per day for more than 3 days per week, over a period exceeding 1 month within the 12 months prior to surgery).\n9. Pregnant or breastfeeding women, or those with a positive pregnancy test at screening or on the day of surgery; or participants (including males) planning for pregnancy.\n10. Significant hepatic or renal dysfunction (e.g., ALT\u002FAST \\> 3 times the upper limit of normal, or requiring renal replacement therapy).\n11. Planned admission to the Intensive Care Unit (ICU) for postoperative management.\n12. Participation in another interventional clinical trial within the 3 months prior to randomization.\n13. Any other condition deemed by the investigator as unsuitable for participation in this trial.",{"count":102,"type":22},152,[25],"Title: Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery: A Multicenter, Randomized, Controlled Trial\n\nThe goal of this clinical trial is to evaluate the effectiveness and safety of tegileridine, a biased μ-opioid receptor agonist, for patient-controlled intravenous analgesia (PCIA) after abdominal surgery.\n\nThe main question it aims to answer is:\n\nIs tegileridine superior to morphine in promoting the recovery of gastrointestinal function within 72 hours after abdominal surgery?\n\nResearchers will compare the experimental group (receiving Fumarate Tegileridine Injection) to the active control group (receiving Morphine Hydrochloride Injection). Both groups will also receive dexmedetomidine in their PCIA pumps. This comparison will determine if tegileridine is more effective for bowel recovery and has a better safety profile.\n\nParticipants who are scheduled for elective abdominal surgery under general anesthesia will:\n\n1. Be randomly assigned to receive either a tegileridine-based or a morphine-based pain relief pump after surgery.\n2. Use the patient-controlled analgesia (PCA) pump for up to 72 hours postoperatively to manage their pain.\n3. Be assessed for the time it takes for their bowel function to return (tolerating food and having gas or bowel movement).\n4. Have their pain levels, overall recovery quality, sleep quality, and any side effects monitored during hospitalization.\n5. Be followed up 30 days after surgery.",[28,106],"Postoperative Ileus",[108,106,109,110,111],"Tegileridine","Postoperative Pain","GI-3 composite endpoint","Abdominal Surgery","2026-08-12",{"date":62,"type":35},{"date":115,"type":35},"2026-02-24",{"date":117,"type":22},"2027-02-24",{"name":119,"class":42},"Xiangya Hospital of Central South University",3,{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":12,"sex":18,"minAge":128,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":43},"100574268","phase-4-management-of-postoperative-discomfort-in-young-children-following-dental-rehabilitation-under-general-anesthesia-100574268","NCT06757075","Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia","A Comparison of Standard Dose of Ibuprofen Alone, Alternating, or Combined With Acetaminophen for the Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I-II\n* Requiring Oral Rehabilitation under General Anesthesia\n* Possess legal guardians proficient in English\n* Not have a history of any adverse\u002Fallergic reaction to nonsteroidal anti-inflammatory drugs (NSAIDs) or Acetaminophen\n\nExclusion Criteria:\n\n* ASA III or IV\n* Asthma diagnosis\n* Contraindication to acetaminophen or ibuprofen","4 Years","6 Years",{"count":131,"type":22},75,[25],"The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA). In this randomized controlled trial, three analgesic regimens following DRGA in Franciscan Children's Hospital will be compared using both self-report and behavioral measures.\n\nThe analgesic therapies to be investigated are ibuprofen monotherapy, alternating ibuprofen and acetaminophen dual-therapy, and combined ibuprofen and acetaminophen dual-therapy. For the purposes of this study, combined therapy is defined as the simultaneous administration of acetaminophen and ibuprofen at regular intervals, whereas alternating therapy is defined as one analgesic (acetaminophen or ibuprofen) administered within a 3 hour interval of the other.",[28],[136,137,138,139,140],"Dental rehabilitation under general anesthesia (DRGA)","Dental surgery patients 4-6 years","Acetominophen","Ibuprofen","Pacing analgesics","2026-08-10",{"date":112,"type":35},{"date":144,"type":35},"2025-04-16",{"date":146,"type":22},"2027-03",{"name":148,"class":42},"Boston University",{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":165,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":173,"leadSponsor":175,"locationsCount":43},"100649779","transverse-vs-longitudinal-serratus-anterior-plane-block-in-breast-surgery-100649779","NCT07739277","Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery","Efficacy of Transverse Versus Longitudinal Ultrasound Probe Orientation for Serratus Anterior Plane Block on Postoperative Pain in Breast Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* BMI between 18 - 30 kg\u002Fm2\n* Patients scheduled for elective breast surgery\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Infection at the injection site\n* Severe coagulopathy or use of anticoagulants\n* Chronic opioid use or history of neuropathic pain",{"count":157,"type":22},70,[82],"The aim of this prospective, randomized controlled trial is to compare the analgesic efficacy of transverse versus longitudinal ultrasound probe orientations during Serratus Anterior Plane (SAP) block in patients undergoing breast surgery. The study hypothesizes that the longitudinal approach (probe parallel to the ribs) may provide better craniocaudal spread of the local anesthetic, thereby resulting in lower postoperative Visual Analog Scale (VAS) scores and reduced opioid consumption compared to the standard transverse approach.",[161,28,162,163,164],"Fascial Plane Block","Breast Surgery","Acute Pain","Mastectomy",[166,167,168,162],"Serratus Anterior Plane Block","Regional Anesthesia","Postoperative Analgesia","2026-08-06",{"date":171,"type":35},"2026-08-07",{"date":169,"type":35},{"date":174,"type":22},"2027-02-19",{"name":176,"class":177},"Ankara Etlik City Hospital","OTHER_GOV",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":18,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":189,"briefSummary":190,"conditions":191,"keywords":195,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":205,"locationsCount":43},"100541300","comparing-efficiency-of-mirogabalin-and-pregabalin-in-primary-tka-100541300","NCT06328062","Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA","Comparison Efficacy of Mirogabalin and Pregabalin in Total Knee Arthroplasty. a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 50-85 years old\n2. Unilateral primary osteoarthritis undergoing primary TKA\n3. ASA I-III\n\nExclusion Criteria:\n\n1. GFR \\<60\n2. Allergy to drug in this study\n3. Cannot underwent spinal anesthesia and adductor canal block\n4. Taking gabapentinoid within 3 months before surgery\n5. History of previous knee surgery\n6. Severe liver disease","50 Years","85 Years",{"count":188,"type":22},80,[82],"The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty.\n\nThe main question\\[s\\] it aims to answer are:\n\n• Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty.\n\nParticipants will randomized to mirogabalin or pregabalin group and will take the drug for 2 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.",[192,193,194],"Pain Postoperative","Osteoarthritis","Total Knee Arthroplasty",[196,197,198,199],"mirogabalin","pregabalin","pain postoperative","TKA","2026-08-04",{"date":171,"type":35},{"date":203,"type":35},"2024-04-01",{"date":39,"type":22},{"name":206,"class":42},"Thammasat University Hospital",{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":215,"sex":216,"minAge":19,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":43},"100470019","maternal-mindfulness-depression-and-postpartum-pain-100470019","NCT05400382","Maternal Mindfulness: Depression and Postpartum Pain","Maternal Mindfulness to Prevent Depression and Reduce Postpartum Pain (MaMiDaPP) Intervention","MaMiDaPP","1. Women must self-identify as Latina\u002FLatinx\u002FHispanic, Asian, African American, or non-Hispanic White.\n2. Scheduled to undergo a planned cesarean delivery.\n3. Be of 18-45 years of age\n4. Have a singleton pregnancy\n5. Score between 5 and 13 on the Edinburgh Postnatal Depression Scale (EPDS)\n6. A history of depression\n7. Have no chronic pain condition (e.g., fibromyalgia)\n8. Own a computer, smartphone, or tablet\n9. Have a reliable internet access to complete the online surveys.\n10. Be proficient in English or Spanish.",true,"FEMALE","45 Years",{"count":131,"type":22},[82],"This phase I clinical trial tests the feasibility and safety of a self-guided, mobile mindfulness-based intervention to reduce post-cesarean pain and prevent postpartum depression.",[222,28],"Depression, Unipolar",[224,225,226,227],"postpartum","depression","pain","cesarean","2026-08-03",{"date":169,"type":35},{"date":231,"type":35},"2025-12-01",{"date":233,"type":22},"2028-03-31",{"name":235,"class":42},"University of Illinois at Urbana-Champaign",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":216,"minAge":19,"maxAge":243,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":4,"overallStatus":250,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":43},"100650425","one-level-and-bi-level-espb-application-in-patients-undergoing-breast-surgery-100650425","NCT07747623","One-level and Bi-level ESPB Application in Patients Undergoing Breast Surgery","Comparison of the Efficiency of One-Level and Bi-Level ESPB ESPB for Postoperative Analgesia in Patients Undergoing Breast Surgery","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* American Society of Anesthesiologists physical status I-II-III\n* Body mass index between 18 and 30 kg\u002Fm²\n* Patients undergoing elective breast surgery\n\nExclusion Criteria:\n\n* Patient refusing the procedure\n* History of chronic analgesic or opioid therapy\n* History of local anesthetic allergy\n* Infection in the intervention area","80 Years",{"count":157,"type":22},[82],"Acute pain after breast surgery can significantly reduce the quality of life for patients. If acute pain is not adequately treated, it can develop into chronic pain. Thoracic epidural analgesia, thoracic paravertebral block, erector spinae plane block, and serratus anterior plane block are frequently applied blocks. However, ESPB, being a fascial plane block, can yield inconsistent results regarding distribution and dermatomal area. In recent years, there has been an increase in publications applying ESPB from two levels to achieve wider distribution. As a result, this study aims to compare the analgesic efficacy of single-level (Thoracic 3) and two-level (Thoracic 2, Thoracic 4) ESPB applications.",[28,162,248,249],"Erector Spinae Plane Block","Multimodal Analgesia","NOT_YET_RECRUITING","2026-07-31",{"date":253,"type":35},"2026-08-05",{"date":255,"type":22},"2026-08-14",{"date":257,"type":22},"2027-01-20",{"name":259,"class":42},"Atatürk Chest Diseases and Chest Surgery Training and Research Hospital",{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":18,"minAge":267,"maxAge":243,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":281,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":43},"100373633","closed-loop-deep-brain-stimulation-for-refractory-chronic-pain-100373633","NCT04144972","Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain","Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain Using Summit RC+S","Inclusion Criteria:\n\n1. Age 22-80 years old\n2. Clinical diagnosis of a refractory chronic pain syndrome including\n\n   1. post-traumatic pain syndromes (e.g. root avulsions, nerve crush injuries, spinal cord injury)\n   2. postsurgical pain syndromes (e.g., postmastectomy syndrome, post-thoracotomy syndrome, phantom limb pain, post-surgical spinal pain)\n   3. postherpetic neuralgia\n   4. complex regional pain syndrome\n   5. atypical facial pain\n   6. central pain syndromes (e.g. post-stroke pain, multiple sclerosis pain, post-radiation pain)\n   7. post-radiation plexopathy\n3. Two or more years or more of medically refractory severe pain\n4. Average daily pain for the past 30 days reported as \\>6 on a 0-10 numeric rating scale (NRS)\n5. Pain that fluctuates over a range of at least 3 points on the NRS\n6. Patient has failed at least two pain medications from different classes as determined by a neurologist or pain management specialist with stable doses of medications for 30 days prior to baseline visit.\n7. Lack of a surgically correctible etiology for the pain as determined by 2 independent surgeons\n8. Ability to speak \u002F read English\n9. Capable of understanding and providing informed consent\n10. Absence of significant cognitive impairment - score of 25 or greater on the Montreal Cognitive Assessment (MoCA)\n11. Successful detection of pain biomarkers or positive symptomatic response to inpatient stimulation trial period if performed.\n\nExclusion Criteria:\n\n1. Major medical co-morbidities increasing the risk of surgery including uncontrolled hypertension, coagulopathy, severe diabetes, major organ system failure, active infection or history of implant related infections, immunocompromised state or malignancy with \\\u003C 5 years life expectancy\n2. Presence of cardiac pacemakers\u002Fdefibrillators, implanted medication pumps, intra-cardiac lines, any intracranial implants (e.g., aneurysm clip, shunt, cochlear implant, electrodes) or other implanted stimulators not compatible with RC+S system\n3. Pregnancy or breast feeding: all women of child bearing potential will have a negative urine pregnancy test prior to undergoing their surgical procedure.\n4. Active depression (BDI \\> 20), Suicide attempt \\\u003C\u002F= 12 months or imminent suicide risk, or other untreated or uncontrolled psychiatric illness that evaluating psychiatrist would recommend exclusion of patient after neuropsychiatric evaluation.\n5. History of substance abuse in past 3 years\n6. Inability to stop anticoagulation or platelet anti-aggregation therapy for surgery and recovery.\n7. Implantable hardware not compatible with MRI or with the study.\n8. MR abnormalities that suggest an alternative diagnosis or contraindicate surgery\n9. Previous cranial ablative surgery.\n10. Previous deep brain stimulation surgery using an RC+S incompatible system\n11. Major neurological disorder other than the one that led to the chronic pain including epilepsy or a neurodegenerative condition including inability to recharge the device.\n12. Requires diathermy, electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS)\n13. Allergies or known hypersensitivity to materials in the Summit RC+S system\n14. Patients may be excluded from enrollment due to a condition that, in the judgment of the PI, significantly increases risk or reduces significantly the likelihood of benefit from DBS.","22 Years",{"count":269,"type":22},12,[82],"Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24\u002F7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.",[273,274,28,275,276,277,278,279,280],"Spinal Cord Injuries","Nerve Injury","Post Herpetic Neuralgia","Complex Regional Pain Syndromes","Post-Stroke Pain","Post Radiation Brain Injury","Post Radiation Plexopathy","Nerve Root Avulsion",[282],"Chronic Pain","2026-07-29",{"date":251,"type":35},{"date":286,"type":35},"2019-10-24",{"date":288,"type":22},"2030-10-24",{"name":290,"class":42},"University of California, San Francisco",{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":23,"phases":301,"briefSummary":302,"conditions":303,"keywords":307,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":43},"100601002","autonomic-neural-blockade-in-bariatric-surgery-100601002","NCT07104825","Autonomic Neural Blockade in Bariatric Surgery","Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery","Inclusion Criteria:\n\n* Individuals able and willing to consent and participate in all study activities\n* Adults, ages 18-90\n* All patients with severe obesity undergoing laparoscopic\u002Frobotic gastric bypass or sleeve gastrectomy\n\nExclusion Criteria:\n\n* Patients taking opiates chronically\n* Patients allergic to study medications\n* Patients with any prior adverse reaction to ingredients included in the block\n* Adults unable to consent\n* Pregnant women\n* Prisoners","90 Years",{"count":300,"type":22},200,[82],"The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain\u002Fnausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.",[304,28,305,306],"Bariatric Surgery Candidate","Nausea and Vomiting, Postoperative","Opioid Use",[308],"Autonomic, blockade, bariatric surgery","2026-07-27",{"date":283,"type":35},{"date":312,"type":35},"2026-02-05",{"date":314,"type":22},"2027-12",{"name":316,"class":42},"Endeavor Health",{"id":318,"slug":319,"hasResults":12,"nctId":320,"briefTitle":321,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":215,"sex":18,"minAge":324,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":23,"phases":328,"briefSummary":329,"conditions":330,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":43},"100649062","ipaws-improving-pain-management-after-wisdom-tooth-extraction-surgery-100649062","NCT07731295","iPAWS: Improving Pain Management After Wisdom Tooth Extraction Surgery","iPAWS","Inclusion Criteria:\n\n* Ages 15 to 20 years\n* Undergoing wisdom tooth extraction for the first time\n* Able to read simple English\n* \\*Endorse cannabis use at least two days per week on average in the past 28 days\n\n  \\*The investigator aims to recruit at least 50 participants who are using cannabis at least two days per week in the past 28 days on average and will recruit up to 100 additional participants who use other substances, use cannabis at a lesser intensity, or do not use any substances.\n* (Parent\u002FGuardian only) - Have a child who is undergoing wisdom tooth surgery and is participating in the study\n\nExclusion Criteria:\n\n\\- N\u002FA","15 Years","20 Years",{"count":327,"type":22},150,[82],"This is a clinical trial that will evaluate the feasibility and acceptability of a virtual brief program for adolescents and young adults undergoing wisdom tooth extraction and their parents. The program aims to teach youth safe and effective ways to manage post-surgical pain as well as decrease risky health behaviors.",[28,331],"Substance Use","2026-07-24",{"date":334,"type":35},"2026-07-28",{"date":336,"type":35},"2026-06-29",{"date":338,"type":22},"2026-12-31",{"name":340,"class":42},"Brown University",{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":250,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":4},"100648394","phase-4-acetaminophen-vs-placebo-for-postoperative-analgesia-after-abdominal-surgery-100648394","NCT07720791","Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery","Comparison of Placebo and Acetaminophen on Postoperative Opioid Consumption in Non-Cardiac Abdominal Surgery","Inclusion Criteria:\n\n* Written informed consent\n* Age ≥ 18 years\n* ASA physical status I, II, or III\n* Scheduled for elective non-cardiac abdominal surgery with expected surgery duration ≥ 2 h-hours\n* General anesthesia\n* Planned hospital stay of at least 48 hours\n\nExclusion Criteria:\n\n* Pregnant or nursing (breastfeeding) women\n* Neurologic deficit or chronic pain disease\n* Planned use of regional anesthesia techniques for postoperative pain\n* Emergency surgery",{"count":349,"type":22},1504,[25],"This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill). Patients undergoing planned abdominal surgery under general anesthesia will be randomly assigned to receive either acetaminophen or a placebo tablet before surgery and every 6 hours afterward for 48 hours, in addition to their usual pain medication. Researchers will measure how much opioid pain medication patients need, how much pain they report, and how satisfied they are with their pain control during the first two days after surgery. The goal is to determine whether oral acetaminophen provides a genuine benefit beyond placebo in reducing opioid use while maintaining adequate pain control.",[28],"2026-07-17",{"date":355,"type":35},"2026-07-22",{"date":357,"type":22},"2026-07-15",{"date":359,"type":22},"2027-08-01",{"name":361,"class":42},"Konya City Hospital",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":373,"conditions":374,"keywords":375,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":43},"100632745","phase-4-methadone-for-post-operative-spine-surgery-100632745","NCT07517679","Methadone for Post-operative Spine Surgery","Effect of Post-Induction Methadone on Postoperative Pain, Opioid Use, and Recovery in Spine Surgery","Inclusion Criteria:\n\n* Undergoing elective spine surgery (e.g., fusion, decompression)\n* Expected postoperative inpatient admission\n* Able to provide informed consent\n* Patients with opioid use disorder (OUD) may be included if on stable maintenance therapy\n\nExclusion Criteria:\n\n* Use of regional or neuraxial anesthesia\n* Contraindication to methadone use (e.g., prolonged QTc, allergy, severe hepatic disease)\n* Cognitive impairment precluding consent or accurate pain scoring","120 Years",{"count":371,"type":22},30,[25],"The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes in adult patients undergoing elective spine surgery, with the goal of improving postoperative analgesia and enhancing recovery efficiency. The main questions it aims to answer are the perioperative pain control and opioid requirements between the two groups.\n\nPost-induction methadone can offer equivalent or improved pain control following major spine procedures and reduce intra- and postoperative opioid requirements, improve perioperative pain control and shorten PACU stay.\n\nResearchers will compare perioperative opioid use (morphine equivalents (ME), during the intraoperative and postoperative periods (PACU and 24-hour totals) between the standard intraoperative opioid regimen group and the methadone group.\n\nPatients will be randomized preoperatively to one of two groups: (both groups will receive additional multimodal pain control including opioids, not including methadone, as needed) Standard intraoperative opioid regimen (control) Methadone 0.2 mg\u002Fkg (max 20 mg)\n\nIf the patient is in the methadone group, the patient will receive a predetermined dose of Methadone (0.2mg\u002Fkg) intravenously after induction (they are given medications to sleep for surgery). They will proceed with surgery, and all patients will receive standard of care management regardless of whether they receive Methadone or not. Following the surgery, all study participants will be asked at set times about their pain level and, 24 hours after the surgery, will be asked if they are satisfied with their pain management for the surgery. Data regarding their clinical progression and pain control\u002Fpain medication requirements will be collected for the duration of the hospitalization.",[28],[376,377,378],"methadone","opioids","spine surgery",{"date":380,"type":35},"2026-07-20",{"date":382,"type":35},"2026-06-10",{"date":384,"type":22},"2027-04",{"name":386,"class":42},"Brandon Knopp",{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":18,"minAge":394,"maxAge":395,"enrollmentInfo":396,"targetDuration":4,"studyType":23,"phases":398,"briefSummary":399,"conditions":400,"keywords":404,"overallStatus":250,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":423,"leadSponsor":425,"locationsCount":43},"100645791","phase-4-intravenous-dexamethasone-with-single-shot-versus-continuous-brachial-plexus-block-for-rebound-pain-after-shoulder-surgery-100645791","NCT07699744","Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery","Pain Management Protocol Optimization for Rebound Pain Prevention and Enhanced Recovery After Shoulder Surgery: A Randomized Noninferiority Trial of Intravenous Dexamethasone Combined With Single-Shot Versus Continuous Brachial Plexus Block","Inclusion Criteria:\n\n* Adult patients aged 19 to 79 years scheduled for elective shoulder surgery under brachial plexus block and monitored anesthesia care (MAC)\n\nExclusion Criteria:\n\n* Pre-existing neurological deficit of the brachial plexus\n* Emergency surgery\n* American Society of Anesthesiologists (ASA) physical status classification IV or higher\n* Contraindication or history of hypersensitivity to local anesthetics or dexamethasone\n* Severe pulmonary disease (e.g., chronic obstructive pulmonary disease)\n* Body mass index (BMI) ≥ 35 kg\u002Fm²\n* Long-term use of steroids\n* Long-term use of analgesics\n* Inability to cooperate or communicate\n* Pregnancy","19 Years","79 Years",{"count":397,"type":22},92,[25],"Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area. However, when the effect of a single-injection nerve block wears off, many patients experience sudden, intense pain known as \"rebound pain\".\n\nOne way to prevent rebound pain is to place a thin catheter near the nerves so that local anesthetic can be given continuously for a longer period (continuous nerve block). However, this method is technically demanding and can cause problems such as catheter dislodgement, infection, and inconvenience for patients. Another simpler option is to give a single-injection nerve block together with an intravenous (IV) injection of dexamethasone, a steroid medication known to prolong the effect of nerve blocks and reduce rebound pain.\n\nThe purpose of this study is to determine whether a single-injection nerve block combined with IV dexamethasone (5 mg) is not inferior to a continuous nerve block in preventing rebound pain after shoulder surgery. A total of 92 adult patients scheduled for elective shoulder surgery will be randomly assigned to one of the two groups. The main outcome is the rebound pain score, defined as the difference between the last pain score recorded in the recovery room (while the nerve block is still working) and the highest pain score reported within the first 24 hours after the nerve block. The investigators expect that the simpler single-injection method with IV dexamethasone will provide comparable pain control while avoiding the complications and inconvenience of catheter-based continuous nerve blocks.",[28,401,402,403],"Rebound Pain","Shoulder Injuries","Rotator Cuff Injuries",[405,406,407,408,409,410,411,412,413,414,415,416,417,418],"Rebound pain","Interscalene brachial plexus block","Single-shot nerve block","Continuous peripheral nerve block","Perineural catheter","Dexamethasone","Intravenous dexamethasone","Shoulder surgery","Rotator cuff repair","Regional anesthesia","Postoperative analgesia","Multimodal analgesia","Non-inferiority trial","Enhanced recovery after surgery","2026-07-09",{"date":421,"type":35},"2026-07-13",{"date":357,"type":22},{"date":424,"type":22},"2027-07-15",{"name":426,"class":42},"Seoul National University Hospital",{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":436,"briefSummary":437,"conditions":438,"keywords":439,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":43},"100567130","analgesic-efficacy-of-quadratus-lumborum-vs-transversalis-fascia-block-in-inguinal-hernia-surgery-100567130","NCT06664177","Analgesic Efficacy of Quadratus Lumborum vs. Transversalis Fascia Block in Inguinal Hernia Surgery","Comparison of the Postoperative Analgesic Efficacy of Quadratus Lumborum Block and Transversalis Fascia Block in Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Ages 18-65\n* ASA Classification 1-2\n\nExclusion Criteria:\n\n* Allergy to local anesthetics\n* Presence of infection at the procedure site\n* BMI \\> 35 kg\u002Fm²\n* Bleeding disorders or anticoagulant use\n* Chronic analgesic or opioid use\n* Mental or psychiatric disorders\n* ASA Classification 3-4 patients(Severe COPD, history of cerebrovascular events, liver and kidney disease will be excluded from the study.)",{"count":435,"type":22},60,[82],"It is planned to compare the postoperative analgesic efficacy of the Transversalis Fascia Plane Block and the anterior Quadratus Lumborum Block in elective inguinal hernia surgeries.",[28],[440,441,442],"quadratus lumborum block","Transversalis Fascia Plane Block","inguinal hernia","2026-07-03",{"date":445,"type":35},"2026-07-07",{"date":447,"type":35},"2024-11-01",{"date":449,"type":22},"2026-09-10",{"name":451,"class":177},"Gaziosmanpasa Research and Education Hospital",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":23,"phases":462,"briefSummary":463,"conditions":464,"keywords":469,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":478,"locationsCount":43},"100646601","vr-effects-after-hip-replacement-surgery-pain-100646601","NCT07689461","VR Effects After Hip Replacement Surgery Pain","The Effect of Virtual Reality on Pain, Anxiety, and Comfort Levels After Total Hip Replacement Surgery","THA","Inclusion Criteria:\n\n* Patients scheduled for elective surgery who agree to participate in the study,\n* Individuals 18 years of age or older,\n* Those with adequate cognitive function,\n* Those who have not previously undergone total hip replacement surgery,\n* Those who volunteer to participate in the study and sign the informed consent form,\n* Patients with a pain score (on a scale of 1 to 10) of 4 or higher were included in the study.\n\nExclusion Criteria:\n\n* Individuals under the age of 18,\n* Those previously diagnosed with a chronic pain syndrome (other than hip osteoarthritis),\n* Individuals with impaired cognitive function (severe psychiatric disorders),\n* Individuals who have previously undergone total hip replacement surgery,\n* Individuals with severe hearing or visual impairments,\n* Individuals with a history of opioid dependence,\n* Patients with a pain score (on a scale of 1 to 10) of 4 or lower were excluded from the study.","99 Years",{"count":188,"type":22},[82],"Total Hip Arthroplasty (THA), a procedure performed to enhance the quality of life, is accompanied by postoperative challenges such as pain and anxiety that adversely affect patient comfort. Inadequate management of these complications can prolong the length of hospital stay, delay recovery, lead to functional impairments, and elevate the risk of chronic pain development. Conventional pharmacological interventions employed for management are limited due to their potential for adverse effects and dependency. Virtual reality (VR) is a non-pharmacological distraction technique utilized in the healthcare sector, leveraging advanced technology to maximize patient comfort by alleviating pain and minimizing anxiety.\n\nA review of the literature reveals that while the use of VR has positive effects on pain and anxiety, there is a notable scarcity of high-quality randomized controlled trials concurrently evaluating its impact on pain, anxiety, and comfort levels in postoperative orthopedic procedures such as THA. In this randomized controlled trial, participants in the control group will receive standard care, whereas those in the experimental group will receive a 30-minute VR intervention-offering three distinct options-in addition to standard care during the acute phase of the first 48 hours. Postoperative assessments will be conducted using the Visual Analogue Scale (VAS) for pain intensity, the State Anxiety Inventory for anxiety levels, and the Perianesthesia Comfort Scale for comfort levels.\n\nBy evaluating the potential of VR as a non-pharmacological adjuvant in post-THA care, the findings of this study will provide significant contributions to evidence-based nursing practices aimed at developing multimodal pain management strategies, reducing opioid consumption, and enhancing patient satisfaction.",[465,466,467,468,28],"Virtual Reality","Hip Arthropathy","Comfort","Anxiety",[465,470,109,468,471],"Total Hip Arthroplasty","Comfort Level","2026-07-01",{"date":474,"type":35},"2026-07-08",{"date":476,"type":35},"2025-10-21",{"date":338,"type":22},{"name":479,"class":42},"Adiyaman University",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":4,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":243,"enrollmentInfo":487,"targetDuration":4,"studyType":23,"phases":488,"briefSummary":489,"conditions":490,"keywords":492,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":43},"100471170","randomized-control-trial-cryoablation-as-an-adjunct-to-surgical-stabilization-of-rib-fractures-100471170","NCT05415384","Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures","Single Center, Randomized Control Trial of Cryoablation During Surgical Stabilization of Rib Fractures","Inclusion Criteria:\n\n* The patient is admitted to the trauma service.\n* The patient has multiple displaced rib fractures (≥2 ribs), offered fixation, and consents to SSRF\n* The patient is not being treated for chronic pain\n* The patient is \\>18 years of age.\n* Surgery anticipated \\\u003C120 hours from injury\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or ≥ 80 years\n* Flail chest: either radiographic or clinical. Radiographic flail chest is defined on CT chest as ≥ 2 ribs each fractured in ≥ 2 places. Clinical flail is defined as visualization of a segment of chest wall with paradoxical motion on physical exam.\n* Moderate or severe traumatic brain injury (Intra-cranial hemorrhage visualized on CT head with GCS at the time of consideration for enrollment \\\u003C 12)\n* Prior or expected emergency exploratory laparotomy during this admission\n* Prior or expected emergency thoracotomy during this admission\n* Prior or expected emergency craniotomy during this admission\n* Spinal cord injury\n* Pelvic fracture that has required, or is expected to require, operative intervention during this admission\n* The patient was unable to accomplish activities of daily living independently prior to injury (e.g., dressing, bathing, preparing meals)\n* The patient is incarcerated\n* The patient is known to be pregnant\n* Unable to perform Video Assisted Thoracoscopy (VATS) at time of SSRF due to lung isolation or previous pathology",{"count":188,"type":22},[82],"To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation",[28,491],"Rib Fracture Multiple",[493,494],"Locoregional pain","thoracotomy","2026-06-26",{"date":336,"type":35},{"date":498,"type":35},"2022-08-01",{"date":500,"type":22},"2026-11",{"name":502,"class":42},"Wake Forest University Health Sciences",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":509,"targetDuration":511,"studyType":512,"phases":4,"briefSummary":513,"conditions":514,"keywords":517,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":525,"leadSponsor":527,"locationsCount":43},"100577856","postoperative-pain-of-robotic-endoscopic-and-open-lateral-neck-dissection-100577856","NCT06803732","Postoperative Pain of Robotic, Endoscopic and Open Lateral Neck Dissection","Inclusion Criteria:\n\n* Patients underwent lateral neck dissection via robotic, endoscopic or open approach\n* Clinical diagnosis of differentiated thyroid cancer\n* Clinical diagnosis of metastatic lateral lymph nodes\n\nExclusion Criteria:\n\n* Participants with distant metastasis\n* Participants with history of neck surgery or radiation\n* Participants with vocal fold fixation by preoperative fibrolaryngoscope",{"count":510,"type":22},600,"6 Months","OBSERVATIONAL","Postoperative pain is a good indicator to confirm the advantages of the surgical methods in the era of minimally invasive surgery. Lateral neck dissection requires extensive dissection which may leads to postoperative numbness and pain. Robotic thyroid surgery has the advantage of precise and careful dissection and avoid the L-shape incision in the open approach. The study aims to explore the pain intensity and severity of lateral neck dissection on operation day, postoperative month 1 and postoperative month 3 among the robotic, endoscopic and open approach.",[28,515,516],"Thyroid Diseases","Surgery",[518,519,520],"Lateral neck dissection","Robotic thyroid surgery","Minimally invasive surgery","2026-06-20",{"date":523,"type":35},"2026-06-24",{"date":447,"type":35},{"date":526,"type":22},"2027-12-31",{"name":528,"class":42},"Shanghai 6th People's Hospital",{"id":530,"slug":531,"hasResults":12,"nctId":532,"briefTitle":533,"officialTitle":534,"acronym":4,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":298,"enrollmentInfo":536,"targetDuration":4,"studyType":23,"phases":538,"briefSummary":540,"conditions":541,"keywords":545,"overallStatus":250,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":43},"100644172","phase-3-liposomal-bupivacaine-plus-plain-bupivacaine-versus-dexamethasone-plus-plain-bupivacaine-in-the-supraclavicular-brachial-plexus-block-in-patients-with-risk-factors-for-severe-acute-postoperative-pain-100644172","NCT07665762","Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain","Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologist (ASA) status I-III\n* Age 18-90 years old\n* Scheduled for distal radial fracture fixation (Open reduction and internal fixation with volar approaching locking plate)\n* Informed consent obtained\n* Patients identified to be at an elevated risk of suffering from poor postoperative pain control. Patients with one or more of the following risk factors:\n\n  * Severe preoperative pain: defined as worse numerical rating scale (NRS) pain score equal or higher than 6\u002F10 with arm movements at day before surgery.\n  * Preoperative use of opioid: use of strong opioids such as morphine, oxycodone\n  * Depressive symptoms: Patient health questionnaire (PHQ-9) score of 10 or above\n  * Anxiety symptoms: General Anxiety Disorder (GAD-7) score of 10 or above\n  * Higher energy and high-grade fracture cases - road traffic accident, fall from height, open fractures, combined distal radius and distal ulna fractures, fractures requiring external fixation, fractures with severe articular comminution or severe metaphyseal extension, comminuted fractures requiring more than a single volar approach incision and a single volar locking plate implant\n\nExclusion Criteria:\n\n* Revision surgery\n* Previous fractures or surgery in the affected distal radius\n* Surgery involving more than the affected arm\n* Cases with baseline (pre-injury) QuickDASH score worse (higher) than 10 out of 100\n* Respiratory compromise (requires long term oxygen)\n* History of seizures\n* Pre-existing neurological disorder\u002Fdeficit\n* Alcohol or substance abuse\n* Impaired mental state\n* Local infection\n* Allergy to analgesic drugs: local anaesthetic drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), opioids\n* Impaired renal function (defined as effective glomerular filtration rate \\\u003C 30ml\u002Fmin\u002F1.73m2\n* Impaired liver function (defined as plasma bilirubin over 34μmol\u002FL; international normalized ratio \\[INR\\] ≥1.7, alanine aminotransferase \\[ALT\\] over 100U\u002FL, aspartate aminotransferase \\[AST\\] over 100U\u002FL)\n* Coagulopathy (platelet count \\\u003C100,000\u002Fml and\u002For INR ≥ 1.5) or the use of anticoagulants (not including aspirin) that precludes the use of supraclavicular BPB\n* Pregnancy\n* Patient refusal for regional nerve blocks\n* Patient refusal to join the clinical trial\n* Patient unable\u002Funwilling to attend post-op rehabilitation programme",{"count":537,"type":22},90,[539],"PHASE3","The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery. Adding liposomal bupivacaine to BPB has shown promise in enhancing postoperative pain control. A previous randomized controlled trial demonstrated that it reduced pain scores and OBAS compared to plain bupivacaine alone, especially on postoperative day (POD) 1. Adding adjuncts to non-liposomal local anaesthetics can also enhance and prolong postoperative pain relief. The effectiveness of liposomal bupivacaine compared to adjuncts like dexamethasone and dexmedetomidine remains unclear. Since liposomal bupivacaine is more expensive, it is crucial to compare its analgesic efficacy with these alternatives. A randomized controlled trial comparing liposomal bupivacaine versus dexamethasone in the interscalene BPB for shoulder surgery found that liposomal bupivacaine resulted in statistically significantly lower pain scores and less pain interference in the Brief Pain Inventory, although the reduction was not considered clinically relevant. Its high cost may therefore limit its routine use unless specific clinical contexts where its efficacy is maximized are identified. Notably, patients with risk factors like psychological factors, preoperative pain, and prior analgesic use may benefit most from its application.\n\nA randomized controlled trial to compare the analgesic efficacy of liposomal bupivacaine plus plain bupivacaine versus dexamethasone plus plain bupivacaine in supraclavicular BPB for patients at higher risk of poor acute pain control post distal radial fracture surgery will be conducted. Patients with severe preoperative pain, opioid use, depressive symptoms, anxiety symptoms, and\u002For higher energy and high-grade fracture cases will be selected. The primary outcome measured is the intensity of acute postoperative pain with movement in the first 48 hours after surgery. Important secondary outcomes include pain intensity at rest, opioid consumption, OBAS scores, chronic pain, and upper limb functionality.",[28,61,410,542,543,544],"Supraclavicular Brachial Plexus Block","High Risk Factors","Distal Radial Fracture",[546,547,548,549,226],"supraclavicular brachial plexus block","liposomal bupivacaine","dexamethasone","distal radial fracture","2026-06-18",{"date":523,"type":35},{"date":553,"type":22},"2026-06-15",{"date":555,"type":22},"2029-03-01",{"name":557,"class":42},"The University of Hong Kong",{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":564,"enrollmentInfo":565,"targetDuration":4,"studyType":23,"phases":567,"briefSummary":568,"conditions":569,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":582},"100429589","phase-3-prevention-of-persistent-pain-with-lidocaine-infusions-in-breast-cancer-surgery-plan-100429589","NCT04874038","Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. Undergoing a unilateral or bilateral lumpectomy or mastectomy, inclusive of all pathologies, including prophylactic surgery (e.g., family history or BRCA gene mutation)\n\nExclusion Criteria:\n\n1. Previous breast surgery within 6 months of index surgery\n2. Undergoing any autologous flap procedure during index surgery\n3. Presence known chronic pain disorder involving surgical site or ipsilateral chest wall, shoulder, or arm during the 3-months prior to index surgery\n4. Documented hypersensitivity or allergy to lidocaine\n5. Surgery not planned to be performed under general anesthesia and\u002For planned use of regional or neuraxial anesthetic techniques before surgery (i.e., epidural, paravertebral, serratus plane block, pectoralis or modified pectoralis block)\n6. History of ventricular tachycardia, ventricular fibrillation, or atrioventricular block without a pacemaker\n7. Known cirrhotic liver disease\n8. Pregnant\n9. Unlikely to comply with follow-up (e.g. no fixed address, language difficulties that would impede valid completion of questionnaires, plans to move out of town)","100 Years",{"count":566,"type":22},1602,[539],"Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.",[570,571,28,572],"Post-mastectomy Pain Syndrome","Breast Cancer","Pain, Chronic","2026-06-17",{"date":575,"type":35},"2026-06-22",{"date":577,"type":35},"2021-09-22",{"date":579,"type":22},"2026-11-01",{"name":581,"class":42},"University Health Network, Toronto",17,{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":590,"enrollmentInfo":591,"targetDuration":4,"studyType":23,"phases":592,"briefSummary":593,"conditions":594,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":601,"leadSponsor":603,"locationsCount":43},"100642944","comparison-of-the-rhomboid-intercostal-block-and-serratus-posterior-superior-intercostal-plane-block-100642944","NCT07650877","Comparison of the Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block","Comparison of the Effects of Ultrasound-Guided Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Acute Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Patients undergoing elective VATS\n* Patients aged 18-75 years\n* Patients with ASA (American Society of Anesthesiologists) class I-III\n* Patients who have given informed consent\n\nExclusion Criteria:\n\n* Patients allergic to local anesthetics\n* Patients with bleeding disorders or those undergoing anticoagulant therapy\n* Pregnant and breastfeeding women\n* Patients with impaired consciousness, inability to communicate, or mental\u002Fcognitive impairment\n* Patients who refuse block application\n* Patients with infection in the area where the block will be applied","75 Years",{"count":537,"type":22},[82],"Video-assisted thoracic surgery (VATS) is widely performed for the management of various thoracic pathologies and is generally associated with reduced surgical trauma compared with open thoracotomy. Nevertheless, patients may still experience considerable postoperative pain, which can adversely affect respiratory function, mobilization, and recovery. Various regional analgesic techniques have been incorporated into multimodal pain management strategies for VATS, including thoracic paravertebral block (TPVB), erector spinae plane block (ESPB), intercostal nerve block, serratus anterior plane block (SAPB), rhomboid intercostal block (RIB), and serratus posterior superior intercostal plane block (SPSIPB). Among these approaches, ultrasound-guided TPVB has traditionally been regarded as a reference regional analgesic technique. More recently, interfascial plane blocks have gained increasing attention because of their technical simplicity and favorable safety profile. RIB and SPSIPB are two novel interfascial plane blocks that may provide effective postoperative analgesia following thoracic surgery. The present study aims to compare the analgesic efficacy of RIB and SPSIPB in patients undergoing VATS and to evaluate their impact on postoperative pain outcomes.",[28,249,595,596,597],"Rhomboid Intercostal Block","Serratus Posterior Superior Intercostal Plane Block","Thoracic Surgery, Video-Assisted",{"date":599,"type":35},"2026-06-16",{"date":553,"type":35},{"date":602,"type":22},"2026-11-30",{"name":604,"class":42},"Ankara City Hospital Bilkent",{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":215,"sex":18,"minAge":19,"maxAge":78,"enrollmentInfo":612,"targetDuration":4,"studyType":23,"phases":614,"briefSummary":615,"conditions":616,"keywords":618,"overallStatus":250,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":627,"completionDateStruct":628,"leadSponsor":630,"locationsCount":43},"100641067","phase-2-phase-ii-randomized-double-blind-placebo-controlled-clinical-trial-to-evaluate-the-efficacy-and-safety-of-omega-3-fatty-acids-as-an-adjunct-to-morphine-in-acute-postoperative-pain-100641067","NCT07657468","Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain","O3MORPH","Inclusion Criteria:\n\n1. Able to provide written informed consent prior to any study procedures;\n2. Able to communicate clearly with the Investigator and staff;\n3. Males and females aged 18 to 65;\n4. American Society of Anesthesiologists (ASA) risk class of I to II;\n5. Patients with an indication for laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with reduced kidney function (serum creatinine level above 2 mg\u002Fdl).\n* Sensitive to local anesthetics.\n* A history of hepatic insufficiency.\n* Chronic pain.\n* Patients with diabetes.\n* Patients with Body Mass Index (BMI) greater than 35 kg\u002Fm2.\n* Daily intake of analgesics or corticosteroids.\n* Patients with Inflammatory bowel disease.\n* Chronic opioid use.",{"count":613,"type":22},40,[54],"This is a single-center, randomized, double-blind, placebo-controlled, parallel-group proof-of-concept study to evaluate the analgesic efficacy and safety of omega-3 fatty acids as an adjunct to morphine for acute postoperative pain following laparoscopic cholecystectomy.\n\nPatients will receive either omega-3 fatty acid supplementation or a placebo before and after surgery. At the end of surgery, a loading dose of morphine of 0.04 mg\u002Fkg body weight will be administered intravenously as a bolus in both groups. The primary endpoint will be the total amount of rescue morphine used during the first 24 postoperative hours.",[192,617],"Analgesia",[619,620,621,622,623,624],"analgesia","post-operation pain","analgesic adjunct","morphine reduction","omega-3 fatty acids","lapararoscopic cholecystectomy","2026-06-13",{"date":550,"type":35},{"date":553,"type":22},{"date":629,"type":22},"2026-10-31",{"name":631,"class":42},"National University of La Rioja",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":638,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":23,"phases":641,"briefSummary":642,"conditions":643,"keywords":649,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":658,"startDateStruct":660,"completionDateStruct":662,"leadSponsor":664,"locationsCount":43},"100611379","peng-block--lia-for-endoprosthesis-surgery-100611379","NCT07239817","PENG Block + LIA For Endoprosthesis Surgery","PENG 360°: PENG Block + LIA Nella Endoprotesi di Anca.","PENG 360°","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form.\n* Scheduled for hip endoprosthesis surgery for femoral fracture with an anterior approach.\n* Age 18 years or older.\n* Willing and able to comply with the study protocol.\n\nExclusion Criteria:\n\n* Failure to provide informed consent.\n* Age less than 18 years.\n* Known allergy to local anesthetics or other medications used in the protocol.\n* Presence of infection at the planned injection site.\n* Pre-existing hip prosthesis or prior major surgery on the same hip (e.g., revision surgery).\n* ASA physical status class \\> IV.\n* Administration of intraoperative opiates or conversion to general anesthesia.",{"count":21,"type":22},[82],"The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery. The main questions it aims to answer are:\n\n* Is the new local anesthesia technique as effective as standard spinal anesthesia in managing pain during the first two days after surgery?\n* Does the new technique allow participants to move their leg sooner after the operation?\n\nResearchers will compare the new local anesthesia technique (numbing medicine injected directly around the hip joint) to standard spinal anesthesia (a numbing injection in the back) to see if the new technique works just as well for pain control while possibly causing fewer side effects like nausea.\n\nParticipants who join this study will be randomly placed into one of two groups.\n\nOne group will receive the standard spinal anesthesia before their surgery.\n\nThe other group will receive the new local anesthesia technique before their surgery.\n\nAfter the operation, researchers will track the amount of extra pain medicine each participant uses and will check their ability to move their hip, knee, and foot.",[644,645,28,646,647,648],"Hip Fractures","Arthroplasty, Replacement, Hip","Anesthesia and Analgesia","Nerve Block","Local Anesthesia Infiltration",[650,651,652,653,654,109,655,656,657],"Pericapsular Nerve Group Block","PENG block","Local Infiltration Analgesia","Spinal Anesthesia","Hip Arthroplasty","Femoral Fractures","Ultrasound Guidance","Early Mobilization",{"date":659,"type":35},"2026-06-12",{"date":661,"type":35},"2025-12-09",{"date":663,"type":22},"2026-12-30",{"name":665,"class":42},"ASST Gaetano Pini-CTO",{"id":667,"slug":668,"hasResults":12,"nctId":669,"briefTitle":670,"officialTitle":670,"acronym":4,"eligibilityCriteria":671,"healthyVolunteers":215,"sex":216,"minAge":19,"maxAge":4,"enrollmentInfo":672,"targetDuration":4,"studyType":23,"phases":673,"briefSummary":674,"conditions":675,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":677,"startDateStruct":678,"completionDateStruct":680,"leadSponsor":682,"locationsCount":43},"100541060","analgesic-efficacy-of-surgeon-administered-transversus-abdominis-plane-blocks-for-caesarean-section-100541060","NCT06324942","Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.","Inclusion Criteria:\n\n* ASA status II to III\n* All patients undergoing elective CS under regional anesthesia at any gestational age.\n\nExclusion Criteria:\n\n* \\- Known drug allergy to local anesthetics\n* Planned general anesthetic\n* NSAID use contraindicated post partum\n* Chronic pain disorder or chronic narcotic use\u002Fdependence\n* Planned vertical abdominal incision\n* Planned Cesarean Hysterectomy.\n* Placenta Previa or suspected Placenta Accreta",{"count":188,"type":22},[82],"The purpose of this research study is to evaluate whether or not adding a Transversus Abdominis Plane Block (TAP block) improves pain control for patients having a cesarean section. A TAP block is a type of nerve block where at the end of the surgery an injection of a long acting local anesthetic is made into the abdominal wall. In studies in patient's having other abdominal surgeries this has reduced the amount of narcotics patients need for pain control. This may also led to patients being more active after surgery and maybe spending less time in hospital.",[676,28],"Cesarean Section Complications",{"date":553,"type":35},{"date":679,"type":35},"2025-02-19",{"date":681,"type":22},"2026-12",{"name":683,"class":42},"University of Calgary"]