[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"partially-edentulous-maxilla\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:partially-edentulous-maxilla":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100657209","early-phase-1-radiographic-changes-in-the-maxillary-sinus-following-closed-sinus-augmentation-with-leukocyte-platelet-rich-fibrin-100657209",false,"NCT07836725","Radiographic Changes in the Maxillary Sinus Following Closed Sinus Augmentation With Leukocyte Platelet Rich Fibrin","Radiographic Changes in the Maxillary Sinus Following Closed Sinus Augmentation With Leukocyte Platelet Rich Fibrin (L-PRF)","Inclusion Criteria:\n\n1. Ability of participant to understand and the willingness to sign a written informed consent document.\n2. English speaking.\n3. Individuals who are normal healthy or have a diabetes diagnosis with a current HbA1c \\\u003C 7.0.\n4. Partially edentulous patients (18-85 years of age) requiring maxillary sinus augmentation for dental implant placement\n5. At minimum 5mm of native bone below the maxillary sinus inferior border\n\nExclusion Criteria:\n\n1. Maxillary sinus disease\n2. Diabetes diagnosis with a current HbA1c \\> 7.1 or greater, or if HbA1c status cannot be confirmed, due to diabetes effect on bone metabolism\n3. Pregnant or attempting to become pregnant\n4. Having a disease that affects bone metabolism\n5. Use of medications known to affect bone metabolism\n6. Tobacco, cannabis or vaping use\n7. Alcoholism or other recreational drugs","ALL","18 Years","85 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","An examination of the participants mouth is done first. If they do not have enough bone to place a dental implant as a tooth replacement, and they have chosen sinus augmentation to treat this issue during implant placement a leukocyte platelet rich fibrin (L-PRF) will be performed instead of using other available options. The only difference from usual care is that L-PRF alone will be used as the bone formation material and two additional x-rays, Cone Beam Computed Tomography (CBCTs) will be taken right after the procedure and then again six months after treatment. CBCT is a special type of 3D X-ray commonly used in dentistry and oral surgery. Unlike traditional X-rays, which create flat 2D images, CBCT produces detailed 3D images of your teeth, jawbone, nerves, and nearby tissues.",[27],"Partially Edentulous Maxilla",[29,30,31],"Dental implant","Maxillary sinus augmentation","L-PRF","NOT_YET_RECRUITING","2026-09-17",{"date":35,"type":36},"2026-09-23","ACTUAL",{"date":38,"type":21},"2027-01",{"date":40,"type":21},"2029-01",{"name":42,"class":43},"The University of Texas Health Science Center at San Antonio","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100551439","peri-implant-bone-formation-of-grafted-sites-around-hydrophilic-and-non-hydrophilic-dental-implants-100551439","NCT06460103","Peri-implant Bone Formation of Grafted Sites Around Hydrophilic and Non-hydrophilic Dental Implants","Effect of Implant Surface Hydrophilicity on Peri-Implant Bone Formation Around Simultaneously Grafted Transiently Placed Titanium Zirconium Dental Small Diameter Implants - A Randomized Controlled Human Histometric Clinical Trial","Inclusion Criteria:\n\n* Patient age ≥ 18 years\n* Patients with a diagnosed indication for single tooth extraction and scheduled for consented replacement by an implant-based restoration requiring prior bone augmentation\n* Only patients displaying periodontally healthy teeth adjacent to the extracted teeth shall be included (probing depth (PD) \\\u003C 4mm, no bleeding on probing (BOP)\n* Patients must be physically and psychologically able to undergo implant surgery and restorative procedures (American Academy of Anesthesiologist class I or II)\n\nExclusion Criteria:\n\n* Presence of any general contra-indication related to implant therapy\n* Heavy smokers ( ≥10 cigarettes\u002Fday)\n* Patients displaying a history of uncontrolled metabolic disorders (e.g. diabetes mellitus)\n* Patients with a history of malignancy, radiotherapy, or chemotherapy\n* Pregnant or breast feeding patients\n* Patients with a history of immunodeficiencies\n* Patients displaying any metabolic bone disease\n* Patients with disturbed bone or wound healing\n* Patients with untreated or active periodontitis (BOP and PD\\>5mm)\n* Extraction sites displaying an absent or defections buccal bone plate\n* Vulnerable patients will be excluded from the study.",{"count":53,"type":21},70,[55],"NA","Although bone grafting at the same time as the placement of dental implants is a common procedure in implantology, there are currently no data on the influence of different types of implant surfaces on bone healing, which is crucial for implant stability.\n\nThe primary objective of this study is to assess if implant surface properties, i.e. hydrophilicity, affect the osseointegration of the implant in simultaneously augmented bone.\n\nThe secondary objective is to assess if implant surface properties, i.e. surface hydrophilicity, may affect the quantity of newly formed bone in the implant in simultaneously augmented bone.\n\nSurface hydrophilicity modification is a well-adapted concept in dental implantology and is clinically well-established.\n\nIn this prospective study, all participants will receive a bone graft after extraction. After randomization, one group will receive a provisional SLA surface implant and another group will receive a provisional SLActive surface implant. The same standard surgical procedure will be performed for both groups when the definitive implant will be placed.\n\nThe study will run for a total of 3 year, and 35 patients per group will be included.\n\nThe Straumann SLA and SLActive implants, Maxgraft allograft and collprotect collagen membranes used in this study are all approved products on the Swiss market.",[27,58],"Partially Edentulous Mandible",[60,61,62],"Dental implants","SLActive","Hydrophile surface","2024-06-10",{"date":65,"type":36},"2024-06-14",{"date":67,"type":21},"2024-07",{"date":69,"type":21},"2027-12",{"name":71,"class":43},"University Hospital, Geneva"]