[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"panoramic-radiography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:panoramic-radiography":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100650871","effects-of-long-term-antihistamine-use-on-mandibular-bone-in-children-100650871",false,"NCT07752485","Effects of Long-Term Antihistamine Use on Mandibular Bone in Children","Effects of Long-Term H1 Antihistamine Use on Mandibular Trabecular Bone Structure and Panoramic Mandibular Index in Children: A Retrospective Radiographic Study","Inclusion Criteria\n\n* Children aged 8 to 10 years.\n* Availability of a diagnostic-quality digital panoramic radiograph obtained as part of routine dental care.\n* Presence of complete mandibular permanent first molars and permanent incisors.\n* Belonging to one of the following study groups:\n* Children receiving regular H1 antihistamine therapy for at least 12 months.\n* Children diagnosed with an allergic disease who have not received H1 antihistamine therapy during the previous 12 months.\n* Healthy children without allergic disease or long-term antihistamine use.\n* Availability of complete medical and dental records. Exclusion Criteria\n* History of systemic diseases or conditions known to affect bone metabolism.\n* Use of medications affecting bone metabolism (other than H1 antihistamines in the antihistamine group).\n* Craniofacial anomalies or syndromes.\n* History of orthodontic treatment.\n* Previous mandibular trauma or surgery.\n* Presence of radiographic pathology affecting the mandibular regions of interest (e.g., cysts, tumors, fractures, or extensive bone lesions).\n* Poor-quality panoramic radiographs with positioning errors or artifacts that interfere with image analysis.\n* Missing permanent first molars or incomplete eruption of teeth required for the analysis.",true,"ALL","8 Years","10 Years",{"count":21,"type":22},84,"ESTIMATED","OBSERVATIONAL","The purpose of this retrospective radiographic study is to evaluate the effects of long-term H1 antihistamine use on mandibular trabecular bone structure in children aged 8-10 years. Mandibular trabecular bone will be assessed using fractal dimension analysis and the panoramic mandibular index on digital panoramic radiographs. Three groups will be compared: children receiving long-term H1 antihistamine therapy, allergic children without antihistamine use, and age- and sex-matched healthy controls. The findings will provide information on whether long-term antihistamine therapy is associated with alterations in mandibular bone microarchitecture.",[26,27],"Fractals","Panoramic Radiography","NOT_YET_RECRUITING","2026-08-03",{"date":31,"type":32},"2026-08-07","ACTUAL",{"date":29,"type":22},{"date":35,"type":22},"2026-09-03",{"name":37,"class":38},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER"]